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Search Results for " inositol "

Targets Recommended: Others

99

抑制剂 & 化合物

14

天然产物

20

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T4509	Inositol nicotinate Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate	Others	Others
	Inositol nicotinate (Mesotal) 是一种血管扩张剂，可用于研究外周动脉疾病。
T35933	D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4	Others	Others
	D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal tran...
T35935	D-myo-Inositol-1,4,5-triphosphate trisodium Inositol 1,4,5-trisphosphate trisodium,Ins(1,4,5)-P3 trisodium,D-myo-Inositol-1,4,5-triphosphate (sodium salt),Ins(1,4,5)P3	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	D-myo-Inositol-1,4,5-triphosphate trisodium (Inositol 1,4,5-trisphosphate trisodium) 是由磷脂酶 C 介导的磷脂酰肌醇-4,5-二磷酸酯水解在细胞中产生的第二信使。D-myo-Inositol-1,4,5-triphosphate (sodium salt)与 Ins(1,4,5)P3受体结合，会导致钙通道的打开和细胞内钙的增加。
T37057	D-myo-Inositol-1,2-diphosphate (sodium salt)	Others	Others
	Ins(1,2)P2 (sodium salt) is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2)P2 (te...
T35938	D-myo-Inositol-4-phosphate (ammonium salt)	Others	Others
	D-myo-Inositol-4-phosphate (Ins(4)P1) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-diphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intr...
T36069	L-myo-Inositol-1,4,5-triphosphate (sodium salt)	Others	Others
	Ins(1,4,5)P3 is an isomer of the biologically important D-myo-inositol-1,4,5-triphosphate. Unlike its isomer, Ins(1,4,5)P3 does not evoke a rise in intracellular calcium when added to cells. It is not known if Ins(1,4,5)P3 can act as a competitive inhibitor of biologically-active inositol phosphates.
T37060	D-myo-Inositol-1,3-diphosphate (sodium salt)	Others	Others
	D-myo-Inositol-1,3-phosphate (Ins(1,3)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in in...
T35936	D-myo-Inositol-1,4,6-triphosphate (sodium salt)	Others	Others
	D-myo-Inositol-1,4,6-phosphate (Ins(1,4,6)-P3) is a member of the inositol phosphate (InsP) family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-P3, is a second messenger produced in cells by phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. Binding of Ins(1,4,5)-P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in int...
T37058	D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)	Others	Others
	D-myo-Inositol-1,3,4,5-tetraphosphate (Ins(1,3,4,5)-P4) is formed by the phosphorylation of Ins(1,4,5)P3 by inositol 1,4,5-triphosphate 3-kinase. Ins(1,3,4,5)-P4 increases intracellular calcium levels by two distinct mechanisms: opening calcium channels on both the endoplasmic reticulum to release calcium from internal stores and on the plasma membrane to allow the influx of calcium from outside the cell.
T35937	D-myo-Inositol-1,5,6-triphosphate (sodium salt)	Others	Others
	The inositol phosphates are a family of mono- to poly-phosphorylated compounds that act as messengers, regulating cellular functions including cell cycling, apoptosis, differentiation, andmotility. D-myo-Inositol-1,5,6-triphosphate is an intermediate compound, produced by the dephosphorylation of various inositol-tetrakisphosphate forms. The triphosphate can be further metabolized to produce inositol-biphosphate mediators. The biological roles of D-myo-inositol-1,5,6-triphosphate remain to be de...
T35934	D-myo-Inositol-1,4,5-triphosphate (potassium salt)	Others	Others
