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Search Results for " mutants "

Targets Recommended: EGFR HER BTK RIP kinase

94

抑制剂 & 化合物

2

天然产物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9072	Tuxobertinib BDTX-189	EGFR; HER; BTK; RIP kinase	Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂，具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。
TQ0092	Naquotinib ASP8273	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Naquotinib (ASP8273) 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂，对EGFR 突变体和EGFR 的IC50值分别为8-33和230 nM。
T24943	VPC-14228 VPC 14228,VPC14228	Androgen Receptor	Endocrinology/Hormones
	VPC-14228 是一种特异性 AR-DBD 抑制剂，通过抑制 Y594A 和 Q592A 突变体起作用。
T31014	Corrector C4 Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a	Others	Others
	Corrector C4 是一种常用于研究囊性纤维化突变体的校正子，通过减轻CFTR跨膜结构域突变体与蛋白稳态的相互作用来发挥作用。
T72062	BI-2865	Ras	GPCR/G Protein; MAPK
	BI-2865 是一种非共价的泛-KRAS 抑制剂。BI-2865 可与 KRAS WT、G12C、G12D、G12V 和 G13D 突变体结合，KD 值分别为 6.9、4.5、32、26、4.3 nM。BI-2865在对表达 KRAS G12C、G12D 或 G12V 突变体的 BaF3 细胞实验的过程中显示出抗增殖活性，平均 IC50值大约为 140 nM。
T11761	Tarlox-TKI Kinase inhibitor-1	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tarlox-TKI (Kinase inhibitor-1) 是一种 pan-ErbB 抑制剂，是 Tarloxotinib 的活性成分，具有抗肿瘤活性。Tarlox-TKI 抑制 NRG1，抑制HER2 突变体。
T22592	ATPγS tetralithium salt ATP-gamma-S tetralithium salt	PERK	Apoptosis
	ATPγS tetralithium salt 是真核生物翻译起始因子 eIF4A 的核苷酸水解和RNA解链活性的底物，与 p97 突变体和朊病毒相关。
T15442	GSK864 GSK 864,GSK-864	Dehydrogenase	Metabolism
	GSK864是异柠檬酸脱氢酶1 (IDH1) 突变体抑制剂，对IDH1突变体R132C，R132H和R132G 有抑制作用，可用于研究心血管疾病和肿瘤疾病。
T6824	EAI045	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EAI045是突变体EGFR 的变构抑制剂，在10 μM ATP 时抑制EGFR、EGFRL858R、EGFRT790M 和 EGFRL858R/T790M 的IC50值分别为1.9、0.019、0.19 和 0.002 μM。
T2104	AGI-5198 IDH-C35	Dehydrogenase; Isocitrate Dehydrogenase (IDH)	Metabolism
	AGI-5198 (IDH-C35) 是一种选择性的突变体 IDH1R132H 抑制剂，IC50=0.07 μM。
T34656	SKLB 1028 Ruserontinib	EGFR; FLT; Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	SKLB 1028 (Ruserontinib) 是口服活性的、新型的EGFR、FLT3和Abl 多激酶抑制剂。SKLB 1028 在FLT3驱动的AML 模型中显示出优异的活性，在含有Abl 突变体的CML 模型中显示了相当大的效力
T6198	Dolutegravir S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir (GSK1349572) 是口服HIV 整合酶链转移高效抑制剂，抑制 HIV-1 病毒在外周血单个核细胞中的复制。它对耐拉替拉韦的特征突变体 Y143R、Q148K、N155H 和 G140S/Q148H 具有中等活性。
T2620	G-749 G749	Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	G-749 是一种新型 FLT3 抑制剂，对 FLT3 野生型和突变体有持续的抑制作用，IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。
T74637	Sonrotoclax BGB 11417	BCL	Apoptosis
	Sonrotoclax (BGB 11417) 是一种靶向 WT 和 G101V 突变体Bcl-2的选择性抑制剂，具有潜在的抗肿瘤活性，可用于研究淋巴瘤和白血病。
T2147	Nilotinib monohydrochloride monohydrate Nilotinib (monohydrochloride monohydrate),尼洛替尼盐酸盐一水合物,AMN107 (monohydrochloride monohydrate),尼罗替尼中间体	Bcr-Abl; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Nilotinib monohydrochloride monohydrate (Nilotinib (monohydrochloride monohydrate)) 是酪氨酸酶抑制剂，有效抑制 BCR-ABL 及其突变体。
T16516	PG01 Phenylglycine-01	CFTR	Membrane transporter/Ion channel
	PG01是一种有效的CFTR Cl-通道增效剂,PG01对 ΔF508（Ka 为 0.3 μM）有效。PG01 对 E193K，G970R 和 G551D (CFTR 突变体)也有效，Kd 值分别为 0.22 μM，0.45 μM 和 1.94 μM 。PG01在加入Forskolin 后可增加ΔF508-CFTR Cl-电流，纠正CFTR 突变体的门控缺陷。
T7861	Flumatinib mesylate 甲磺酸氟马替尼/氟马替尼,HHGV678 mesylate,甲磺酸氟马替尼	Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Flumatinib mesylate (HHGV678 mesylate) 是一种具有口服活性的选择性Bcr-Abl 抑制剂，能够作用于 c-Abl (IC50:1.2 nM)，PDGFRβ (IC50:307.6 nM) 和 c-Kit (IC50:665.5 nM)。
