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Targets Recommended: Others

126

抑制剂 & 化合物

14

天然产物

1

化合物库

96

重组蛋白

3

同位素标记化合物

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Cat. No. Product Name
L5800 药物代谢杂质库

197 compounds
197 种药物异构体/代谢产物的特有集合,可用于高通量、高内涵筛选;

化合物库

药物代谢杂质库
Cat.No: L5800
Compounds: 197
Cat. No. Product Name Target Signaling Pathways
T8701 GRP-60367

Others Others
GRP-60367 是一种小分子狂犬病病毒进入抑制剂,对某些 RABV 株具有纳摩尔作用效果。
T9231 Mbx2329

Antiviral Immunology/Inflammation
MBX2329 是一种流感病毒抑制剂,能特异性地抑制血凝素介导的病毒进入,HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T8793 CBS1117

Influenza Virus Microbiology/Virology
CBS1117 是一种病毒进入抑制剂,对甲型流感病毒 A/Puerto Rico/8/34 的 IC50为 70 nM。它干扰血凝素介导的融合过程。
T12174 Naphthoquine phosphate

Parasite Microbiology/Virology
Naphthoquine phosphate 是一种具有口服活性的广谱4-氨基喹啉类抗疟化合物,可能影响病毒进入和进入后复制。Naphthoquine phosphate 具有肝血管中心毒性,常与青蒿素一起使用来治疗疟疾。
T9717 Chlorcyclizine

HCV Protease; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Chlorcyclizine 是一种有效的组胺 H1拮抗剂。
T35373L Bulevirtide (Myrcludex B) acetate

HBV Microbiology/Virology
Bulevirtide (Myrcludex B) acetate 是一种病毒粒子进入抑制剂,可阻断病毒粒子的肝细胞进入途径,即肝钠/牛磺胆酸盐协同转运多肽 (NTCP) 受体。它可用于 HBV 和 HDV 感染研究。
T6256 YYA-021

YYA 021

gp120/CD4; HIV Protease Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
YYA-021具有高抗HIV 活性和低细胞毒性,是一种抑制HIV 进入的小分子CD4模拟物,。
T12108 MRS1845

Calcium Channel Membrane transporter/Ion channel; Metabolism
MRS1845 是一种 ORAI1 抑制剂和钙进入 (SOCE) 阻滞剂,可阻断VP 诱导的 SOCE、OS 和 Ca(2+) 沉积。
T24141 HIV-1 Inhibitor 18A

HIV-1 Inhibitor-18A

HIV Protease Microbiology/Virology; Proteases/Proteasome
HIV-1 Inhibitor 18A (HIV-1 Inhibitor-18A) 特异性抑制多种 HIV-1 分离株的进入。
T16688 Pyr6

N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide

TRP/TRPV Channel Membrane transporter/Ion channel
Pyr6 (N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide)是选择性的 TRPC3抑制剂,IC50值为0.49uM。
T13684 Equilin

7-Dehydroestrone

Calcium Channel Membrane transporter/Ion channel; Metabolism
Equilin (7-Dehydroestrone) 是神经营养性雌激素类固醇,具有血管扩张活性,通过 NF-κB 信号传导增加单核细胞-内皮粘附。Equilin 通过阻断Ca(2+)进入平滑肌来同样放松肠系膜动脉的阻力。
T24984 5J-4

Calcium Channel Membrane transporter/Ion channel; Metabolism
5J-4 是一种有效的钙释放激活钙通道 (CRAC) 和钙池操纵性钙内流(SOCE) 阻滞剂。 5J-4 减少 IL-17 的产生并降低 RORα 和 RORγt 的表达。
T13047 Synta66

Calcium Channel Membrane transporter/Ion channel; Metabolism
Synta66 是一种钙池操纵钙离子通道 Orai 抑制剂,用于神经系统疾病的研究。
T26357 Pitstop 2

Apoptosis Apoptosis
Pitstop2 是一种选择性的两性蛋白结合的网格蛋白末端结构域抑制剂,IC50 值为 12 μM。 Pitstop2 严重干扰受体介导的内吞作用、HIV 进入和突触小泡循环。
T6016 Maraviroc

Celsentri,马拉维若,UK-427857,Selzentry

HIV Protease; CCR Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
Maraviroc (Selzentry) 是一种 C-C 趋化因子受体 5 拮抗剂,具有抑制HIV 的活性。
T8502 N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide

Influenza Virus Microbiology/Virology
N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide 通过与表面糖蛋白结合抑制埃博拉病毒进入宿主细胞,该化合物抑制埃博拉病毒,EC50 为 3.9 μM。
T15641 K777

APC-3316

P450; Cysteine Protease; CCR Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome
K777 是有效的,具有口服活性的,不可逆的半胱氨酸蛋白酶 (cysteine protease) 抑制剂。K777是有效的 CYP3A4 抑制剂(IC50= 60 nM)。K777也是选择性的 CCR4 拮抗剂,显示出强的趋化性抑制作用。K777 对 Cruzain(克鲁斯锥虫的主要半胱氨酸蛋白酶)和组织蛋白酶 B 和 L 具有不可逆的抑制作用。K777 通过靶向组织蛋白酶介导的细胞进入,显示出广谱的抗病毒作用。K777 抑制 EBOV 和 SARS-CoV 病毒的进入,IC50 值分别为 0.87 nM 和 0.68 nM。
T60085 MM3122

