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Search Results for " beta catenin "

Targets Recommended: Wnt/beta-catenin

36

抑制剂 & 化合物

7

天然产物

21

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9696	β-catenin-IN-2	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	β-catenin-IN-2 是有效的β-catenin 抑制剂。β-catenin-IN-2在结直肠癌中有研究的价值。
T9988	Wnt/β-catenin agonist 3	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。
T8400	Pamidronic acid	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Pamidronic acid 可用于各种骨吸收类疾病的研究。
T6868	KYA1797K	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KYA1797K 是一种选择性 Wnt/β-catenin 抑制剂(IC50:0.75 µM)。
T67884	β-catenin modulator IIa-661	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	β-catenin modulator IIa-661是 Wnt 途径小分子抑制剂，具有抗肿瘤活性。
T8710	MSAB	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	MSAB 是一种Wnt/β-catenin 信号传导的选择性抑制剂。它能够与 β-catenin 结合，诱导其降解，并能够下调 Wnt/β-catenin 靶基因。它对 Wnt 依赖性癌细胞表现出有效的抗肿瘤特性。
T41094	Wnt/β-catenin agonist 2	GSK-3; Wnt/beta-catenin	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	Wnt/β-catenin agonist 2激活 Wnt/β-catenin 信号传导，是一种有效的 Wnt 激动剂。 Wnt/β-catenin agonist 2可用于与信号转导相关的疾病研究，与癌症侵袭转移密切相关。
T7399	LF3	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	LF3 是一种典型 Wnt 信号传导的特异性抑制剂，通过破坏 β-catenin 和 TCF4 之间的相互作用（IC50 < 2 μM）
T9182	NRX-252262	Others; Wnt/beta-catenin	Cytoskeletal Signaling; Others; Stem Cells
	NRX-252262 是 β-Catenin 与同源 E3 ligaseSCFβ-TrCP 的相互作用增强剂，能够诱导 β-catenin 的降解，其 EC50=3.8 nM。
T1971	WAY-262611	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	WAY262611是一种 Wnt/β- 联蛋白激动剂，也是一种Dkk1的抑制剂。它能够增加骨形成速率，在 TCF- 荧光素酶测定实验中的EC50=0.63 μM。
T15137	DK419	Wnt/beta-catenin; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	DK419 是一种具有口服活性的 Wnt/β-catenin 信号通路抑制剂，IC50 为 0.19 μM。 DK419 降低 Axin2、β-catenin、c-Myc、Cyclin D1 和 Survivin 的蛋白质水平。它还诱导 pAMPK 的产生。
T9151	Teplinovivint	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Teplinovivint 是 wnt/β-catenin 信号通路抑制剂。它具有抗炎作用，对用于肌腱病具有潜在的研究价值。
T6989	SKL2001	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	SKL2001 是一种Wnt/β-catenin 信号通路的激动剂，具有抗肿瘤作用。它能够破坏 Axin/β-catenin 相互作用，稳定细胞内 β-catenin。
T15677	KY1220	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY1220 通过靶向 Wnt/β-连环蛋白通路，使 β-连环蛋白和 Ras 不稳定。它在 HEK293 报告细胞中的 IC50 为 2.1 μM。
T5642	Tegatrabetan BC2059	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Tegatrabetan (BC2059) 是β-Catenin 拮抗剂，能够破坏 β-catenin 与转导素 β 样蛋白 1 (TBL1) 结合。
T7204	PNU-74654	Apoptosis; Wnt/beta-catenin	Apoptosis; Cytoskeletal Signaling; Stem Cells
	PNU 74654是一种Wnt/β-catenin 通路抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。
T6113	ICG-001	Apoptosis; Epigenetic Reader Domain; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 是β-catenin/TCF 介导的一种转录抑制剂，选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。它可特异性结合 CREB 蛋白，IC50为3 μM。
T3062	WIKI4	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	WIKI4 是tankyrase 有效抑制剂，其对TNKS2的IC50值为 26 nM。它有效抑制Wnt/β-catenin 信号传导，其EC50值为 75 nM。它通过抑制TNKS2的酶活性来介导其对Wnt/β-catenin 信号传导的影响。它对 SCLC 细胞具有细胞毒性，其IC50值为 0.02 μM。
