GSK2945

Name: GSK2945
Brand: TargetMol
SKU: T11490
Price: 116 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11490Cas号 1438071-12-5

GSK2945 is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

GSK2945

还可以

产品编号 T11490Cas号 1438071-12-5

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	GSK2945 is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
体外活性	GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment increases levels of Cyp7a1/CYP7A1 in mouse and human primary hepatocytes. GSK2945 (20 μM) treatment also increases Lrh-1/LRH-1 (a known hepatic activator of Cyp7a1/CYP7A.GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter (EC50 of 2.05 μM). 1) mRNA and protein.
体内活性	GSK2945 treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice.

化学信息

分子量	421.34
分子式	C₂₀H₁₈Cl₂N₂O₂S
CAS No.	1438071-12-5
密度	1.363 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 83.33 mg/mL (197.77 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3734 mL	11.8669 mL	23.7338 mL	118.6690 mL
5 mM	0.4747 mL	2.3734 mL	4.7468 mL	23.7338 mL
10 mM	0.2373 mL	1.1867 mL	2.3734 mL	11.8669 mL
20 mM	0.1187 mL	0.5933 mL	1.1867 mL	5.9335 mL
50 mM	0.0475 mL	0.2373 mL	0.4747 mL	2.3734 mL
100 mM	0.0237 mL	0.1187 mL	0.2373 mL	1.1867 mL