GTPL11533,MM-3122,Ac-GQFR-kbt

SARS-CoV Microbiology/Virology
MM3122 (MM-3122) 是一种选择性的 II 型跨膜丝氨酸蛋白酶 (TMPRSS2) 抑制剂,IC50为 0.34 nM。MM3122 可以有效阻断 TMPRSS2,从而抑制 SARS-CoV-2 和 MERS-CoV 进入人类细胞。
T25365 EGA

Others Others
EGA 抑制致命毒素的中毒,并阻止多种其他酸依赖性细菌毒素和病毒进入哺乳动物细胞。EGA 是研究膜运输的有力工具,可用于治疗传染病。
T3052 Sancycline

Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline

Antibacterial Microbiology/Virology
Sancycline (Bonomycin) 是半合成四环素,通过可逆地结合 30S 核糖体亚基并通过阻断氨酰-tRNA 进入核糖体 A 位点来抑制蛋白质翻译。
TP1828 N-Acetyl-Ser-Asp-Lys-Pro

RAAS Endocrinology/Hormones
N-Acetyl-Ser-Asp-Lys-Pro 通过酶促处理胸腺素 β4 在骨髓细胞中形成。 它抑制多能造血干细胞进入细胞周期的 S 期,并防止小鼠中的 Ara-C 致死性。
T11076 Dooku1

Others Others
Dooku1 是Yoda1 的类似物,是一种内源性Piezo1通道的选择性拮抗剂,能够抑制Yoda1 诱导的主动脉舒张。它在HEK 293 细胞以及HUVEC 中测得对2 μM Yoda1 诱导的钙离子流的IC50值分别为1.3 μM 和1.5 μM。
T9807 CPDS

Others Others
CPDS 是一种非渗透性硫醇剂,可影响多种线粒体功能。在大鼠肝线粒体中,它仅抑制 Pi/OH- 载体。它和丙二酸正丁酯都是完全抑制 Pi 进入所必需的。
T0860L Mefloquine

Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Others Others
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T1127 Beclometasone dipropionate

Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase

Glucocorticoid Receptor Endocrinology/Hormones
Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
T8501 3-​Phenyl-​N-​[1-​(phenylmethyl)​-​4-​piperidinyl]​-tricyclo[3.3.1.13,​7]​decane-​1-​carboxamide

Influenza Virus Microbiology/Virology
3-​Phenyl-​N-​[1-​(phenylmethyl)​-​4-​piperidinyl]​-tricyclo[3.3.1.13,​7]​decane-​1-​carboxamide 具有抗埃博拉病毒的抗病毒活性靶向表面暴露的糖蛋白并抑制病毒进入宿主细胞。 Vero 细胞的体外研究表明,该化合物抑制病毒复制,EC50 为 0.38 μM。
T76687 Ibalizumab

TNX-355,TMB-355

HIV Protease Microbiology/Virology; Proteases/Proteasome
Ibalizumab(TMB-355) 是一种人源化 IgG4 单克隆抗体,可作为 CD4 受体抑制, 通过与 CD4 受体结合来阻止 HIV-1进入细胞。Ibalizumab 具有抗HIV-1感染活性,可用于维持机体正常免疫功能。
T0806 Flunarizine dihydrochloride

Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪

Calcium Channel; Dopamine Receptor; Sodium Channel GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。
T27407 GDC0575 monohydrochloride

ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575

Chk Cell Cycle/Checkpoint
GDC0575 monohydrochloride (ARRY575) 是一种有效的、选择性的细胞周期检查点激酶 1(Chk1) 抑制剂,IC50 为 1.2 nM。GDC0575 monohydrochloride (ARRY575) 特异性结合并抑制 Chk1;这可能导致肿瘤细胞在 S 期和 G2/M 期绕过 Chk1 依赖性细胞周期停滞,从而允许细胞在进入有丝分裂之前进行 DNA 修复。
T9864 Debio-0123

WEE1-IN-5

Wee1 Cell Cycle/Checkpoint
Debio-0123 (WEE1-IN-5) 是一种口服有效且高度特异性的WEE1抑制剂,IC50值在低纳摩尔范围内。Debio-0123 抑制磷酸化 CDC2。Debio-0123 可增强卡铂在体内的抗肿瘤活性,而这两种药物单独使用都没有活性。
T0957 Isradipine

PN 200-110,伊拉地平

Calcium Channel; Autophagy Autophagy; Membrane transporter/Ion channel; Metabolism
Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂,具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂,也是一种潜在可行的帕金森病神经保护剂。
T27625 IQP-0528

SJ-3991,SJ3991,IQP0528

Antiviral; HIV Protease; Reverse Transcriptase Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
IQP-0528是一种高效的非核苷类逆转录酶抑制剂(NNRTI),通过阻断病毒进入,有可能用于治疗HIV 感染,并且作为杀微生物凝胶显示出抗病毒活性。IQP-0528对HIV-1和HIV-2都显示出抑制作用,对HIV-1的EC50为0.2 nM,对HIV-2的EC50为100 nM。
T16686 Pyr10

TRP/TRPV Channel Membrane transporter/Ion channel
Pyr10 是吡唑衍生物,是TRPC3通道的选择性抑制剂。Pyr10抑制卡巴可刺激的TRPC3转染的 HEK293 细胞中的 Ca2+流入。它具有区分受体操纵的TRPC3和天然基质相互作用分子 1 (STIM1)/Orai1 通道的能力。
T2170 SKF-96365 hydrochloride

1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365

Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism
SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂,也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流,延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。
T24522 NBD-10007

NBD 10007

Others Others
NBD-10007 is an inhibitor of HIV-1 entry.
T23770 B07 hydrochloride

B 07 HCl,B-07 HCl,B-07 hydrochloride,B07 HCl,B 07 hydrochloride

Others Others
B07 hydrochloride is a CCR5 antagonist-based inhibitor of HIV-1 entry.
T71871 EI-1