	D-myo-Inositol-1,4,5-triphosphate (Ins(1,4,5)P3) is a second messenger produced in cells by phospholipase C (PLC) mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels and an increase in intracellular calcium.
T37059	D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)	Others	Others
	The inositol phosphates (IPs) are a family of molecules produced by altering the phosphorylation status of each of the six carbons on the cyclic inositol structure. They act as second messengers, regulating a wide array of cellular functions. D-myo-inositol-1,3,4,6-tetraphosphate(Ins(1,3,4,6)-P4) largely acts an intermediate, serving as substrate for inositol-1,3,4,6-tetraphosphate 5-kinase to produce inositol-1,3,4,5,6-pentaphosphate, or inositol-1,3,4,6-tetraphosphate 2-kinase to give inositol...
T77247	D-myo-Inositol 4-monophosphate	Others	Others
	D-myo-Inositol 4-mono-phos-phate 是一种生化试剂，可作为生物材料或有机化合物，用于生命科学相关研究。
T83390	2-C-methylene-myo-inositol oxide NSC 45109	Others	Others
	2-C-methylene-myo-inositol oxide (NSC 45109)是一种诱导裂糖酵母假菌丝形成的肌醇衍生物。
TQ0076	KIRA6	IRE1	Cell Cycle/Checkpoint
	KIRA6 是一种 IRE1α RNase 激酶的有效抑制剂，IC50为0.6 µM。它可以触发细胞凋亡反应。
T12071	MKC9989	IRE1	Cell Cycle/Checkpoint
	MKC9989 是一种羟基芳基醛 (HAA) 的抑制剂，抑制 IRE1α的 IC50值在 0.23 到 44 μM 之间。
T3654	APY29	IRE1	Cell Cycle/Checkpoint
	APY29 是 IRE1α 的变构调节剂；抑制 IRE1α 自磷酸化，IC50值为 280 nM，并激活 IRE1α RNase 活性。
T6363	4μ8C IRE1 Inhibitor III	IRE1	Cell Cycle/Checkpoint
	4μ8C (IRE1 Inhibitor III) 是一种有效且特异性的 IRE1α 抑制剂。
T6681	STF-083010 STF083010	IRE1	Cell Cycle/Checkpoint
	STF-083010 是一种 IRE1α 核酸内切酶的选择性抑制剂。
T11488	GSK2850163	IRE1	Cell Cycle/Checkpoint
	GSK2850163 是新型的肌醇需要酶-1α (IRE1α) 抑制剂，抑制 IRE1α 激酶活性的 IC50为 20nM，对 RNA 酶活性也有抑制活性，IC50为200 nM。
T15594	MKC8866	IRE1	Cell Cycle/Checkpoint
	MKC8866 是一种选择性IRE1 RNase 抑制剂，在体外的IC50为 0.29 μM，是水杨醛类似物。它抑制乳腺癌细胞中的 IRE1 RNase，导致促肿瘤因子的产生减少，并且可以抑制前列腺癌 (PCa) 肿瘤的生长。它强烈抑制二硫苏糖醇诱导的 XBP1s 表达，EC50为 0.52 μM。
T19266	Ins(1,4,5)-P3 hexapotassium salt 1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt	Others	Others
	D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt is promotes endoplasmic The second messenger of net calcium ions.
TQ0101	MKC3946	IRE1	Cell Cycle/Checkpoint
	MKC3946 是一种有效的可溶性 IRE1α 抑制剂，可在多发性骨髓瘤细胞系中引发适度的生长抑制，可用于癌症研究。
T11762L	Kira8 AMG-18	IRE1	Cell Cycle/Checkpoint
	Kira8 (AMG-18) 是一种单选择性 IRE1α 抑制剂，可变构减弱 IRE1α RNase 活性，IC50为 5.9 nM。
T9349	IXA4	IRE1	Cell Cycle/Checkpoint
	IXA4 是一种高选择性、无毒的 IRE1/XBP1s 激活剂，通过激活 IRE1 来减少 APP 的分泌。它刺激的 IRE1 激活也增强了胰腺功能。
T9564	IRE1α kinase-IN-1	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。
T7483	6-Bromo-2-hydroxy-3-methoxybenzaldehyde 6-溴-2-羟基于-甲氧基苯甲醛,NSC95682	IRE1	Cell Cycle/Checkpoint
	6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) 是一个 IRE-1α抑制剂，其 IC50值为 0.08 μM。
T21980	PD 198306	MEK	MAPK
	PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。
T8531	m-3M3FBS 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺	Apoptosis; Phospholipase	Apoptosis; Metabolism
	m-3M3FBS 是一种有效的磷脂酶C 激活剂，刺激人中性粒细胞产生超氧物，上调细胞内钙离子浓度，刺激多种细胞产生磷酸肌醇。它诱导单核细胞白血病细胞凋亡。
T0374L	Sunitinib 苏尼替尼,舒尼替尼,SU 11248	Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶 (RTK) 抑制剂，可以抑制 VEGFR2 和 PDGFRβ (IC50=80/2 nM)。Sunitinib 具有抗肿瘤活性，可以用于治疗肾癌和胃肠道肿瘤。
T0374	Sunitinib Malate 苏尼替尼苹果酸盐,Sutent,SU 11248 (Malate),SU 11248,Sunitinib	Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	Sunitinib Malate (Sunitinib) 是一种基于吲哚酮的酪氨酸激酶抑制剂，抑制 VEGFR2和 PDGFRβ的 IC50分别为80 nM 和 2 nM。它是 ATP 竞争性抑制剂，可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制 Ire1α的磷酸化。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T85008	Phosphatidylinositol (plant, wheat germ) sodium	Others	Others
