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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T39868 |
Anticancer agent 11
|
Others | Others |
Anticancer agent 11 an effective broad-spectrum anticancer agent, exerts its therapeutic potential by suppressing angiogenesis and facilitating the formation of DNA cross-links. | |||
T40330 |
Anticancer agent 15
|
Others | Others |
Anticancer agent 15, an anticancer agent, exerts its efficacy by elevating intracellular levels of reactive oxygen species (ROS) and inducing cell death in melanoma cancer cells through necroptosis. | |||
T40479 |
Anticancer agent 13
|
Others | Others |
Anticancer agent 13 is an anticancer agent from dicarboxylic acids and amines. | |||
T39501 |
Anticancer agent 7
|
Others | Others |
Anticancer agent 7 (Example 5) is an anti-cancer agent that exhibits potent anticancer activity against H1650 lung cancer cells, with an IC50 value of 5 μM. | |||
T10331 |
Anticancer agent 3
|
Others | Others |
Anticancer agent 3 (Compound 4) is a anti-cancer agent. | |||
T61046 |
Anticancer agent 43
|
Apoptosis | Apoptosis |
Anticancer agent 43 是一种有效的抗癌剂,通过 caspase 3, PARP1,Bax 蛋白依赖性途径诱导癌细胞凋亡 (apoptosis)。Anticancer agent 43 能够诱导 DNA 损伤,可用于研究大鼠胶质母细胞瘤 。 | |||
T60420 |
Anticancer agent 73
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Anticancer agent 73 是一种抗癌剂,它能有效地靶向反式激活反应(TAR)RNA 结合蛋白2(TRBP),并破坏TRBP-Dicer 的相互作用。Anticancer agent 73 通过调节 HCC 细胞中 miRNA 组和蛋白质组的表达谱,在体外和体内抑制 HCC 的生长和转移。 | |||
T60852 |
Anticancer agent 46
|
Others | Others |
Anticancer agent 46是一种有效的抗癌剂, 在细胞实验中显示出抗增殖活性,对 MGC803细胞的 IC50为0.986μM。 | |||
T27998 |
MDK-4204
Anticancer AgentI,MDK 4204,Anticancer Agent I,MDK4204,Anticancer Agent-I |
Others | Others |
MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively. | |||
T4434 |
Tirapazamine
Tirazone,Win59075,SR4233,替拉扎明,SR259075 |
Others | Others |
Tirapazamine (Win59075) 是抗癌剂,对实体瘤中的缺氧细胞具有选择性细胞毒性,促使 DNA 中的单链和双链断裂,碱基损伤和细胞死亡。 | |||
T62667 |
Anticancer agent 51
|
Others | Others |
Anticancer agent 51 (compound 3d) 是一种有效的抗癌剂 (Ki: 731.62 nM),具有抗癌活性。Anticancer agent 51 具有潜力进行前列腺癌的研究。 | |||
T64002 |
Anticancer agent 61
|
Others | Others |
Anticancer agent 61 是一种口服具有活力的抗癌剂。Anticancer agent 61 能够抗 HepG2、Bel-7402 和 MCF-7 癌细胞的增殖,他们的 IC50 值分别为 1.12、1.97 和 1.08 μM。Anticancer agent 61 能够抑制肿瘤生长。 | |||
T72502 |
Anticancer agent 92
|
Others | Others |
Anticancer agent 92 是一种对非癌细胞无毒的抗癌剂。 | |||
T62124 |
Anticancer agent 80
|
Others | Others |
Anticancer agent 80 (Compound 3c) 是一种抗癌剂。Anticancer agent 80 对 T47-D 表现出明显的暗毒性作用 (IC50: 10.14 μM)。 | |||