Others Others
EI-1 is an inhibitor of Hepatitis C virus entry.
T27641 ITX-4520

ITX 4520

Others Others
ITX-4520 novel highly potent, orally bioavailable inhibitor of hepatitis C virus (HCV) entry.
T71712 NPD8716

Others Others
NPD8716 is a hepatitis B/D virus entry inhibitor, targeting sodium taurocholate cotransporting polypeptide (NTCP).
T68501 Noremopamil

Others Others
Noremopamil is a calcium entry blocker, also being used as the precursor for radiolabelling emopamil.
T12947 SOCE inhibitor 1

Others Others
SOCE inhibitor 1 is a inhibitor of store-operated calcium entry (SOCE)(IC50 of 4.4 μM).
T15733 Lemildipine

NB-818,NPK-1886

Others Others
Lemildipine is a new blocker of dihydropyridine calcium entry.
T70517 CB5660386

Others Others
CB5660386 inhibitor of HIV-1 entry.
T68454 IAV inhibitor 4l

Others Others
IAV inhibitor 4l is an IAV inhibitor targeting hemagglutinin and mediates viral entry by preventing HA-membrane fusion.
T71996 VU0621623

Others Others
VU0621623 is an arenavirus multiplication inhibitor which blocks lymphocytic choriomeningitis virus (LCMV) cell entry.
T71056 SJP-L-5

Others Others
SJP-L-5 is a inhibitor of HIV-1 infection by blocking viral DNA nuclear entry.
T24521 NBD-09027

NBD 09027

Others Others
NBD-09027 is an inhibitor of HIV-1 entry.
T70836 DMJ-I-228

Others Others
DMJ-I-228 is a specific inhibitor of HIV-1 entry through interaction with the Env spike by virtue of the incorporation of a guandinium group.
T81217 SAP6

SAP6为具有抑制病毒进入细胞生物活性的肽。
T69935 L0909

Others Others
L0909 is an orally available inhibitors of Hepatitis C virus with a novel mechanism of action (EC50 = 0.022 μM, SI > 600). L0909 could block HCV replication by acting on the HCV entry stage. The high sensitivity to clinical resistant HCV mutants and synergistic effect with clinical drugs were observed for this compound. L0909 as a promising HCV entry inhibitor for single or combinational therapeutic potential.

化合物

GRP-60367
Cat.No: T8701
Synonym:
Target: Others
Mbx2329
Cat.No: T9231
Synonym:
Target: Antiviral
CBS1117
Cat.No: T8793
Synonym:
Target: Influenza Virus
Naphthoquine phosphate
Cat.No: T12174
Synonym:
Target: Parasite
Chlorcyclizine
Cat.No: T9717
Synonym:
Target: HCV Protease, Histamine Receptor
Bulevirtide (Myrcludex B) acetate
Cat.No: T35373L
Synonym:
Target: HBV
YYA-021
Cat.No: T6256
Synonym: YYA 021
Target: gp120/CD4, HIV Protease
MRS1845
Cat.No: T12108
Synonym:
Target: Calcium Channel
HIV-1 Inhibitor 18A
Cat.No: T24141
Synonym: HIV-1 Inhibitor-18A
Target: HIV Protease
Pyr6
Cat.No: T16688
Synonym: N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide
Target: TRP/TRPV Channel
Equilin
Cat.No: T13684
Synonym: 7-Dehydroestrone
Target: Calcium Channel
5J-4
Cat.No: T24984
Synonym:
Target: Calcium Channel
Synta66
Cat.No: T13047
Synonym:
Target: Calcium Channel
Pitstop 2
Cat.No: T26357
Synonym:
Target: Apoptosis
Maraviroc
Cat.No: T6016
Synonym: Celsentri,马拉维若,UK-427857,Selzentry
Target: HIV Protease, CCR
N-(1-benzyl-4-piperidyl)adamantane-1-carboxamide
Cat.No: T8502
Synonym:
Target: Influenza Virus
K777
Cat.No: T15641
Synonym: APC-3316
Target: P450, Cysteine Protease, CCR
MM3122
Cat.No: T60085
Synonym: GTPL11533,MM-3122,Ac-GQFR-kbt
Target: SARS-CoV
EGA
Cat.No: T25365
Synonym:
Target: Others
Sancycline
Cat.No: T3052
Synonym: Bonomycin,Norcycline,Sancyclinum,山环素,6-Demethyl-6-deoxytetracycline
Target: Antibacterial
N-Acetyl-Ser-Asp-Lys-Pro
Cat.No: TP1828
Synonym:
Target: RAAS
Dooku1
Cat.No: T11076
Synonym:
Target: Others
CPDS
Cat.No: T9807
Synonym:
Target: Others
Mefloquine
Cat.No: T0860L
Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998
Target: Others
Beclometasone dipropionate
Cat.No: T1127
Synonym: Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase
Target: Glucocorticoid Receptor
3-​Phenyl-​N-​[1-​(phenylmethyl)​-​4-​piperidinyl]​-tricyclo[3.3.1.13,​7]​decane-​1-​carboxamide
Cat.No: T8501
Synonym:
Target: Influenza Virus
Ibalizumab
Cat.No: T76687
Synonym: TNX-355,TMB-355
Target: HIV Protease
Flunarizine dihydrochloride
Cat.No: T0806
Synonym: Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪
Target: Calcium Channel, Dopamine Receptor, Sodium Channel
GDC0575 monohydrochloride
Cat.No: T27407
Synonym: ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575
Target: Chk
Debio-0123
Cat.No: T9864
Synonym: WEE1-IN-5
Target: Wee1
Isradipine
Cat.No: T0957
Synonym: PN 200-110,伊拉地平
Target: Calcium Channel, Autophagy
IQP-0528
Cat.No: T27625
Synonym: SJ-3991,SJ3991,IQP0528
Target: Antiviral, HIV Protease, Reverse Transcriptase
Pyr10
Cat.No: T16686
Synonym:
Target: TRP/TRPV Channel
SKF-96365 hydrochloride
Cat.No: T2170
Synonym: 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365
Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy
NBD-10007
Cat.No: T24522
Synonym: NBD 10007
Target: Others
B07 hydrochloride
Cat.No: T23770
Synonym: B 07 HCl,B-07 HCl,B-07 hydrochloride,B07 HCl,B 07 hydrochloride
Target: Others
EI-1
Cat.No: T71871
Synonym:
Target: Others
ITX-4520
Cat.No: T27641
Synonym: ITX 4520
Target: Others
NPD8716
Cat.No: T71712
Synonym:
Target: Others
Noremopamil
Cat.No: T68501
Synonym:
Target: Others
SOCE inhibitor 1
Cat.No: T12947
Synonym:
Target: Others
Lemildipine
Cat.No: T15733
Synonym: NB-818,NPK-1886
Target: Others
CB5660386
Cat.No: T70517
Synonym:
Target: Others
IAV inhibitor 4l
Cat.No: T68454
Synonym:
Target: Others
VU0621623
Cat.No: T71996
Synonym:
Target: Others
SJP-L-5
Cat.No: T71056
Synonym:
Target: Others
NBD-09027
Cat.No: T24521
Synonym: NBD 09027
Target: Others
DMJ-I-228
Cat.No: T70836
Synonym:
Target: Others
SAP6
Cat.No: T81217
Synonym:
Target:
L0909
Cat.No: T69935
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T2S0731 Trilobatin