	Phosphatidylinositols, comprising about 10% of total cellular phospholipids, are glycerophospholipids featuring a glycerol backbone, two non-polar fatty acid tails (primarily C16:0 and C18:0), and a polar inositol head group. Synthesized from cytidine diphosphate diacylglycerol (CPD-DAG) and myoinositol via phosphoinositol synthase, these compounds play pivotal roles in cellular processes, including calcium regulation, vesicle trafficking, mitogenesis, cell survival, and actin rearrangement. Pho...
T75688	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol	Others	Others
	1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol 是一种内源性代谢物，是细胞膜成分。
T77212	L-α-lysophosphatidylinositol (Soy) (sodium)	Others	Others
	L-α-lysophosphatidylinositol Soy sodium 作为GPR55的内源性配体，是一种既属于内源性溶血磷脂也是内源性大麻素神经递质的化合物。
T31951	Glycerophosphoinositol choline Plain	Others	Others
	Glycerophosphoinositol choline is the salt of choline and glycerophosphoinositol.
T24094	Glycerophosphoinositol lysine Distinctive gpi lysine,Gpi lysine	Others	Others
	Glycerophosphoinositol lysine has an anti-dandruff, anti-inflammatory, anti-aging activity. It significantly suppresses UVB - induced PGE secretion in NHEK keratinocytes.
T41270	Phosphatidylinositols, soya, sodium salts
	Phosphatidylinositols, soya, sodium salts 在生命科学相关研究中具有广泛的应用。
T30203	Atrinositol	Others	Others
	Atrinositol improves energy homeostasis in a mouse model of pancreatic cancer.
T10877	CPDA	Phosphatase	Metabolism
	CPDA 是新型 SH2 domain-containing inositol phosphatase 2 抑制剂，能够作用于3T3-L1脂肪细胞，改善胰岛素抗性。
T60164	UNC7467	Others	Others
	UNC7467 是一种有效的IP6K 抑制剂，IP6K2、IP6K1 和 IP6K6 的IC50值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平，而不会显着干扰其他肌醇磷酸盐的水平。UNC7467 可用于肥胖研究。
T36442L	(Hyp³)-Bradykinin acetate (Hyp³)-Bradykinin acetate (37642-65-2 Free base)	Bradykinin Receptor	GPCR/G Protein
	(Hyp³)-Bradykinin acetate 是一种缓激肽 B2 受体激动剂，可刺激培养的人成纤维细胞中磷酸肌醇的产生。
T14037	3α-Aminocholestane 5α-Cholestan-3α-amine	Phosphatase	Metabolism
	3α-Aminocholestane (5α-Cholestan-3α-amine) 是包含 SH2 结构域的肌醇-5'-磷酸酶 1 (SHIP1) 的有效抑制剂(IC50 ： 2.5 μM)，可用于研究和免疫相关的疾病。
T9848	GSK2850163 (S enantiomer)	IRE1	Cell Cycle/Checkpoint
	GSK2850163 (S enantiomer) 是 GSK2850163 的无活性对映体。GSK2850163 是一种新型的肌醇需求酶-1α (IRE1a) 抑制剂。
T6347	Ki16198	LPA Receptor; LPL Receptor	GPCR/G Protein
	Ki16198 是一种可口服的 LPA 受体拮抗剂，是 Ki16425 的甲酯衍生物。它抑制 LPA1 和 LPA3 诱导的肌醇磷酸的Ki值分别为 0.34 和 0.93 μM，可用于胰腺癌发生和转移的研究。
T14496	BAMB-4 ITPKA-IN-C14	Others	Others
	BAMB-4 (ITPKA-IN-C14) 是一种新型的膜渗透型ITPKA 抑制剂，在ADP-Glo 实验中的IC50值为37uM。
T14327	AS1949490	Phosphatase	Metabolism
	AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。
T22954	LY 456236 hydrochloride MPMQ hydrochloride	EGFR; GluR	Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	LY 456236 hydrochloride (MPMQ hydrochloride) 是一种 mGlu1 受体拮抗剂，ic50值为143 nM。LY456236具有选择性、非竞争性和具有口服活性，对磷酸肌醇水解具有抑制作用， IC50值为 0.145 μM。LY 456236 hydrochloride 对EGFR 具有抑制作用，其IC50 为 0.91 μM。
T11137	(E)-GABAB receptor antagonist 1	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	(E)-GABAB receptor antagonist 1 是 GABAB receptor antagonist 1 的反式结构。(E)-GABAB receptor antagonist 1 降低 GABA 诱导的 IP3 (三磷酸肌醇) 产生，IC50 为 37.9 μM。GABAB receptor antagonist 1是选择性的 GABAB (γ-氨基丁酸) 受体的负变构调节剂。
TP1896L1	Kisspeptin 234 acetate(1145998-81-7 free base)	GPR; Kisspeptin	Endocrinology/Hormones; GPCR/G Protein
	Kisspeptin 234 acetate(1145998-81-7 free base) 是Kisspeptin 受体 (KISS1, GPR54) 拮抗剂；是Kisspeptin-10 类似物。它抑制 Kisspeptin-10 对磷酸肌醇 (IP) (IC50 = 7 nM) 的刺激和促性腺激素释放激素 (GnRH) 的释放。

