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Search Results for " sphingosine "

Targets Recommended: Others

137

抑制剂 & 化合物

17

天然产物

5

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T38685	C12-Sphingosine C12-Sphingosine	Others	Others
	C12-Sphingosine is a short-chain homologue of Sphingosine. It effectively inhibits the activity of serine palmitoyltransferase in primary cultured cerebellar cells.
T83883	Biotin Sphingosine Biotinyl Sphingosine
	Biotin sphingosine（d18:1）是一种衍生自sphingosine的生物素化合物。它被用于检测细胞裂解物中sphingosine kinase 1 (SPHK1)和SPHK2的磷酸化活性的实验中。
T37954	Sphingosine (d20:1) Sphingosine (d20:1)	Others	Others
	Sphingosines are long-chain base precursors of cellular sphingolipids used directly in the synthesis of ceramide, which in combination with sialic acid forms ganglioside. Sphingosine can exist in four stereoisomers, however only sphingosine occurs naturally. Compared to other sphingolipids throughout the body, which are predominantly composed of C-18 sphingosine, only central nervous system (CNS) gangliosides contain significant amounts of sphingosine. The concentration of sphingosine within mam...
T24044	Erythro-sphingosine, (+)- L-Erythro-c18-sphingosine,L-Erythro-sphingosine	Others	Others
	Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 µM) and enhances Src kinase activity.
T84509	Sphingosine (d15:1) D-erythro-Sphingosine C-15	Others	Others
	Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds.
T85010	Sphingosine (d16:1) D-erythro-Sphingosine C-16	Others	Others
	Sphingosine (d16:1), an unconventional sphingolipid, is synthesized through enzymatic reactions starting with the condensation of myristoyl-CoA and serine by serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), which shows a preference for myristoyl-CoA. This compound is found in minute quantities in its free form in human plasma and as a component of various plasma sphingolipids, such as sphingosine-1-phosphate, ceramides, sphingomyelins, and in brain cerebrosides, albeit at lower co...
T37955	Sphingosine-1-phosphate (d16:1) Sphingosine-1-phosphate (d16:1)	Others	Others
	C16 Sphingosine-1-phosphate (C16 S1P) is a derivative of sphingosine-1-phosphate that binds to S1P1/EDG-1, S1P3/EDG-3, and S1P2/EDG-5 receptors with affinities of 115%, 83%, and 103%, respectively, relative to S1P in CHO cells. C16 S1P was increased in postmortem primary open angle glaucoma trabecular meshwork samples.
T34693	Sphingosine phosphorylcholine	Others	Others
	Sphingosine phosphorylcholine is a wound healing agent.
T85161	N,N-dihexyl Sphingosine (d18:1/6:0/6:0) N,N-dihexyl-D-erythro-Sphingosine	Others	Others