T21685	CCT 031374 hydrobromide	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT 031374 hydrobromide 是一种 TCF/β-catenin 抑制剂，具有抗肿瘤活性。
T2413	FH535	Wnt/beta-catenin; PPAR	Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; Stem Cells
	FH535 是一种具有抗肿瘤活性的Wnt/β-catenin 和PPAR 抑制剂。
T10904	CWP232228	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CWP232228 是一种高效的、选择性的Wnt/β-catenin 信号通路抑制剂，在细胞核中，拮抗 β-catenin 与 T 细胞因子结合。它能够抑制乳腺癌和肝癌干细胞的生长，抑制肿瘤的形成和转移，且没有毒性。
T17142	Toxoflavin 毒黄素,Xanthothricin,PKF-118-310,Toxoflavine	Wnt/beta-catenin; Antibacterial; Antibiotic	Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Toxoflavin (Xanthothricin) 是一种 TCF4/β-catenin 复合物抑制剂，也是一种 KDM4A 抑制剂，有抗肿瘤和抗菌作用。
T0470	Nefopam hydrochloride 盐酸奈福泮,Fenazoxine hydrochloride,Nefopam HCl	Wnt/beta-catenin; Sodium Channel	Cytoskeletal Signaling; Membrane transporter/Ion channel; Stem Cells
	Nefopam hydrochloride (Nefopam HCl) 作用于体外和体内间充质细胞β-连环蛋白水平，是一种中枢性但非阿片类缓解中度和重度疼痛。
T1878	XAV-939 XAV939,NVP-XAV939	PARP; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Stem Cells
	XAV-939 (NVP-XAV939) 是一种 Tankyrase (TNKS) 抑制剂，抑制 TNKS1 和 TNKS2 (IC50=11/4 nM)。XAV-939 可以选择性抑制 Wnt/β-catenin 介导的转录。
T2310	CHIR-99021 Laduviglusib,CT99021,CHIR-99021	GSK-3; Wnt/beta-catenin; Autophagy	Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	CHIR-99021 (CT99021) 是一种 Wnt/β-catenin 信号通路激活剂，也是一种 GSK-3α/β抑制剂 (IC50=10/6.7 nM)，具有选择性和口服活性。CHIR-99021 可以诱导细胞自噬，可增强小鼠和人类胚胎干细胞的自我更新。
T16079	Mirodenafil 米罗那非,SK3530	PDE	Metabolism
	Mirodenafil 是一种磷酸二酯酶5（PDE-5）抑制剂，可用于勃起功能紊乱的研究。
TP1730	β-catenin peptide
	β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.
T39200	β-catenin-IN-37	Others	Others
	β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
T8005	Cardiogenol C hydrochloride 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C hydrochloride (Cardiogenol C) 是一种细胞渗透性嘧啶诱导剂，能够促使 ESCs 分化为心肌细胞。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌生成效应，是一种心肌生成试剂，在动物模型中可以用作细胞移植研究中提高心脏修复的工具。
T11571	HLY78 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) 是 Wnt/β-catenin 信号通路的激活剂，通过靶向通道中 Axin 的 DIX 域，增强 Axin-LRP6 交联，诱导 Wnt 信号转导。
TQ0126	Mirodenafil dihydrochloride SK-3530 dihydrochloride,米罗那非二盐酸盐	PDE	Metabolism
	Mirodenafil dihydrochloride 是一种磷酸二酯酶5（PDE-5）抑制剂，可作用于勃起功能紊乱的研究。
T12537	β-catenin/CBP-IN-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
T13344	Wnt/β-catenin agonist 1	Others	Others
	Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM).
T9025	KY19382 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051	Others; GSK-3; Wnt/beta-catenin	Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Stem Cells
	KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) 是一种具有口服活性的 CXXC5-DVL (IC50:19 nM) 和 GSK3β (IC50:10 nM) 的双重抑制剂。它通过对 CXXC5-DVL 相互作用和 GSK3β 活性的抑制作用激活 Wnt/β-catenin 信号传导。它可用于高脂饮食诱发的代谢性疾病的研究。
T2161	Cardiogenol C	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Cardiogenol C 是一种细胞渗透性嘧啶诱导剂，能够诱导 ESCs 分化为心肌细胞(EC50:100 nM)。在有限的可塑性范围内，它可以对已经沿袭的祖细胞类型产生心肌病，是一种心肌发生剂。
T26456	A 83586C A83586C,A-83586C	Others	Others
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating o