T61412 |
Anticancer agent 47
|
Others | Others |
Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1]. | |||
T63982 |
Anticancer agent 50
|
Others | Others |
Anticancer agent 50 (compound 6) 是 ABCB1 外排泵的有效调节剂,具有细胞毒活性和抗增殖活性。Anticancer agent 50 能够减少细胞周期蛋白 D1 的表达,并诱导 p53 表达。Anticancer agent 50 对 T 淋巴瘤表现出研究潜力。 | |||
T60776 |
Anticancer agent 68
|
Others | Others |
Anticancer agent 68 is (Compound 12) 是一种抗癌剂。Anticancer agent 68 将细胞阻滞在 G2/M 期并诱导程序性细胞死亡。Anticancer agent 68 通过激活 p53 和 PTEN 诱导上调肿瘤抑制。 | |||
T64179 |
Anticancer agent 65
|
Others | Others |
Anticancer agent 65 在肿瘤细胞系中显示出良好的效果,尤其是 A549 细胞 (IC50: 1.07 μM)。Anticancer agent 65 能够将 A549 细胞的细胞周期阻滞在 S 期,诱导细胞凋亡,增加 p53、p21 的表达水平,并促使 ROS 生成和 MMP 崩溃。 | |||
T61379 |
Anticancer agent 30
|
Others | Others |
Anticancer agent 30 (compound 6f-Z) is a potent anticancer compound. It belongs to the class of 3-arylidene-2-oxindole derivatives and acts as a selective inhibitor of CDK2. Extensive research has demonstrated its significant anticancer activity, making it a promising candidate for cancer treatment [1]. | |||
T83093 |
Anticancer agent 107
|
Others | Others |
Anticancer agent 107(Compd 11jc) 具有显著的抗肿瘤活性,是研究肺转移性黑色素瘤的潜在抗癌剂。 | |||
T78929 |
Anticancer agent 126
|
Histone Methyltransferase | Chromatin/Epigenetic |
Anticanceragent 126 (compound 12) 作为WDR5抑制剂,能够破坏WDR5-MYC间的相互作用,并降低MYC靶基因的表达,表现出其抗癌活性。 | |||
T79844 |
Anticancer agent 143
|
Phosphatase | Metabolism |
Anticanceragent 143(化合物 369),作为PTPN2/PTP1B双重抑制剂,表现出强效活性,其IC50值均低于2.5 nM。该化合物主要用于癌症研究领域。 | |||
T79482 |
Anticancer agent 137
|
PI3K | PI3K/Akt/mTOR signaling |
Anticanceragent 137 (8q) 是一种高效的 PI3k 抑制剂,展现出广谱的抗肿瘤活性。它能够诱导 G2/M 阶段的细胞周期阻滞与细胞凋亡(apoptosis),并促进 PARP、caspase 3 和 caspase 7 的裂解。该化合物主要用于癌症相关的生物医学研究。 | |||
T79202 |
Anticancer agent 118
|
Others | Others |
Anticanceragent 118是一种N-酰化环丙沙星衍生物,展现了针对革兰氏阳性(bacterial)菌株的高度活性,以及对前列腺癌PC3细胞的抗增殖能力,适用于抗肿瘤研究。 | |||
T83078 |
Anticancer agent 33
|
Others | Others |
Anticanceragent 33 (compound 3) 为Squamocin与Bullatacin衍生物,展现出有效的抗癌特性。本化合物对4T1乳腺癌细胞系(包括A549、HeLa、HepG2和MCF-7细胞)的生长抑制作用显著,其IC50范围为1.9-5.4 µM。 | |||
T83087 |
Anticancer agent 158
|
Others | Others |
Anticanceragent 158 (compound 7c) 作为一种有效的抗癌剂,其对HepG-2、MDA-MB-231、HCT-116细胞系的IC50值分别为7.93 μM、9.28 μM、13.28 μM。 | |||
T78780 |
Anticancer agent 139
|
Others | Others |
Anticanceragent 139(Compound 6h)展现了针对多种癌细胞株的抗癌效能。该化合物能够与Tubulin的Lys352残基发生π-阳离子相互作用。在对SNB-19、OVCAR-8和NCI-H460细胞株的测试中,Anticanceragent 139展现出较高的生长抑制率(PGI),数值分别为86.61、85.26和75.99。同时,该化合物对于HOP-62、SNB-75、ACHN、NCI/ADR-RES、786-O、A549/ATCC、HCT-116以及MDA-MB-231细胞株亦表现出中等的生长抑制作用,其PGI值分别为67.55、65.46、59.09、59.02、57.88、56.88、56.53和56.4、51.88。 | |||