T22917	L-threo-Sphingosine C-18	Others	Others
	L-threo-Sphingosine C-18 is a protein kinase C inhibitor.
T81700	NBD Sphingosine
	NBD Sphingosine是带有荧光的鞘氨醇衍生物，常用于通过荧光方法测定鞘氨醇激酶活性。
T84961	SOCLAC N-chloroacetyl Sphingosine	Others	Others
	SOCLAC, a derivative of the acid ceramidase inhibitor SABRAC, functions as an irreversible inhibitor of acid ceramidase with an inhibition constant (Ki) of 40.2 nM.
T40849	C20 Ceramide N-Arachidoyl-D-sphingosine	Endogenous Metabolite	Metabolism
	C20 Ceramide (N-Arachidoyl-D-sphingosine) 是一种存在于大脑中的 20:0 神经酰胺，可穿越血脑屏障激活小胶质细胞，诱导抑郁样行为。
T12436	PF-543 Citrate Sphingosine Kinase 1 Inhibitor II Citrate	S1P Receptor	GPCR/G Protein
	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T21260	Psychosine Sphingosine galactoside,Galactosylsphingosine,Galactosylsphingosine (d18:1)	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Psychosine (Galactosylsphingosine) 是一种 PKC 抑制剂，是半乳糖脑苷脂酶 (GALC) 酶的底物，是 Krabbe 病的潜在生物标志物。Psychosine 具有很强的细胞毒性，可诱导多种细胞死亡。
T35803	C14 Ceramide (d18:1/14:0) Cer(d18:1/14:0),N-Myristoyl-D-sphingosine
	C14 Ceramide (d18:1/14:0) 是由神经酰胺合成酶 6 生成的一种内源性神经酰胺,可用于研究帕金森。
T37436	C12-Ceramide N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine
	C12-Ceramide (C12 Ceramide (d18:1/12:0)) 是一种存在于先兆子痫妇女所生婴儿围绕脐带血管的保护膜的神经酰胺，是 C12 鞘磷脂被酸性鞘磷脂酶（ASM）水解后形成的，可用于评估 A 型或 B 型尼曼-皮克病患者血浆中的 ASM 活性水平。
T8461	SKI V	Apoptosis; PI3K; S1P Receptor	Apoptosis; GPCR/G Protein; PI3K/Akt/mTOR signaling
	SKI V 是一种非竞争性非脂质鞘氨醇激酶抑制剂，对 GST-hSK 的IC50为 2 μM。它减少有丝分裂的第二信使鞘氨醇-1-磷酸的形成，可诱导细胞凋亡并具有抗肿瘤活性。它还抑制PI3K，对 hPI3k 的IC50为 6 μM。
T8840	PF-543 hydrochloride PF-543	Apoptosis; S1P Receptor; Autophagy; LPL Receptor	Apoptosis; Autophagy; GPCR/G Protein
	PF-543 hydrochloride (PF-543) 是一种选择性可逆和鞘氨醇竞争性SPHK1抑制剂，对SPHK1的选择性是 SPHK2 的 100 倍以上。它还是全血中 1-磷酸鞘氨醇形成的有效抑制剂，诱导细胞凋亡、坏死和自噬。
T6085	PF-543 Sphingosine Kinase 1 Inhibitor II,PF 543	Apoptosis; S1P Receptor; Autophagy; LPL Receptor	Apoptosis; Autophagy; GPCR/G Protein
	PF-543 (Sphingosine Kinase 1 Inhibitor II) 是一种选择性可逆和鞘氨醇竞争性 SPHK1抑制剂，可诱导细胞凋亡、坏死和自噬。它对 SPHK1的选择性是 SPHK2 的 100 倍以上。它还抑制全血中 1-磷酸鞘氨醇形成，IC50为 26.7 nM。
TQ0138	K145 hydrochloride K145盐酸盐	Apoptosis; S1P Receptor	Apoptosis; GPCR/G Protein
	K145 hydrochloride 是选择性的，底物竞争性的和口服有效的SphK2抑制剂，IC50为 4.3 µM，Ki 为 6.4 µM。它可诱导细胞凋亡，显示出强大的抗肿瘤活性。
T6750	Opaganib ABC294640	S1P Receptor	GPCR/G Protein
	Opaganib (ABC294640) 是选择性和竞争性的鞘氨醇激酶 2 (SK2) 抑制剂，Ki 为 9.8 μM。
T4658	MHP Methyl caprooyl tyrosinate	S1P Receptor	GPCR/G Protein
	MHP (Methyl caprooyl tyrosinate) 是一种鞘氨醇激酶 (SPHK1) 激活剂，可显著增加 CAMP mRNA 和蛋白水平，还可增强抗微生物防御能力和先天免疫力。
T16128	MP-A08	S1P Receptor	GPCR/G Protein
	MP-A08 是高度选择性和 ATP 竞争性的 SPHK1 抑制剂。
T21658	ARN14974	Others	Others
	ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。
T84383	C2 dihydro Ceramide (d18:0/2:0) Cer(d18:0/2:0),N-acetyl-D-erythro-Sphinganine,N-acetyl-dihydro-Sphingosine,Ceramide (d18:0/2:0),N-acetyl-D-erythro-dihydro-Sphingosine	Others	Others

