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Search Results for " cdk2 "

190

抑制剂 & 化合物

2

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP1875	CDK2
	CDK2 is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate.
T36933	Cdk2 Inhibitor II Cdk2 Inhibitor II,CDK2-IN-3	CDK	Cell Cycle/Checkpoint
	Cdk2 Inhibitor II 是一种具有选择性和有效性的 CDK2 抑制剂，50 为 60 nM。
T14916	CDK2-IN-4	CDK	Cell Cycle/Checkpoint
	CDK2-IN-4 是选择性的CDK2抑制剂，对 CDK2/cyclin A 的IC50值为 44 nM，选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
TP1875L	CDK2 acetate(255064-79-0 free base)	Others	Others
	CDK2 acetate(255064-79-0 free base) 是真核生物 S/T 蛋白激酶家族的成员，其功能是催化 ATP γ-磷酸磷酸基转移到蛋白质底物中的丝氨酸或苏氨酸羟基（表示为 S0/T0）。
T40160	CDK2-IN-7 CDK2-IN-7	Others	Others
	CDK2-IN-7 is a CDK2 inhibitor for treating cancer ( IC 50 < 50 nM).
T3195	CVT-313 CVT 313,Cdk2 Inhibitor III,CVT313,NG26	CDK	Cell Cycle/Checkpoint
	CVT-313 (NG26) 是一种有效的、选择性的、可逆的和 ATP 竞争性抑制剂，可抑制 CDC5L 磷酸化，对 CDK2的 IC50为 0.5 μM。
T35555	GSK-3/CDK5/CDK2-IN-1 GSK-3/CDK5/CDK2-IN-1	Others	Others
	GSK-3/CDK5/CDK2-IN-1 is an imidazole derivative compound that inhibits cdk5, cdk2, and GSK-3.it has demonstrated applications in cancer research and the study of neurodegenerative diseases [1].
T60154	CDK2-IN-13	Others	Others
	CDK2-IN-13 是一种有效的 Cyclin-dependent kinase 2（CDK2）抑制剂(IC50 值: 12 µM) 。CDK2-IN-13 参与细胞周期的调节，可使细胞周期停滞.。CDK2-IN-13可阻止细胞的分裂和增殖，诱导细胞凋亡，可用于癌症的研究。
T12552	PROTAC CDK2/9 Degrader-1	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
TP2192	Cdk2/Cyclin Inhibitory Peptide I	Others	Others
	Cyclin-dependent kinase 2 also known as cell division protein kinase 2. The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases. This protein kinase is highly similar to the gene products of S. cerevis
T78813	CDK2/Bcl2-IN-1	CDK	Cell Cycle/Checkpoint
	CDK2/Bcl2-IN-1（化合物1）为皂素类CDK-2抑制剂（IC50=117.6 nM），对癌细胞显示显著细胞毒性，并能够抑制Bcl-2，诱导A549肺癌细胞的凋亡。
T62038	CDK2-IN-8	Others	Others
	CDK2-IN-8 是有效的 CDK2抑制剂(IC50= 1.74 μM)。CDK2-IN-8 具有抗增殖活性，可用于研究黑色素瘤。
T62567	CDK2-IN-9	Others	Others
	CDK2-IN-9 是一种 CDK2 的有效抑制剂 (IC50: 0.63 μM)，具有抗增殖作用。CDK2-IN-9 能够将细胞周期阻滞在 S 和 G2/M 期，并诱导细胞凋亡。CDK2-IN-9 具有潜力进行黑色素瘤的研究。
T62668	CDK2-IN-12	Others	Others
	CDK2-IN-12 (compound 10b) 是一种 CDK2 的有效抑制剂 (IC50: 11.6 μM)。CDK2-IN-12 对 hCA 亚型 I、II、IX 和 XII 表现出抑制作用，他们的 KI 值分别为 3534、638.4、44.3 和 48.8 nM。CDK2-IN-12 显示出抗癌作用。
T82759	CDK2-IN-20	CDK	Cell Cycle/Checkpoint
	CDK2-IN-20 是一种对CDK2具有抑制作用的化合物。该化合物对肿瘤细胞表现出细胞毒性，其半抑制浓度(IC50)介于5.52至17.09 µM之间。CDK2-IN-20 作用于MCF-7细胞，能够引起细胞周期在S期的阻滞，并诱导细胞发生凋亡。
T2029	Bohemine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。
T62337	CDK2-IN-11	Others	Others
	CDK2-IN-11 (compound 9d) 是一种 CDK2 的有效抑制剂 (IC50: 6.4 μM)，能够作用于 hCA II (Ki: 23.4 nM)、hCA IX (Ki: 56.3 nM) 和 hCA XII (Ki: 44.3 nM)。CDK2-IN-11 能够用于抗癌的研究。
T79648	CDK2-IN-19	CDK	Cell Cycle/Checkpoint
	CDK2-IN-19 (Compound 32)为一种口服活性的选择性CDK2抑制剂（Ki：0.18 nM），在带OVCAR3肿瘤的小鼠模型中表现出显著的抗癌效果。
T79729	EGFR/CDK2-IN-4	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-4（化合物4c）是一种EGFR与CDK-2的双重抑制剂，其IC50值分别为89.6 nM和165.4 nM。该化合物在MCF-7细胞中能诱导(apoptosis)凋亡，并导致细胞周期在S期停滞。EGFR/CDK2-IN-4显示出显著的抗癌细胞毒性，对MCF-7细胞的IC50为2.74 μM。