T79301 |
Anticancer agent 140
|
Parasite | Microbiology/Virology |
Anticanceragent 140(Compd 3)是一种化合物,具备潜在的抗癌和抗寄生虫活性。 | |||
T62601 |
Anticancer agent 48
|
Others | Others |
Anticancer agent 48 (compound 48) 是一种广谱抗癌剂,其表现出抗增殖活性。Anticancer agent 48 对微管蛋白聚合具有抑制作用。Anticancer agent 48 在体内显示抗肿瘤活性。Anticancer agent 48 具有潜力进行实体瘤和血液肿瘤的研究。主语 | |||
T61777 |
Anticancer agent 42
|
Others | Others |
Anticancer agent 42 (compound 10d) is an orally active, potent anticancer agent with demonstrated efficacy against MDA-MB-231 cells, exhibiting an IC50 of 0.07 μM. It exerts its anticancer activity through the activation of apoptotic pathways and p53 expression. Anticancer agent 42 is a valuable tool for investigating metastatic breast cancer [1]. | |||
T63587 |
Anticancer agent 45
|
Others | Others |
Anticancer agent 46 是有效的、选择性的抗癌剂,能够诱导细胞凋亡 (apoptosis)。Anticancer agent 46 在癌细胞中表现出细胞毒效果,对人血的活化淋巴细胞显示出低毒性。 | |||
T63913 |
Anticancer agent 41
|
Others | Others |
Anticancer agent 41 是一种有效的抗癌剂,对 MDA-MB-231 细胞表现出良好的抗肿瘤效果 (IC50: 3.99 μM)。 | |||
T63917 |
Anticancer agent 67
|
Others | Others |
Anticancer agent 67 是环丙沙星类似物,是一种抗癌剂,在 MCF-7 细胞中能够诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。 | |||
T63671 |
Anticancer agent 60
|
Others | Others |
Anticancer agent 60 对人 HepG2 细胞具有抗增殖效果,其 IC50 值为 4.13 μM。在人 HepG2 异种移植小鼠模型中,Anticancer agent 60 表现出抗肿瘤活性。 | |||
T63159 |
Anticancer agent 28
|
Others | Others |
Anticancer agent 28 在体内 H22 同种异体移植小鼠中具有良好的抗肿瘤作用。Anticancer agent 28 对 K562 细胞的作用是 Oridonin 的50倍,其 IC50 值为 0.09 μM。 | |||
T61750 |
Anticancer agent 72
|
Others | Others |
Anticancer agent 72 (compound 8c) effectively inhibits the K+ channel, displaying significant potential as an anticancer treatment. Additionally, it induces apoptosis, a programmed cell death process [1]. | |||
T63354 |
Anticancer agent 17
|
Others | Others |
Anticancer agent 17 对 HeLa 细胞 (IC50: 0.19 μM) 和 A2780 细胞 (IC50: 0.09 μM) 具有有效抗癌作用。 | |||
T61673 |
Anticancer agent 56
|
Others | Others |
Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat... | |||
T79204 |
Anticancer agent 122
|
Others | Others |
Anticanceragent 122,作为一种hLDHA抑制剂,表现出显著的抗癌活性,主要应用于抗肿瘤研究。 | |||
T83080 |
Anticancer agent 171
|
Others | Others |
Anticanceragent 171(Compound 6a)是一款肟类似物,对HCT116细胞表现出显著的抗癌活性,IC50值为3.43 μM,主要用于癌症研究领域。 | |||
T83084 |
Anticancer agent 162
|
Others | Others |
Anticanceragent 162 (compound 1d)作为一种抗癌药物,显示出亲脂性和针对性细胞毒性,能够特异性诱导Hela细胞系的癌细胞死亡。 | |||
T83075 |
Anticancer agent 94
|
Others | Others |