化合物

Inositol nicotinate

Cat.No: T4509

Synonym: Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate

Target: Others

D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)

Cat.No: T35933

Synonym: D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4

Target: Others

D-myo-Inositol-1,4,5-triphosphate trisodium

Cat.No: T35935

Synonym: Inositol 1,4,5-trisphosphate trisodium,Ins(1,4,5)-P3 trisodium,D-myo-Inositol-1,4,5-triphosphate (sodium salt),Ins(1,4,5)P3

Target: Calcium Channel

D-myo-Inositol-1,2-diphosphate (sodium salt)

Cat.No: T37057

Target: Others

D-myo-Inositol-4-phosphate (ammonium salt)

Cat.No: T35938

Target: Others

L-myo-Inositol-1,4,5-triphosphate (sodium salt)

Cat.No: T36069

Target: Others

D-myo-Inositol-1,3-diphosphate (sodium salt)

Cat.No: T37060

Target: Others

D-myo-Inositol-1,4,6-triphosphate (sodium salt)

Cat.No: T35936

Target: Others

D-myo-Inositol-1,3,4,5-tetraphosphate (sodium salt)

Cat.No: T37058

Target: Others

D-myo-Inositol-1,5,6-triphosphate (sodium salt)

Cat.No: T35937

Target: Others

D-myo-Inositol-1,4,5-triphosphate (potassium salt)

Cat.No: T35934

Target: Others

D-myo-Inositol-1,3,4,6-tetraphosphate (ammonium salt)

Cat.No: T37059

Target: Others

D-myo-Inositol 4-monophosphate

Cat.No: T77247

Target: Others

2-C-methylene-myo-inositol oxide

Cat.No: T83390

Synonym: NSC 45109

Target: Others

Cat.No: TQ0076

Target: IRE1

Cat.No: T12071

Target: IRE1

Cat.No: T3654

Target: IRE1

Cat.No: T6363

Synonym: IRE1 Inhibitor III

Target: IRE1

Cat.No: T6681

Synonym: STF083010

Target: IRE1

Cat.No: T11488

Target: IRE1

Cat.No: T15594

Target: IRE1

Ins(1,4,5)-P3 hexapotassium salt

Cat.No: T19266

Synonym: 1,4,5-IP3 hexapotassium salt,D-myo-Inositol 1,4,5-trisphosphate hexapotassium salt

