Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) serves as a moderately effective autotaxin (ATX) inhibitor, exhibiting an IC50 value of 620 nM. This compound finds utility in melanoma research[1].

Palmitoleoyl 3-环磷脂酸（3 μM, 22小时）显著降低了ATX和LPC诱导的A2058细胞侵袭，降低率达81% [1]。

棕榈烯酰基3-环磷脂酸（250 μg/kg，腹腔注射，在每只小鼠静脉注射5×10^5个B16F10黑色素瘤细胞的15分钟和48小时后注射）与对照组（57±14个肿瘤）相比，显著降低了约1/3的黑色素瘤细胞在肺部的转移数量（37±10个肿瘤）[1]。