Anticanceragent 94, 一种4-羟基香豆素衍生物,能抑制肺癌细胞的侵袭和迁移,其机制为调节(EMT)效应子表达。 | |||
T83076 |
Anticancer agent 93
|
Others | Others |
Anticanceragent 93, 一种4-羟基香豆素衍生物,能够抑制肺癌细胞的侵袭与迁移,其机制为调节上皮间质转化(EMT)效应子的表达。 | |||
T78957 |
Anticancer agent 105
|
Apoptosis | Apoptosis |
Anticanceragent 105 是基于噻吩嘧啶支架的抗癌化合物,显示出高度的安全性与抗肿瘤活性。该化合物对黑色素瘤细胞表现出选择性毒性,并能诱导细胞凋亡(apoptosis)。在肺转移性黑色素瘤小鼠模型中,Anticanceragent 105 能够显著地抑制转移性结节的形成。 | |||
T79359 |
Anticancer agent 147
|
Ferroptosis | Apoptosis |
Anticanceragent 147(化合物6j),作为槐定碱的衍生物,功能为铁死亡(Ferroptosis)诱导剂。该化合物能促进Fe2+、活性氧(ROS)及丙二醛(MDA)在细胞内的积累,并通过增加内质网(ER)应激和上调转录因子ATF3的表达发挥作用。在体外及体内实验中,Anticanceragent 147展现了出色的抗肝癌活性。 | |||
T79388 |
Anticancer agent 154
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Anticanceragent 154 (Compound 8h) 增加活性氧水平、导致线粒体损伤,并诱导细胞凋亡和 DNA 损伤。此外,该化合物通过降低 GSH 和 GPX4 水平,增加脂质过氧化,进而诱导铁死亡。Anticanceragent 154 对多种癌细胞株(HT29、H1975、A549 及 MCF-7)显示抑制作用,IC50 值在 1.0-1.9 μM 范围。 | |||
T83090 |
Anticancer agent 131
|
Others | Others |
HCT-116-IN-1, 一种与γ-内酰胺融合的吡啶酮衍生物,展现了针对HCT116细胞的强抗癌活性,其细胞毒性测定显示IC50值为5.59 μM。 | |||
T62602 |
Anticancer agent 49
|
Others | Others |
Anticancer agent 49 (compound 69) 是一种广谱抗癌剂,其表现出抗增殖活性。Anticancer agent 49 对微管蛋白聚合具有抑制作用。Anticancer agent 49 在体内显示抗肿瘤活性。Anticancer agent 49 具有潜力进行实体瘤和血液肿瘤的研究。 | |||
T62427 |
Anticancer agent 32
|
Others | Others |
Anticancer agent 32 (compound 2g) 是一种抗癌剂。Anticancer agent 32 能够影响细胞周期并诱导细胞凋亡,表现出抗癌效果。Anticancer agent 32 能够用于研究癌症。 | |||
T60314 |
Anticancer agent 38
|
Others | Others |
Anticancer agent 38 (compound 19) 是芳基脲化合物,是一种有效的抗癌剂。Anticancer agent 38 抑制 A431 细胞生长的 IC50为 5.2 μg/mL。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83089 |
Anticancer agent 149
|
||
Anticanceragent 149 (compound 3) 是一种从薯蓣 (DM) 根茎中分离出的抗癌剂,其对MCF-7 细胞呈现选择性细胞毒活性,特有IC50值为31.41 μM。 | |||
T83073 |
Anticancer agent 96
|
||
Anticanceragent 96 (Compound 4) 对人癌细胞表现出显著的细胞毒性。 | |||
T83086 |
Anticancer agent 160
|
Others | Others |
Anticanceragent 160 (Compound 6),源自Parthenium hysterophorus的天然化合物,对HCT-116细胞表现出细胞毒作用,其半数抑制浓度(IC50)为5.0 μM。 | |||
T83088 |
Anticancer agent 156
|
||
Anticanceragent 156(compound 11)是一种基于Miliusanes的强效抗癌剂,有效抑制人源癌细胞生长,并对胃癌细胞展现出显著细胞毒性。 | |||
T5S0620 |
3-Dehydrotrametenolic acid
Dehydrotrametenolic acid,松苓新酸,3-氢化去氢松苓酸 |
Apoptosis; Others; Dehydrogenase | Apoptosis; Metabolism; Others |
3-Dehydrotrametenolic acid 是从茯苓菌核分离的一种乳酸脱氢酶抑制剂,可诱导细胞凋亡,具有抗癌活性。它促进体外脂肪细胞分化,在体内起胰岛素增敏剂的作用。 | |||
TN1727 |
Helichrysetin
4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Helichrysetin 是从豆蔻果实中分离出的一种天然产物,是一种 DNA 结合抑制剂,可抑制原位导管癌DCIS 的形成。它抑制细胞生长,可诱导 A549 细胞凋亡。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
