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Search Results for " ischemia "

Targets Recommended: Ferroptosis

157

抑制剂 & 化合物

41

天然产物

5

化合物库

10

重组蛋白

5

同位素标记化合物

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Cat. No.	Product Name
L8700	铁死亡化合物库		779 compounds
	779 种与铁死亡通路相关的化合物，可用于高通量和高内涵筛选；
L4800	血管生成库		1353 compounds
	1353 个高潜力的抑制或促进血管生成的小分子集合，可用于药物靶点开发、血管生成机理研究的高通量筛选，高内涵筛选；
L9000	细胞凋亡化合物库		1760 compounds
	1760 种与凋亡相关的生物活性小分子化合物的特有集合，多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选；
L9700	内质网应激化合物库		193 compounds
	193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；
L6750	活血化瘀中药单体库		580 compounds
	580种来源于常见活血化瘀中药的单体化合物，是药物开发、药理研究等领域的有效工具。

化合物库

铁死亡化合物库

Cat.No: L8700

Compounds: 779

血管生成库

Cat.No: L4800

Compounds: 1353

细胞凋亡化合物库

Cat.No: L9000

Compounds: 1760

内质网应激化合物库

Cat.No: L9700

Compounds: 193

活血化瘀中药单体库

Cat.No: L6750

Compounds: 580

Cat. No.	Product Name	Target	Signaling Pathways
T9073	SRS16-86	Ferroptosis	Apoptosis
	SRS16-86 是一种铁死亡抑制剂，可研究肾缺血再灌注损伤和脊髓损伤。它在体内比 Ferrostatin-1 对代谢和血浆更稳定。
T10979	DCPIB	Potassium Channel; Chloride channel	Membrane transporter/Ion channel
	DCPIB 是选择性可逆体积调节性阴离子通道抑制剂，抑制肿胀激活氯电流，在 CPAE 细胞中，IC50值为 4.1 μM。它能够电压依赖性激活钾离子通道 TREK1 和 TRAAK，抑制 TRESK、TASK1 和 TASK3的 IC50值分别为 0.14、0.95 和 50.72 μM。
T22537	9-Phenanthrol	TRP/TRPV Channel	Membrane transporter/Ion channel
	9-Phenanthrol 是瞬时受体电位 melastatin 4 (TRPM) 通道的抑制剂，这是一种 Ca2+ 激活的非选择性阳离子通道。
T10696	CB2 modulator 1	Cannabinoid Receptor	GPCR/G Protein
	CB2 modulator 1 是一种有效的 CB2 调节剂。可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。
T3102	NS-1619	Apoptosis; Potassium Channel	Apoptosis; Membrane transporter/Ion channel
	NS 1619 是 Ca2+激活的 K+(BK) 通道的激活剂，是一种高效的松弛剂，在血管和其他组织的几个平滑肌中的 EC50约为 10 – 30 μM。它抑制A2780卵巢癌细胞增殖并诱导细胞凋亡。
T9714	Atpenin A5	Potassium Channel	Membrane transporter/Ion channel
	Atpenin A5 是高度特异性的complex II 抑制剂，IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂，具有心脏保活的作用。
T9232	Mitochondrial fusion promoter M1	Mitochondrial Metabolism	Metabolism
	Mitochondrial fusion promoter M1 是一种线粒体动态调节剂，能够保持线粒体功能并促进细胞呼吸，减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。
T4612	NS309	EGFR; Potassium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂，在 BK 通道上没有激活作用。
T24109	GSK329 GSK 329,GSK-329	Others	Others
	GSK329 是一种有效的选择性 TNNI3 相互作用激酶 (TNNI3K) 抑制剂。 GSK329 在缺血/再灌注心脏损伤模型中表现出积极的心脏保护作用。
T2058	Palosuran ACT-058362	GPR	Endocrinology/Hormones; GPCR/G Protein
	Palosuran (ACT-058362) 是人类 UT 受体的新型强效特异性拮抗剂，对表达人重组受体的 CHO 细胞膜的IC50值为 3.6 nM。它可改善糖尿病大鼠的胰腺和肾脏功能。
T9765	TJ-M2010-5	MyD88	Immunology/Inflammation
	TJ-M2010-5 是一种 MyD88 抑制剂，可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
T1677	Montelukast 孟鲁司特,Singular	Leukotriene Receptor; Lipoxygenase; LTR	GPCR/G Protein; Immunology/Inflammation; Metabolism
	Montelukast (Singular) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T1101	Minocycline hydrochloride Minocycline HCl,盐酸米诺环素,美满霉素	HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Minocycline hydrochloride (Minocycline HCl) 属于四环素类抗生素，具有出色的吸收和组织渗透性。Minocycline hydrochloride 是一种广谱的抗菌剂，可用于多种细菌感染以及痤疮的治疗。
T14186	17-ODYA 17-十八炔酸,Alkynyl Stearic Acid	Others; PROTAC Linker	Others; PROTAC