T6673	SKI II SphK-I2	Apoptosis; Wnt/beta-catenin; S1P Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Stem Cells
	SKI II (SphK-I2) 是一种口服有效的合成鞘氨醇激酶 (SK)抑制剂，抑制 SK1 和 SK2，IC50值分别为 78 μM 和 45 μM。它通过诱导溶酶体/蛋白酶体降解，不可逆地抑制SK1。
T20827	C8-Ceramide N-辛酰基-D-神经鞘氨醇,N-Octanoyl-D-erythro-Sphingosine	Others	Others
	C8 Ceramide, a cell-permeable analog, is analog to naturally occur ceramides.
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31	Others	Others
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。
T85165	EOS (d18:1/30:0/18:2) C48:2 EOS (d18:1/30:0w18:2 (9Z,12Z)),N-(30-linoleoyloxy-triacontanoyl)-Sphingosine	Others	Others

T85275	C32 Ceramide (d18:1/32:0) Cer(d18:1/32:0),N-dotriacontanoyl-D-erythro-Sphingosine,Ceramide (d18:1/32:0)	Others	Others

T85189	C15 Ceramide (d18:1/15:0) Ceramide (d18:1/15:0),N-pentadecanoyl-D-erythro-Sphingosine,Cer(d18:1/15:0)	Others	Others

T83880	C18 Ceramide-1-phosphate (d18:1/18:0) ammonium Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate	Others	Others
	C18 Ceramide-1-phosphate (d18:1/18:0) 是一种在鼠皮肤中发现的长链ceramide-1-phosphate。它能在0.5至5 µM的浓度范围内促进分离的小鼠骨髓来源的多能间充质细胞和人脐静脉内皮细胞（HUVECs）的迁移。与胰腺癌干细胞相比，CFPAC-1胰管腺癌细胞中C18 Ceramide-1-phosphate (d18:1/18:0)的水平有所增加。在Langendorff分离的灌流小鼠心脏的离体缺血模型中，心肌中C18 ceramide-1-phosphate (d18:1/18:0)的水平有所增加。
T85193	C10 Ceramide (d18:1/10:0) Ceramide (d18:1/10:0),N-decanoyl-D-erythro-Sphingosine,C10 Ceramide,Cer(d18:1/10:0)	Others	Others

T85188	C2 L-erythro Ceramide (d18:1/2:0) L-erythro Cer(d18:1/2:0),L-erythro Ceramide (d18:1/2:0),N-acetyl-L-erythro-Sphingosine	Others	Others

TQ0064	Peretinoin NIK333	HCV Protease; Retinoid Receptor; S1P Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Peretinoin (NIK333) 是口服非环状类视黄醇，靶向类视黄醇核受体，结构类维生素 A 。
T9014	SKI-178	Apoptosis; S1P Receptor	Apoptosis; GPCR/G Protein
	SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂，以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。
T12148	N-Desmethyltamoxifen hydrochloride	Estrogen Receptor/ERR; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	N-Desmethyltamoxifen hydrochloride 是 Tamoxifen 在人体内主要的三苯氧胺代谢物。它是蛋白激酶 C 抑制剂，也是人体 AML 细胞神经酰胺代谢的有效调节因子，可限制神经酰胺糖基化、水解和鞘氨醇磷酸化。
T85039	C12 1-Deoxyceramide (m18:1/12:0) Cer(m18:1/12:0),C12:0 Ceramide (m18:1/12:0),C12:0 1-Deoxyceramide,N-Dodecanoyl-1-deoxy-4,5-dihydro-Sphingosine	Others	Others

T85052	C16 1-Deoxyceramide (m18:1/16:0) C16:0 Ceramide (m18:1/16:0),Cer(m18:1/16:0),C16:0 1-Deoxyceramide,N-Hexadecanoyl-1-deoxy-4,5-dihydro-Sphingosine	Others	Others

T85289	C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) ((±)-2'-hydroxy) Cer(d18:1/18:0),((±)-2'-hydroxy) Ceramide (d18:1/18:0),18:0 (2R/S-OH)-Ceramide,N-(2'-(R,S)-hydroxystearoyl)-D-erythro-Sphingosine	Others	Others

