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Targets Recommended: Reverse Transcriptase HIV Protease

273

抑制剂 & 化合物

25

天然产物

1

化合物库

28

重组蛋白

9

同位素标记化合物

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Cat. No.	Product Name
L1720	核苷类化合物库		334 compounds
	334 种核苷类化合物，包括核苷酸、核苷酸类似物及衍生物等，适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发；

化合物库

核苷类化合物库

Cat.No: L1720

Compounds: 334

Cat. No.	Product Name	Target	Signaling Pathways
T12715	Reverse transcriptase-IN-1	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Reverse transcriptase-IN-1 是一种二芳基苯并嘧啶类似物，是一种有效的 HIV-1 非核苷类逆转录酶抑制剂，IC50 为 13.7 nM。
T7578	REVERSE T3 碘塞罗宁,3,3',5'-triiodo-L-thyronine	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Reverse T3 (3,3',5'-triiodo-L-thyronine) 是由甲状腺素原脱碘后产生的甲状腺激素。它可抑制由其它甲状腺激素类似物引起的新生大鼠心肌细胞中钠电流增加的作用。
T72206	Reverse transcriptase-IN-4	Others	Others
	Reverse transcriptase-IN-4 是一种有效的选择性非核苷类逆转录酶 (NNRT) 抑制剂，作用于野生型HIV-1的EC50值为 0.053 μM，作用于HIV-1突变株 E138K 的EC50值为 0.26 μM。
T72203	Reverse transcriptase-IN-3	Others	Others
	Reverse transcriptase-IN-3, 作为一种嘧啶-5-羧酰胺衍生物，主要用于抑制HIV-1。它对HIV-1野生型及其突变型病毒株均展示出高效的抑制活性。
T7447	Adefovir	HBV; Reverse Transcriptase; Telomerase	DNA Damage/DNA Repair; Microbiology/Virology
	Adefovir 是一种单磷酸腺苷类似物抗病毒剂，在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。
T12609	R-10015	LIM Kinase; Reverse Transcriptase	Cell Cycle/Checkpoint; Microbiology/Virology
	R-10015 是一种高效选择性 LIMK 抑制剂，通过结合 ATP 结合口袋阻断 LIMK，抑制人 LIMK1 的 IC50值为 38 nM。它还发挥广谱抗病毒作用，可用于 HIV 感染研究。
T9223	RO-0335	Reverse Transcriptase	Microbiology/Virology
	RO-0335 是新高效二苯醚非核苷逆转录酶抑制剂。它 (IC50= 1.1 nM) 可以抑制Wt HIV-1病毒，对 92% 的 NNRTI 耐药临床分离株具有保留活性 (IC50<100 nM)。
T16530	BF738735	Antiviral; PI4K	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂，IC50为 5.7 nM。
T16098	Islatravir MK-8591	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Islatravir (MK-8591) 是一种核苷逆转录酶抑制剂，是抗HIV-1药物，对 HIV-1 (WT)，HIV-1 (M184V)，HIV-1 (MDR) 的EC50值分别为 0.068 nM，3.1 nM 和 0.15 nM。
T10133	3'-Azido-3'-deoxy-5-methylcytidine	Antiviral; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	3'-Azido-3'-deoxy-5-methylcytidine 抑制 HIV-1 逆转录酶 (EC50 = 0.06 μM)，是异嗜性鼠白血病相关逆转录病毒 (XMRV, CC50 = 43.5 μM) 的有效抑制剂。
T2330	Rilpivirine TMC278,R278474,利匹韦林,DB08864	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Rilpivirine (R278474) 是一种二芳基嘧啶衍生物和非核苷逆转录酶抑制剂，具有抗 HIV-1 的抗病毒活性，用于治疗 HIV 感染。
T1267	Abacavir Epzicom,Ziagen,阿巴卡韦	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。
T27154	Dexelvucitabine D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC	Reverse Transcriptase	Microbiology/Virology
	Dexelvucitabine (RVT) 是一种胞苷类似物，一种口服有活性的核苷逆转录酶抑制剂。它是一种 2'-脱氧胞苷抗逆转录病毒剂。它是一种有效的抗 HIV-1病毒剂，这些病毒聚合酶中含有胸苷类似物和/或 M184V 突变。
T7700	Lersivirine 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lersivirine (UK-453061) 是非核苷逆转录的抑制剂 (NNRTI)，有效抑制 NNRTI 耐药病毒。它对野生型人类免疫缺陷病毒和临床相关 NNRTI 耐药菌株显示出强大的抗逆转录病毒活性。
T6214	Emtricitabine 恩曲他滨,FTC,Emtriva,BW1592	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Emtricitabine (FTC) 是一种核苷逆转录酶抑制剂，在 PBMC 细胞中的 EC50值为0.01 µM，可研究 HIV 感染。
T5981	2,2'-Anhydrouridine O2,2'-Cyclouridine,2,2'-脱水尿苷,2,2'-Cyclouridine	Antiviral; Reverse Transcriptase	Immunology/Inflammation; Microbiology/Virology
	2,2'-Anhydrouridine (2,2'-Cyclouridine) 有抗肿瘤和抗病毒活性。
T3632	Doravirine 多拉维林,多拉韦林,MK-1439	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Doravirine (MK-1439) 是一种高度特异性的HIV-1非核苷逆转录酶抑制剂，对野生型以及K103N 和Y181C 逆转录酶突变体的IC50值分别为 4.5 nM，5.5 nM 和 6.1 nM。
T2551	Etravirine TMC125,依曲韦林,R165335	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Etravirine (R165335) 是一种非核苷逆转录酶抑制剂，具有抗 HIV 的作用。
T2578	Didanosine ddI,去羟肌苷,2',3'-Dideoxyinosine	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Didanosine (ddI) 是一种逆转录酶抑制剂，IC50为490nM。
T1649	Tenofovir 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂，可研究 HIV 和慢性乙型肝炎。
T2409	Tenofovir alafenamide 替诺福韦艾拉酚胺,替诺福韦,GS-7340	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。
T0682	Lamivudine GR109714X,BCH-189,拉米夫定	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂，可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
T1675	Adefovir dipivoxil Hepsera,GS 0840,阿德福韦酯,Preveon	Others; HBV; Reverse Transcriptase	Microbiology/Virology; Others
	Adefovir dipivoxil (GS 0840) 是一种腺苷类似物，是核苷逆转录酶抑制剂 Adefovir 的口服前药，具有抗乙型肝炎病毒、疱疹病毒和人类免疫缺陷病毒的活性。
T1815	Dapivirine R147681,达匹维林,TMC120	Apoptosis; HIV Protease; Reverse Transcriptase; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Dapivirine (R147681) 是一种二芳基嘧啶非核苷类逆转录酶抑制剂。