	Alkynyl Stearic Acid 是 CYP450 ω-羟化酶抑制剂。它能够抑制与花生四烯酸孵育的大鼠肾皮质微粒体形成 20-HETE 、dihydroxyeicosatrienoic acids、epoxyeicosatrienoic acids。它可以改善异丙肾上腺素诱导的培养心肌细胞凋亡和坏死。
T1677L	Montelukast sodium MK0476,孟鲁司特钠	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	Montelukast sodium (MK0476) 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T19930	Nitrosoglutathione S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO	RAAS; NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体，是大鼠酒精脱氢酶III 类同工酶的底物，能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。
T8505	SC-236 4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236	Apoptosis; COX; PPAR	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	SC-236 (Sc 236) 是一种具有口服活性的COX-2特异性抑制剂和PPARγ激动剂。它可通过 c-Jun 氨基端抑制激活蛋白-1活性，在小鼠模型中通过抑制 ERK 的磷酸化发挥抗炎作用。
T21334	Bucillamine DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019	VEGFR; Antioxidant	Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors
	Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤，抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。
T1046	Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律	AhR; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Mexiletine hydrochloride (KOE-1173 hydrochloride) 是一种电压门控钠通道阻滞剂，是 IB 类抗心律失常药。 Mexiletine hydrochloride 通过抑制心肌细胞内钠电流，从而降低心脏动作电位（0相）上升速率，并且降低浦肯野纤维的自律性而发挥抗心律失常作用。
T6986	Sivelestat ONO5046,EI546,西维来司他,LY544349	Others; SARS-CoV; Serine Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Sivelestat (ONO5046) 是一种选择性的中性粒细胞弹性蛋白酶抑制剂，其 IC50值为 44 nM，Ki 值为 200 nM。它有潜力研究 COVID-19 的急性肺损伤、急性呼吸窘迫综合征或弥散性血管内凝血。
T3230	NLRP3-IN-2 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR); NOD	Immunology/Inflammation; NF-κB
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide) 是一种能够合成格列本脲的中间物，对心肌细胞中NLRP3炎症小体的形成具有抑制作用，在小鼠心肌缺血/再灌注后限制梗死面积，且对代谢无影响。
T8435	YM90K YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-,1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride 是一种选择性的、有效的AMPA 受体拮抗剂，Ki=84 nM。YM90K 抑制海藻酸酯 (Ki 为 2.2 μM) 和 NMDA (Ki 为 37 μM) 受体的效力较低，并具有神经保护活性。
T0143	Bisoprolol hemifumarate 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
T34648	Sinitrodil ITF296,ITF-296,ITF 296	Guanylate cyclase	GPCR/G Protein
	Sinitrodil (ITF-296) 是一种鸟苷酸环化酶兴奋剂，可用于治疗心肌缺血和心绞痛。
T27087	Cronidipine LF 2.0254,LF-20254,LF20254,LF 20254	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cronidipine (LF 20254) 是一种钙通道拮抗剂，可用于治疗高血压和心肌缺血。
T27828	Licostinel CGP 63446,ACEA1021,ACEA 1021,ACEA-1021,CGP-63446	GluR	Neuroscience
	Licostinel (CGP 63446) 是一种谷氨酸受体拮抗剂。 Licostinel 可防止永久性局灶性脑缺血。
T7098	BAPTA 1,2-双(2-氨基苯氧基)-乙烷-N,N,N`,N`-四乙酸	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	BAPTA 是非渗透性、选择性的钙离子螯合剂，对 Ca2+的亲和力是 Mg2+的 105 倍。它是一个有价值的研究钙在细胞信号传导中的作用的工具。
T15379	GGsTop Nahlsgen	Others	Others
	GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /(M·s) against E.coli GGT and human GGT, respectively.
T31795	FK-330 LS-192510,FR-260330,FK330,FK 330	NOS	Immunology/Inflammation
	FK-330（FR-260330）是一种新型口服活性诱导型一氧化氮合酶抑制剂，具有潜在的抗癌和抗肿瘤活性，可预防大鼠肝移植缺血和再灌注损伤。
T17105	TM6089	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	TM6089 是一种脯氨酰羟化酶抑制剂，可在没有铁螯合的情况下刺激 HIF 活性，诱导血管生成，并保护器官免受缺血。