T76377	Cdk2/Cyclin Inhibitory Peptide II	Others	Others
	Cdk2/Cyclin Inhibitory Peptide II (Tat-LDL) 是一种 CDK2抑制剂，能以剂量依赖的方式杀死 U2OS 骨肉瘤细胞。
T79727	EGFR/CDK2-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-2（compound 6a）是一种针对EGFR和CDK-2的双重抑制剂，具有19.6 nM和87.9 nM的IC50s。该化合物能在MCF-7细胞内诱导凋亡，并在S期引发细胞周期停滞。此外，EGFR/CDK2-IN-2展现出IC50为0.39 μM的显著抗癌活性，对MCF-7细胞具有强效的细胞毒性。
T72844	EGFR/CDK2-IN-1	Others	Others
	EGFR/CDK2-IN-1 (化合物 3b) 是一种 EGFR/CDK2抑制剂。EGFR/CDK2-IN-1 对 MCF7 和 HepG2 细胞显示出较强的细胞毒性。EGFR/CDK2-IN-1 可用于癌症的研究。
T79728	EGFR/CDK2-IN-3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-3（compound 4b）是一种针对EGFR与CDK-2的双重抑制剂，分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡，导致细胞周期在S期停滞，并显示出对癌细胞的明显毒性，其对MCF-7细胞的IC50值为3.16 μM。
T9615	CK7	CDK	Cell Cycle/Checkpoint
	CK7是有效的Cdk2/9抑制剂。CK7可用于合成 Nek1 抑制剂 BSc5231 和BSc5367。
T63209	HDAC1/2 and CDK2-IN-1	Others	Others
	HDAC1/2 and CDK2-IN-1 (compound 14d) 是 HDAC1、HDAC2 和 CDK2 的有效抑制剂，他们的IC50值分别为 70.7，23.1 和 0.80 μM。HDAC1/2 and CDK2-IN-1 能够阻断细胞周期，诱导细胞凋亡 (apoptosis)，在体内显示出良好的抗肿瘤作用。
T6612	NU6027	ATM/ATR; DNA-PK; CDK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	NU6027 是一种有效的 ATR/CDK 抑制剂，抑制 CDK1/2、ATR 和 DNA-PK，Ki 为 2.5 μM/1.3 μM、0.4 μM 和 2.2 μM。它以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T6866	AUZ 454 K03861	CDK	Cell Cycle/Checkpoint
	AUZ 454 (K03861) 是一种 II 型 CDK2 抑制剂，Kd 值是 8.2 nM。它对 CDK2(WT)、CDK2(C118L)、CDK2(A144C) 和 CDK2(C118L/A144C) 的 Kd 分别为 50 nM、18.6 nM、15.4 nM 和 9.7 nM。
T7426	ALSTERPAULLONE	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Alsterpaullone 是高效的 CDK 抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。
T4327	Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis; Chk; S6 Kinase	Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling
	Prexasertib dihydrochloride (LY2606368) 是一种选择性的，ATP 竞争性的细胞周期检测点激酶 1 抑制剂，Ki 为 0.9 nM，IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变，导致细胞凋亡，有抗肿瘤活性。
T2028	NG 52 NG52,NG-52,Compound 52	CDK	Cell Cycle/Checkpoint
	NG 52 (NG-52) 是可逆和 ATP 相容性且具有口服活性的Cdc28p 和Pho85p 激酶抑制剂，IC50分别为 7 μM 和 2 μM。它还抑制磷酸甘油酸激酶 1 的活性，IC50值为 2.5 μM。
T4205	AG-494 Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR; CDK	Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-494 (Tyrphostin B48) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂，IC50为0.7 μM。它阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。它抑制 EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化，IC50为 1.1、39、45 和 6 μM。
T7167	Purvalanol B NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇	CDK; Parasite	Cell Cycle/Checkpoint; Microbiology/Virology
	Purvalanol B (NG 95) 是选择性可逆的 ATP 竞争性 CDK 抑制剂。它在一系列其他蛋白激酶 (IC50>1000 nM) 中显示出对 CDK 的选择性。它抑制耐氯喹菌株 P. falciparum 的生长。
T4310	Prexasertib 5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368	Apoptosis; Chk	Apoptosis; Cell Cycle/Checkpoint
	Prexasertib (LY2606368) 是一种具有潜在抗肿瘤活性的检查点激酶 1 抑制剂。它可引起双链 DNA 断裂和复制突变，导致细胞凋亡。