Target: Others

Cat.No: TQ0101

Target: IRE1

Cat.No: T11762L

Synonym: AMG-18

Target: IRE1

Cat.No: T9349

Target: IRE1

IRE1α kinase-IN-1

Cat.No: T9564

Target: IRE1

6-Bromo-2-hydroxy-3-methoxybenzaldehyde

Cat.No: T7483

Synonym: 6-溴-2-羟基于-甲氧基苯甲醛,NSC95682

Target: IRE1

Cat.No: T21980

Target: MEK

Cat.No: T8531

Synonym: 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺

Target: Apoptosis, Phospholipase

Cat.No: T0374L

Synonym: 苏尼替尼,舒尼替尼,SU 11248

Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy

Sunitinib Malate

Cat.No: T0374

Synonym: 苏尼替尼苹果酸盐,Sutent,SU 11248 (Malate),SU 11248,Sunitinib

Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Phosphatidylinositol (plant, wheat germ) sodium

Cat.No: T85008

Target: Others

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol

Cat.No: T75688

Target: Others

L-α-lysophosphatidylinositol (Soy) (sodium)

Cat.No: T77212

Target: Others

Glycerophosphoinositol choline

Cat.No: T31951

Synonym: Plain

Target: Others

Glycerophosphoinositol lysine

Cat.No: T24094

Synonym: Distinctive gpi lysine,Gpi lysine

Target: Others

Phosphatidylinositols, soya, sodium salts

Cat.No: T41270

Cat.No: T30203

Target: Others

Cat.No: T10877

Target: Phosphatase

Cat.No: T60164

Target: Others

(Hyp³)-Bradykinin acetate

Cat.No: T36442L

Synonym: (Hyp³)-Bradykinin acetate (37642-65-2 Free base)

Target: Bradykinin Receptor

3α-Aminocholestane

Cat.No: T14037

Synonym: 5α-Cholestan-3α-amine

Target: Phosphatase

GSK2850163 (S enantiomer)

Cat.No: T9848

Target: IRE1

Cat.No: T6347

Target: LPA Receptor, LPL Receptor

Cat.No: T14496

Synonym: ITPKA-IN-C14

Target: Others

Cat.No: T14327

Target: Phosphatase

LY 456236 hydrochloride

Cat.No: T22954

Synonym: MPMQ hydrochloride

Target: EGFR, GluR

(E)-GABAB receptor antagonist 1

Cat.No: T11137

Target: GABA Receptor

Kisspeptin 234 acetate(1145998-81-7 free base)

Cat.No: TP1896L1

Target: GPR, Kisspeptin

Cat. No.	Product Name	Target	Signaling Pathways
T0421	i-Inositol Inositol,myo-Inositol,肌醇,meso-Inositol	Endogenous Metabolite	Metabolism
	i-Inositol (myo-Inositol) 是一种细胞内磷酸化合物，参与细胞信号传导，可能刺激肿瘤细胞分化。
T5915	D-chiro-Inositol D-手性肌醇,D-(+)-CHIRO-INOSITOL	Endogenous Metabolite	Metabolism
	D-chiro-Inositol (D-(+)-CHIRO-INOSITOL) 是肌醇差向异构体，存在于某些哺乳动物糖基磷脂酰肌醇蛋白锚和具有胰岛素样生物特性的肌醇磷脂聚糖中。它能够抑制高血糖，改善胰岛素抵抗。它用于多囊卵巢综合征和糖尿病的相关研究。
T8012	Scyllo-Inositol Scyllitol,鲨肌醇	Beta Amyloid; Endogenous Metabolite	Metabolism; Neuroscience
	Scyllo-Inositol (Scyllitol) 是淀粉样抑制剂，能够抑制 α-突触核蛋白聚集。它在体外能够稳定非纤维状无毒形式的淀粉样蛋白-β 肽，逆转阿尔茨海默病小鼠模型的认知缺陷，抑制突触毒性和淀粉样斑块。
T2971	Phytic acid Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid	Xanthine Oxidase; Endogenous Metabolite	Metabolism
	Phytic acid (Fytic Acid) 是种子和谷粒的磷储存化合物。它被称为食品抑制剂，具有很强的螯合多价金属离子的能力，特别是钙，铁，锌和蛋白质残留物。它抑制超氧化物来源黄嘌呤氧化酶并具有抗氧化，抗炎以及神经保护作用。
T33632	Neo-inositol J101.890F,Neo inositol,Inositol, neo-,Neoinositol	Others	Others
	Neo-Inositol is a group of chemically very stable small polar molecules with a variety of properties. It is one of the naturally occurring but rare inositol stereoisomers.
T5075	Phytic acid potassium 植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt	Others; BACE; Endogenous Metabolite	Metabolism; Neuroscience; Others
	Phytic acid dipotassium salt 是内源性代谢产物的一种，抑制 β-分泌酶 1 (BACE1) 。
T16527	Phytic acid dodecasodium salt hydrate 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate	Others; Xanthine Oxidase; Endogenous Metabolite	Metabolism; Others
	Phytic acid dodecasodium salt hydrate (myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate) 是种子和谷物的磷储存化合物。 Phytic acid dodecasodium salt hydrate 抑制酶促超氧化物源黄嘌呤氧化酶，IC50 为 6 mM，并具有抗氧化、神经保护和抗炎作用。
TMS0719	Sequoyitol 5-O-Methyl-Myo-Inositol,红杉醇,红杉醇,西曲依醇	Others	Others
	Sequoyitol (5-O-Methyl-Myo-Inositol) 来源于植物。它可以改善体内葡萄糖耐量，降低血糖，可用于糖尿病的研究。
T3823	D-Pinitol Pinitol,Inzitol,D-(+)-Pinitol,D-松醇,Methylinositol,3-O-Methyl-D-chiro-inositol	Others; Influenza Virus	Microbiology/Virology; Others
	D-Pinitol (Methylinositol) 是一种存在于几种植物中，如松科和豆科植物的天然产物，具有抗病毒、杀幼虫、降血糖活性和心血管系统保护作用。
T5584	Phytic acid sodium salt Sodium phytate hydrate,玉米	Others	Others
	Phytic acid sodium salt (Sodium phytate hydrate) 源于豆类种子中，具有抗营养活性。它是 [PO4]3-储藏库，是其他肌醇磷酸酯和焦磷酸酯的前体，在植物中被植酸酶逐步水解。
TN7492	(E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol	Others	Others