T33824	Orotirelin CG 3509,Orotireline	Others	Others
	Orotirelin(CG 3509) 是促甲状腺激素释放激素类似物，可逆转了戊巴比妥诱导的睡眠时间。Orotirelin 可能对局灶性脑缺血的动物有益。
T13603	CDDO-3P-Im	Necroptosis	Apoptosis
	CDDO-3P-Im 是一种具有口服活性的坏死性凋亡抑制剂，具有化学预防作用。 CDDO-3P-Im 可用于有关缺血/再灌注的研究。
T3649	BGP-15 BGP15,BGP-15 2HCl	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BGP-15 (BGP-15 2HCl) 是一种PARP 抑制剂，IC50和Ki 值分别为 120 和 57 μM，在缺血再灌注损伤后具有保护作用。
T68088	Iodofiltic acid	Others	Others
	Iodofiltic acid 可用于辅助治疗急性冠脉综合征（Zeus-ACS），可成像以检测心肌缺血。
T8687	diaminohydroxypropanetetraacetic acid	Others	Others
	diaminohydroxypropanetetraacetic acid 已被研究用于治疗血管疾病、冠状动脉疾病、心肌缺血、冠状动脉再狭窄和冠状动脉疾病等。
T32105	Cipepofol HSK3486,HSK-3486,CS-0064163,HSK 3486	Apoptosis; GABA Receptor	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Cipepofol (HSK3486) 是一种 GABAA 受体激动剂，具有镇静作用，在多种心血管疾病中起保护作用。Cipepofol 可激活 Sirtuin1 (Sirt1)/Nrf2 通路，可诱导心肌细胞凋亡，可用于研究心肌梗塞、心肌缺血再灌注损伤和章鱼壶综合征。
T83977	BIIB 722 Mesylate	Sodium Channel	Membrane transporter/Ion channel
	BIIB 722 Mesylate 是一种选择性钠氢交换抑制剂，具有心脏保护作用，可用于研究心肌缺血和心肌梗死。
T61933	MK-0159	CD38	Immunology/Inflammation
	MK-0159 是一种可口服且具有高效性的 CD38 抑制剂，具有心肌损伤保护作，可用于研究心脏缺血和再灌注损伤。
T5483	DMX-5804 DMX-5084	MAPK	MAPK
	DMX-5804 是一种口服有活性的MAP4K4选择性抑制剂，其对人 MAP4K4 的IC50=3 nM，pIC50=8.55。对 MINK1/MAP4K6 (pIC50=8.18) 和 TNIK/MAP4K7 (pIC50=7.96) 的作用相对较弱。它可以提高心肌细胞存活率，降低小鼠的缺血再灌注损伤。
T9180	LUF6096 CF-602	Adenosine Receptor	GPCR/G Protein; Neuroscience
	LUF6096 (CF-602) 是一种有效的腺苷 A3 受体 (adenosine A3 receptor) 变构增强剂。LUF6096 对任何腺苷受体显示出低正构亲和力。LUF6096 在心肌缺血/再灌注损伤中显示出保护作用。
T22900	L-701252 L-701,252	NMDAR	Neuroscience
	L-701252 是一种有效的甘氨酸位点 NMDA 受体拮抗剂，IC50 值为 420 nM。L-701252 对全脑缺血提供小范围的神经保护。
T28978	Tirilazad mesylate U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate	Antiviral	Immunology/Inflammation
	Tirilazad mesylate (U 74006F) 是一种非糖皮质激素，是一种脂质过氧化抑制剂，具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化，可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤，抑制狗体内毒素的作用，降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。
T68161L	Tienoxolol FA Tienoxolol FA (90055-97-3 Free base)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tienoxolol FA 是一种小分子 β-肾上腺素能受体拮抗剂，可用于治疗心血管疾病和研究高血压、心机缺血。
T20563	PD-166793 PD-166793-0000,PD 166793,PD166793	MMP	Proteases/Proteasome
	PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂，对 MMP-2，MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。
T34268	Raxofelast IRFI016,IRFI-016,IRFI 016	Others	Others
	Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力
T81034L	TAT-NSF700 Fusion Peptide acetate
	TAT-NSF700 Fusion Peptide acetate 是一种可渗透细胞膜的 N-乙基-马来酰亚胺敏感因子 (NSF) 抑制剂，是一种融合多肽，具有潜在的抗炎活性。TAT-NSF700 Fusion Peptide acetate 与细胞内细胞器相互作用，可用于研究心肌缺血和再灌注损伤。
T37379	Protectin D1 Neuroprotectin D1,NPD1	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素，是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤，抑制咪喹莫特诱导的银屑病样皮肤炎症。
T68879	FK-330 dihydrate FR-260330 dihydrate	NO Synthase	Immunology/Inflammation
	FK-330 dihydrate（FR-260330 dihydrate）是一种新型口服活性诱导型一氧化氮合酶抑制剂，具有潜在的抗癌和抗肿瘤活性，可预防大鼠肝移植缺血和再灌注损伤。
T11879	LS-102 LS102	Ligand for E3 Ligase	PROTAC
	LS-102 是一种选择性的 E3 连接酶 synoviolin (Syvn1) 抑制剂，是黄芪甲苷IV衍生物，通过抑制线粒体裂变来缓解心肌缺血再灌注损伤。LS-102 抑制 Syvn1 自泛素化，可改善阿霉咪唑诱导的心率减慢，有研究心血管疾病。