T19963	Alizarin Complexone Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂	Reverse Transcriptase	Microbiology/Virology
	Alizarin Complexone (Alizarin-3-methyliminodiacetic acid) 是 Rous 相关病毒 2 逆转录酶的抑制剂。 Alizarin Complexone 可用作生物研究的钙示踪剂和螯合剂。
T7111	Tenofovir Disoproxil 替诺福韦酯,GS 4331,Bis(POC)-PMPA	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir Disoproxil (GS 4331) 是一种核苷酸逆转录酶抑制剂，用于治疗 HIV 和慢性乙型肝炎。
T1595	Nevirapine NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂，Ki 值为 270 μM，可用于研究 HIV/AIDS。
T0110	Zalcitabine Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Zalcitabine (Dideoxycytidine) 是一种核苷类似物逆转录酶抑制剂，用于HIV 感染相关研究。
T6367	Abacavir sulfate Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir sulfate (Ziagen) 是一种核苷类似物逆转录酶抑制剂，可用于 HIV 和 AIDS。
T4326	AG 555 Tyrphostin B46,Tyrphostin AG 555	EGFR; Reverse Transcriptase	Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	AG 555 (Tyrphostin B46)是一种选择性EGFR 的有效抑制剂，可阻断Cdk2活化。它是一种抗逆转录病毒药。
T7282	Tenofovir alafenamide hemifumarate GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。
T2393	Efavirenz EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726	HIV Protease; Reverse Transcriptase; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Efavirenz (DMP 266) 是一种人类免疫缺陷病毒 1 非核苷类似物逆转录酶抑制剂。它也是一种野生型HIV-1 RT 抑制剂，Ki 为 2.93 nM，有效抑制 HIV-1 复制，IC95为 1.5 nM。
T1404	Stavudine d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定	Apoptosis; Nucleoside Antimetabolite/Analog; HIV Protease; NOD-like Receptor (NLR); Reverse Transcriptase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Stavudine (BMY-27857) 是一种口服活性核苷逆转录酶抑制剂，还抑制线粒体 DNA 的复制，具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬，诱导细胞凋亡。
T2409L	Tenofovir Disoproxil Fumarate GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir Disoproxil Fumarate (GS-1278 Disoproxil Fumarate) 是一种核苷酸逆转录酶抑制剂，有潜力研究艾滋病和慢性乙型肝炎。
T7212	Delavirdine mesylate U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Delavirdine mesylate (BHAP-U 90152(mesylate)) 是一种口服活性非核苷逆转录酶抑制剂。它抑制 HIV-1 病毒复制，可以用于艾滋病的相关研究。它选择性地抑制 HIV-1 逆转录酶，其选择性超过 DNA 聚合酶 α 和 DNA 聚合酶 δ 。
T14489	Azvudine 4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622	HCV Protease; HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI)，对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株，高效抑制 HIV-1和 HIV-2。
T9854	HIV-1 inhibitor-6 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) 是一种有效的HIV-1 pre-mRNA 选择性剪接抑制剂，可以阻断HIV 复制。
T2160	Suramin Sodium Salt 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060	Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K，是抗寄生虫，抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂，也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。
T21474	Navuridine AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU,3'-叠氮-2',3'-双脱氧尿苷	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Navuridine (AZdU) 是一种口服活性的 HIV 逆转录酶抑制剂，半衰期相对较短。
T7455	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	4-Chloro-2-(trifluoroacetyl)aniline hydrochloride 是 HIV-1 RT（HIV 逆转录酶）的抑制剂。
T12814	(S)-Tenofovir (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF	Others	Others
	(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体，Tenofovir 是一种核苷酸逆转录酶抑制剂。
T1513	Telbivudine NV 02B,L-Thymidine,Epavudine,替比夫定	Others; HBV; Reverse Transcriptase	Microbiology/Virology; Others
	Telbivudine (NV 02B) 是一种乙型肝炎病毒复制的抗病毒抑制剂，是一种具有口服活性的胸腺嘧啶核苷类似物。
T3172	Trovirdine 曲韦定,LY300046	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Trovirdine (LY300046) 是一种硫脲类非核苷类逆转录酶抑制剂。
T68103L	Mk-6186 HCl Mk-6186 HCl（1034474-19-5 Free base)	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	MK-6186 HCl，一种新型非核苷类逆转录酶抑制剂，具有抗病毒活性，可用于研究HIV。
T4252	ML327	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	ML327 是 MYC 的阻断剂，还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。
TQ0151	L-655708	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	L-655708 是一种具有选择性和高效性的 GABAA 受体反向激动剂，Ki 值为 0.45 nM。
T27260	Emivirine MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Emivirine (MKC-442) 是一种有效和选择性的人类免疫缺陷病毒1型(HIV-1)的非核苷逆转录酶抑制剂。
T68103	MK-6186	Reverse Transcriptase	Microbiology/Virology
	MK-6186 是一种新型非核苷类逆转录酶抑制剂，具有抗病毒活性，可用于研究病毒感染。
T31860	Fosdevirine GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T15210	Elsulfavirine Elpida,VM-1500	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Elsulfavirine (VM-1500) 是一种 HIV-1 感染的逆转录酶抑制剂，也是抗 HIV 的新药。