T21503	(E/Z)-Zotiraciclib (E/Z)-TG02,(E/Z)-SB1317	FLT; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	(E/Z)-Zotiraciclib ((E/Z)-TG02) 是一种 CDK2、JAK2和FLT3的抑制剂，IC50分别为 13、73 和 56 nM。
T2032	WHI-P180 Janex 3	EGFR; VEGFR; c-RET; CDK	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	WHI-P180 (Janex 3) 是 EGFR 和 Cdk2 抑制剂，IC50 分别为 4.0 和 1.0 μM。
T6126	JNJ-7706621 JNJ 7706621	Apoptosis; CDK; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	JNJ-7706621 是一种aurora kinase 抑制剂，有效抑制CDK1和CDK2，对CDK1，CDK2，aurora-A 和aurora-B 的IC50值分别为 9 nM，3 nM，11 nM 和 15 nM。
T8230	PNU112455A hydrochloride PNU 112455A	CDK	Cell Cycle/Checkpoint
	PNU112455A hydrochloride 是 CDK2 和 CDK5 的 ATP 位点竞争性抑制剂，与 CDK2 和 CDK5 的 ATP 位点结合，Km 值为 3.6 和 3.2 μM。
T6081	Milciclib PHA-848125	Trk receptor; CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	Milciclib (PHA-848125) 是一种 ATP 竞争性的 CDK 和原肌球蛋白受体激酶双重抑制剂，作用于 CDK2，IC50 为 45 nM。
T28218	NU6102 NU-6102,NU 6102	CDK	Cell Cycle/Checkpoint
	NU6102 是一种具有选择性和有效性的 ATP 竞争性 CDK2 抑制剂，具有抗肿瘤活性，对 CDK1/cyclinB、CDK2/cyclinA3、CDK1/CDK2、 CDK4、DYRK1A 、PDK1、ROCKII 具有抑制作用，可用于研究直肠癌。
T10550	Bisindolylmaleimide X hydrochloride BIM-X hydrochloride,Ro31-8425 hydrochloride	CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling
	Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).
T2059	Purvalanol A NG-60	Apoptosis; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Purvalanol A (NG-60) 是一种CDK 抑制剂，对 cdc2-cyclin B、cdc2-cyclin B、cdk2-cyclin E、cdk4-cyclin D1 和 cdk5-p35 的IC50值分别为 4、70、35、850 和 75 nM。
TQ0053	Fadraciclib CYC065	CDK	Cell Cycle/Checkpoint
	Fadraciclib (CYC065) 是一种口服有效的 ATP 竞争性的CDK2/CDK9激酶抑制剂，IC50分别为 5 和 26 nM。
T4227	SB1317 hydrochloride (1204918-72-8(free base)) TG-02 hydrochloride,14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯	FLT; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) 是一种有效的 CDK2/JAK2/FLT3 抑制剂（IC50：13/73/56 nM）。
T6049	SNS-032 SNS032,BMS-387032	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	SNS-032 (BMS-387032) 是选择性的CDK2/7/9有效抑制剂，IC50值分别为 48 nM/62 nM/4 nM。它有抗肿瘤作用。
T2506	AZD-5438 AZD5438	CDK	Cell Cycle/Checkpoint
	AZD-5438 有效抑制 CDK1,CDK2,CDK9，IC50值分别为 16 nM, 6 nM, 20 nM，但它对 GSK3β，CDK5，CDK6 的抑制作用较弱。
TQ0068	NVP-LCQ195 AT9311,LCQ-195	CDK	Cell Cycle/Checkpoint
	NVP-LCQ195 (LCQ-195) 是CDK 杂环类抑制剂，对CDK1，CDK2，CDK3和CDK5的IC50为1到42 nM 之间。
T6167	SU9516	Apoptosis; p38 MAPK; CDK; PKC; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK
	SU9516 是一种 CDK2抑制剂，IC50值为 22 nM，对 CDK1 和 CDK4 也有抑制作用，IC50值分别为 40 和 200 nM。
T2247	KenPaullone 9-Bromopaullone,NSC-664704,9-溴-7,12-二氢吲哚并[3,2-D][1]苯并氮杂卓-6(5H)-酮	GSK-3; CDK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	KenPaullone (9-Bromopaullone) 是一种CDK1/cyclin B 和GSK-3β抑制剂，IC50值分别为 0.4 μM 和 23 nM。它也抑制 CDK2/cyclin A、CDK2/cyclin E 和 CDK5/p25 的活性，IC50值分别为 0.68 μM、7.5 μM 和 0.85 μM。。它通过增强 TGFβ-Smad3 信号通路增加和延长 foxp3 基因的转录来促进 iTreg 细胞分化。
T34888	TL12-186 TL12 186,TL12186	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	TL12-186 是一种依赖于 Cereblon 的激酶降解剂，可降解 CDK，BTK，FLT3，Aurora 等激酶。TL12-186 对 CDK2/cyclin A 和 CDK9/cyclin T1 有抑制作用，IC50 分别为 73 和 55 nM。