T22324	Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride	Others; Trk receptor; c-Met/HGFR; ALK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂，IC50分别 <0.4 nM 和 0.74 nM。
TQ0277	Pralsetinib 普拉替尼,Blu667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	Pralsetinib (Blu667) 是高效的、选择性的RET 抑制剂。它能够抑制 WT RET (IC50:0.4 nM)，RET 突变体 V804L (IC50:0.3 nM)，V804M (IC50:0.4 nM)，M918T (IC50:0.4 nM) 和 CCDC6-RET (IC50:0.4 nM) 的融合。
T2329	Dolutegravir sodium 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Dolutegravir sodium (GSK-1349572A) 是一种高效、口服的 HIV 整合酶链转移抑制剂，在 HIV-1 整合酶催化的链转移中的 IC50值为 2.7 nM，抑制 HIV-1 病毒在外周血单个核细胞中的复制，IC50为 0.51 nM。它对 Y143R，N155H 和 G140S/Q148H 突变体也保持高效。
T2287	PIK-75 hydrochloride PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75	Apoptosis; DNA-PK; PI3K	Apoptosis; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PIK-75 hydrochloride (PIK-75 HCl) 是一种可逆的 DNA-PK 和 p110α-选择性抑制剂，抑制 DNA-PK，p110α和 p110γ，可诱导凋亡。
T11438	GNE-1858	Others; MAPK	MAPK; Others
	GNE-1858 是高效的 ATP 竞争性造血祖细胞激酶-1抑制剂，能够抑制野生型(IC50:1.9 nM)、活性模拟突变株 HPK1-TSEE (IC50:1.9 nM)、 HPK1-SA (IC50:4.5 nM)的活性。
T8758	Poziotinib hydrochloride HM 781-36B hydrochloride,NOV120101 hydrochloride,波齐替尼盐酸盐	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Poziotinib hydrochloride 不可逆地抑制 EGFR（HER1 或 ErbB1），包括 EGFR 突变体、HER2 和 HER4，从而抑制过度表达这些受体的肿瘤细胞的增殖。它是一种口服生物可利用的、基于喹唑啉的泛表皮生长因子受体（EGFR 或 HER）抑制剂，具有潜在的抗肿瘤活性。
T4428	CCT241736	FLT; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂，还抑制临床相关的 FLT3 耐药突变体，包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物，是治疗人类恶性肿瘤的临床前开发候选物。
T79578	CFTR corrector 12	CFTR	Membrane transporter/Ion channel
	CFTRcorrector 12（compound 17C）作为一种双噻唑衍生物，本身是CFTR校正剂。它具有校正控制氯离子跨膜运输通道的特定折叠缺陷突变的功能，并能够在带有突变的细胞中恢复α-肌聚糖（α-SG）的含量。
T75129	Luxdegalutamide ARV-766	Androgen Receptor; PROTACs	Endocrinology/Hormones; PROTAC
	Luxdegalutamide (ARV-766) 是一种可口服且有效的蛋白水解靶向嵌合体 (PROTAC) 的蛋白质降解剂。Luxdegalutamide降解野生型雄激素受体 AR，也降解包括最普遍的致病性 AR L702H、H875Y 和 T878A 突变相关的 AR LBD 突变体。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T81490	PHI-101	Others	Others
	PHI-101是口服FLT3抑制剂，在克服多耐药突变方面表现出高效。该化合物对FLT3的ITD或TKD单突变体表现出显著抑制作用，同时也能抑制包括双重（ITD/D835Y或ITD/F691L）和三重（ITD/D835Y/F691L）耐药突变。PHI-101在治疗复发或难治性急性髓系白血病（AML）的研究中显示出应用潜力。
T41068	P53R3	p53	Apoptosis
	P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合，包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用，其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5（DR5）的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。
T9533	BC-LI-0186 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide	Others	Others
	BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长，能够用于肺癌的相关研究。
T1283	Clinafloxacin 克林沙星,PD 127391,CI-960,AM-1091	Antibacterial; Antibiotic	Microbiology/Virology
	Clinafloxacin (CI-960) 是一种高效广谱氟喹诺酮类抗生素，抑制革兰氏阳性、革兰氏阴性和厌氧病原体。它对金黄色葡萄球菌的 DNA 促旋酶和拓扑异构酶 IV 有抑制作用，IC50值分别为 0.92 µg/ml 和 1.62 µg/ml。
TQ0277L	Pralsetinib HCl (2097132-94-8 free base) Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667	Others	Others
	Pralsetinib is a selective and next-generation RET inhibitor (IC50: 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T, and CCDC6-RET fusion). BLU-667 is an effective and selective inhibitor of RET mutations, fusions, and predicted resistant mutants.