化合物

Cat.No: T9073

Target: Ferroptosis

Cat.No: T10979

Target: Potassium Channel, Chloride channel

Cat.No: T22537

Target: TRP/TRPV Channel

CB2 modulator 1

Cat.No: T10696

Target: Cannabinoid Receptor

Cat.No: T3102

Target: Apoptosis, Potassium Channel

Cat.No: T9714

Target: Potassium Channel

Mitochondrial fusion promoter M1

Cat.No: T9232

Target: Mitochondrial Metabolism

Cat.No: T4612

Target: EGFR, Potassium Channel, HER

Cat.No: T24109

Synonym: GSK 329,GSK-329

Target: Others

Cat.No: T2058

Synonym: ACT-058362

Target: GPR

Cat.No: T9765

Target: MyD88

Cat.No: T1677

Synonym: 孟鲁司特,Singular

Target: Leukotriene Receptor, Lipoxygenase, LTR

Minocycline hydrochloride

Cat.No: T1101

Synonym: Minocycline HCl,盐酸米诺环素,美满霉素

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Cat.No: T14186

Synonym: 17-十八炔酸,Alkynyl Stearic Acid

Target: Others, PROTAC Linker

Montelukast sodium

Cat.No: T1677L

Synonym: MK0476,孟鲁司特钠

Target: Leukotriene Receptor, LTR

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Nitrosoglutathione

Cat.No: T19930

Synonym: S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO

Target: RAAS, NO Synthase

Cat.No: T8505

Synonym: 4-(5-(4-氯苯基)-3-(三氟甲基)-1H-,Sc 236

Target: Apoptosis, COX, PPAR

Cat.No: T21334

Synonym: DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019

Target: VEGFR, Antioxidant

Mexiletine hydrochloride

Cat.No: T1046

Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173,盐酸美西律

Target: AhR, Sodium Channel

Cat.No: T6986

Synonym: ONO5046,EI546,西维来司他,LY544349

Target: Others, SARS-CoV, Serine Protease

Cat.No: T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,4-[2-(5-氯-2-甲氧基苯甲酰氨基)乙基]苯磺酰胺,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Cat.No: T8435

Synonym: YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-,1,4-二氢-6-(1H-咪唑-1-基)-7-硝基-2,3-喹喔啉二酮单盐酸盐

Target: GluR, iGluR

Bisoprolol hemifumarate

Cat.No: T0143

Synonym: 富马酸比索洛尔,(±)-Bisoprolol hemifumarate,Bisoprolol fumarate,Bisoprolol hemifumarate salt,EMD33512,(±)-Bisoprolol (hemifumarate)