T85031	C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) N-tetracosenoyl-1-deoxy-4,5-dihydro-Sphingosine,C24:1(15Z) 1-Deoxyceramide,C24:1 Ceramide (m18:1/24:1(15Z)),Cer(m18:1/24:1(15Z))	Others	Others

T6923	Ozanimod 奥扎莫德,RPC-1063	S1P Receptor; LPL Receptor	GPCR/G Protein
	Ozanimod (RPC-1063) 是一种选择性S1P1和S1P5受体激动剂，在[35S]-GTPγS 结合实验中，EC50分别为 410 pM 和 11 nM。它可研究治疗克罗恩病、溃疡性结肠炎、多发性硬化症和复发性多发性硬化症的试验。
T85290	C6 Biotin Ceramide (d18:1/6:0) N-hexanoyl-biotin-D-erythro-Sphingosine,N-C6:0-biotin-D-erythro-Ceramide,Biotin Cer(d18:1/6:0),Biotin Ceramide (d18:1/6:0),C6 Ceramide-biotin	Others	Others

T85284	C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0) N-(2'-(S)-hydroxypalmitoyl)-D-erythro-Sphingosine,2'(S)-hydroxy Cer(d18:1/16:0),2'-hydroxy C16-Ceramide,(2'(S)-hydroxy) Ceramide (d18:1/16:0),16:0 (2S-OH)-Ceramide	Others	Others

T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T35806	N-Stearoylsphingosine C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide	Phosphatase	Metabolism
	N-Stearoylsphingosine (Cer(d18:1/18:0)) 是一种广泛存在真核生物体内的酰胺类化合物，通过干扰PP2A与PP2A抑制剂2的结合来增强蛋白质磷酸酶2A(PP2A)活性，导致Akt去磷酸化。N-Stearoylsphingosine 可用于研究前列腺癌。
T23045	N,N-Dimethylsphingosine	Others	Others
	sphingosine kinase (SphK) inhibitor
T38354	Lactosylsphingosine (d18:1) Lactosylsphingosine (d18:1)	Others	Others
	Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide,lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.
T38090	3'-sulfo Galactosylsphingosine (ammonium salt)	Others	Others
	3'-sulfo Galactosylsphingosine is a form of sulfatide that is lacking the fatty acyl group. It decreases migration and adhesion of B35 neuroblastoma cells and increases cell rounding when used at a concentration of 20 μM. It also inhibits PKC and cytochrome c oxidase activity when used at concentrations of 150 and 50-100 μM, respectively. 3'-sulfo Galactosylsphingosine accumulates in patients with metachromatic leukodystrophy, a lysosomal storage disorder characterized by arylsulfatase A (ASA) d...

化合物

C12-Sphingosine

Cat.No: T38685

Synonym: C12-Sphingosine

Target: Others

Biotin Sphingosine

Cat.No: T83883

Synonym: Biotinyl Sphingosine

Sphingosine (d20:1)

Cat.No: T37954

Synonym: Sphingosine (d20:1)

Target: Others

Erythro-sphingosine, (+)-

Cat.No: T24044

Synonym: L-Erythro-c18-sphingosine,L-Erythro-sphingosine

Target: Others

Sphingosine (d15:1)

Cat.No: T84509

Synonym: D-erythro-Sphingosine C-15

Target: Others

Sphingosine (d16:1)

Cat.No: T85010

Synonym: D-erythro-Sphingosine C-16

Target: Others

Sphingosine-1-phosphate (d16:1)

Cat.No: T37955

Synonym: Sphingosine-1-phosphate (d16:1)

Target: Others

Sphingosine phosphorylcholine

Cat.No: T34693

Target: Others

N,N-dihexyl Sphingosine (d18:1/6:0/6:0)

