63
6
14
11
2
Cat. No. | Product Name | ||
---|---|---|---|
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L4510 | 抗寄生虫库 | 419 compounds | |
419 种具有抗寄生虫活性的小分子化合物; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L4520 | 抗菌活性库 | 904 compounds | |
904 种具有抗菌活性的化合物,是抗菌药物研发的有力工具; | |||
L4400 | 抗生素库 | 692 compounds | |
692 个具有抗菌活性化合物的独特集合,是医药研究的优良工具库和药物筛选的有效载体; | |||
L9300 | 大环化合物库 | 210 compounds | |
210 种活性已知的大环化合物,用于高通量、高内涵筛选; | |||
L9240 | 农药化合物库 | 270 compounds | |
270种农药相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6730 | 抗病毒中药单体化合物库 | 268 compounds | |
268 种具有抗病毒活性的中药单体集合,是药物开发、药理研究的有效工具; | |||
L7110 | 抗高血压化合物库 | 678 compounds | |
678 种高血压相关的小分子,用于高通量和高内涵筛选; | |||
L6610 | 抗感染天然产物库 | 1060 compounds | |
1060 个抗感染相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L2140 | 癌细胞分化化合物库 | 406 compounds | |
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2130 | 抗癌细胞代谢库 | 1268 compounds | |
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选; | |||
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; | |||
DO2200 | 共价抑制剂库CD | 12000 compounds | |
数量多:超过12000种共价结合化合物,并且数量在持续增加; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3971 |
CASIN
Pirl1-related Compound 2 |
CDK; STAT; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; JAK/STAT signaling; MAPK; Stem Cells |
CASIN (Pirl1-related Compound 2) 是选择性GTPase Cdc42抑制剂,IC50值是 2 uM。 | |||
T27617 |
Inz-1
|
P450 | Metabolism |
Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂,对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。 | |||
T2620 |
G-749
G749 |
Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。 | |||
T16339 |
Norverapamil hydrochloride
(±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米 |
Calcium Channel; P-gp; Drug Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物,是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。 | |||
T6018 |
Zosuquidar trihydrochloride
唑喹达三盐酸盐,Zosuquidar (LY335979) 3HCl,RS 33295-198 trihydrochloride,RS 33295-198 (D06387) 3HCl,Zosuquidar 3HCl,LY-335979 trihydrochloride |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂,Ki 值为 59 nM。 | |||
T6287 |
Tariquidar
XR9576,他立喹达 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂,Kd 为 5.1 nM。 | |||
T7861 |
Flumatinib mesylate
甲磺酸氟马替尼/氟马替尼,HHGV678 mesylate,甲磺酸氟马替尼 |
Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Flumatinib mesylate (HHGV678 mesylate) 是一种具有口服活性的选择性Bcr-Abl 抑制剂,能够作用于 c-Abl (IC50:1.2 nM),PDGFRβ (IC50:307.6 nM) 和 c-Kit (IC50:665.5 nM)。 | |||
T0002 |
Ethamsylate
Cyclonamine,Etamsylate,酚磺乙胺,Dicynene,Aglumin |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Ethamsylate (Dicynene) 通常用作止血药,增加毛细血管内皮阻力和血小板粘附,抑制前列腺素的生物合成和作用。 | |||
T25770 |
116-9e
MAL-2-11B,MAL2-11B,MAL211B,MAL 2 11B,MAL2 11B |
Virus Protease | Microbiology/Virology |
116-9e (MAL2-11B) 是一种有效的 Hsp70 共伴侣 DNAJA1 抑制剂,具有抗病毒,抑制猿猴病毒40 (SV40) 的复制,抑制肿瘤抗原 (TAg) 内源性 ATP 酶活性和 TAg 介导的 Hsp70 激活。116-9e 可用于研究癌症耐药性。 | |||
T3335 |
Darunavir Ethanolate
地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir Ethanolate (UIC 94017) 是一种HIV 蛋白酶抑制剂,可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki 值为1 nM。 | |||
T2324 |
Darunavir
地瑞那韦,达芦那韦,TMC114 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂,用于治疗艾滋病和 HIV 感染。 由于单独使用时会出现抗病毒药物耐药性,因此与其他抗 HIV 药物联合使用。 | |||
T1649 |
Tenofovir
替诺福韦,泰诺福韦,PMPA,TDF,GS 1278 |
HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂,可研究 HIV 和慢性乙型肝炎。 | |||
T81490 |
PHI-101
|
Others | Others |
PHI-101是口服FLT3抑制剂,在克服多耐药突变方面表现出高效。该化合物对FLT3的ITD或TKD单突变体表现出显著抑制作用,同时也能抑制包括双重(ITD/D835Y或ITD/F691L)和三重(ITD/D835Y/F691L)耐药突变。PHI-101在治疗复发或难治性急性髓系白血病(AML)的研究中显示出应用潜力。 | |||
T8488 |
GMB-475
|
Bcr-Abl; PROTACs | Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors |
GMB-475 是一种基于PROTAC 的BCR-ABL1酪氨酸激酶降解剂,克服了BCR-ABL1依赖的耐药性。 GMB-475 靶向 BCR-ABL1 蛋白并募集 E3 连接酶 Von Hippel Lindau (VHL)。导致泛素化和随后的致癌融合蛋白降解 | |||
T2328 |
Radotinib
IY-5511,Supect,雷度替尼 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Radotinib (IY-5511) 有时被称为 IY5511,是一种用于治疗不同类型 Y 的药物,最显着的是费城染色体阳性 (Ph+) 慢性粒细胞白血病 (CML) 对其他酪氨酸激酶 Bcr-Abl 的耐药性或不耐受性抑制剂 | |||
T1496 |
Amiodarone hydrochloride
盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T31019 |
CP 117227