化合物

Cat.No: TP1875

Cdk2 Inhibitor II

Cat.No: T36933

Synonym: Cdk2 Inhibitor II,CDK2-IN-3

Target: CDK

Cat.No: T14916

Target: CDK

CDK2 acetate(255064-79-0 free base)

Cat.No: TP1875L

Target: Others

Cat.No: T40160

Synonym: CDK2-IN-7

Target: Others

Cat.No: T3195

Synonym: CVT 313,Cdk2 Inhibitor III,CVT313,NG26

Target: CDK

GSK-3/CDK5/CDK2-IN-1

Cat.No: T35555

Synonym: GSK-3/CDK5/CDK2-IN-1

Target: Others

Cat.No: T60154

Target: Others

PROTAC CDK2/9 Degrader-1

Cat.No: T12552

Target: CDK, PROTACs

Cdk2/Cyclin Inhibitory Peptide I

Cat.No: TP2192

Target: Others

CDK2/Bcl2-IN-1

Cat.No: T78813

Target: CDK

Cat.No: T62038

Target: Others

Cat.No: T62567

Target: Others

Cat.No: T62668

Target: Others

Cat.No: T82759

Target: CDK

Cat.No: T2029

Target: ERK, CDK

Cat.No: T62337

Target: Others

Cat.No: T79648

Target: CDK

EGFR/CDK2-IN-4

Cat.No: T79729

Target: EGFR

Cdk2/Cyclin Inhibitory Peptide II

Cat.No: T76377

Target: Others

EGFR/CDK2-IN-2

Cat.No: T79727

Target: EGFR

EGFR/CDK2-IN-1

Cat.No: T72844

Target: Others

EGFR/CDK2-IN-3

Cat.No: T79728

Target: EGFR

Cat.No: T9615

Target: CDK

HDAC1/2 and CDK2-IN-1

Cat.No: T63209

Target: Others

Cat.No: T6612

Target: ATM/ATR, DNA-PK, CDK

Cat.No: T21588

Target: ERK, CDK

Cat.No: T6866

Synonym: K03861

Target: CDK

Cat.No: T7426

Target: Apoptosis, GSK-3, CDK

Prexasertib dihydrochloride

Cat.No: T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

Cat.No: T2028

Synonym: NG52,NG-52,Compound 52

Target: CDK

Cat.No: T4205

Synonym: Tyrphostin AG-494,AG 494,Tyrphostin B48

Target: EGFR, CDK

Cat.No: T7167

Synonym: NG 95,(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇

Target: CDK, Parasite

Cat.No: T4310

Synonym: 5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈,LY2606368

Target: Apoptosis, Chk

(E/Z)-Zotiraciclib

Cat.No: T21503

Synonym: (E/Z)-TG02,(E/Z)-SB1317

Target: FLT, JAK, CDK

Cat.No: T2032

Synonym: Janex 3

Target: EGFR, VEGFR, c-RET, CDK

Cat.No: T6126

Synonym: JNJ 7706621

Target: Apoptosis, CDK, Aurora Kinase

PNU112455A hydrochloride

Cat.No: T8230

Synonym: PNU 112455A

Target: CDK

Cat.No: T6081

Synonym: PHA-848125

Target: Trk receptor, CDK, Autophagy

Cat.No: T28218

Synonym: NU-6102,NU 6102

Target: CDK

Bisindolylmaleimide X hydrochloride

Cat.No: T10550

Synonym: BIM-X hydrochloride,Ro31-8425 hydrochloride

Target: CDK, PKC

Cat.No: T2059

Synonym: NG-60

Target: Apoptosis, CDK, Autophagy

Cat.No: TQ0053

Synonym: CYC065

Target: CDK

SB1317 hydrochloride (1204918-72-8(free base))

Cat.No: T4227

Synonym: TG-02 hydrochloride,14-甲基-20-氧杂-5,7,14,27-四氮杂四环[19.3.1.1(2,6).1(8,12)]二十七碳-1(25),2,4,6(27),8,10,12(26),16,21,23-十烯

Target: FLT, JAK, CDK

Cat.No: T6049

Synonym: SNS032,BMS-387032

Target: Apoptosis, GSK-3, CDK

Cat.No: T2506

Synonym: AZD5438

Target: CDK

Cat.No: TQ0068

Synonym: AT9311,LCQ-195

Target: CDK

Cat.No: T6167

Target: Apoptosis, p38 MAPK, CDK, PKC, Autophagy

Cat.No: T2247

Synonym: 9-Bromopaullone,NSC-664704,9-溴-7,12-二氢吲哚并[3,2-D][1]苯并氮杂卓-6(5H)-酮

Target: GSK-3, CDK

Cat.No: T34888

Synonym: TL12 186,TL12186

Target: CDK, PROTACs