Cat.No: T85161

Synonym: N,N-dihexyl-D-erythro-Sphingosine

Target: Others

L-threo-Sphingosine C-18

Cat.No: T22917

Target: Others

NBD Sphingosine

Cat.No: T81700

Cat.No: T84961

Synonym: N-chloroacetyl Sphingosine

Target: Others

Cat.No: T40849

Synonym: N-Arachidoyl-D-sphingosine

Target: Endogenous Metabolite

Cat.No: T12436

Synonym: Sphingosine Kinase 1 Inhibitor II Citrate

Target: S1P Receptor

Cat.No: T21260

Synonym: Sphingosine galactoside,Galactosylsphingosine,Galactosylsphingosine (d18:1)

Target: PKC

C14 Ceramide (d18:1/14:0)

Cat.No: T35803

Synonym: Cer(d18:1/14:0),N-Myristoyl-D-sphingosine

Cat.No: T37436

Synonym: N-Laurylsphingosine,C12 Ceramide (d18:1/12:0),N-Lauroyl-D-erythro-sphingosine

Cat.No: T8461

Target: Apoptosis, PI3K, S1P Receptor

PF-543 hydrochloride

Cat.No: T8840

Synonym: PF-543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

Cat.No: T6085

Synonym: Sphingosine Kinase 1 Inhibitor II,PF 543

Target: Apoptosis, S1P Receptor, Autophagy, LPL Receptor

K145 hydrochloride

Cat.No: TQ0138

Synonym: K145盐酸盐

Target: Apoptosis, S1P Receptor

Cat.No: T6750

Synonym: ABC294640

Target: S1P Receptor

Cat.No: T4658

Synonym: Methyl caprooyl tyrosinate

Target: S1P Receptor

Cat.No: T16128

Target: S1P Receptor

Cat.No: T21658

Target: Others

C2 dihydro Ceramide (d18:0/2:0)

Cat.No: T84383

Synonym: Cer(d18:0/2:0),N-acetyl-D-erythro-Sphinganine,N-acetyl-dihydro-Sphingosine,Ceramide (d18:0/2:0),N-acetyl-D-erythro-dihydro-Sphingosine

Target: Others

Cat.No: T6673

Synonym: SphK-I2

Target: Apoptosis, Wnt/beta-catenin, S1P Receptor

Cat.No: T20827

Synonym: N-辛酰基-D-神经鞘氨醇,N-Octanoyl-D-erythro-Sphingosine

Target: Others

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Target: Others

EOS (d18:1/30:0/18:2)

Cat.No: T85165

Synonym: C48:2 EOS (d18:1/30:0w18:2 (9Z,12Z)),N-(30-linoleoyloxy-triacontanoyl)-Sphingosine

Target: Others

C32 Ceramide (d18:1/32:0)

Cat.No: T85275

Synonym: Cer(d18:1/32:0),N-dotriacontanoyl-D-erythro-Sphingosine,Ceramide (d18:1/32:0)

Target: Others

C15 Ceramide (d18:1/15:0)

Cat.No: T85189

Synonym: Ceramide (d18:1/15:0),N-pentadecanoyl-D-erythro-Sphingosine,Cer(d18:1/15:0)

Target: Others

C18 Ceramide-1-phosphate (d18:1/18:0) ammonium

Cat.No: T83880

Synonym: Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate

Target: Others

C10 Ceramide (d18:1/10:0)

Cat.No: T85193

Synonym: Ceramide (d18:1/10:0),N-decanoyl-D-erythro-Sphingosine,C10 Ceramide,Cer(d18:1/10:0)

Target: Others

C2 L-erythro Ceramide (d18:1/2:0)

Cat.No: T85188

Synonym: L-erythro Cer(d18:1/2:0),L-erythro Ceramide (d18:1/2:0),N-acetyl-L-erythro-Sphingosine

Target: Others

Cat.No: TQ0064

Synonym: NIK333

Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy

Cat.No: T9014

Target: Apoptosis, S1P Receptor

N-Desmethyltamoxifen hydrochloride

Cat.No: T12148

Target: Estrogen Receptor/ERR, Endogenous Metabolite, PKC

C12 1-Deoxyceramide (m18:1/12:0)

Cat.No: T85039

Synonym: Cer(m18:1/12:0),C12:0 Ceramide (m18:1/12:0),C12:0 1-Deoxyceramide,N-Dodecanoyl-1-deoxy-4,5-dihydro-Sphingosine