T26388	4-CPI 4 CPI	Others	Others
	4-CPI inhibits non-active site mutants of cytochrome P450 2B4.
T70565	Saussureamine C	Others	Others
	Saussureamine C is an inhibitor of H274Y and N294S mutants.
T28988	TNK-6123 TNK6123	Others	Others
	TNK-6123 is an emivirine analog. TNK-6123 has improved activity against drug-resistant HIV mutants.
T69045	ON012380	Others	Others
	ON012380 is a non-ATP-competitive Bcr-Abl inhibitor, potently inhibiting imatinib-resistant Bcr-Abl mutants such as T315I.
T71006	BI-1388	Others	Others
	BI-1388 is a highly potent inhibitor of HCV NS3 protease activity, inhibiting viral replication for various HCV genotypes and for resistant mutants D168V and R155K.
T40150	Trk-IN-6	Others	Others
	Trk-IN-6 shows excellent in vitro potency on a panel of TRK mutants ( IC 50 = 0.2-0.7 nM).
T12175	Naquotinib mesylate ASP8273 (mesylate)	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Naquotinib mesylate (ASP8273 (mesylate)) 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂，对 EGFR 突变体和 EGFR 的 IC50值分别为8-33和230 nM。
T68368	HWY-5069 bromide	Others	Others
	HWY-5069 bromide is an isoquinolinium derivative that inhibits the proliferation of wild-type and all mutants of Schizosaccharomyces pombe.
T61179	EMI48	Others	Others
	EMI48, a derivative of EMI1, exhibits increased efficacy against mutant EGFR compared to EMI1. It specifically inhibits EGFR triple mutants [1].
T70844	CM-118	Others	Others
	CM-118 is a potent and selective dual inhibitor of c-Met and ALK which potently abrogates hepatocyte growth factor (HGF)-induced c-Met phosphorylation and cell migration, as well as phosphorylation of ALK, EML4-ALK, and ALK resistance mutants in transfected cells.
T24944	VPC-14449 VPC14449,VPC 14449	Others	Others
	VPC-14449 is a specific inhibitor of AR-DBD that acts by inhibiting both Y594A and Q592A mutants.
T70668	GNE-431	Others	Others
	GNE-431 is a potent, selective and noncovalent Btk inhibitor with IC50 of 3.2 nM. GNE-431 showed excellent potency against the C481R, T474I, and T474M mutants. GNE-431 may provide a treatment option to patients, especially those who have acquired resistance to ibrutinib by mutation of Cys481 or Thr474.
T70597	G-749 hydrochloride	Others	Others
	G-749 hydrochloride is a novel FLT3 inhibitor that showed potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays.
T23975	Deacylcortivazol UNII-3JO09QT49F,DAC,NSC 325316	Others	Others
	Deacylcortivazol (DAC) is a potent glucocorticoid. When incubated with glucocorticoid-resistant mutants derived from the glucocorticoid-sensitive human leukemic cell line CEM-C7, DAC caused significant growth inhibition. The cytotoxicity of DAC at concent
T28898	T145 T 145,T-145	Others	Others
	T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolo
T35913	EMI56	Others	Others
	EMI56, a derivative of EMI1, exhibits enhanced potency against mutant EGFR compared to EMI1. Additionally, EMI56 effectively inhibits EGFR triple mutants[1].
T20163L	Acetyltrialanine acetate Acetyltrialanine acetate(19245-85-3 Free base)	Others	Others
	Acetyltrialanine acetate 是鼠伤寒沙门氏菌突变体的氮源。
T31218	DBHDA	Others	Others
	DBHDA is a reagent to convert a Cys into a Dha moiety by reacting with a C-terminal Cys residue and thus allowing the use of recombinant Ubl G76C mutants to prepare probes.