Cat. No.	Product Name	Target	Signaling Pathways
TN1299	Desmethylglycitein 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone	PI3K; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。

天然产物

Desmethylglycitein

Cat.No: TN1299

Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p...	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPH-02131	SKP2 Protein, Human, Recombinant (His & SUMO) S-phase kinase-associated protein 2,SKP2,F...	Human	E. coli
	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB...
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His) DOC-1R,p14,cyclin-dependent kinase 2 associated pro...	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las...
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kinase Inhibitor p...	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) GROES,Hsp10,Chaperonin 10,HSPE1,EPF,CPN10	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated Hsp10,Chaperonin 10,HSPE1,GROES,EPF,Cpn10	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
TMPY-03599	RPRD1B Protein, Human, Recombinant (His) C20orf77,regulation of nuclear pre-mRNA domain cont...	Human	HEK293 Cells
	RPRD1B, together with RPRD1A, can accompany RNAP II from promoter regions to 3'-untranslated regions during transcription in vivo, predominantly interact with phosphorylated RNAP II, and can reduce CTD S5- and S7-phosphorylated RNAP II at target gene promoters. RNA polymerase II C-terminal domain (CTD) phosphorylation is important for various transcription-related processes. RPRD1B is a transcriptional regulator that enhances expression of CCND1. It also enhances the transcription of a number of...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His) UBC2,HHR6A,MRXS30,MRXSN,RAD6A,ubiquitin-conjugating...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene, a member of the family of ubiquitin-conjugating enzymes. In vivo, HHR6A phosphorylation peaks during the G2/M phase o...
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His) cyclin A1,CT146	Human	Baculovirus Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His) IRF1,Interferon regulatory factor 1	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm...

重组蛋白

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

SKP2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02131

Species: Human

Expression System: E. coli

CDK2AP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02921

Species: Human

Expression System: E. coli

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

Cat.No: TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

RPRD1B Protein, Human, Recombinant (His)

Cat.No: TMPY-03599

Species: Human

Expression System: HEK293 Cells

Rad6/UBE2A Protein, Human, Recombinant (His)

Cat.No: TMPY-02496

Species: Human

Expression System: E. coli

Cyclin A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01401

Species: Human

Expression System: Baculovirus Insect Cells

IRF1 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01552

Species: Human

Expression System: Baculovirus Insect Cells

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