三叶苷,三叶甙,P-Phlorizin

Amylase Metabolism
Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂,是一种HIV-1抑制剂,靶向 Gp41 包膜蛋白,具有神经保护作用。它还是SGLT1/2抑制剂,可选择性诱导人肝母细胞瘤细胞增殖。
T19719 TBMP

butylated hydroxyanisole

Others Others
TBMP (butylated hydroxyanisole) 是病毒包膜蛋白血凝素 (HA) 介导的进入新型抑制剂。
T11287 Filipin complex

Antifungal Microbiology/Virology
Filipin complex 是一种 28 元环戊烯大环内酯类抗真菌抗生素,由 S. filipinensis、S. avermitilis 和 S. miharaensis 产生的混合物,抑制 PRRSV 病毒进入细胞,通过与膜固醇相互作用发挥作用。
T0846 L-Carnitine

L(-)-Carnitine,Levocarnitine,左旋肉碱

Endogenous Metabolite; Fatty Acid Synthase Metabolism
L-Carnitine (L(-)-Carnitine) 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A 转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。
T4S1422 Praeruptorin E

白花前胡素 E,白花前胡素E

Others; Calcium Channel Membrane transporter/Ion channel; Metabolism; Others
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。
T2A2498 L-Lysine

Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸

Virus Protease; Endogenous Metabolite; Antifection Metabolism; Microbiology/Virology
L-Lysine (Aminutrin) 是一种人类必需氨基酸,能增加钙吸收,减少糖尿病相关疾病和改善肠道健康,可用于疱疹的研究。
T0884 1-Docosanol

Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Antifection; HSV Microbiology/Virology
1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇,局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
TN6508 Trachelogenin

(-)-Trachelogenin

Virus Protease; c-Myc; HCV Protease; Wnt/beta-catenin Cell Cycle/Checkpoint; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
Trachelogenin ((-)-Trachelogenin) 分离自Combretum fruticosum,是一种 HCV 进入抑制剂 具有抗增殖作用,其机制与影响β-Catenin 信号通路中的 β-Catenin、c-Myc 和 GSK3 等关键蛋白的磷酸化有关,且呈浓度依赖性。Trachelogenin具有抗病毒、抗炎和镇痛活性,在 HCVcc 和 HCVpp 模型中的 IC50 分别为 0.325 和 0.259 μg/mL。
T0798 Triamcinolone

Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Glucocorticoid Receptor; COX Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。
TN5234 Vindorosine

Calcium Channel; Sodium Channel Membrane transporter/Ion channel; Metabolism
Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
TN4605 Myriceric acid B

HIV Protease Microbiology/Virology; Proteases/Proteasome
Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val
T20123 L-Carnitine hydrochloride

L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80

Others Others
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en
T75444 Peniterphenyl A

Others Others
Peniterphenyl A,一种源于深海青霉属植物的天然产物,能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用,干扰病毒的吸附和膜融合过程,进而有效阻断病毒感染。因此,Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。
T35415 α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)

Others Others
α-D-Glucose-1,6-bisphosphate is abis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism.1It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate.2It is also a cofactor for the bacterial enzyme phosphopentomutase.3,4α-D-Glucose-1,6-bisphosphate has been used in the study of carbohydrate metabolism. 1.Beitner, R.Regulation of carbohydrate metabol...

