|
TMPH-03605
|
CHOD Protein, Streptomyces sp., Recombinant (GST)
choA,Cholesterol isomerase,CHOD,Cholesterol
|
Streptomyces
|
E. coli
|
|
Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product. CHOD Protein, Streptomyces sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 81.9 kDa and the accession number is P12676. |
|
TMPY-00055
|
LCAT Protein, Human, Recombinant (His)
lecithin-cholesterol acyltransferase
|
Human
|
HEK293 Cells
|
|
Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an... |
|
TMPH-01084
|
CYP11A1 Protein, Human, Recombinant (His & SUMO)
Cholesterol side-chain cleavage enzyme, mitochondri...
|
Human
|
E. coli
|
|
CYP11A1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.1 kDa and the accession number is P05108. |
|
TMPH-01623
|
GBA Protein, Human, Recombinant (His & Myc & SUMO)
Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc...
|
Human
|
E. coli
|
|
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... |
|
TMPH-02772
|
GBA Protein, Mouse, Recombinant (His)
Cholesteryl-beta-glucosidase,Lysosomal galactosylceramidase,...
|
Mouse
|
P. pastoris (Yeast)
|
|
GBA Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 57.5 kDa and the accession number is P17439. |
|
TMPH-02771
|
GBA Protein, Mouse, Recombinant (His & SUMO)
Lysosomal galactosylceramidase,Cholesteryl-beta-glucosidase,...
|
Mouse
|
E. coli
|
|
GBA Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. |
|
TMPH-01624
|
GBA Protein, Human, Recombinant
Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera...
|
Human
|
E. coli
|
|
Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha... |
|
TMPH-03342
|
GBA2 Protein, Rat, Recombinant (His)
Bile acid glucosyl transferase GBA2,Glucosylceramidase 2,Non...
|
Rat
|
E. coli
|
|
GBA2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 42.6 kDa and the accession number is Q5M868. |
|
TMPH-01186
|
CYP2C9 Protein, Human, Recombinant (His & Myc)
CYP2C10,Cytochrome P450 2C9,S-mephenytoin 4-hydroxylase,(R)-...
|
Human
|
E. coli
|
|
CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
|
TMPH-00007
|
HMGCR Protein, Human, Recombinant (His)
HMGCR,3-hydroxy-3-methylglutaryl-coenzyme A reductase
|
Human
|
E. coli
|
|
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR is the main target of statins, a class of cholesterol-lowering drugs. |
|
TMPY-02956
|
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L
|
Human
|
Baculovirus Insect Cells
|
|
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... |
|
TMPH-00225
|
APOA1 Protein, Bovine, Recombinant (His)
Apolipoprotein A-I,APOA1,ApoA-I,Apo-AI,Apolipoprotein A1
|
Bovine
|
P. pastoris (Yeast)
|
|
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P15497. |
|
TMPH-03593
|
Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (Avi & His)
Thiol-activated cytolysin,Pneumolysin,ply
|
Streptococcus pneumoniae
|
E. coli
|
|
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum... |
|
TMPK-00835
|
LCAT Protein, Mouse, Recombinant (His)
PAF acetylhydrolase,LCAT
|
Mouse
|
HEK293 Cells
|
|
Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. |
|
TMPH-03592
|
Pneumolysin Protein, S. pneumoniae serotype 4, Recombinant (His)
Thiol-activated cytolysin,ply,Pneumolysin
|
Streptococcus pneumoniae
|
P. pastoris (Yeast)
|
|
A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation. Pneum... |
|
TMPJ-00158
|
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I
|
Human
|
E. coli
|
|
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T... |
|
TMPK-01291
|
ANXA1 Protein, Cynomolgus, Recombinant (His)
Lipocortin I,Calpactin-2,ANX1,ANXA1,Annexin A1,Annexin I,LPC...
|
Cynomolgus
|
E. coli
|
|
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activities in an apoA-I- or ANXA1-dependent manner. The latter activity occurs by mediating the efflux of ANXA1, which plays a critical role in anti-inflammatory effects, cholesterol transport, exosome and microparticle secretion, and apoptotic cell clearance. ANXA1 Protein, Cynomolgu... |
|
TMPK-00768
|
ANXA1 Protein, Human, Recombinant (His)
Annexin A1,Calpactin II,ANX1,p35,Lipocortin I,ANXA1,Calpacti...
|
Human
|
E. coli
|
|
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activities in an apoA-I- or ANXA1-dependent manner. The latter activity occurs by mediating the efflux of ANXA1, which plays a critical role in anti-inflammatory effects, cholesterol transport, exosome and microparticle secretion, and apoptotic cell clearance. ANXA1 Protein, Human, Re... |
|
TMPH-00224
|
APOA1 Protein, Bovine, Recombinant (E. coli, His)
APOA1,Apolipoprotein A-I,ApoA-I,Apo-AI,Apolipoprotein A1
|
Bovine
|
E. coli
|
|
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.6 kDa and the accession number is P15497. |
|
TMPK-00799
|
ANXA1 Protein, Mouse, Recombinant (His)
Calpactin-2,LPC1,Annexin-1,Annexin I,ANXA1,p35,Chromobindin-...