化合物

Reverse transcriptase-IN-1

Cat.No: T12715

Target: HIV Protease

Cat.No: T7578

Synonym: 碘塞罗宁,3,3',5'-triiodo-L-thyronine

Target: Thyroid hormone receptor(THR)

Reverse transcriptase-IN-4

Cat.No: T72206

Target: Others

Reverse transcriptase-IN-3

Cat.No: T72203

Target: Others

Cat.No: T7447

Target: HBV, Reverse Transcriptase, Telomerase

Cat.No: T12609

Target: LIM Kinase, Reverse Transcriptase

Cat.No: T9223

Target: Reverse Transcriptase

Cat.No: T16530

Target: Antiviral, PI4K

Cat.No: T16098

Synonym: MK-8591

Target: HIV Protease, Reverse Transcriptase

3'-Azido-3'-deoxy-5-methylcytidine

Cat.No: T10133

Target: Antiviral, HIV Protease

Cat.No: T2330

Synonym: TMC278,R278474,利匹韦林,DB08864

Target: HIV Protease, Reverse Transcriptase

Cat.No: T1267

Synonym: Epzicom,Ziagen,阿巴卡韦

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Dexelvucitabine

Cat.No: T27154

Synonym: D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC

Target: Reverse Transcriptase

Cat.No: T7700

Synonym: 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061

Target: HIV Protease, Reverse Transcriptase

Cat.No: T6214

Synonym: 恩曲他滨,FTC,Emtriva,BW1592

Target: HIV Protease, Reverse Transcriptase

2,2'-Anhydrouridine

Cat.No: T5981

Synonym: O2,2'-Cyclouridine,2,2'-脱水尿苷,2,2'-Cyclouridine

Target: Antiviral, Reverse Transcriptase

Cat.No: T3632

Synonym: 多拉维林,多拉韦林,MK-1439

Target: HIV Protease, Reverse Transcriptase

Cat.No: T2551

Synonym: TMC125,依曲韦林,R165335

Target: HIV Protease, Reverse Transcriptase

Cat.No: T2578

Synonym: ddI,去羟肌苷,2',3'-Dideoxyinosine

Target: HIV Protease, Reverse Transcriptase

Cat.No: T1649

Synonym: 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278

Target: HBV, HIV Protease, Reverse Transcriptase

Tenofovir alafenamide

Cat.No: T2409

Synonym: 替诺福韦艾拉酚胺,替诺福韦,GS-7340

Target: HIV Protease, Reverse Transcriptase

Cat.No: T0682

Synonym: GR109714X,BCH-189,拉米夫定

Target: HIV Protease, Reverse Transcriptase

Adefovir dipivoxil

Cat.No: T1675

Synonym: Hepsera,GS 0840,阿德福韦酯,Preveon

Target: Others, HBV, Reverse Transcriptase

Cat.No: T1815

Synonym: R147681,达匹维林,TMC120

Target: Apoptosis, HIV Protease, Reverse Transcriptase, Autophagy

Alizarin Complexone

Cat.No: T19963

Synonym: Alizarin Fluorine Blue,Alizarin-3-methyliminodiacetic acid,茜素络合指示剂

Target: Reverse Transcriptase

Tenofovir Disoproxil

Cat.No: T7111

Synonym: 替诺福韦酯,GS 4331,Bis(POC)-PMPA

Target: HBV, HIV Protease, Reverse Transcriptase

Cat.No: T1595

Synonym: NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP

Target: HIV Protease, Reverse Transcriptase

Cat.No: T0110

Synonym: Dideoxycytidine,ddC,扎西他滨,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine

Target: HIV Protease, Reverse Transcriptase

Abacavir sulfate

Cat.No: T6367

Synonym: Abacavir Hemisulfate,硫酸阿巴卡韦,1592U89,ABC sulfate,Ziagen

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Cat.No: T4326

Synonym: Tyrphostin B46,Tyrphostin AG 555

Target: EGFR, Reverse Transcriptase

Tenofovir alafenamide hemifumarate

Cat.No: T7282

Synonym: GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐

Target: HIV Protease, Reverse Transcriptase

Cat.No: T2393

Synonym: EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726

Target: HIV Protease, Reverse Transcriptase, Autophagy

Cat.No: T1404

Synonym: d4T,Sanilvudine,BMY-27857,NSC 163661,司他夫定

Target: Apoptosis, Nucleoside Antimetabolite/Analog, HIV Protease, NOD-like Receptor (NLR), Reverse Transcriptase, Autophagy

Tenofovir Disoproxil Fumarate

Cat.No: T2409L

Synonym: GS-1278 Disoproxil Fumarate,Tenofovir DF,富马酸替诺福韦酯

Target: HBV, HIV Protease, Reverse Transcriptase

Delavirdine mesylate

Cat.No: T7212

Synonym: U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)

Target: HIV Protease, Reverse Transcriptase

Cat.No: T14489

Synonym: 4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622

Target: HCV Protease, HBV, HIV Protease, Reverse Transcriptase

HIV-1 inhibitor-6

Cat.No: T9854

Synonym: 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-

Target: HIV Protease

Suramin Sodium Salt

Cat.No: T2160

Synonym: 苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060

Target: Apoptosis, Phosphatase, SARS-CoV, Sirtuin, Reverse Transcriptase, Topoisomerase, Parasite

Cat.No: T21474

Synonym: AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU,3'-叠氮-2',3'-双脱氧尿苷

Target: HIV Protease

4-Chloro-2-(trifluoroacetyl)aniline hydrochloride

Cat.No: T7455

Target: HIV Protease

Cat.No: T12814

Synonym: (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF

Target: Others

Cat.No: T1513

Synonym: NV 02B,L-Thymidine,Epavudine,替比夫定

Target: Others, HBV, Reverse Transcriptase

Cat.No: T3172

Synonym: 曲韦定,LY300046

Target: HIV Protease

Cat.No: T68103L

Synonym: Mk-6186 HCl（1034474-19-5 Free base)