天然产物

Trilobatin
Cat.No: T2S0731
Synonym: 三叶苷,三叶甙,P-Phlorizin
Target: Amylase
TBMP
Cat.No: T19719
Synonym: butylated hydroxyanisole
Target: Others
Filipin complex
Cat.No: T11287
Synonym:
Target: Antifungal
L-Carnitine
Cat.No: T0846
Synonym: L(-)-Carnitine,Levocarnitine,左旋肉碱
Target: Endogenous Metabolite, Fatty Acid Synthase
Praeruptorin E
Cat.No: T4S1422
Synonym: 白花前胡素 E,白花前胡素E
Target: Others, Calcium Channel
L-Lysine
Cat.No: T2A2498
Synonym: Aminutrin,Lysine Acid,lysine,L-赖氨酸,赖氨酸
Target: Virus Protease, Endogenous Metabolite, Antifection
1-Docosanol
Cat.No: T0884
Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol
Target: Antifection, HSV
Trachelogenin
Cat.No: TN6508
Synonym: (-)-Trachelogenin
Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin
Triamcinolone
Cat.No: T0798
Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone
Target: Glucocorticoid Receptor, COX
Vindorosine
Cat.No: TN5234
Synonym:
Target: Calcium Channel, Sodium Channel
Myriceric acid B
Cat.No: TN4605
Synonym:
Target: HIV Protease
L-Carnitine hydrochloride
Cat.No: T20123
Synonym: L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80
Target: Others
Peniterphenyl A
Cat.No: T75444
Synonym:
Target: Others
α-D-Glucose-1,6-bisphosphate (potassium salt hydrate)
Cat.No: T35415
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPY-00748 Nectin-2 Protein, Human, Recombinant

PRR2,Nectin-2,PVRR2,poliovirus receptor-related 2 (herpesvir...

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-00747 Nectin-2 Protein, Human, Recombinant (His)

PVRR2,Nectin-2,poliovirus receptor-related 2 (herpesvirus

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
TMPY-05579 PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated

PRR1,ED4,PVRR,nectin-1,OFC7,SK-12,CD111,CLPED1,HVEC,poliovir...

Human HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61 kDa and the accession number is Q15223-1.
TMPJ-00323 Nectin-2 Protein, Mouse, Recombinant (hFc)

Herpes Virus Entry Mediator B,PVRL2,Poliovirus Rece...

Mouse HEK293 Cells
CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens ju...
TMPY-02561 Nectin-2 Protein, Cynomolgus, Recombinant (His)

poliovirus receptor-related 2 (herpesvirus entry me...

Cynomolgus HEK293 Cells
Nectin-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.2 kDa and the accession number is Q0MSE5.
TMPY-03030 PVRL1/NECTIN1 Protein, Rat, Recombinant (hFc)

poliovirus receptor-related 1 (herpesvirus entry me...

Rat HEK293 Cells
PVRL1/NECTIN1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 63.3 kDa and the accession number is A6J3U6.
TMPY-03036 Nectin-2 Protein, Rat, Recombinant (His)

poliovirus receptor-related 2 (herpesvirus entry me...

Rat HEK293 Cells
Nectin-2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is Q9ESS6.
TMPY-02937 PVRL1/NECTIN1 Protein, Rat, Recombinant (His)

poliovirus receptor-related 1 (herpesvirus entry me...

Rat HEK293 Cells
PVRL1/NECTIN1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is A6J3U6.
TMPH-03659 Vaccinia virus (strain Western Reserve) OPG094 Protein (His)

Protein F1,Myristoylated protein G9,Entry-fusion co...

VACV P. pastoris (Yeast)
Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry. Also plays a role in cell-cell fusion (syncytium formation). Vaccinia virus (strain Western Reserve) OPG094 Protein (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 37.8 kDa and the accession number is P07611.
TMPJ-00620 HVEM Protein, Rhesus macaque, Recombinant (His)

TNFRSF14,HVEA,Tumor Necrosis Factor Receptor Superfamily Mem...

Rhesus HEK293 Cells
HVEM Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-40 KDa and the accession number is F7GSW4.
TMPY-06383 Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated

poliovirus receptor-related 2 (herpesvirus entry me...

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 38.80 kDa and the accession number is Q92692-2.
TMPJ-01416 HVEM Protein, Rhesus macaque, Recombinant (hFc)

CD270,TNFRSF14,TR2,Herpesvirus Entry Mediator A,Tum...

Rhesus HEK293 Cells
HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.
TMPY-00746 Nectin-2 Protein, Human, Recombinant (hFc)

Nectin-2,HVEB,poliovirus receptor-related 2 (herpesvirus

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.3 kDa and the accession number is Q92692-2.
TMPH-03676 Vaccinia virus (strain Western Reserve) L1 Protein (His)

Entry-fusion complex associated protein OPG095,EFC-...

VACV P. pastoris (Yeast)
Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Western Reserve) L1 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P07612.
TMPY-06295 Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Nectin-2,HVEB,PVRR2,CD112,PRR2,poliovirus receptor-related 2...

Human HEK293 Cells
Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 64.08 kDa and the accession number is Q92692-2.
TMPY-01150 Nectin-2 Protein, Mouse, Recombinant (His)

MPH,Pvs,Pvr,Cd112,AI325026,AI987993,poliovirus receptor-rela...

Mouse HEK293 Cells
Nectin-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P32507-1.
TMPH-03675 Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His)

Entry-fusion complex associated protein OPG095,EFC-...

VACV E. coli
Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.8 kDa and the accession number is P07612.
TMPH-03673 Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc)

EFC-associated protein OPG095,Entry-fusion complex ...

VACV Baculovirus Insect Cells
Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 23.2 kDa and the accession number is P20540.
TMPY-05560 PVRL1/NECTIN1 Protein, Mouse, Recombinant (His)

PRR1,PRR,nectin-1,HIgR,Cd111,AI835281,HveC,poliovirus recept...