T30969 |
Clitocine
|
Apoptosis; BCL | Apoptosis |
Clitocine 是一种来从蘑菇中提取的一种腺苷类似物,是一种有效的转录通读剂,是一种无义突变的抑制剂,具有抗癌活性,可诱导携带 p53 无义突变等位基因的细胞产生 p53 蛋白。Clitocine 通过促进 Mcl-1 降解来增强 TRAIL 介导的人结肠癌细胞凋亡。 | |||
T2830 |
Betulinic acid
白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid |
Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物,是真核细胞拓扑异构酶 I 的抑制剂,IC50值为 5 μM,具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。 | |||
TN1206 |
2,4,6-Trihydroxybenzaldehyde
|
Others | Others |
2,4,6-Trihydroxybenzaldehyde 是一种天然产物。 2,4,6-三羟基苯甲醛是一种潜在的抗肥胖治疗药物,可抑制 C57BL/6 小鼠的 3T3-L1 细胞中的脂肪细胞分化和高脂饮食诱导的脂肪积累。它也是一种有效的抗糖尿病药物。 2,4,6-三羟基苯甲醛具有潜在的抗癌活性。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T2S1865 |
Octyl gallate
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯 |
Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN2238 |
Stigmasterol glucoside
豆甾醇葡萄糖苷 |
Others | Others |
Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent. | |||
TN4932 |
Sageone
|
PARP; Akt; Caspase; Antifection | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity. | |||
T40578 |
β-Bisabolene
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Others | Others |
β-Bisabolene is a sesquiterpene isolated from opoponax ( Commiphora guidotti ). β-Bisabolene, an anti-cancer agent , can be used for the study of breast cancer. | |||
T83134 |
Alterbrassicene B
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Alterbrassicene B,一种从甘蓝链格孢菌(Alternaria brassicicola)分离得到的抗癌化合物。 | |||
TN4341 |
IVHD-valtrate
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Mdm2; BCL; PARP; Caspase; p53 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a basis for development of the compound as a novel chemotherapeutic agent. | |||
T1033L |
Monensin
Elancoban,Rumensin,莫能菌素 |
Others | Others |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling. | |||
TN2567 |
10-Hydroxycanthin-6-one
|
Antifection | Microbiology/Virology |
10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent. | |||
T21523 |
β-Tocotrienol
Beta-Tocotrienol |
Caspase | Apoptosis; Proteases/Proteasome |
Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. | |||
T72795 |
(S)-Erypoegin K
|
Others | Others |
(S)-Erypoegin K,一种显示对HL-60细胞具有有效抗增殖活性的抗癌剂,能诱导细胞凋亡(apoptosis)。 | |||
T81995 |
Kadsuphilin J
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Kadsuphilin J,一种木脂素,从长柄山竹根部分离得到。 | |||
T81690 |
Neocucurbitacin A
|
STAT | JAK/STAT signaling; Stem Cells |
Neocucurbitacin A (compound 7)是一种从沉香果皮提取的STAT3抑制剂,常用于抗癌研究。 | |||
T83282 |
5β-Hydroxybufotalin
|
Others | Others |