Target: Adrenergic Receptor

Cat.No: T34648

Synonym: ITF296,ITF-296,ITF 296

Target: Guanylate cyclase

Cat.No: T27087

Synonym: LF 2.0254,LF-20254,LF20254,LF 20254

Target: Calcium Channel

Cat.No: T27828

Synonym: CGP 63446,ACEA1021,ACEA 1021,ACEA-1021,CGP-63446

Target: GluR

Cat.No: T7098

Synonym: 1,2-双(2-氨基苯氧基)-乙烷-N,N,N`,N`-四乙酸

Target: Reactive Oxygen Species

Cat.No: T15379

Synonym: Nahlsgen

Target: Others

Cat.No: T31795

Synonym: LS-192510,FR-260330,FK330,FK 330

Target: NOS

Cat.No: T17105

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T33824

Synonym: CG 3509,Orotireline

Target: Others

Cat.No: T13603

Target: Necroptosis

Cat.No: T3649

Synonym: BGP15,BGP-15 2HCl

Target: PARP

Iodofiltic acid

Cat.No: T68088

Target: Others

diaminohydroxypropanetetraacetic acid

Cat.No: T8687

Target: Others

Cat.No: T32105

Synonym: HSK3486,HSK-3486,CS-0064163,HSK 3486

Target: Apoptosis, GABA Receptor

BIIB 722 Mesylate

Cat.No: T83977

Target: Sodium Channel

Cat.No: T61933

Target: CD38

Cat.No: T5483

Synonym: DMX-5084

Target: MAPK

Cat.No: T9180

Synonym: CF-602

Target: Adenosine Receptor

Cat.No: T22900

Synonym: L-701,252

Target: NMDAR

Tirilazad mesylate

Cat.No: T28978

Synonym: U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate

Target: Antiviral

Cat.No: T68161L

Synonym: Tienoxolol FA (90055-97-3 Free base)