Mouse HEK293 Cells
PVRL1/NECTIN1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.6 kDa and the accession number is Q9JKF6.
TMPH-03674 Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc)

Virion membrane protein M25,OPG099,Protein L1,Entry...

VACV E. coli
Envelope protein which probably plays a role in virus entry into the host cell. Is probably involved in the virus attachment to the host cell surface and associates with the entry/fusion complex (EFC). Needed for fusion and penetration of the virus core into host cell. Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.8 kDa and the accession number is P20540.
TMPJ-00168 HVEM Protein, Mouse, Recombinant (hFc)

Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necr...

Mouse HEK293 Cells
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPY-05196 PVRL1/NECTIN1 Protein, Mouse, Recombinant (hFc)

AI835281,poliovirus receptor-related 1 (herpesvirus entr...

Mouse HEK293 Cells
PVRL1/NECTIN1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.9 kDa and the accession number is Q9JKF6.
TMPY-01572 PVRL1/NECTIN1 Protein, Human, Recombinant (His)

HVEC,ED4,PRR1,PVRR1,nectin-1,HIgR,poliovirus receptor-relate...

Human HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.4 kDa and the accession number is Q15223-1.
TMPY-01571 PVRL1/NECTIN1 Protein, Human, Recombinant (hFc)

HV1S,ED4,poliovirus receptor-related 1 (herpesvirus entr...

Human HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61 kDa and the accession number is Q15223-1.
TMPJ-00651 CD155/PVR Protein, Human, Recombinant (aa 21-343, His)

Poliovirus Receptor,PVS,Nectin-Like Protein 5,NECL-5,CD155,P...

Human HEK293 Cells
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension be...
TMPY-03221 Intrinsic Factor Protein, Human, Recombinant (His)

IF,IFMH,gastric intrinsic factor (vitamin B synthesis),INF,T...

Human HEK293 Cells
Gastric intrinsic factor, also known as GIF, belongs to the of the cobalamin transport protein family. It is a glycoprotein produced by the parietal cells of the stomach. Gastric intrinsic factor plays a key role in the absorption of vitamin B12 on in the small intestine. Vitamin B12 bounds to haptocorrin after entry into the stomach. The resulting complex enters the duodenum, where pancreatic enzymes digest haptocorrin. In the less acidic environment of the small intestine, B12 can then bind to...
TMPH-01279 CRACR2B Protein, Human, Recombinant (His)

CRACR2B,EFCAB4A,EF-hand calcium-binding domain-containing pr...

Human E. coli
Plays a role in store-operated Ca(2+) entry (SOCE).
TMPH-03426 Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His)

Hemagglutinin,Outer capsid protein VP4

RVX P. pastoris (Yeast)
Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. It is subsequently lost, together with VP7, following virus entry into the host cell. Following entry into the host cell, low intracellular o...
TMPH-01194 Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO)

UL130,Uncharacterized protein UL130

HHV-5 E. coli
Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection. Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37....
TMPH-00776 Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His & Myc)

Griffithsin

Griffithsia Baculovirus Insect Cells
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.
TMPH-03716 Invasin Protein, Yersinia enterocolitica, Recombinant (His & SUMO)

Invasin

Yersinia enterocolitica E. coli
Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins.
TMPH-03669 Vaccinia virus (strain Western Reserve) OPG190 Protein (His)

OPG190,Plaque-size/host range protein,Protein OPG190

VACV P. pastoris (Yeast)
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EV) to allow virion entry into host cells. Participates also in wrapping mature virions (MV) to form enveloped virions (EV). Vaccinia virus (strain Western Reserve) OPG190 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is Q01227.
TMPH-01548 IFI6 Protein, Human, Recombinant (B2M & His)

Interferon-induced protein 6-16,IFI6,Interferon alpha-induci...

Human E. coli
Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells.
TMPH-00696 OmpC Protein, E. coli, Recombinant

Outer membrane protein 1B,Porin OmpC,Outer membrane porin C,...

E. coli E. coli
Forms pores that allow passive diffusion of small molecules across the outer membrane.; (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.; (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.
TMPH-00813 Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)

Protein ORF2,Pro-secreted protein ORF2

HEV-1 Baculovirus Insect Cells
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation. Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes. Hepatitis E virus gen...
TMPK-00130 LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag)

TNFSF14, TR2,CD258,LTg,LIGHT,HVEM-L

Human HEK293 Cells
LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells.
TMPK-00308 Nectin-4 Protein, Human, Recombinant (His & Avi)

PVRL4,LNIR,NECTIN4,PRR4,EDSS1

Human HEK293 Cells
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 37.2 kDa and the accession number is Q96NY8.
TMPH-00894 Human adenovirus B serotype 11 (strain BC34) Fiber protein (His)

Protein IV,Fiber protein

HAdV-11 E. coli
Forms spikes that protrude from each vertex of the icosahedral capsid. Interacts with host receptor CD46 to provide virion initial attachment to target cell. Fiber proteins are shed during virus entry, when virus is still at the cell surface. Human adenovirus B serotype 11 (strain BC34) Fiber protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 40.6 kDa and the accession number is P35773.
TMPH-00777 Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His)

Griffithsin

Griffithsia E. coli
Mixed specificity lectin with anti-HIV activity. Binds to HIV envelope glycoproteins, including exterior membrane glycoprotein gp120, and inhibits viral entry into cells. Binding to gp120 is dependent on gp120 being glycosylated, and is inhibited by mannose, glucose and N-acetylglucosamine.
TMPY-06855 Varicella-zoster virus (VZV) (strain Oka vaccine) Glycoprotein B/gB Protein