CP117227,CP-117227 |
Others | Others |
CP 117227 is a multi-drug resistance regulator. | |||
T25820 |
ML358
ML-358,ML 358 |
Others | Others |
ML358 is a selective SKN-1 pathway inhibitor involved in drug detoxification and resistance in nematodes. | |||
T24785 |
S-Fcme
S Fcme,SFcme |
Others | Others |
S-Fcme is an activator of multidrug resistance transporter that acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding. | |||
T24130 |
HCI-2184
HCI2184,HCI 2184 |
Others | Others |
HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma. | |||
T13725 |
Hsp90-Cdc37-IN-1
|
Others | Others |
Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance. | |||
T24005 |
DJ101
DJ-101,DJ 101 |
Others | Others |
DJ101is an effective and metabolically stable inhibitor of tubulin. It can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors. | |||
T30767 |
CB-181963
CB 181963,CB181963,UNII-6784994L0W,CAB 175 |
Others | Others |
CB-181963, a new cephalosporin, is an effective antistaphylococcal drug, showing excellent activity against the resistance of MRSA strains to other cephalosporins in planktonic and biofilm cultures. | |||
T15587 | Inz-5 | Others | Others |
Inz-5 is a fungal-selective inhibitor of mitochondrial cytochrome bc1. Inz-5 impairs fungal virulence. It also prevents the evolution of drug resistance. | |||
T23574 |
(+)-Carbovir triphosphate
LCBVTP,L CBVTP,L-CBVTP |
Others | Others |
(+)-Carbovir triphosphate is an active metabolite of Abacavir. It was used to study the molecular mechanism of inhibition and drug resistance for HIV-1 reverse transcriptase. | |||
T25633 |
Lascufloxacin HCl
KRP-AM1977X,KRP-AM-1977,KRP-AM1977Y,KRP-AM 1977,KRP-AM1977,Lascufloxacin hydrochloride |
Others | Others |
Lascufloxacin (KRP-AM-1977) is a potent antibacterial drug candidate. It exhibited the most potent activity against gram-positive bacteria among the quinolones tested. Lascufloxacin showed incomplete cross-resistance against existing quinolone-resistant s | |||
T26733 |
B 746
B-746,B746 |
Others | Others |
B 746 is an antibacterial agent primarily. B 746 is used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance. | |||
T34270 |
Razupenem
SMP601,SMP 601,PTZ601,PTZ 601,PTZ-601,SMP-601 |
Others | Others |
Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a | |||
T11115 |
Duocarmycin GA
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Duocarmycin GA, an antibody drug conjugate (ADC) toxin and a DNA alkylating agent, effectively targets and binds in the minor groove of DNA. It is particularly potent against multi-drug resistant cell lines, offering a strategic approach in combating resistance. | |||
T26413 |
A 30312
A-30312,A30312 |
Others | Others |
A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells. | |||
T21323 |
Picoplatin
NX 473,AMD-473,AMD473,NX-473,NX473,AMD 473 |
Others | Others |
Picoplatin has a broad spectrum of antineoplastic activity and is designed to overcome platinum drug resistance. Picoplatin alkylates DNA, forming both intra- and inter-strand cross-linkages, resulting in the inhibition of DNA replication and transcriptio | |||
T61485 |
S07-2010
|
Others | Others |
S07-2010 is a potent pan-AKR1C inhibitor, effectively inhibiting AKR1C3, AKR1C4, AKR1C1, and AKR1C2 with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM, respectively. This compound induces apoptosis in A549/DDP cells and enhances the cytotoxicity of chemotherapeutic agents in drug-resistant cells, making it a viable option for combating drug resistance. Furthermore, S07-2010 significantly inhibits the proliferation of drug-resistant cells [1]. | |||
T71865 |
DSM43
|
Others | Others |
DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen | |||
T4047L |
Bisantrene HCl
CL216942,CL-216942,NSC-337766,CL 216942 |
Others | Others |
Bisantrene (CL-216942; NSC 337766) is a topoisomerase II poison and DNA intercalator. It can be used as a Rac1 inhibitor or model compound to study P-glycoprotein-mediated multi-drug resistance (MDR1). Bisantrene inserts and disrupts the configuration of | |||
T70760 |
NVP018
|
Others | Others |