Target: HIV Protease, Reverse Transcriptase

Cat.No: T4252

Target: c-Myc, Autophagy

Cat.No: TQ0151

Target: GABA Receptor

Cat.No: T27260

Synonym: MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302

Target: HIV Protease

Cat.No: T68103

Target: Reverse Transcriptase

Cat.No: T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease

Cat.No: T15210

Synonym: Elpida,VM-1500

Target: HIV Protease

Cat. No.	Product Name	Target	Signaling Pathways
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T6519	Gramine NSC 16892,芦竹碱,Donaxine	Adiponectin receptor; Reverse Transcriptase; Adrenergic Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Gramine (Donaxine) 是从芦竹中得到的一种生物碱，是脂联素受体激动剂，对 AdipoR2 和 AdipoR1 的 IC50值分别为 3.2 和 4.2 µM。它也是小鼠和人β2-肾上腺素受体激动剂，具有抗肿瘤、抗炎和抗病毒作用。
T2901	Daidzin NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside	Dehydrogenase; Reverse Transcriptase; Mitochondrial Metabolism	Metabolism; Microbiology/Virology
	Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮，具有抗氧化、抗癌和抗动脉粥样硬化的活性。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T3578	Pyridoxal phosphate PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate	Reverse Transcriptase; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式，可抑制逆转录酶活性，用于研究迟发性运动障碍症。
TN1427	Baicalin methyl ester	Anti-infection	Microbiology/Virology
	Baicalin methyl ester 是黄芩苷根的一种成分。
T4972	2'-Deoxycytidine-5'-diphosphate trisodium dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐	Endogenous Metabolite	Metabolism
	2'-Deoxycytidine-5'-diphosphate trisodium (dCDP) 是内源性代谢产物的一种。
T3730	Methyl gallate NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯	Reactive Oxygen Species; HIV Protease; Reverse Transcriptase; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Methyl gallate (Gallincin) 是具有抗氧化，抗癌和抗炎活性的植物酚类。它也可抑制细菌活性。它还具有抗HIV-1和HIV-1酶的抑制活性。
T4S1718	Punicalin	HBV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。
T3S0335	Soyasaponin Bb Soyasaponin I,大豆皂苷Bb	NF-κB; Caspase	Apoptosis; NF-κB; Proteases/Proteasome
	Soyasaponin Bb (Soyasaponin I) 是一种分离自菜豆科中的大豆皂苷，可用作醛糖还原酶差异抑制剂。
T9086	Deoxythymidine-5'-triphosphate trisodium dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Deoxythymidine-5'-triphosphate trisodium (Deoxythymidine-5'-triphosphate(dTTP) trisodium salt) 是四种天然脱氧核苷酸之一，用于通过 DNA 聚合酶和逆转录酶生物合成脱氧核糖核酸。
T2S0265	Robinin NSC 9222,刺槐素	TLR	Immunology/Inflammation
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
TN1163	2'-Hydroxychalcone	Others	Others
	2'-Hydroxychalcone 是一种药物合成中间体，可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1，VCAM-1和E-选择素的稳态转录水平，因此可能会干扰其基因的转录。
T4A2399	Cinobufotalin 华蟾毒它灵,华蟾素	IL Receptor; Akt; MRP; P-gp	Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling
	Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药，利尿药和止血药，也是潜在的抗肺癌药物。
T37984	Fosfructose, sodium salt, hydrate (1:3:8) D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8)	Others	Others
	D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体，包括糖酵解和糖异生。在糖酵解过程中，它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中，D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源，这一途径已成为癌症化疗的主要靶点。
T4838	(S)-Malic acid L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。
T2S0605	Liquidambaric lactone	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Liquidambaric lactone 是一种分离自Euonymus grandiflorusWall 中的化合物。
T13796	Nigranoic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Nigranoic acid is a natural product,and inhibits HIV-1 reverse transcriptase.
TN4934	Salaspermic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Salaspermic acid is an inhibitor of HIV reverse transcriptase and HIV replication in H9 lymphocyte cells.
TN5243	Vitexilactone	NADPH-oxidase; HIV Protease; Antifection	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes
T74516	CI-39	Others	Others
	CI-39 是一种抗病毒天然产物。CI-39 是一种 NNRTI (非核苷类逆转录酶抑制) 抗病毒剂，对野生型HIV 的EC50为 3.40 µM，CC50>30 µM。CI-39 抑制HIV-1RT DNA 聚合酶和核糖核酸酶 H 活性。
T2S0118	Daurinoline	Calcium Channel; 5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.
T74196	Inophyllum B	Others	Others
	Inophyllum B ((+)-Inophyllum B) 是一种有效的HIV 逆转录酶 (Reverse Transcriptase) 抑制剂，IC50为 38 nM。Inophyllum B 在体外细胞培养中抑制HIV-1(IC50=1.4 μM)。Inophyllum B 可从非洲大蜗牛Achatina fulica 的丙酮提取物中分离得到。
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	HIV Protease; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
TN6198	Mahanine
	Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g

天然产物

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Cat.No: T6519

Synonym: NSC 16892,芦竹碱,Donaxine

Target: Adiponectin receptor, Reverse Transcriptase, Adrenergic Receptor

Cat.No: T2901

Synonym: NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside

Target: Dehydrogenase, Reverse Transcriptase, Mitochondrial Metabolism

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Pyridoxal phosphate

Cat.No: T3578

Synonym: PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate

Target: Reverse Transcriptase, Endogenous Metabolite

Baicalin methyl ester

Cat.No: TN1427

Target: Anti-infection

2'-Deoxycytidine-5'-diphosphate trisodium

Cat.No: T4972

Synonym: dCDP,2'-脱氧胞苷-5'-二磷酸三钠盐

Target: Endogenous Metabolite

Cat.No: T3730

Synonym: NSC 363001,Gallicin,Gallic acid methyl ester,Gallincin,没食子酸甲酯

Target: Reactive Oxygen Species, HIV Protease, Reverse Transcriptase, Antibacterial

Cat.No: T4S1718

Target: HBV, HIV Protease

Cat.No: T3S0335

Synonym: Soyasaponin I,大豆皂苷Bb

Target: NF-κB, Caspase

Deoxythymidine-5'-triphosphate trisodium

Cat.No: T9086

Synonym: dTTP trisodium salt,thymidine 5'-(trisodium hydrogen triphosphate),胸苷-5'-三磷酸三钠盐,脱氧胸苷三磷酸三钠盐,Deoxythymidine-5'-triphosphate (dTTP) trisodium salt

Target: DNA/RNA Synthesis

Cat.No: T2S0265

Synonym: NSC 9222,刺槐素

Target: TLR

2'-Hydroxychalcone

Cat.No: TN1163

Target: Others

Cat.No: T4A2399

Synonym: 华蟾毒它灵,华蟾素

Target: IL Receptor, Akt, MRP, P-gp

Fosfructose, sodium salt, hydrate (1:3:8)

Cat.No: T37984

Synonym: D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8)