|
Mouse
|
E. coli
|
|
Atherosclerosis, characterized by the formation of fat-laden plaques, is a chronic inflammatory disease. ABCA1 promotes cholesterol efflux, reduces cellular cholesterol accumulation, and regulates anti-inflammatory activities in an apoA-I- or ANXA1-dependent manner. The latter activity occurs by mediating the efflux of ANXA1, which plays a critical role in anti-inflammatory effects, cholesterol transport, exosome and microparticle secretion, and apoptotic cell clearance. ANXA1 Protein, Mouse, Re... |
|
TMPH-02316
|
YJEFN3 Protein, Human, Recombinant
YjeF N-terminal domain-containing protein 3,YJEFN3,ApoA-I-bi...
|
Human
|
E. coli
|
|
May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progeni... |
|
TMPH-02476
|
HMGCR Protein, Mouse, Recombinant (His)
Hmgcr,3-hydroxy-3-methylglutaryl-coenzyme A reductase
|
Mouse
|
E. coli
|
|
Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular cholesterol homeostasis. HMGCR Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.4 kDa and the accession number is Q01237. |
|
TMPY-04767
|
PMVK Protein, Human, Recombinant (His)
PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE
|
Human
|
E. coli
|
|
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. |
|
TMPH-02842
|
CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)
CD133,Prom1,Prominin-like protein 1,Prom,Proml1,Antigen AC13...
|
Mouse
|
E. coli
|
|
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. |
|
TMPY-04813
|
ACAT2 Protein, Rat, Recombinant (His)
acetyl-CoA acetyltransferase 2
|
Rat
|
E. coli
|
|
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two enzymes are involved in storing cholesteryl esters as lipid droplets, in macrophage foam-cell formation, in absorbing dietary cholesterol, and in supplying cholesteryl esters as part of the core lipid for lipoprotein synthesis and assembly. The key difference in tissue distributio... |
|
TMPJ-00756
|
Apolipoprotein E/APOE3 Protein, Human, Recombinant (His)
Apolipoprotein E,Apo-E,APOE,ApoE3
|
Human
|
HEK293 Cells
|
|
ApoE, a glycoprotein, is a structural component of very low density lipoprotein (vLDL) synthesized by the liver and intestinally synthesized chylomicrons . ApoE is also a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport .ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma .Apo... |
|
TMPH-03323
|
LIPA Protein, Rat, Recombinant (His)
Lysosomal acid lipase/cholesteryl ester hydrolase,Lipa,Lipas...
|
Rat
|
E. coli
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194. |
|
TMPH-00001
|
CD133/PROM1 Protein-VLP, Human, Recombinant (His)
Proml1,Prom1,CD133,Prominin-like protein 1,Antigen AC133 hom...
|
Human
|
HEK293 Cells
|
|
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. CD133/PROM1 Protein... |
|
TMPH-01625
|
LIPA Protein, Human, Recombinant (His)
Cholesteryl esterase,Lysosomal acid lipase/cholesteryl ester...
|
Human
|
P. pastoris (Yeast)
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571. |
|
TMPH-00831
|
PMP2 Protein, Horse, Recombinant (His & SUMO)
PMP2,Myelin P2 protein
|
Horse
|
E. coli
|
|
May play a role in lipid transport protein in Schwann cells. May bind cholesterol. PMP2 Protein, Horse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is P0C6G6. |
|
TMPY-00131
|
Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)
NPC,Niemann-Pick disease, type C1
|
Human
|
HEK293 Cells
|
|
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty... |
|
TMPH-00491
|
PNLIPRP1 Protein, Canine, Recombinant (His)
Inactive pancreatic lipase-related protein 1,PNLIPRP1
|
Canine
|
P. pastoris (Yeast)
|
|
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.7 kDa and the accession number is P06857. |
|
TMPH-01626
|
LIPA Protein, Human, Recombinant (GST)
Lysosomal acid lipase/cholesteryl ester hydrolase,Lipase A,S...
|
Human
|
E. coli
|
|
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571. |
|
TMPH-01603
|
Lanosterol synthase/LSS Protein, Human, Recombinant (His)
Lanosterol synthase,LSS,2,3-epoxysqualene--lanosterol cyclas...