Target: Adrenergic Receptor

Cat.No: T20563

Synonym: PD-166793-0000,PD 166793,PD166793

Target: MMP

Cat.No: T34268

Synonym: IRFI016,IRFI-016,IRFI 016

Target: Others

TAT-NSF700 Fusion Peptide acetate

Cat.No: T81034L

Cat.No: T37379

Synonym: Neuroprotectin D1,NPD1

Target: Akt, PI3K

FK-330 dihydrate

Cat.No: T68879

Synonym: FR-260330 dihydrate

Target: NO Synthase

Cat.No: T11879

Synonym: LS102

Target: Ligand for E3 Ligase

Cat. No.	Product Name	Target	Signaling Pathways
T3672	Nomilin	MAPK	MAPK
	Nomilin 是一种柠檬苦素类化合物，从柑桔类提取物中获得，是抗肥胖症和降糖药。
TN1895	Luteolinidin chloride	CD38	Immunology/Inflammation
	Luteolinidin chloride 是天然的脱氧花青素，分离自苔藓和蕨类植物中。它是一种有效的 CD38 抑制剂，可以保留 eNOS 功能并预防体内内皮功能障碍，同时可以保护心脏免受 I/R 损伤。
T2919	Sesamin Fagarol,Fsesamin,芝麻素	Others	Others
	Sesamin 是多不饱和脂肪酸生物合成中的选择性delta 5 去饱和酶抑制剂，是在芝麻油中存在丰富的木脂素。它对脑缺血具有有效的神经保护作用。
TN6490	Regaloside C	Others	Others
	Regaloside C 是一种从百合属的中分离出来的甘油葡糖苷，具有抗炎作用。
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
T3890	Verbenalin Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin	Others	Others
	Verbenalin (Verbenaloside) 是马鞭草苷，具有抗炎、抗真菌、抗病毒等活性。它能减轻脑缺血再灌注损伤。它可用于前列腺炎的研究。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
T4S1725	Galanthamine Galantamine,加兰他敏	Apoptosis; AChE	Apoptosis; Neuroscience
	Galanthamine (Galantamine) 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。
T1208	Citicoline sodium Citicoline sodium salt,CDP-choline,胞磷胆碱钠	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体，有神经保护作用。
T3S0289	Araloside X	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi
TN1494	Cimicifugoside H-1 黑升麻苷H-1	Others	Others
	Cimicifugoside H1 是C. foetidaL.C 提取物的主要成分，是一种环甾烷醇木糖苷。它对骨吸收及卵巢切除术引起的骨质流失具有抑制作用。
TN1984	Neoisoliquiritin	Others	Others
	Neoisoliquiritin 是一种提取自甘草中的活性物质。
T4S0647	Butylphthalide 丁基苯酞,3-Butylphthalide,3-n-Butylphathlide,3-n-Butylphthalide	Others	Others
	Butylphthalide (3-Butylphthalide) 是一种抗脑缺血药物，最初分离自芹菜种中，对中风动物模型有效。
T6S0654	Isocorynoxeine 7-Isocorynoxeine,异去氢钩藤碱	5-HT Receptor	GPCR/G Protein; Neuroscience
	Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱，剂量依赖性抑制5-HT2A 受体介导的电流反应，IC50为 72.4 μM。
T5217	2-(2-Phenylacetamido)acetic acid Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine	Others; Endogenous Metabolite	Metabolism; Others
	Phenyl-ac-Gly-OH 是内源性代谢产物的一种，可激活 β2AR，可用于研究缺血/再灌注引起的心脏损伤。
TN4661	Nodosin	IL Receptor; Autophagy	Autophagy; Immunology/Inflammation
	Nodosin 是一种二萜化合物，从Isodon trichocarpusKudo 和I. JaponicusHARA 中提取得到。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T2S0500	Ilexsaponin A 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1	Others	Others
	Ilexsaponin A (Ilexsaponin A1)1 是分离自冬凌草的根中，利用抗凋亡途径减轻缺血再灌注引起的心肌损伤。它能够减少心肌梗塞的大小，减少 LDH，AST 和 CK-MB 的血清水平，促进细胞活力并抑制缺氧/复氧心肌细胞的凋亡。
T4S2084	3'-Methoxypuerarin 3'-甲氧基葛根素,3’- Methoxy Puerarin	Antioxidant	oxidation-reduction
	3'-Methoxypuerarin 是一种提取自葛根中的异黄酮，具有神经元保护作用。
T3900	Emodin-8-glucoside 大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B	Others	Others
	Emodin-8-glucoside (Anthraglycoside B) 是从芦荟中分离出的蒽醌衍生物，与 DNA 的小沟结合。它具有保护缺血和再灌注引起的局灶性脑损伤的作用。它直接刺激成骨细胞的细胞增殖和分化。
T5S2178	Fargesin 辛夷脂素,(+/-)-Fargesin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fargesin ((+/-)-Fargesin) 是一种活性新木脂素，从木兰植物中分离得到，具有抗高血压和抗炎活性。
T3920	Pseudoginsenoside F11 Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11	Others; Endogenous Metabolite	Metabolism; Others
	Pseudoginsenoside F11 (Ginsenoside A1) 从人参根和叶中分离得到。PF11在一系列心血管和中枢神经系统疾病中具有广泛的保护作用。
T8074	Esafosfan trisodium Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium	Others; Endogenous Metabolite	Metabolism; Others
	Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐，用于镰状细胞性贫血，心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷。
T2S1008	Oxysophoridine Sophoridine N-oxide,氧化槐定碱	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱，具有抗发炎，抗氧化应激和抗凋亡的作用。
TN1969	N-(p-Coumaroyl) serotonin	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚，具有抗氧化、抗动脉粥样硬化和抗炎作用，常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。
T3228	Fosfructose D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan	Others; Endogenous Metabolite	Metabolism; Others
	D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐，Fosfructose 通过刺激无氧糖酵解起作用，其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血，镰状细胞性贫血和哮喘的研究。
T3388	Calycosin-7-O-β-D-glucoside 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) 是一种异黄酮，从黄芪中分离得到。它具有多种生物活性，包括心脏保护、神经保护、抗炎和抗氧化作用。
T3414	Morroniside 莫诺苷,奎宁树	Apoptosis; MMP; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用，可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。
T4518	Licochalcone D	ERK; NF-κB	MAPK; NF-κB
	Licochalcone D 是一种 NF-κB p65的有效抑制剂，是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物，具有抗氧化、抗炎、抗癌等作用。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
T3893	Forsythoside B 连翘酯苷 B,连翘脂苷B	TNF; NF-κB	Apoptosis; NF-κB
	Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB，调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。
T3779	Crocin II Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B	Caspase; COX; NO Synthase	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
TN1101	20(R)-Notoginsenoside R2 R-三七皂苷R2,20(R)-三七皂苷R	Others	Others
	20(R)-Notoginsenoside R2 is a natural product with Promote blood circulation and improve myocardial ischemia
TN4115	Gardenine	Others	Others
	Gardenin has regulatory effect on the gene expression in rats with focal cerebral ischemia.
TN1618	Erigeroside	Others	Others
	Erigeroside has the protective effects on cerebral ischemia-reperfusion injury in rat, its ability of anti-oxidation and scavenging oxidation free radical may be one of its protective mechanisms.
TN1431	Baohuoside VII 宝藿苷,宝藿苷VII	Others	Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti
TN3914	Echinatine	ATPase; IL Receptor; TNF	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel
	Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil
T73764	L-Palmitoylcarnitine TFA	Others	Others
	L-Palmitoylcarnitine TFA 是一种长链酰基肉碱和脂肪酸代谢产物，在缺血期间积聚于肌膜并扰乱膜脂环境。L-Palmitoylcarnitine TFA 通过与Kir6.2的相互作用抑制KATP 通道活性，而不影响单通道电导。
T36448	(E)-Ajoene	Others	Others
	(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth...