T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T73812	Phosphatidylinositol 4,5-bisphosphate	Others	Others
	Phosphatidylinositol 4,5-bisphosphate（L-alpha-Phosphatidylinositol-4,5-bisphosphate）为细胞膜磷脂成分，主要作为磷脂酶C（PLC）与磷酸肌醇3-激酶（PI3K）的底物，充当重要信使。
TN7278	Araguspongin B	Others	Others
	Xestospongins and araguspongins, marine natural products originally isolated from sponges in the Pacific basin, exhibit vasodilatory effects. Inositol phosphates (IP) serve as crucial signal transduction messengers, activating IP3 receptors to facilitate Ca2+ release from intracellular stores. Araguspongin B specifically hinders the calcium-releasing function of inositol 1,4,5-trisphosphate at the receptor level within cerebral microsomes, demonstrating an inhibition concentration (IC50) of 0.6 ...

天然产物

Cat.No: T0421

Synonym: Inositol,myo-Inositol,肌醇,meso-Inositol

Target: Endogenous Metabolite

D-chiro-Inositol

Cat.No: T5915

Synonym: D-手性肌醇,D-(+)-CHIRO-INOSITOL

Target: Endogenous Metabolite

Scyllo-Inositol

Cat.No: T8012

Synonym: Scyllitol,鲨肌醇

Target: Beta Amyloid, Endogenous Metabolite

Cat.No: T2971

Synonym: Inositol hexaphosphate,inositol hexakisphosphate,inositol polyphosphate,myo-Inositol, hexakis(dihydrogen phosphate),植酸,Fytic Acid

Target: Xanthine Oxidase, Endogenous Metabolite

Cat.No: T33632

Synonym: J101.890F,Neo inositol,Inositol, neo-,Neoinositol

Target: Others

Phytic acid potassium

Cat.No: T5075

Synonym: 植酸二钾盐,Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt

Target: Others, BACE, Endogenous Metabolite

Phytic acid dodecasodium salt hydrate

Cat.No: T16527

Synonym: 植酸十二钠盐,myo-Inositol, hexakis(dihydrogen phosphate) dodecasodium salt hydrate,Inositol hexaphosphate dodecasodium salt hydrate

Target: Others, Xanthine Oxidase, Endogenous Metabolite

Cat.No: TMS0719

Synonym: 5-O-Methyl-Myo-Inositol,红杉醇,红杉醇,西曲依醇

Target: Others

Cat.No: T3823

Synonym: Pinitol,Inzitol,D-(+)-Pinitol,D-松醇,Methylinositol,3-O-Methyl-D-chiro-inositol