化合物

β-catenin-IN-2

Cat.No: T9696

Target: Wnt/beta-catenin

Wnt/β-catenin agonist 3

Cat.No: T9988

Target: Wnt/beta-catenin

Pamidronic acid

Cat.No: T8400

Target: Wnt/beta-catenin

Cat.No: T6868

Target: Wnt/beta-catenin

β-catenin modulator IIa-661

Cat.No: T67884

Target: Wnt/beta-catenin

Cat.No: T8710

Target: Wnt/beta-catenin

Wnt/β-catenin agonist 2

Cat.No: T41094

Target: GSK-3, Wnt/beta-catenin

Cat.No: T7399

Target: Wnt/beta-catenin

Cat.No: T9182

Target: Others, Wnt/beta-catenin

Cat.No: T1971

Target: Wnt/beta-catenin

Cat.No: T15137

Target: Wnt/beta-catenin, AMPK

Cat.No: T9151

Target: Wnt/beta-catenin

Cat.No: T6989

Target: Wnt/beta-catenin

Cat.No: T15677

Target: Wnt/beta-catenin

Cat.No: T5642

Synonym: BC2059

Target: Wnt/beta-catenin

Cat.No: T7204

Target: Apoptosis, Wnt/beta-catenin

Cat.No: T6113

Target: Apoptosis, Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: T3062

Target: PARP, Wnt/beta-catenin

CCT 031374 hydrobromide

Cat.No: T21685

Target: Wnt/beta-catenin

Cat.No: T2413

Target: Wnt/beta-catenin, PPAR

Cat.No: T10904

Target: Wnt/beta-catenin

Cat.No: T17142

Synonym: 毒黄素,Xanthothricin,PKF-118-310,Toxoflavine

Target: Wnt/beta-catenin, Antibacterial, Antibiotic

Nefopam hydrochloride

Cat.No: T0470

Synonym: 盐酸奈福泮,Fenazoxine hydrochloride,Nefopam HCl

Target: Wnt/beta-catenin, Sodium Channel

Cat.No: T1878

Synonym: XAV939,NVP-XAV939

Target: PARP, Wnt/beta-catenin

Cat.No: T2310

Synonym: Laduviglusib,CT99021,CHIR-99021

Target: GSK-3, Wnt/beta-catenin, Autophagy

Cat.No: T16079

Synonym: 米罗那非,SK3530

Target: PDE

β-catenin peptide

Cat.No: TP1730

β-catenin-IN-37

Cat.No: T39200

Target: Others

Cardiogenol C hydrochloride

Cat.No: T8005

Synonym: 2-[[2-[(4-甲氧基苯基)氨基]-4-嘧啶基]氨基]乙醇盐酸盐,Cardiogenol C HCl,Cardiogenol C

Target: Wnt/beta-catenin

Cat.No: T11571

Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Target: Wnt/beta-catenin

Mirodenafil dihydrochloride

Cat.No: TQ0126

Synonym: SK-3530 dihydrochloride,米罗那非二盐酸盐

Target: PDE

β-catenin/CBP-IN-1

Cat.No: T12537

Target: Wnt/beta-catenin

Wnt/β-catenin agonist 1

Cat.No: T13344

Target: Others

Cat.No: T9025

Synonym: 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382,A3051

Target: Others, GSK-3, Wnt/beta-catenin

Cat.No: T2161

Target: Wnt/beta-catenin

Cat.No: T26456

Synonym: A83586C,A-83586C

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5729	L-quebrachitol L-白雀木醇,(-)-白雀木醇	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	L-Quebrachitol 是一种从多种植物中分离得到的天然产物，能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-catenin 信号通路，诱导成骨细胞生成。
T3925	Astragaloside I 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化，可用于成骨活性研究。
TQ0215	Salinomycin sodium salt 盐霉素钠,Sodium salinomycin,Salinomycin sodium	Apoptosis; Wnt/beta-catenin; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Stem Cells
	Salinomycin sodium salt (Sodium salinomycin) 是钾离子载体抗生素，是作用于 Wnt/Fzd/LRP 复合物的Wnt/β-catenin 信号传导抑制剂，能阻断 Wnt 诱导的 LRP6 磷酸化，导致 LRP6 蛋白降解。它选择性抑制人肿瘤干细胞。
T5679	(E)-Ferulic acid trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid	BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite	Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells
	(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体，阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。它引起 β-catenin 的磷酸化，导致其蛋白酶体降解，增加促凋亡因子 Bax 的表达，降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。
T5S1058	Triptonide 雷公藤内酯酮,PG 492,NSC 165677	Apoptosis; Wnt/beta-catenin; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells
	Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物，是一种 Wnt 信号抑制剂，其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
T5S1982	Periplocin Periplocoside,杠柳毒苷	Apoptosis; Others	Apoptosis; Others
	Periplocin (Periplocoside) 是从黑龙骨中分离出的一种强心类固醇。它可促进肿瘤细胞凋亡并抑制肿瘤生长。它通过激活 Na/K-ATPase 介导的 Src/ERK 和 PI3K/Akt 途径，具有促进伤口愈合的潜力。