天然产物

Cat.No: T3672

Target: MAPK

Luteolinidin chloride

Cat.No: TN1895

Target: CD38

Cat.No: T2919

Synonym: Fagarol,Fsesamin,芝麻素

Target: Others

Cat.No: TN6490

Target: Others

Cat.No: T5654

Target: Others

Cat.No: T3890

Synonym: Verbenalol β-D-glucopyranoside,马鞭草苷,Verbenaloside,Verbenalol glucoside,Cornin

Target: Others

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Cat.No: T4S1725

Synonym: Galantamine,加兰他敏

Target: Apoptosis, AChE

Citicoline sodium

Cat.No: T1208

Synonym: Citicoline sodium salt,CDP-choline,胞磷胆碱钠

Target: Apoptosis, Others, Endogenous Metabolite

Cat.No: T3S0289

Target: Calcium Channel

Cimicifugoside H-1

Cat.No: TN1494

Synonym: 黑升麻苷H-1

Target: Others

Neoisoliquiritin

Cat.No: TN1984

Target: Others

Cat.No: T4S0647

Synonym: 丁基苯酞,3-Butylphthalide,3-n-Butylphathlide,3-n-Butylphthalide

Target: Others

Cat.No: T6S0654

Synonym: 7-Isocorynoxeine,异去氢钩藤碱

Target: 5-HT Receptor

2-(2-Phenylacetamido)acetic acid

Cat.No: T5217

Synonym: Phenaceturic acid,Phenyl-ac-Gly-OH,苯乙酰甘氨酸,Phenylacetyl glycine

Target: Others, Endogenous Metabolite

Cat.No: TN4661

Target: IL Receptor, Autophagy

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Cat.No: T2S0500

Synonym: 毛冬青皂苷A,毛冬青皂苷甲,Ilexsaponin A1

Target: Others

3'-Methoxypuerarin

Cat.No: T4S2084

Synonym: 3'-甲氧基葛根素,3’- Methoxy Puerarin

Target: Antioxidant

Emodin-8-glucoside

Cat.No: T3900

Synonym: 大黄素-8-β-D-吡喃葡萄糖苷,Emodin glucoside B,Anthraglycoside B

Target: Others

Cat.No: T5S2178

Synonym: 辛夷脂素,(+/-)-Fargesin

Target: Adrenergic Receptor

Pseudoginsenoside F11

Cat.No: T3920

Synonym: Ginsenoside A1,拟人参皂苷 F11,拟人参皂苷F11

Target: Others, Endogenous Metabolite

Esafosfan trisodium

Cat.No: T8074

Synonym: Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium

Target: Others, Endogenous Metabolite

Cat.No: T2S1008

Synonym: Sophoridine N-oxide,氧化槐定碱

Target: Apoptosis, Antioxidant

N-(p-Coumaroyl) serotonin

Cat.No: TN1969

Target: PDGFR

Cat.No: T3228

Synonym: D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan

Target: Others, Endogenous Metabolite

Calycosin-7-O-β-D-glucoside

Cat.No: T3388

Synonym: 毛蕊异黄酮苷,calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Cat.No: T3414