Target: Others, Influenza Virus

Phytic acid sodium salt

Cat.No: T5584

Synonym: Sodium phytate hydrate,玉米

Target: Others

(E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol

Cat.No: TN7492

Target: Others

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Phosphatidylinositol 4,5-bisphosphate

Cat.No: T73812

Target: Others

Cat.No: TN7278

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01200	IMPA3 Protein, Mouse, Recombinant (His) Inositol monophosphatase 3,Impad1	Mouse	HEK293 Cells
	IMPAD1 protein (IMPA3, gPAPP or IMPase 3) belongs to the inositol monophosphatase family. It is found in Purkinje cells, brain stem, lung and chondrocytes. Mouse IMPAD1 gene encodes a type II transmembrane Golgi-embedded glycoprotein with 356 amino acid residues which generates a 306 amino acid residues mature protein after processing. It is expressed in embryo, and in theory may catalyze myo-inositol monophosphate to myo-inositol. Free myo-inositol is used to generate inositol phospholipid, an ...
TMPH-01534	ITPKB Protein, Human, Recombinant (His & SUMO) ITPKB,Inositol-trisphosphate 3-kinase B,Inosito...	Human	E. coli
	N/A. ITPKB Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 72.5 kDa and the accession number is P27987.
TMPJ-00660	IMPase2 Protein, Human, Recombinant (His) Inositol-1(or 4)-Monophosphatase 2,IMPA2,IMP 2,IMPa...	Human	E. coli
	Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphat...
TMPJ-00984	INPP1 Protein, Human, Recombinant (His) IPP,IPPase,Inositol Polyphosphate 1-Phosphatase,INP...	Human	HEK293 Cells
	Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibited by Li+. Removing the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. INPP1 is involved in signal transduction and phosphatidylinositol signaling pathway.
TMPY-04478	IP6K1/IHPK1 Protein, Human, Recombinant (His & GST) inositol hexakisphosphate kinase 1,IHPK1,PiUS	Human	Baculovirus Insect Cells
	IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth-suppressive and...
TMPJ-01117	INPP5A Protein, Human, Recombinant (His) INPP5A,Type I inositol 1,5-trisphosphate 5-phosphat...	Human	HEK293 Cells
	Type I inositol 1,4,5-trisphosphate 5-phosphatase is a 412 amino acids protein that belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene. It is expressed in brain and high level in Purkinje cells. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
TMPY-02394	IMPA1 Protein, Human, Recombinant (His) IMPA,inositol(myo)-1(or 4)-monophosphatase 1,IMP	Human	E. coli
	IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. This gene encodes an enzyme that dephosphorylates Myo-inositol monophosphate to generate free Myo-inositol, a precursor of phosphatidylinositol, and is, therefore, an important modulator of intracellular signal transduction via the production of the second messenger's myoinositol 1,4,5-trisphosphate and diacylglycerol. Despite its many physiological functions, no clinical phenotype has been assigned to this gene dysfunction to date. Ad...
TMPH-00076	At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His) 2,3-bisphosphoglycerate 3-phosphatase,Multiple inositol<...	Arabidopsis thaliana	Baculovirus Insect Cells
	At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 55.2 kDa and the accession number is Q941B2.
TMPH-00125	3-phytase A Protein, Aspergillus niger, Recombinant (His) EC:3.1.3.8,Phytase A,EC:3.1.3.-,Myo-inositol hexaki...	Aspergillus niger	P. pastoris (Yeast)
	Catalyzes the hydrolysis of inorganic orthophosphate from phytate. 3-phytase A Protein, Aspergillus niger, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 50.8 kDa and the accession number is P34752.
TMPH-00124	3-phytase A Protein, Aspergillus niger, Recombinant (E. coli, His) EC:3.1.3.-,EC:3.1.3.8,phyA,Phytase A,Myo-inositol h...	Aspergillus niger	E. coli
	Catalyzes the hydrolysis of inorganic orthophosphate from phytate. 3-phytase A Protein, Aspergillus niger, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 52.8 kDa and the accession number is P34752.
TMPH-00075	At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (E. coli, His) Multiple inositol polyphosphate phosphatase 1,2,3-b...	Arabidopsis thaliana	E. coli
	At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 58.8 kDa and the accession number is Q941B2.
TMPJ-01390	MINPP1 Protein, Human, Recombinant (His) 3,4,5)-Tetrakisphosphate 3-Phosphatase,2,5)P(4) 3-Phosphatas...	Human	HEK293 Cells
	Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re...
TMPH-00936	ANXA3 Protein, Human, Recombinant (His) Annexin-3,Annexin III,35-alpha calcimedin,Inositol ...	Human	E. coli
	ANXA3 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-00840	ANXA3 Protein, Human, Recombinant Annexin III,Placental anticoagulant protein III,35-alpha cal...	Human	E. coli
	Annexin A3（ANXA3）contains 4 annexin repeats and belongs to the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. ANXA3 is Inhibitor of phospholipase A2 and cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. ...
TMPK-00020	CD59 Protein, Human, Recombinant (hFc) CD59,HRF20,MACIF,MIN1,MIC11,MAC-IP,MIN3,MIN2,HRF-20,MEM43,MA...	Human	HEK293 Cells
	CD59 regulates complement activation cascade at the final step, inhibiting formation of membrane attack complex (MAC). This protein, being anchored to the cell membrane via glycosyl phosphatidyl inositol (GPI), is expressed ubiquitously on cells which are in contact with body fluids containing components.
TMPH-01715	CHRM2 Protein, Human, Recombinant (His) CHRM2,Muscarinic acetylcholine receptor M2	Human	E. coli
	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. CHRM2 Protein, Human, Recombinant (His) is expressed in E. col...
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His) MLKL,Mixed lineage kinase domain-like protein	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB...
TMPJ-00978	PIP4K2A Protein, Human, Recombinant (His) Diphosphoinositide kinase 2-α,PtdIns(5)P-4-kinase isoform 2-...	Human	HEK293 Cells
	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the...
TMPY-01614	VNN2 Protein, Human, Recombinant (His) vanin 2,FOAP-4,VNN2,GPI-80	Human	HEK293 Cells
	Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-8, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein that belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a fe...
TMPJ-00226	SLAMF1 Protein, Mouse, Recombinant (His) signaling lymphocytic activation molecule,SLAM family member...	Mouse	HEK293 Cells
	Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been...