化合物

Cat.No: T9072

Synonym: BDTX-189

Target: EGFR, HER, BTK, RIP kinase

Cat.No: TQ0092

Synonym: ASP8273

Target: EGFR

Cat.No: T24943

Synonym: VPC 14228,VPC14228

Target: Androgen Receptor

Cat.No: T31014

Synonym: Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a

Target: Others

Cat.No: T72062

Target: Ras

Cat.No: T11761

Synonym: Kinase inhibitor-1

Target: EGFR

ATPγS tetralithium salt

Cat.No: T22592

Synonym: ATP-gamma-S tetralithium salt

Target: PERK

Cat.No: T15442

Synonym: GSK 864,GSK-864

Target: Dehydrogenase

Cat.No: T6824

Target: EGFR

Cat.No: T2104

Synonym: IDH-C35

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Cat.No: T34656

Synonym: Ruserontinib

Target: EGFR, FLT, Bcr-Abl

Cat.No: T6198

Synonym: S/GSK1349572,GSK1349572,度鲁特韦,多替拉韦

Target: HIV Protease

Cat.No: T2620

Synonym: G749

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Cat.No: T74637

Synonym: BGB 11417

Target: BCL

Nilotinib monohydrochloride monohydrate

Cat.No: T2147

Synonym: Nilotinib (monohydrochloride monohydrate),尼洛替尼盐酸盐一水合物,AMN107 (monohydrochloride monohydrate),尼罗替尼中间体

Target: Bcr-Abl, Autophagy

Cat.No: T16516

Synonym: Phenylglycine-01

Target: CFTR

Flumatinib mesylate

Cat.No: T7861

Synonym: 甲磺酸氟马替尼/氟马替尼,HHGV678 mesylate,甲磺酸氟马替尼

Target: Bcr-Abl, PDGFR, c-Kit

Ensartinib hydrochloride

Cat.No: T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

Cat.No: TQ0277

Synonym: 普拉替尼,Blu667

Target: c-RET

Dolutegravir sodium

Cat.No: T2329

Synonym: 度鲁特韦钠,GSK1349572,度鲁特韦钠盐,GSK-1349572A

Target: HIV Protease

PIK-75 hydrochloride

Cat.No: T2287

Synonym: PIK-75 HCl,2-甲基-5-硝基苯磺酸 [(6-溴咪唑并[1,2-a]吡啶-3-基)亚甲基]甲基肼盐酸盐,PIK-75

Target: Apoptosis, DNA-PK, PI3K

Cat.No: T11438

Target: Others, MAPK

Poziotinib hydrochloride

Cat.No: T8758

Synonym: HM 781-36B hydrochloride,NOV120101 hydrochloride,波齐替尼盐酸盐

Target: EGFR

Cat.No: T4428

Target: FLT, Aurora Kinase

CFTR corrector 12

Cat.No: T79578

Target: CFTR

Luxdegalutamide

Cat.No: T75129

Synonym: ARV-766

Target: Androgen Receptor, PROTACs

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Cat.No: T81490

Target: Others

Cat.No: T41068

Target: p53

Cat.No: T9533

Synonym: 4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide

Target: Others

Cat.No: T1283

Synonym: 克林沙星,PD 127391,CI-960,AM-1091

Target: Antibacterial, Antibiotic

Pralsetinib HCl (2097132-94-8 free base)

Cat.No: TQ0277L

Synonym: Pralsetinib HCl,Pralsetinib hydrochloride,BLU-667,BLU667,BLU 667

Target: Others

Cat.No: T26388

Synonym: 4 CPI

Target: Others

Saussureamine C

Cat.No: T70565

Target: Others

Cat.No: T28988

Synonym: TNK6123

Target: Others

Cat.No: T69045

Target: Others

Cat.No: T71006

Target: Others

Cat.No: T40150

Target: Others

Naquotinib mesylate

Cat.No: T12175

Synonym: ASP8273 (mesylate)