Synonym: 莫诺苷,奎宁树

Target: Apoptosis, MMP, Pyroptosis

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

Cat.No: T4518

Target: ERK, NF-κB

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Cat.No: T3893

Synonym: 连翘酯苷 B,连翘脂苷B

Target: TNF, NF-κB

Cat.No: T3779

Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

20(R)-Notoginsenoside R2

Cat.No: TN1101

Synonym: R-三七皂苷R2,20(R)-三七皂苷R

Target: Others

Cat.No: TN4115

Target: Others

Cat.No: TN1618

Target: Others

Cat.No: TN1431

Synonym: 宝藿苷,宝藿苷VII

Target: Others

Cat.No: TN3914

Target: ATPase, IL Receptor, TNF

L-Palmitoylcarnitine TFA

Cat.No: T73764

Target: Others

Cat.No: T36448

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04424	MST3 Protein, Human, Recombinant (His) HEL-S-95,STE20,MST3B,RP11-111L24.5,MST3,STK3,serine/threonin...	Human	Baculovirus Insect Cells
	Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
TMPK-00481	PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His) PDGF R beta,PDGFRB,PDGFR-2,PDGF-R-β,PDGF-R-beta,PDGFR-β,PDGF...	Cynomolgus	HEK293 Cells
	Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity after cerebral ischemia and therefore represents a novel potential therapeutic target.
TMPJ-01051	Pleiotrophin/PTN Protein, Mouse, Recombinant (His) HBGF-8,OSF-1,PTN,HBBM,Pleiotrophin,Heparin-binding brain mit...	Mouse	HEK293 Cells
	Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or greater. PTN and midkine share 50% amino acid (aa) sequence identity, share some functions, and constitute a family. During development, PTN is involved in development of brain, bone, and organs undergoing branching morphogenesis. PTN causes PTPRB dimerization and inactivates it...
TMPK-01168	LOX-1 Protein, Mouse, Recombinant (His) LOXIN,LOX-1,CLEC8A,Ox-LDL receptor 1,SLOX1,LOX1,SCARE1,SR-E1...	Mouse	HEK293 Cells
	LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
TMPJ-01074	PKCE Protein, Human, Recombinant (His) PRKCE,PKCE,nPKC-ε,nPKC-Epsilon,Protein Kinase C Epsilon Type...	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has m...
TMPJ-01022	SUMO3 Protein, Human, Recombinant (HEK293, His) SMT3 homolog 1,Smt3A,Small ubiquitin-related modifier 3,Ubiq...	Human	HEK293 Cells
	Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect...
TMPJ-00082	NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2...	Mouse	HEK293 Cells
	Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig...
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His) DJ1,HEL-S-67p,DJ-1,parkinson protein 7	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress...
TMPY-01000	BVES Protein, Human, Recombinant (GST) CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,...	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent protein kinase II beta,CAM2,CAM...	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state. As a multifunctional protein kinase, the loss of activity may play a critical role in initiating the changes leading to...

重组蛋白

MST3 Protein, Human, Recombinant (His)

Cat.No: TMPY-04424

Species: Human

Expression System: Baculovirus Insect Cells

PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00481

Species: Cynomolgus

Expression System: HEK293 Cells

Pleiotrophin/PTN Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01051

Species: Mouse

Expression System: HEK293 Cells

LOX-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01168

Species: Mouse

Expression System: HEK293 Cells

PKCE Protein, Human, Recombinant (His)

Cat.No: TMPJ-01074

Species: Human

Expression System: E. coli

SUMO3 Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPJ-01022

Species: Human

Expression System: HEK293 Cells

NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00082

Species: Mouse

Expression System: HEK293 Cells

PARK7/DJ-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02043

Species: Human

Expression System: E. coli

BVES Protein, Human, Recombinant (GST)

Cat.No: TMPY-01000

Species: Human

Expression System: E. coli

CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04408

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0130	Butylphthalide-d7 NBP-d7
	Butylphthalide-d7 是 Butylphthalide 的氘代化合物。Butylphthalide 的 CAS 号为 6066-49-5。Butylphthalide 是一种抗脑缺血药物，最初分离自芹菜种中，对中风动物模型有效。
TMIJ-0105	3-Butylphthalide-d9
	3-Butylphthalide-d9 是 3-Butylphthalide 的氘代化合物。3-Butylphthalide 的 CAS 号为 6066-49-5。Butylphthalide 是一种抗脑缺血药物，最初分离自芹菜种中，对中风动物模型有效。
TMID-0287	Galanthamine-O-methyl-d3
	Galanthamine-O-methyl-d3 是 Galanthamine-O-methyl 的氘代化合物。Galanthamine-O-methyl 的 CAS 号为 357-70-0。Galanthamine 是一种乙酰胆碱酯酶抑制剂，IC50为 500 nM。
T70883	Moexipril-d5
	Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ...
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...

同位素标记化合物

Butylphthalide-d7

Cat.No: TMIH-0130

Synonym: NBP-d7

3-Butylphthalide-d9

Cat.No: TMIJ-0105

Galanthamine-O-methyl-d3

Cat.No: TMID-0287

Cat.No: T70883

Cat.No: T71402

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