Target: Others

Cat.No: T4838

Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸

Target: Others, Endogenous Metabolite

Liquidambaric lactone

Cat.No: T2S0605

Target: HIV Protease

Cat.No: T13796

Target: HIV Protease

Salaspermic acid

Cat.No: TN4934

Target: HIV Protease

Cat.No: TN5243

Target: NADPH-oxidase, HIV Protease, Antifection

Cat.No: T74516

Target: Others

Cat.No: T2S0118

Target: Calcium Channel, 5-HT Receptor, Histamine Receptor

Cat.No: T74196

Target: Others

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cat.No: TN5133

Target: HIV Protease, Topoisomerase

Cat.No: TN6198

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02926	TRET Protein, Mouse, Recombinant (His & SUMO) Telomerase catalytic subunit,Telomerase reverse tra...	Mouse	E. coli
	TRET Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.1 kDa and the accession number is O70372.
TMPH-02186	TERT Protein, Human, Recombinant (His) Telomerase reverse transcriptase,Telomerase catalyt...	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de...
TMPY-02956	Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L	Human	Baculovirus Insect Cells
	APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer...
TMPY-00055	LCAT Protein, Human, Recombinant (His) lecithin-cholesterol acyltransferase	Human	HEK293 Cells
	Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport. Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism.LCAT is intimately involved in HDL maturation an...
TMPK-00835	LCAT Protein, Mouse, Recombinant (His) PAF acetylhydrolase,LCAT	Mouse	HEK293 Cells
	Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport.
TMPH-00224	APOA1 Protein, Bovine, Recombinant (E. coli, His) APOA1,Apolipoprotein A-I,ApoA-I,Apo-AI,Apolipoprotein A1	Bovine	E. coli
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.6 kDa and the accession number is P15497.
TMPH-00225	APOA1 Protein, Bovine, Recombinant (His) Apolipoprotein A-I,APOA1,ApoA-I,Apo-AI,Apolipoprotein A1	Bovine	P. pastoris (Yeast)
	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P15497.
TMPH-00335	FBA1 Protein, Candida albicans, Recombinant (His & Myc) Fructose-1,6-bisphosphate aldolase,IgE-binding allergen,Fruc...	Candida albicans	E. coli
	Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. FBA1 Protein, Candida albicans, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is Q9URB4.
TMPH-03087	ODH1 Protein, Pecten maximus, Recombinant (His & Myc) Octopine dehydrogenase,odh1	Pecten maximus	E. coli
	Catalyzes the reverse reaction of octopine dehydrogenation. Acts on L-arginine in preference to other substrates such as canavanine, cysteine, L-alanine, ornithine or norvaline, owing to the presence of the positively charged guanidium group. ODH1 Protein, Pecten maximus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.8 kDa and the accession number is Q9BHM6.
TMPY-01843	SEMA6A Protein, Human, Recombinant (His) HT018,VIA,sema domain, transmembrane domain (TM), and cytopl...	Human	HEK293 Cells
	SEMA6A, the first identified class 6 semaphorin, is contributed to regulate vascular development and adult angiogenesis. SEMA6A could inhibit proliferation, migration, and invasion in different glioma cell lines. That SEMA6A may be a potential prognostic biomarker in the treatment of GBM. Among different semaphorins tested by reverse transcriptase-polymerase chain reaction in human immune cells, the expression of class 6 transmembrane semaphorin SEMA6A was restricted to dendritic cells (DCs).
TMPH-03377	SULT1B1 Protein, Rat, Recombinant (His & Myc & SUMO) DOPA/tyrosine sulfotransferase,Sult1b1,Sulfotransferase fami...	Rat	E. coli
	Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3). SULT1B1 Protein, Rat, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 54.8 kDa and the accession number is P...
TMPH-02677	GPI Protein, Mouse, Recombinant (B2M & His) Gpi,Phosphohexose isomerase,Phosphoglucose isomerase,Neurole...	Mouse	E. coli
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion.
TMPK-00725	Hyaluronidase 2/HYAL2 Protein, Mouse, Recombinant (His) Hyaluronidase-2,Hyal-2,Hyaluronidase 2,HYAL2	Mouse	HEK293 Cells
	Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries. Hyaluronidase...
TMPK-00954	Hyaluronidase 2/HYAL2 Protein, Human, Recombinant (His) LuCa-2,Hyaluronidase 2,LUCA2,HYAL2,Hyal-2,Hyaluronidase-2	Human	HEK293 Cells
	Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries. Hyaluronidase...
TMPH-02678	GPI Protein, Mouse, Recombinant (His) Phosphoglucose isomerase,Autocrine motility factor,Glucose-6...	Mouse	P. pastoris (Yeast)
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Mous...
TMPJ-01357	NHP2 Protein, Human, Recombinant (His) NOLA2,Nucleolar protein family A member 2,snoRNP protein NHP...	Human	E. coli
	NHP2 belongs to the H/ACA snoRNPs gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been organized into 2 families: C/D and H/ACA. NHP2 forms a small ribonucleoprotein particle with GAR1 (NOLA1). NHP2 is involved in a variety of aspects of rRNA processing and modification. NHP2 localizes to the dense fibrillar component of the nucleolus and in nuclear Cajal bodies. NHP2 may also be required for correct processing or intranuclear trafficking of TERC...
TMPH-01391	GPI Protein, Human, Recombinant (His) Sperm antigen 36,Neuroleukin,Glucose-6-phosphate isomerase,G...	Human	E. coli
	In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. GPI Protein, Huma...
TMPJ-01310	TRIM5 Protein, Human, Recombinant (His) RNF88,Tripartite motif-containing protein 5,RING finger prot...	Human	E. coli
	Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. TRIM5 present in the cytoplasm recognizes motifs within the capsid proteins and interferes with the uncoating process, therefore preventing successful reverse transcription and transport to the nucleus of the viral genome. The exact mechanism of actio...
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His) vpx,Viral protein X,X ORF protein,Protein Vpx	HIV-2	P. pastoris (Yeast)
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by...
TMPJ-00797	LDHB Protein, Human, Recombinant (His) LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH Heart Subu...	Human	E. coli
	L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver....
TMPJ-00523	SAA2 Protein, Human, Recombinant (His) SAA2,SAA,Serum Amyloid A2	Human	E. coli
	Serum amyloid A-2 protein (SAA2) belongs to the SAA family. It expressed by the liver and secreted in plasma. SAA2 functions as major acute phase reactant and could works as apolipoprotein of the HDL complex. Increased levels of A-SAA in serum are indicative of inflammatory disease. When highly expressed, SAA can displace ApoA1 as the major apolipoprotein in HDL complexes, weakening the function of HDL as a reverse (lipid clearing) cholesterol transporter. A highly charged region of SAA2 and SAA...
TMPH-01624	GBA Protein, Human, Recombinant Lysosomal glycosylceramidase,Acid beta-glucosidase,Alglucera...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPH-01623	GBA Protein, Human, Recombinant (His & Myc & SUMO) Lysosomal acid glucosylceramidase,GBA1,Lysosomal galactosylc...	Human	E. coli
	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction tha...
TMPY-04137	ATP6V1F Protein, Human, Recombinant (GST) Vma7,ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F,...	Human	E. coli
	ATP6V1F encodes a component of vacuolar ATPase mediating acidification. The cDNA and the genomic sequences of ATP6V1F were cloned successfully for the first time from the Giant Panda (Ailuropoda melanoleuca) using reverse transcription polymerase chain reaction and touchdown-polymerase chain reaction, respectively. Topology prediction showed that there is one protein kinase C phosphorylation site, two Casein kinase II phosphorylation sites, and one N-myristoylation site in the ATP6V1F protein. U...
TMPY-01617	SULT1B1 Protein, Human, Recombinant (His) sulfotransferase family, cytosolic, 1B, member 1,SULT1B2,ST1...	Human	E. coli
	Sulfotransferase family cytosolic 1B member 1, also known as Sulfotransferase 1B1, Sulfotransferase 1B2, Thyroid hormone sulfotransferase, SULT1B1 and ST1B2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver, perip...
TMPY-02955	CABP5 Protein, Human, Recombinant (His) calcium binding protein 5,CABP3	Human	E. coli
	CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of CABP3 gene is retina-specific. The mouse homolog of CABP3 has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of CABP3 gene is unknown. Study of the transcripts and genomic structure r...
TMPY-01763	Cadherin 16/CDH16 Protein, Human, Recombinant (His) UNQ695/PRO1340,cadherin 16	Human	HEK293 Cells
	KSP-Cadherin/Cadherin-16 is a member of the cadherin superfamily, calcium-dependent, membrane-associated glycoproteins. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playi...
TMPJ-00100	Artemin Protein, Human, Recombinant ARTN,Artemin,EVN,Enovin,Neublastin	Human	E. coli
	Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I...