5β-Hydroxybufotalin (化合物 6) 是一种来源于中药蟾酥的天然产物,具有有效的抗癌作用,能够抑制癌细胞的生长活性。 | |||
T73067 |
Isodispar B
|
Others | Others |
Isodispar B,一种抗癌剂,能够抑制鼻咽癌和乳腺癌细胞的增殖,并诱导(apoptosis)。它对多种癌细胞系展示出了细胞毒性作用。 | |||
T60581 |
Alkannin
|
Others | Others |
Alkannin 是一种有效且特异性的肿瘤型丙酮酸激酶-M2 (PKM2) 抑制剂,不抑制 PKM1 和丙酮酸激酶-L (PKL)。Alkannin 是一种潜在的抗癌剂。 | |||
TN1783 |
Isolicoflavonol
异甘草黄酮醇 |
Lipid | Metabolism |
Isolicoflavonol 以可逆和混合的方式抑制人羧酸酯酶2介导的荧光素二乙酸酯水解, Ki 小于1.0 μM。 | |||
T82046 |
Irisquinone
|
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Irisquinone,一种具有抗癌活性的天然产物,同时作为癌症放射增敏剂。该化合物通过降低GSH水平并抑制DNA单链断裂修复,展现其药理作用。 | |||
T20749 |
Bisabolene
Bisabolene (natural),红没药烯,FEMA 3331,Limene |
Others | Others |
Bisabolene (FEMA 3331) 是从牛至和其他芳香植物中提取的倍半萜。它是一种潜在的抗癌剂,研究表明它可以诱导 A549 癌细胞系凋亡。 | |||
T73069 |
Kurzipene D
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Others | Others |
Kurzipene D是一种有效的抗癌剂(anticanceragent),通过诱导HepG2细胞凋亡(apoptosis)并使其在S期阻滞,显示出明显的抗肿瘤作用。通过体内斑马鱼模型,Kurzipene D展现了其抑制肿瘤增殖和迁移的特性。 | |||
T75569 |
Xerophilusin B
|
Others | Others |
Xerophilusin B 是一种从 Isodon xerophilus 中分离得到的抗癌剂,对食管鳞状细胞癌 (ESCC) 细胞系表现出抗增殖作用,可诱导 G2/M 细胞周期停滞,介导细胞凋亡 apoptosis。 | |||
T19978 |
Puromycin
NSC 3055,NSC3055,Puromycine,嘌呤霉素,NSC-3055 |
Antibiotic | Microbiology/Virology |
Puromycin (NSC-3055) 是一种抗生素蛋白质合成抑制剂。它通过与 RNA 结合来抑制蛋白质合成。它还通过 Akt 磷酸化抑制食道癌细胞的生长和转移而用作抗癌药物。它是一种抗肿瘤剂和抗锥虫剂,在研究中用作蛋白质合成的抑制剂。 | |||
T82031 |
Isoguaiacin
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Isoguaiacin为一种天然产物,具有复杂的多环化合物结构,广泛应用于生物医药研究领域。 | |||
T73403 |
Aviculin
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Others | Others |
Aviculin 是一种木聚糖苷,是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下,IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。 | |||
TN5639 |
Rocaglaol
Ferrugin,Aglaiastatin A |
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Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis | |||
T83323 |
4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside
|
Others | Others |
化合物3(4-Chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside)是一种从Lilium regale提取的抗癌天然产物,具有显著抑制肺癌A549细胞增殖的活性,显示出其研究癌症治疗潜力。 | |||
TN4291 |
Isofuranodiene
|
IL Receptor; NOS | Immunology/Inflammation |
Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo | |||
T79941 |
Antimycin A2c
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Apoptosis | Apoptosis |
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-01865 |
BLMH Protein, Mouse, Recombinant (His)
Bh,bleomycin hydrolase,Bmh,AI035728 |
Mouse | E. coli |
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica... |