HVEM Protein, Rhesus macaque, Recombinant (His)

HVEM Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-40 KDa and the accession number is F7GSW4.

规格	价格/CNY		数量
10 μg	￥ 540	5日内发货
50 μg	￥ 1,170	5日内发货
500 μg	￥ 5,250	5日内发货
1 mg	￥ 7,510	5日内发货

规格

价格/CNY

货期

数量

10 μg

￥ 540

5日内发货

50 μg

￥ 1,170

5日内发货

500 μg

￥ 5,250

5日内发货

1 mg

￥ 7,510

5日内发货

产品描述	HVEM Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-40 KDa and the accession number is F7GSW4.

种属	Rhesus
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	F7GSW4
别名	TNFRSF14, HVEA, Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, HVEM, Herpesvirus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, CD270, TR2
氨基酸序列	Leu39-Val203
蛋白构建	Leu39-Val203
蛋白纯度	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量	22-40 KDa (reducing condition)

内毒素	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

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HVEM Protein, Rhesus macaque, Recombinant (His)

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