Target: Others

C16 1-Deoxyceramide (m18:1/16:0)

Cat.No: T85052

Synonym: C16:0 Ceramide (m18:1/16:0),Cer(m18:1/16:0),C16:0 1-Deoxyceramide,N-Hexadecanoyl-1-deoxy-4,5-dihydro-Sphingosine

Target: Others

C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0)

Cat.No: T85289

Synonym: ((±)-2'-hydroxy) Cer(d18:1/18:0),((±)-2'-hydroxy) Ceramide (d18:1/18:0),18:0 (2R/S-OH)-Ceramide,N-(2'-(R,S)-hydroxystearoyl)-D-erythro-Sphingosine

Target: Others

C24:1 1-Deoxyceramide (m18:1/24:1(15Z))

Cat.No: T85031

Synonym: N-tetracosenoyl-1-deoxy-4,5-dihydro-Sphingosine,C24:1(15Z) 1-Deoxyceramide,C24:1 Ceramide (m18:1/24:1(15Z)),Cer(m18:1/24:1(15Z))

Target: Others

Cat.No: T6923

Synonym: 奥扎莫德,RPC-1063

Target: S1P Receptor, LPL Receptor

C6 Biotin Ceramide (d18:1/6:0)

Cat.No: T85290

Synonym: N-hexanoyl-biotin-D-erythro-Sphingosine,N-C6:0-biotin-D-erythro-Ceramide,Biotin Cer(d18:1/6:0),Biotin Ceramide (d18:1/6:0),C6 Ceramide-biotin

Target: Others

C16 (2'(S)-hydroxy) Ceramide (d18:1/16:0)

Cat.No: T85284

Synonym: N-(2'-(S)-hydroxypalmitoyl)-D-erythro-Sphingosine,2'(S)-hydroxy Cer(d18:1/16:0),2'-hydroxy C16-Ceramide,(2'(S)-hydroxy) Ceramide (d18:1/16:0),16:0 (2S-OH)-Ceramide

Target: Others

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

N-Stearoylsphingosine

Cat.No: T35806

Synonym: C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide

Target: Phosphatase

N,N-Dimethylsphingosine

Cat.No: T23045

Target: Others

Lactosylsphingosine (d18:1)

Cat.No: T38354

Synonym: Lactosylsphingosine (d18:1)

Target: Others

3'-sulfo Galactosylsphingosine (ammonium salt)

