HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 μg | ¥ 540 | 5日内发货 | ||
50 μg | ¥ 1,170 | 5日内发货 | ||
500 μg | ¥ 5,250 | 5日内发货 | ||
1 mg | ¥ 7,510 | 5日内发货 |
产品描述 | HVEM Protein, Rhesus macaque, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60 KDa and the accession number is A0A2K5W0R1. |
种属 | Rhesus |
表达系统 | HEK293 Cells |
标签 | C-hFc |
蛋白编号 | A0A2K5W0R1 |
别名 | CD270, TNFRSF14, TR2, Herpesvirus Entry Mediator A, Tumor Necrosis Factor Receptor-Like 2, Herpes Virus Entry Mediator A, HVEM, Tumor Necrosis Factor Receptor Superfamily Member 14, HVEA |
氨基酸序列 | Pro37-Val203 |
蛋白构建 | Pro37-Val203 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 60 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 |
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on naïve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding. |
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HVEM Protein, Rhesus macaque, Recombinant (hFc) CD270 CD-270 TR 2 TNFRSF14 TR2 Herpesvirus Entry Mediator A TNFRSF-14 Tumor Necrosis Factor Receptor-Like 2 CD 270 Herpes Virus Entry Mediator A TR-2 HVEM Tumor Necrosis Factor Receptor Superfamily Member 14 HVEA TNFRSF 14 recombinant recombinant-proteins proteins protein