VZV CHO Cells
Varicella-zoster virus (VZV) is a highly fusogenic virus, but the degree of fusion is dependent on the cell substrate in which the virus is propagated. Varicella-zoster virus (VZV) is classified as an alphaherpesvirus based on its growth characteristics and its ability to become latent in the nervous system of the host. Like all known herpesviruses, VZV encodes a homolog of glycoprotein B (gB). Glycoprotein B (gB) is the most conserved entry glycoprotein among herpesviruses with an amino acid se...
TMPH-01104 Claudin-9 Protein-VLP, Human, Recombinant (His)

CLDN9,Claudin-9

Human HEK293 Cells
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Claudin-9 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 24.2 kDa and the accession number is O95484.
TMPH-00580 Aquaporin Z Protein, E. coli, Recombinant (His)

Water channel AqpZ,bniP,Aquaporin Z,Bacterial nodulin-like i...

E. coli E. coli
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Aquaporin Z Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.7 kDa and the accession number is P60844.
TMPH-01864 PITHD1 Protein, Human, Recombinant (His & Myc)

PITHD1,PITH domain-containing protein 1

Human E. coli
Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene. PITHD1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.6 kDa and the accession number is Q9GZP4.
TMPH-03666 Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc)

Plaque-size/host range protein,OPG190,Protein OPG190

VACV E. coli
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EEV) to allow virion entry into host cells. Participates also in wrapping intracellular mature virions (IMV) to form intracellular enveloped virions (IEV). Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 36.5 kDa and the accession number is P21115.
TMPH-03667 Vaccinia virus (strain Copenhagen) OPG190 Protein (His)

Plaque-size/host range protein,Protein OPG190,OPG190

VACV P. pastoris (Yeast)
Plays a role in the dissolution of the outermost membrane of extracellular enveloped virions (EEV) to allow virion entry into host cells. Participates also in wrapping intracellular mature virions (IMV) to form intracellular enveloped virions (IEV). Vaccinia virus (strain Copenhagen) OPG190 Protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 31.1 kDa and the accession number is P21115.
TMPK-00309 Nectin-4 Protein IgV Domain, Human, Recombinant (His & Avi)

PRR4,PVRL4,LNIR,NECTIN4,EDSS1

Human HEK293 Cells
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein IgV Domain, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 15.8 kDa and the accession number is Q96NY8-1.
TMPH-03665 Vaccinia virus (strain Copenhagen) OPG185 Protein (His)

Hemagglutinin,Protein OPG185,OPG185

VACV E. coli
Prevents cell to cell fusion by interacting with and directing the viral K2 protein on the host plasma membrane. The A56-K2 complex associates with components of the entry fusion complex (EFC) presumably to avoid superinfection and syncytium formation. Via its interaction with C3/VCP protein, protects the infected cell and probably also the extracellular enveloped virus from complement attack. Vaccinia virus (strain Copenhagen) OPG185 Protein (His) is expressed in E. coli expression system with ...
TMPH-03685 Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc)

Envelope glycoprotein L,gL

HHV-3 E. coli
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Acts as a functional inhibitor of gH and maintains gH in an inhibited form. Upon binding to host integrins, gL dissociates from gH leading to activation of the viral fusion glycoproteins gB and gH. Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The...
TMPK-00842 CD21 Protein, Human, Recombinant (His)

CD21,CR2,C3DRSLEB9,EBV receptor,CVID7,SLEB9,C3DR

Human HEK293 Cells
CD21 mRNA expression, an EBV-entry receptor, was transiently detected in NK cells after exosome treatment, and levels decreased after further culture. CD21 protein expression was also transiently transferred to NK cells after co-culture with an EBV-positive Burkitt lymphoma cell line (Raji) via trogocytosis. However, EBV did not infect NK cells through CD21-mediated trogocytosis.
TMPH-00695 OmpC Protein, E. coli, Recombinant (His)

Outer membrane protein C,ompC,Outer membrane porin C,Porin O...

E. coli E. coli
Forms pores that allow passive diffusion of small molecules across the outer membrane.; (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.; (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity.
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重组蛋白