重组蛋白

IMPA3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01200

Species: Mouse

Expression System: HEK293 Cells

ITPKB Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01534

Species: Human

Expression System: E. coli

IMPase2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00660

Species: Human

Expression System: E. coli

INPP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00984

Species: Human

Expression System: HEK293 Cells

IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04478

Species: Human

Expression System: Baculovirus Insect Cells

INPP5A Protein, Human, Recombinant (His)

Cat.No: TMPJ-01117

Species: Human

Expression System: HEK293 Cells

IMPA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02394

Species: Human

Expression System: E. coli

At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (Baculovirus, His)

Cat.No: TMPH-00076

Species: Arabidopsis thaliana

Expression System: Baculovirus Insect Cells

3-phytase A Protein, Aspergillus niger, Recombinant (His)

Cat.No: TMPH-00125

Species: Aspergillus niger

Expression System: P. pastoris (Yeast)

3-phytase A Protein, Aspergillus niger, Recombinant (E. coli, His)

Cat.No: TMPH-00124

Species: Aspergillus niger

Expression System: E. coli

At1g09870/F21M12_26 Protein, Arabidopsis thaliana, Recombinant (E. coli, His)

Cat.No: TMPH-00075

Species: Arabidopsis thaliana

Expression System: E. coli

MINPP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01390

Species: Human

Expression System: HEK293 Cells

ANXA3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00936

Species: Human

Expression System: E. coli

ANXA3 Protein, Human, Recombinant

Cat.No: TMPJ-00840

Species: Human

Expression System: E. coli

CD59 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00020

Species: Human

Expression System: HEK293 Cells

CHRM2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01715

Species: Human

Expression System: E. coli

MLKL Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01694

Species: Human

Expression System: E. coli

PIP4K2A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00978

Species: Human

Expression System: HEK293 Cells

VNN2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01614

Species: Human

Expression System: HEK293 Cells

SLAMF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00226

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0163	myo-Inositol-d6
	myo-Inositol-d6 是 myo-Inositol 的氘代化合物。myo-Inositol 的 CAS 号为 87-89-8。Inositol是一种细胞内磷酸化合物，参与细胞信号传导，可能刺激肿瘤细胞分化。

同位素标记化合物

myo-Inositol-d6

Cat.No: TMID-0163

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