天然产物

Cat.No: T5729

Synonym: L-白雀木醇,(-)-白雀木醇

Target: Wnt/beta-catenin

Astragaloside I

Cat.No: T3925

Synonym: 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV

Target: Wnt/beta-catenin

Salinomycin sodium salt

Cat.No: TQ0215

Synonym: 盐霉素钠,Sodium salinomycin,Salinomycin sodium

Target: Apoptosis, Wnt/beta-catenin, Antibacterial, Antibiotic, Autophagy

(E)-Ferulic acid

Cat.No: T5679

Synonym: trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Cat.No: T5S1058

Synonym: 雷公藤内酯酮,PG 492,NSC 165677

Target: Apoptosis, Wnt/beta-catenin, Autophagy

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

Cat.No: T5S1982

Synonym: Periplocoside,杠柳毒苷

Target: Apoptosis, Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02205	Beta-Catenin Protein, Human, Recombinant (His & GST) catenin beta 1,armadillo,CTNNB,MRD19,c...	Human	Baculovirus Insect Cells
	Beta-Catenin Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 113 kDa and the accession number is P35222-1.
TMPY-02985	Beta-Catenin Protein, Mouse, Recombinant (His & GST) catenin β1,Bfc,Mesc,catenin beta ...	Mouse	Baculovirus Insect Cells
	Beta-Catenin Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 113 kDa and the accession number is Q02248.
TMPY-04153	RNF43 Protein, Human, Recombinant (His) ring finger protein 43,URCC,RNF43,RNF124	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t...
TMPY-02115	R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) CRISTIN1,THSD2,R-spondin 3,PWTSR	Human	HEK293 Cells
	R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s...
TMPY-02030	CD82 Protein, Human, Recombinant (His) CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1...	Human	HEK293 Cells
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud...
TMPK-01001	RNF43 Protein, Mouse, Recombinant (hFc) Rnf43,RING finger protein 43,RING-type E3 ubiquitin transfer...	Mouse	HEK293 Cells
	RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
TMPH-02437	5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) TPBG,WAIF1,Wnt-activated inhibitory factor 1,Trophoblast gly...	Cynomolgus	HEK293 Cells
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is Q4R8Y9.
TMPH-02436	5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) TPBG,Trophoblast glycoprotein,Wnt-activated inhibitory facto...	Cynomolgus	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q4R8Y9.
TMPH-02861	Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO) Wnt7b,Protein Wnt-7b	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation.
TMPH-03392	5T4/TPBG Protein, Rat, Recombinant (His & SUMO) Wnt-activated inhibitory factor 1,Trophoblast glycoprotein,T...	Rat	E. coli
	May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.8 kDa and the accession number is Q5PQV5.
TMPH-02858	Wnt2 Protein, Mouse, Recombinant (His) Protein Wnt-2,INT-1-related protein,Wnt2	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons.
TMPY-03046	APCDD1 Protein, Human, Recombinant (hFc) HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS...	Human	HEK293 Cells
	Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells...
TMPH-02864	Wnt1 Protein, Mouse, Recombinant (His & Myc) Proto-oncogene Wnt-1,Wnt1,Proto-oncogene Int-1	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.
TMPY-01165	FZD1/Frizzled 1 Protein, Mouse, Recombinant (His) Fzd1,AW227548,frizzled class receptor 1,FZ-1,Fz1	Mouse	HEK293 Cells
	Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. FZD1 is expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney. Frizzled is a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signalin...
TMPY-04149	RNF43 Protein, Human, Recombinant (hFc) RNF43,RNF124,URCC,ring finger protein 43	Human	HEK293 Cells
	RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and t...
TMPH-03756	Wnt7b Protein, Human, Recombinant (His & Myc & SUMO) Protein Wnt-7b,WNT7B	Human	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Wint7b Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 56.3 kDa and ...
TMPJ-00163	R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His) Protein with TSP type-1 repeat,RSPO3,R-spondin-3,Roof plate-...	Human	HEK293 Cells
	R-spondin-3 (RSPO3), also known as Protein with TSP type-1 repeat, Roof plate-specific spondin-3, Thrombospondin type-1 domain-containing protein 2, PWTSR, THSD2 and CRISTIN1, is a member of the thrombospondin type 1 repeat supergene family. RSPO3 is a secreted protein and widely expressed in many tissues. RSPO3 contains two Furin-like repeats which have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases, and one TSP type-...
TMPH-02857	Wnt10a Protein, Mouse, Recombinant (His & Myc) Wnt10a,Protein Wnt-10a	Mouse	E. coli
	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Requir...
TMPY-04144	Kremen-1 Protein, Human, Recombinant (His) KREMEN,KRM1,kringle containing transmembrane protein 1	Human	HEK293 Cells
	KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility...
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) nemo-like kinase,LAK1	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway protein ...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...

重组蛋白

Beta-Catenin Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02205

Species: Human

Expression System: Baculovirus Insect Cells

Beta-Catenin Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-02985

Species: Mouse

Expression System: Baculovirus Insect Cells

RNF43 Protein, Human, Recombinant (His)

Cat.No: TMPY-04153

Species: Human

Expression System: HEK293 Cells

R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)

Cat.No: TMPY-02115

Species: Human

Expression System: HEK293 Cells

CD82 Protein, Human, Recombinant (His)

Cat.No: TMPY-02030

Species: Human

Expression System: HEK293 Cells

RNF43 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01001

Species: Mouse

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc)

Cat.No: TMPH-02437

Species: Cynomolgus

Expression System: HEK293 Cells

5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02436

Species: Cynomolgus

Expression System: E. coli

Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02861

Species: Mouse

Expression System: E. coli

5T4/TPBG Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03392

Species: Rat

Expression System: E. coli

Wnt2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02858

Species: Mouse

Expression System: E. coli

APCDD1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03046

Species: Human

Expression System: HEK293 Cells

Wnt1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02864

Species: Mouse

Expression System: E. coli

FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01165

Species: Mouse

Expression System: HEK293 Cells

RNF43 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04149

Species: Human

Expression System: HEK293 Cells

Wnt7b Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03756

Species: Human

Expression System: E. coli

R-Spondin 3/RSPO3 Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00163

Species: Human

Expression System: HEK293 Cells

Wnt10a Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02857

Species: Mouse

Expression System: E. coli

Kremen-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04144

Species: Human

Expression System: HEK293 Cells

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

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