重组蛋白

TRET Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02926

Species: Mouse

Expression System: E. coli

TERT Protein, Human, Recombinant (His)

Cat.No: TMPH-02186

Species: Human

Expression System: E. coli

Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02956

Species: Human

Expression System: Baculovirus Insect Cells

LCAT Protein, Human, Recombinant (His)

Cat.No: TMPY-00055

Species: Human

Expression System: HEK293 Cells

LCAT Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00835

Species: Mouse

Expression System: HEK293 Cells

APOA1 Protein, Bovine, Recombinant (E. coli, His)

Cat.No: TMPH-00224

Species: Bovine

Expression System: E. coli

APOA1 Protein, Bovine, Recombinant (His)

Cat.No: TMPH-00225

Species: Bovine

Expression System: P. pastoris (Yeast)

FBA1 Protein, Candida albicans, Recombinant (His & Myc)

Cat.No: TMPH-00335

Species: Candida albicans

Expression System: E. coli

ODH1 Protein, Pecten maximus, Recombinant (His & Myc)

Cat.No: TMPH-03087

Species: Pecten maximus

Expression System: E. coli

SEMA6A Protein, Human, Recombinant (His)

Cat.No: TMPY-01843

Species: Human

Expression System: HEK293 Cells

SULT1B1 Protein, Rat, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03377

Species: Rat

Expression System: E. coli

GPI Protein, Mouse, Recombinant (B2M & His)