Cat.No: T38090

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T78473	Sphingosine (d17:1) C17 Sphingosine
	Sphingosine (d17:1) (C17 Sphingosine)是一种存在于人类皮肤中的17碳鞘脂，可被鞘氨醇激酶的磷酸化。Sphingosine C-17作为内标可用于进行鞘脂类化合物的光谱分析。
T5891	D-ERYTHRO-SPHINGOSINE trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇	Phosphatase; Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	D-erythro-Sphingosine (trans-4-Sphingenine) 是一种非常有效的p32激酶活化剂，EC50为 8 μM。它也是一种PP2A 激活剂，抑制蛋白激酶 C (PKC)。
T72100	D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride	Others	Others
	D-erythro-Sphingosine (Erythrosphingosine) hydrochloride 是一种特异性 TRPM3活化剂。D-erythro-Sphingosine 还诱导视网膜母细胞瘤蛋白 (retinoblastoma protein) 去磷酸化。
T38262	Sphingosine (d14:1)	Others	Others
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).
T21500	Sphingosine-1-phosphate S1P	Endogenous Metabolite; S1P Receptor; LPL Receptor	GPCR/G Protein; Metabolism
	Sphingosine-1-phosphate (S1P) 是 S1P1-5 受体 (S1P1-5 receptors) 的激动剂和 GPR3、GPR6、GPR12 的配体。Sphingosine-1-phosphate 是细胞内的第二信使，动员 Ca2+ 作为 G 蛋白偶联受体的细胞外配体。Sphingosine-1-phosphate 是由鞘磷脂 (HY-113498) 或其他膜磷脂生成的重要脂质介质。
TQ0198	Phorbol 12-myristate 13-acetate 佛波醇12-十四酸酯13-乙酸酯,PMA	NF-κB; S1P Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; NF-κB
	Phorbol 12-myristate 13-acetate (PMA) 属于佛波酯类天然产物，是一种 PKC、SphK、NF-κB 的激活剂。Phorbol 12-myristate 13-acetate 可诱导 THP1 细胞分化。
T13632	D-Erythro-dihydrosphingosine Dihydrosphingosine,Octadecasphinganine,D-赤式-C 18 - 二氢-D-神经鞘氨醇,C18-Dihydrosphingosine,D-erythro-Sphinganine	Phospholipase; Endogenous Metabolite	Metabolism
	D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) 可抑制花生四烯酸的释放和cPLA2α活性。
T9503	PHYTOSPHINGOSINE	Apoptosis	Apoptosis
	Phytosphingosine 是具有抗癌作用的一种磷脂。在癌细胞中，它通过 caspase 8 的激活和 Bax 转位诱导细胞凋亡。
T82572	D-Glucosyl-β-1,1′-N-palmitoylsphingosine C16 Glucosyl(β) Ceramide (d18:1/16:0)	Others	Others
	D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体，具免疫刺激活性。
T22723	Dihydrosphingosine	Others	Others
	Dihydrosphingosine is a Protein kinase C inhibitor.
T78493	Glucosylsphingosine Lyso-Gb1,Glucopsychosine	Others	Others
	Glucosylsphingosine（lyso-Gb1）作为糖基神经酰胺的脱酰基产物，同样能被糖脑苷酶所降解。该化合物是监测戈谢病的一个极具潜力、可靠且特异的生物标志物。
T7939	Fingolimod 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德	S1P Receptor; PAK; LPL Receptor	Cytoskeletal Signaling; GPCR/G Protein
	Fingolimod (FTY-720A) 是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它还是pak1激活剂和免疫抑制剂。
T4944	Nervonic acid cis-15-Tetracosenoic acid,神经酸,Selacholeic acid	Endogenous Metabolite	Metabolism
	Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。
T4855	Tricosanoic acid Tricosan-1-oic acid,二十三烷酸	Endogenous Metabolite	Metabolism
	Tricosanoic acid (Tricosan-1-oic acid) 是毛发生长激活剂，是长链脂肪酸。
T15357	Fumonisin B2 伏马菌素B2	Others	Others
	Fumonisin B2 is a mycotoxin produced by Fusarium moniliforme in various grains. It also is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase). Which disrupts de novo sphingolipid biosynthesis.
T75465	Mycestericin G	Others	Others
	Mycestericin G 是一种鞘氨醇样真菌代谢产物，具有免疫抑制活性。
T15356	Fumonisin B1 伏马菌素B1	Others	Others
	Fumonisin B1 is the most abundant and toxic fumonisin and is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is also a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis.

天然产物

Sphingosine (d17:1)

Cat.No: T78473

Synonym: C17 Sphingosine

D-ERYTHRO-SPHINGOSINE

Cat.No: T5891

Synonym: trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine,鞘氨醇,D-鞘氨醇

Target: Phosphatase, Endogenous Metabolite, PKC

D-erythro-Sphingosine hydrochloride

Cat.No: T72100

Synonym: Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride

Target: Others

Sphingosine (d14:1)

Cat.No: T38262

Target: Others

Sphingosine-1-phosphate

Cat.No: T21500

Synonym: S1P

Target: Endogenous Metabolite, S1P Receptor, LPL Receptor

Phorbol 12-myristate 13-acetate

Cat.No: TQ0198

Synonym: 佛波醇12-十四酸酯13-乙酸酯,PMA

Target: NF-κB, S1P Receptor, PKC

D-Erythro-dihydrosphingosine

Cat.No: T13632

Synonym: Dihydrosphingosine,Octadecasphinganine,D-赤式-C 18 - 二氢-D-神经鞘氨醇,C18-Dihydrosphingosine,D-erythro-Sphinganine