|
Human
|
E. coli
|
|
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. |
|
TMPH-00492
|
PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)
Inactive pancreatic lipase-related protein 1,PNLIPRP1
|
Canine
|
E. coli
|
|
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.7 kDa and the accession number is P06857. |
|
TMPH-00218
|
DHCR7 Protein, Bovine, Recombinant (His)
DHCR7,7-dehydrocholesterol reductase,Sterol Delta(7...
|
Bovine
|
E. coli
|
|
7-dehydrocholesterol reductase of the cholesterol biosynthetic pathway reducing the C7-C8 double bond of cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol/7-DHC) and cholesta-5,7,24-trien-3beta-ol, two intermediates in that pathway. DHCR7 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 55.8 kDa and the accession number is Q5E9J5. |
|
TMPY-01616
|
SULT2B1 Protein, Human, Recombinant (His)
SULT2B1,sulfotransferase family 2B member 1,HSST2
|
Human
|
E. coli
|
|
Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 ca... |
|
TMPH-01747
|
FDXR Protein, Human, Recombinant (His & SUMO)
Ferredoxin--NADP(+) reductase,NADPH:adrenodoxin oxidoreducta...
|
Human
|
E. coli
|
|
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. FDXR Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 61.6 kDa and the accession number is P22570. |
|
TMPJ-01302
|
ACAT2 Protein, Human, Recombinant (His)
ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr...
|
Human
|
E. coli
|
|
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus. |
|
TMPH-02717
|
HMGCS1 Protein, Mouse, Recombinant (His & SUMO)
Hmgcs1,3-hydroxy-3-methylglutaryl coenzyme A synthase,Hydrox...
|
Mouse
|
E. coli
|
|
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 73.6 kDa and the accession number is Q8JZK9. |
|
TMPH-01535
|
INSIG2 Protein, Human, Recombinant (His & Myc)
Insulin-induced gene 2 protein,INSIG2
|
Human
|
E. coli
|
|
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycho... |
|
TMPY-02686
|
PON3 Protein, Human, Recombinant (S50N, His)
paraoxonase 3
|
Human
|
Baculovirus Insect Cells
|
|
PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expression of inflammatory genes. PON3 deficiency did not influence atherosclerosis development on an apolipoprotein E null hyperlipidemic background, but it did lead to a significant 60% increase in atherosclerotic lesion size in Pon3KO mice on the C57BL/6J background when fed a cholate... |
|
TMPH-00287
|
Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His)
Ferredoxin--NADP(+) reductase,ADXR,NADPH:adrenodoxin oxidore...
|
Bovine
|
E. coli
|
|
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Adrenodoxin reductase Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 55.8 kDa and the accession number is ... |
|
TMPH-01678
|
MMUT Protein, Human, Recombinant (His)
MMUT,Methylmalonyl-CoA mutase, mitochondrial,Methylmalonyl-C...
|
Human
|
E. coli
|
|
Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. MMUT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 84.8 kDa and the accession number is P22033. |
|
TMPK-01228
|
MARCO Protein, Human, Recombinant (His)
Ly112,SCARA2,AI323439,MARCO
|
Human
|
HEK293 Cells
|
|
Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in macrophages; therefore, in the absence of MARCO, macrophages are more susceptible to a greater inflammatory response by particulates known to cause NLRP3 inflammasome activation and the effect is due to increased LMP. |
|
TMPH-00037
|
Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)
ltxA,Leukotoxin
|
Aggregatibacter actinomycetemcomitans
|
P. pastoris (Yeast)
|
|
Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 38.3 kD... |
|
TMPJ-00443
|
PCSK9 Protein, Macaca nemestrina, Recombinant (His)
Proprotein Convertase Subtilisin/Kexin Type 9,PCSK9,PC9,Prop...
|
Macaca nemestrina
|
HEK293 Cells
|
|
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development. |
|
TMPH-00288
|
Adrenodoxin reductase Protein, Bovine, Recombinant (His)
Ferredoxin reductase,Adrenodoxin reductase,Ferredoxin--NADP(...
|
Bovine
|
P. pastoris (Yeast)
|
|
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Adrenodoxin reductase Protein, Bovine, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 52.8 kDa and the accession number is P08165. |
|
TMPH-00220
|
Adrenodoxin, mitochondrial Protein, Bovine, Recombinant (His)
Hepato-ferredoxin,FDX1,Ferredoxin-1,Adrenodoxin, mitochondri...
|
Bovine
|
E. coli
|
|
Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage to produce pregnenolone, the precursor of most steroid hormones. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Adrenodoxin, mitochondrial Protein, Bov... |
|
TMPH-03128
|
TSPO Protein, Pig, Recombinant (His & Myc & SUMO)
TSPO,Peripheral-type benzodiazepine receptor,Translocator pr...
|
Sus scrofa (Pig)
|
E. coli
|
|
Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. TSPO Protein, Pig, Recombinant (His & Myc & SUMO) is expressed in E. coli e... |
沪公网安备 31010602006700号