Cat.No: TMPH-02677

Species: Mouse

Expression System: E. coli

Hyaluronidase 2/HYAL2 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00725

Species: Mouse

Expression System: HEK293 Cells

Hyaluronidase 2/HYAL2 Protein, Human, Recombinant (His)

Cat.No: TMPK-00954

Species: Human

Expression System: HEK293 Cells

GPI Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02678

Species: Mouse

Expression System: P. pastoris (Yeast)

NHP2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01357

Species: Human

Expression System: E. coli

GPI Protein, Human, Recombinant (His)

Cat.No: TMPH-01391

Species: Human

Expression System: E. coli

TRIM5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01310

Species: Human

Expression System: E. coli

HIV-2 (subtype A, isolate ROD) Protein Vpx (His)

Cat.No: TMPH-01522

Species: HIV-2

Expression System: P. pastoris (Yeast)

LDHB Protein, Human, Recombinant (His)

Cat.No: TMPJ-00797

Species: Human

Expression System: E. coli

SAA2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00523

Species: Human

Expression System: E. coli

GBA Protein, Human, Recombinant

Cat.No: TMPH-01624

Species: Human

Expression System: E. coli

GBA Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01623

Species: Human

Expression System: E. coli

ATP6V1F Protein, Human, Recombinant (GST)

Cat.No: TMPY-04137

Species: Human

Expression System: E. coli

SULT1B1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01617

Species: Human

Expression System: E. coli

CABP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02955

Species: Human

Expression System: E. coli

Cadherin 16/CDH16 Protein, Human, Recombinant (His)

Cat.No: TMPY-01763

Species: Human

Expression System: HEK293 Cells

Artemin Protein, Human, Recombinant

Cat.No: TMPJ-00100

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11814	Lamivudine 13C,15N2	Others	Others
	Lamivudine 13C,15N2, an impurity of Lamivudine (BCH-189), functions as an inhibitor of both HIV-1/2 reverse transcriptase and hepatitis B virus reverse transcriptase, classifying it as a nucleoside reverse transcriptase inhibitor (NRTIs).
TMIH-0555	Telbivudine-d3
	Telbivudine-d3 是 Telbivudine 的氘代化合物。Telbivudine 的 CAS 号为 3424-98-4。Telbivudine 是一种乙型肝炎病毒复制的抗病毒抑制剂，是一种具有口服活性的胸腺嘧啶核苷类似物。
T11247	Etravirine D4 R-165335 D4,TMC-125 D4,依曲韦林 D4	Others	Others
	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV. Etravirine D4 is the deuterium labeled Etravirine.
TMID-0285	Lamivudine-13C-d2
	Lamivudine-13C-d2 是 Lamivudine 的 13C 和氘代化合物。Lamivudine 的 CAS 号为 134678-17-4。Lamivudine 是一种核苷逆转录酶抑制剂，可抑制HIV逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
TMID-0205	Nevirapine-d4
	Nevirapine-d4 是 Nevirapine 的氘代化合物。Nevirapine 的 CAS 号为 129618-40-2。Nevirapine 是一种HIV-1逆转录酶非核苷抑制剂，Ki值为 270 μM，可用于研究 HIV/AIDS。
TMID-0206	Nevirapine-d3
	Nevirapine-d3 是 Nevirapine 的氘代化合物。Nevirapine 的 CAS 号为 129618-40-2。Nevirapine 是一种HIV-1逆转录酶非核苷抑制剂，Ki值为 270 μM，可用于研究 HIV/AIDS。
TMID-0266	Stavudine-α,α,α,6-d4
	Stavudine-α,α,α,6-d4 是 Stavudine 的氘代化合物。Stavudine 的 CAS 号为 3056-17-5。Stavudine 是一种口服活性核苷逆转录酶抑制剂，还抑制线粒体 DNA 的复制，具有抗HIV-1和HIV-2的活性。它降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬，诱导细胞凋亡。
TMIJ-0217	Abacavir-d4
	Abacavir-d4 是 Abacavir 的氘代化合物。Abacavir 的 CAS 号为 136470-78-5。Abacavir是一种核苷类似物逆转录酶抑制剂。
TMID-0188	Mianserin-d3
	Mianserin-d3 是 Mianserin 的氘代化合物。Mianserin 的 CAS 号为 24219-97-4。Mianserin是H1受体反向激动剂，是四环抗抑郁药(TeCA)治疗家族中的一种精神活性化合物，具有抗抑郁、抗焦虑、止吐、促氧、催眠和抗组胺作用，可作为去甲肾上腺素和特定的血清素联合用药能治疗抑郁症。

同位素标记化合物

Lamivudine 13C,15N2

Cat.No: T11814

Target: Others

Cat.No: TMIH-0555

Cat.No: T11247

Synonym: R-165335 D4,TMC-125 D4,依曲韦林 D4

Target: Others

Lamivudine-13C-d2

Cat.No: TMID-0285

Cat.No: TMID-0205

Cat.No: TMID-0206

Stavudine-α,α,α,6-d4

Cat.No: TMID-0266

Cat.No: TMIJ-0217

Cat.No: TMID-0188

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