Target: Phospholipase, Endogenous Metabolite

PHYTOSPHINGOSINE

Cat.No: T9503

Target: Apoptosis

D-Glucosyl-β-1,1′-N-palmitoylsphingosine

Cat.No: T82572

Synonym: C16 Glucosyl(β) Ceramide (d18:1/16:0)

Target: Others

Dihydrosphingosine

Cat.No: T22723

Target: Others

Glucosylsphingosine

Cat.No: T78493

Synonym: Lyso-Gb1,Glucopsychosine

Target: Others

Cat.No: T7939

Synonym: 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇,FTY-720A,FTY-720,芬戈莫德

Target: S1P Receptor, PAK, LPL Receptor

Cat.No: T4944

Synonym: cis-15-Tetracosenoic acid,神经酸,Selacholeic acid

Target: Endogenous Metabolite

Tricosanoic acid

Cat.No: T4855

Synonym: Tricosan-1-oic acid,二十三烷酸

Target: Endogenous Metabolite

Cat.No: T15357

Synonym: 伏马菌素B2

Target: Others

Cat.No: T75465

Target: Others

Cat.No: T15356

Synonym: 伏马菌素B1

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04432	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant SPHK,SPHK1,sphingosine kinase 1,SPK	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
TMPY-04431	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) SPHK,SPHK1,SPK,sphingosine kinase 1	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
TMPK-00516	BST1 Protein, Cynomolgus, Recombinant (His) Bp-3,CD157,Bst1,BST-1,Ly65,Bp3,Antigen BP3	Cynomolgus	HEK293 Cells
	BST1 overexpression conferred resistance to sphingosine in yeast. BST1 deletion produced sensitivity to exogenous D-erythro-sphingosine and phytosphingosine and intracellular accumulation of sphingosine 1-phosphate upon exposure to exogenous sphingosine. sphingoid base metabolism is similar in all eukaryotes and suggests that yeast genetics may be useful in the isolation and identification of other genes involved in sphingolipid signaling and metabolism.
TMPH-02518	APOM Protein, Mouse, Recombinant (His) Ng20,ApoM,Apolipoprotein M,Apo-M	Mouse	P. pastoris (Yeast)
	Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid. APOM Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 23.3 kDa and the accession number is Q9Z1R3.
TMPY-00963	ASAH2 Protein, Mouse, Recombinant (His) N-acylsphingosine amidohydrolase (non-lysosomal cer...	Mouse	HEK293 Cells
	ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. The enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of ASAH2/neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine ASAH2 po...

重组蛋白

Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant

Cat.No: TMPY-04432

Species: Human

Expression System: Baculovirus Insect Cells

Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04431

Species: Human

Expression System: Baculovirus Insect Cells

BST1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00516

Species: Cynomolgus

Expression System: HEK293 Cells

APOM Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02518

Species: Mouse

Expression System: P. pastoris (Yeast)

ASAH2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00963

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T37928	13C6 Glucosylsphingosine (d18:1)
	13C6 Glucosylsphingosine (d18:1) is an isotopically enriched form of 1-β-D-glucosylsphingosine (d18:1) that is intended for use as an internal standard for the quantification of 1-β-D-glucosylsphingosine by GC- or LC-MS. 1-β-D-Glucosylsphingosine is a lysolipid derivative of glucosylcerebroside that decreases activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner.
TMIH-0236	Fingolimod-d4 HCl
	Fingolimod-d4 HCl 是 Fingolimod HCl 的氘代化合物。Fingolimod HCl 的 CAS 号为 162359-56-0。Fingolimod hydrochloride 是一种新型免疫调节剂，是一种 1-磷酸鞘氨醇 (S1P) 拮抗剂，作用于 K562 和 NK 细胞，IC50为 0.033 nM。它诱导 S1P1 的内化，从而抑制 S1P 活性。它被鞘氨醇激酶磷酸化，尤其是被 SK2 磷酸化，从而可与 S1PR1、3、4 和 5 结合

同位素标记化合物

13C6 Glucosylsphingosine (d18:1)

Cat.No: T37928

Fingolimod-d4 HCl

Cat.No: TMIH-0236

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