NVP018, also known as BC 556, is a potent inhibitor of hepatitis B virus, hepatitis C virus (HCV), and HIV-1 replication, shows minimal inhibition of major drug transporters, and has a high barrier to generation of both HCV and HIV-1 resistance.. | |||
T70774 |
Clavicoronic acid
|
Others | Others |
Clavicoronic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins. | |||
T14945 |
CH-0793076
TP3076 |
Topoisomerase | DNA Damage/DNA Repair |
CH-0793076, a hexacyclic camptothecin analog, is an active drug and major metabolite of TP300. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein). CH-0793076 inhibits DNA topoisomerase I (IC50: 2.3 μM). | |||
T80245 |
LL-37(17-32)
|
||
LL-37(17-32)为具有生物活性的肽段,为LL-37抗菌肽C末端结构域源自的活性片段。报道显示,LL-37(17-32)能逆转癌细胞系中ABCG2介导的多药耐药性。 | |||
T64020 |
EGFR-IN-17
|
Others | Others |
EGFR-IN-17 是有效的、选择性的表皮生长因子受体(EGFR)抑制剂,其 IC50 值为0.0002 μM,能够用于克服 C797S 介导的耐药性。 | |||
T82705 |
Clovibactin
|
Antibiotic | Microbiology/Virology |
Clovibactin为一种新型抗生素,能有效消灭耐药细菌病原体,且未观察到耐药性。该化合物能从未培养的土壤细菌中提取。 | |||
T36600 |
Cefsulodin (sodium salt hydrate)
|
Others | Others |
Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2 | |||
T61511 |
S07-2005 (racemic)
|
Others | Others |
S07-2005 racemic is a chemically potent and selective inhibitor of aldo-keto reductase 1C3 (AKR1C3), with an IC50 value of 0.13 μM and 0.75 μM for AKR1C3 and AKR1C4, respectively. Due to its inhibitory properties, it exhibits potential as a chemotherapeutic potentiator, specifically in the context of overcoming drug resistance in cancer [1]. | |||
T68866 |
Ceftolozane
|
Others | Others |
Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics un... | |||
T78747 |
DiPT-4
|
Topoisomerase | DNA Damage/DNA Repair |
DiPT-4为一种TOP1/PARP1双重抑制剂,可引发癌细胞大量DNA双链断裂(DSB)、细胞周期阻滞及凋亡。DiPT-4具有研究癌症耐药性克服潜力。 | |||
TP2222 |
APTSTAT3-9R
|
Others | Others |
APTSTAT3-9R-9R is a STAT3 inhibitor (Ki: 231 nmol/L). STAT3 has been reported to promote the proliferation, survival, metastasis, immune escape, as well as drug resistance of cancer cells, making it a promising target for various diseases. However, though | |||
T61370 |
DNA-PK-IN-6
|
Others | Others |
DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 amplifies the responsiveness of tumor tissues to radiotherapy, overcomes the challenge of drug resistance, and augments its inhibitory impact on a diverse range of solid and hematological tumors[1]. | |||
T61108 |
YXL-13
|
Others | Others |
YXL-13 is a highly effective inhibitor of Pseudomonas aeruginosa (PAO1), with an IC50 value of 3.686 μM. It effectively hinders the expression of virulence factors and inhibits biofilm formation in PAO1. Moreover, YXL-13 significantly diminishes both the pathogenicity and drug resistance of PAO1 by inhibiting the quorum sensing (QS) system. Thus, YXL-13 holds great potential for studying antibacterial properties [1]. | |||
T71275 |
CID16725315
|
Others | Others |
Thiocarbazate, also known as CID16725315, is an inhibitor of human cathepsin L. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection. With respect to the development of antiviral agents, inhibitors of human cathepsin L are not subject to resistance because of rapid mutations of the viral genome. Cathepsin L is therefore an attractive target for drug development. | |||
T64016 |
WS-898
|
Others | Others |
WS-898 是 ABCB1 的高效抑制剂,能够逆转耐药SW620/Ad300、KB-C2 和 HEK293/ABCB1 细胞对紫杉醇(PTX)的耐药性,他们的 IC50 值分别为 5.0、3.67 和 3.68 nM。 | |||
T61033 |
S07-2001
|
Others | Others |
S07-2001 增强Doxorubicin 抗癌细胞的活性,可作为耐药癌症的化疗增强剂。S07-2001 是有效的醛酮还原酶 1C3 (AKR1C3)的选择性抑制剂,IC50值为 2.08 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S2381 |
Perillene
3-Isohexenylfuran,紫苏烯,Perillen |
Others; Antibacterial | Microbiology/Virology; Others |
Perillene (3-Isohexenylfuran) 是促进肠蠕动的药物中的活性成分,它对金黄色葡萄球菌和大肠杆菌具有很强的抗药性。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T4S1419 |
(±)-Praeruptorin A
Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A |
p38 MAPK; Calcium Channel; Akt | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分,用于研究伴有厚痰和呼吸困难的咳嗽,非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物,可作为 Ca2+-反流阻滞剂,用于高血压的研究。 | |||
T40924 |
Tellimagrandin II
Eugeniin |
Others | Others |
Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins. Additionally, it possesses the ability to inhibit antibiotic resistance exhibited by drug-resistant Staphylococcus aureus. | |||
TN2229 |
Soyasaponin Ac
|
Others | Others |
Soyasaponin Ac can decrease the drug resistance via EMT pathway and weaken the migration ability of ovarian cancer cells. | |||
TN3911 |
Ecdysterone 2,3:20,22-diacetonide
|
Others | Others |
Due to the multi-drug resistance reversal activity of the less polar ecdysteroids, several new products( including 20-hydroxyecdysone,20-hydroxyecdysone 2,3;20,22-diacetonide) are promising for being tested against various cancer cell lines. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00407 |
AXL Protein, Human, Recombinant (His & Avi)
AXL oncogene,Axl,EC 2.7.10.1,Tyro7,UFO,ARK,EC 2.7.10,AI32364... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is e... | |||
TMPK-00472 |
AXL Protein, Cynomolgus, Recombinant (His)
Tyro7,JTK11,AI323647,AXL oncogene,EC 2.7.10.1,EC 2.7.10,UFO,... |
Cynomolgus | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is ex... | |||
TMPK-00410 |
AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
ARK,EC 2.7.10.1,EC 2.7.10,Axl,JTK11,AXL oncogene,UFO,AI32364... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Rec... | |||
TMPK-00408 |
AXL Protein, Human, Recombinant (His & Avi), Biotinylated
AXL oncogene,EC 2.7.10.1,AI323647,Axl,JTK11,ARK,EC 2.7.10,UF... |
Human | HEK293 Cells |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Bio... | |||
TMPK-00875 |
CD96 Protein, Human, Recombinant (His & Avi), Biotinylated
TACTILE,CD96,DKFZp667E2122,CD96 molecule |
Human | HEK293 Cells |
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for imm... | |||
TMPJ-01145 |
ABCB5 Protein, Human, Recombinant (Trx)
ABCB5 P-gp,ATP-binding cassette sub-family B member 5,ABCB5,... |
Human | E. coli |
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FL... | |||
TMPY-03416 |
TNFAIP8 Protein, Human, Recombinant (His)
GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S... |
Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom... | |||
TMPJ-00922 |
DCK Protein, Human, Recombinant (His & T7)
DCK,Deoxycytidine Kinase |
Human | E. coli |
Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and c... | |||
TMPY-06836 |
NR3C1 Protein, Human, Recombinant (His)
GCCR,GRL,GR,nuclear receptor subfamily 3, group C, member 1 ... |
Human | E. coli |
NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) is a Protein Coding gene. This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. NR3C1 is a transcriptional regulator of many drug-metabolizing enzymes and anti-inflammatory molecules. NR3C1 polymorphisms associate with obesi... | |||
TMPY-01576 |
Artemin Protein, Mouse, Recombinant (hFc)
artemin,neublastin |
Mouse | HEK293 Cells |
Artemin (ARTN) is a member of glial cell line-derived neurotrophic factor (GDNF) family of ligands, and its signaling is mediated via a multi-component receptor complex including the glycosylphosphatidylinositol-anchored GDNF family receptors a (GFRa1, GFRa3) and RET receptor tyrosine kinase. The major mechanism of ARTN action is via binding to a non-signaling co-receptor. The major function of ARTN is to drive the molecule to induce migration and axonal projection from sympathetic neurons. It a... | |||
TMPY-02072 |
HSF1 Protein, Human, Recombinant (His)
HSTF1,heat shock transcription factor 1 |
Human | E. coli |
Heat shock factor protein 1, also known as heat shock transcription factor 1, HSF1, and HSTF1, is a cytoplasm and nucleus protein that belongs to the HSF family. HSF1 is the major transcription factor of HSPs (heat shock proteins) in response to various stresses. Wild type HSF1 (heat shock transcriptional factor 1) is normally inactive. HSF1 / HSTF1 is a DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0070 |
Amiodarone-d10 Hydrochloride
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Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMID-0069 |
Amiodarone-d4 HCl
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Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 |