Nectin-2 Protein, Human, Recombinant
Cat.No: TMPY-00748
Species: Human
Expression System: HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-00747
Species: Human
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05579
Species: Human
Expression System: HEK293 Cells
Nectin-2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00323
Species: Mouse
Expression System: HEK293 Cells
Nectin-2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-02561
Species: Cynomolgus
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03030
Species: Rat
Expression System: HEK293 Cells
Nectin-2 Protein, Rat, Recombinant (His)
Cat.No: TMPY-03036
Species: Rat
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-02937
Species: Rat
Expression System: HEK293 Cells
Vaccinia virus (strain Western Reserve) OPG094 Protein (His)
Cat.No: TMPH-03659
Species: VACV
Expression System: P. pastoris (Yeast)
HVEM Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPJ-00620
Species: Rhesus
Expression System: HEK293 Cells
Nectin-2 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06383
Species: Human
Expression System: HEK293 Cells
HVEM Protein, Rhesus macaque, Recombinant (hFc)
Cat.No: TMPJ-01416
Species: Rhesus
Expression System: HEK293 Cells
Nectin-2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00746
Species: Human
Expression System: HEK293 Cells
Vaccinia virus (strain Western Reserve) L1 Protein (His)
Cat.No: TMPH-03676
Species: VACV
Expression System: P. pastoris (Yeast)
Nectin-2 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-06295
Species: Human
Expression System: HEK293 Cells
Nectin-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01150
Species: Mouse
Expression System: HEK293 Cells
Vaccinia virus (strain Western Reserve) L1 Protein (E. coli, His)
Cat.No: TMPH-03675
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Copenhagen) L1 Protein (His & Myc)
Cat.No: TMPH-03673
Species: VACV
Expression System: Baculovirus Insect Cells
PVRL1/NECTIN1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-05560
Species: Mouse
Expression System: HEK293 Cells
Vaccinia virus (strain Copenhagen) L1 Protein (E. coli, His & Myc)
Cat.No: TMPH-03674
Species: VACV
Expression System: E. coli
HVEM Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00168
Species: Mouse
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-05196
Species: Mouse
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01572
Species: Human
Expression System: HEK293 Cells
PVRL1/NECTIN1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-01571
Species: Human
Expression System: HEK293 Cells
CD155/PVR Protein, Human, Recombinant (aa 21-343, His)
Cat.No: TMPJ-00651
Species: Human
Expression System: HEK293 Cells
Intrinsic Factor Protein, Human, Recombinant (His)
Cat.No: TMPY-03221
Species: Human
Expression System: HEK293 Cells
CRACR2B Protein, Human, Recombinant (His)
Cat.No: TMPH-01279
Species: Human
Expression System: E. coli
Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His)
Cat.No: TMPH-03426
Species: RVX
Expression System: P. pastoris (Yeast)
Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO)
Cat.No: TMPH-01194
Species: HHV-5
Expression System: E. coli
Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His & Myc)
Cat.No: TMPH-00776
Species: Griffithsia
Expression System: Baculovirus Insect Cells
Invasin Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
Cat.No: TMPH-03716
Species: Yersinia enterocolitica
Expression System: E. coli
Vaccinia virus (strain Western Reserve) OPG190 Protein (His)
Cat.No: TMPH-03669
Species: VACV
Expression System: P. pastoris (Yeast)
IFI6 Protein, Human, Recombinant (B2M & His)
Cat.No: TMPH-01548
Species: Human
Expression System: E. coli
OmpC Protein, E. coli, Recombinant
Cat.No: TMPH-00696
Species: E. coli
Expression System: E. coli
Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)
Cat.No: TMPH-00813
Species: HEV-1
Expression System: Baculovirus Insect Cells
LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag)
Cat.No: TMPK-00130
Species: Human
Expression System: HEK293 Cells
Nectin-4 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00308
Species: Human
Expression System: HEK293 Cells
Human adenovirus B serotype 11 (strain BC34) Fiber protein (His)
Cat.No: TMPH-00894
Species: HAdV-11
Expression System: E. coli
Griffithsin Protein, Griffithsia sp., Recombinant (X31S, His)
Cat.No: TMPH-00777
Species: Griffithsia
Expression System: E. coli
Varicella-zoster virus (VZV) (strain Oka vaccine) Glycoprotein B/gB Protein
Cat.No: TMPY-06855
Species: VZV
Expression System: CHO Cells
Claudin-9 Protein-VLP, Human, Recombinant (His)
Cat.No: TMPH-01104
Species: Human
Expression System: HEK293 Cells
Aquaporin Z Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00580
Species: E. coli
Expression System: E. coli
PITHD1 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01864
Species: Human
Expression System: E. coli
Vaccinia virus (strain Copenhagen) OPG190 Protein (His & Myc)
Cat.No: TMPH-03666
Species: VACV
Expression System: E. coli
Vaccinia virus (strain Copenhagen) OPG190 Protein (His)
Cat.No: TMPH-03667
Species: VACV
Expression System: P. pastoris (Yeast)
Nectin-4 Protein IgV Domain, Human, Recombinant (His & Avi)
Cat.No: TMPK-00309
Species: Human
Expression System: HEK293 Cells
Vaccinia virus (strain Copenhagen) OPG185 Protein (His)
Cat.No: TMPH-03665
Species: VACV
Expression System: E. coli
Varicella-zoster virus (strain Oka vaccine) glycoprotein L/gL Protein (His & Myc)
Cat.No: TMPH-03685
Species: HHV-3
Expression System: E. coli
CD21 Protein, Human, Recombinant (His)
Cat.No: TMPK-00842
Species: Human
Expression System: HEK293 Cells
OmpC Protein, E. coli, Recombinant (His)
Cat.No: TMPH-00695
Species: E. coli
Expression System: E. coli
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Cat. No. Product Name Target Signaling Pathways
TMIJ-0208 Beclomethasone Dipropionate-d6

Beclomethasone Dipropionate-d6 是 Beclomethasone Dipropionate 的氘代化合物。Beclomethasone Dipropionate 的 CAS 号为 5534-09-8。Betamethasone dipropionate是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
TMIJ-0090 L-Carnitine-d9

L-Carnitine-d9 是 L-Carnitine 的氘代化合物。L-Carnitine 的 CAS 号为 541-15-1。L-carnitine 是一种人内源性分子,在人体内以蛋氨酸和赖氨酸为底物进行生物合成,并参与脂肪酸代谢。L-Carnitine 将长链脂肪酰辅酶A转运到线粒体。L-Carnitine 能够改善许多先天性代谢错误的代谢失衡。
T38297 Ribavirin-13C5

Ribavirin-13C5

Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro...

同位素标记化合物

Beclomethasone Dipropionate-d6
Cat.No: TMIJ-0208
Synonym:
Target:
L-Carnitine-d9
Cat.No: TMIJ-0090
Synonym:
Target:
Ribavirin-13C5
Cat.No: T38297
Synonym: Ribavirin-13C5
Target:
TargetMol Loading
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