Target: EGFR

HWY-5069 bromide

Cat.No: T68368

Target: Others

Cat.No: T61179

Target: Others

Cat.No: T70844

Target: Others

Cat.No: T24944

Synonym: VPC14449,VPC 14449

Target: Others

Cat.No: T70668

Target: Others

G-749 hydrochloride

Cat.No: T70597

Target: Others

Deacylcortivazol

Cat.No: T23975

Synonym: UNII-3JO09QT49F,DAC,NSC 325316

Target: Others

Cat.No: T28898

Synonym: T 145,T-145

Target: Others

Cat.No: T35913

Target: Others

Acetyltrialanine acetate

Cat.No: T20163L

Synonym: Acetyltrialanine acetate(19245-85-3 Free base)

Target: Others

Cat.No: T31218

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5084	Xanthosine dihydrate 黄苷二水合物	Others; Endogenous Metabolite	Metabolism; Others
	Xanthosine dihydrate 是衍生自黄嘌呤和核糖的核苷，能够提高牛和山羊的乳腺干细胞数量和产奶量。
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s

天然产物

Xanthosine dihydrate

Cat.No: T5084

Synonym: 黄苷二水合物

Target: Others, Endogenous Metabolite

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03465	Flagellin Protein, Listeria monocytogenes, Recombinant (His) flaA	Listeria monocytogenes	E. coli
	The role of flagella and motility in the attachment of the foodborne pathogen Listeria monocytogenes to various surfaces is mixed with some systems requiring flagella for an interaction and others needing only motility for cells to get to the surface. In nature this bacterium is a saprophyte and contaminated produce is an avenue for infection. Previous studies have documented the ability of this organism to attach to and colonize plant tissue. Motility mutants were generated in three wild ...
TMPH-02503	DEFA1 Protein, Mouse, Recombinant (GST & His) HP-1,HNP-1,Defensin, alpha 1,DEFA1,DEFA2,MRS,Neutrophil defe...	Mouse	E. coli
	Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium. DEFA1 Protein, Mouse, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 34.1 kDa and the accession number is P11477.
TMPY-04152	RAB7A Protein, Rat, Recombinant (His) RAB7A, member RAS oncogene family,Rab7	Rat	E. coli
	RAB7A is a ubiquitous small GTPase, which controls transport to late endocytic compartments. Silencing or overexpression of wild type RAB7A changed the soluble/insoluble rate of peripherin indicating that RAB7A is important for peripherin organization and function. Besides, disease-causing RAB7A mutant proteins bind more strongly to peripherin and their expression causes a significant increase in the amount of soluble peripherin. The altered interaction between disease-causing RAB7A mutants and ...
TMPY-02893	NT5C3A/NT5C3 Protein, Human, Recombinant P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo...	Human	E. coli
	NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but...
TMPY-05062	NRG2 Protein, Human, Recombinant (His) DON1,HRG2,NTAK	Human	HEK293 Cells
	Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted ...
TMPY-02957	DYDC2 Protein, Human, Recombinant (GST) DPY30 domain containing 2	Human	E. coli
	DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv...
TMPH-00561	30S ribosomal protein S4 Protein, E. coli, Recombinant (His) Small ribosomal subunit protein uS4,ramA,rpsD,30S ribosomal ...	E. coli	E. coli
	One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).; Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity c...
TMPY-02072	HSF1 Protein, Human, Recombinant (His) HSTF1,heat shock transcription factor 1	Human	E. coli
	Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable...
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,TP53	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPH-00616	DNA-binding protein H-NS Protein, E. coli, Recombinant (His) hns,DNA-binding protein H-NS,Protein B1,Protein H1,Heat-stab...	E. coli	E. coli
	A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe...

重组蛋白

Flagellin Protein, Listeria monocytogenes, Recombinant (His)

Cat.No: TMPY-03465

Species: Listeria monocytogenes

Expression System: E. coli

DEFA1 Protein, Mouse, Recombinant (GST & His)

Cat.No: TMPH-02503

Species: Mouse

Expression System: E. coli

RAB7A Protein, Rat, Recombinant (His)

Cat.No: TMPY-04152

Species: Rat

Expression System: E. coli

NT5C3A/NT5C3 Protein, Human, Recombinant

Cat.No: TMPY-02893

Species: Human

Expression System: E. coli

NRG2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05062

Species: Human

Expression System: HEK293 Cells

DYDC2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02957

Species: Human

Expression System: E. coli

30S ribosomal protein S4 Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00561

Species: E. coli

Expression System: E. coli

HSF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02072

Species: Human

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

DNA-binding protein H-NS Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00616

Species: E. coli

Expression System: E. coli

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