|
TMPY-04153
|
RNF43 Protein, Human, Recombinant (His)
ring finger protein 43,URCC,RNF43,RNF124
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t... |
|
TMPJ-00249
|
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TGF-Beta-1,TGFB1,Transforming Growth Factor β-1,Latency-Asso...
|
Human
|
HEK293 Cells
|
|
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family... |
|
TMPJ-00735
|
PDGF-BB Protein, Human, Recombinant
PDGF-BB,血小板源生长因子,PDGFBB
|
Human
|
E. coli
|
|
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In a... |
|
TMPY-03855
|
DNase I Protein, Human, Recombinant (His)
DRNI,DNL1,deoxyribonuclease I
|
Human
|
HEK293 Cells
|
|
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i... |
|
TMPY-01009
|
TGFBI Protein, Human, Recombinant (His)
CDG2,CSD,EBMD,CSD1,CDGG1,CSD3,transforming growth factor, be...
|
Human
|
HEK293 Cells
|
|
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dys... |
|
TMPY-03407
|
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...
|
Human
|
E. coli
|
|
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... |
|
TMPY-00828
|
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
MPS2,IDS,SIDS,iduronate 2-sulfatase
|
Human
|
HEK293 Cells
|
|
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an... |
|
TMPH-03462
|
SMT3 Protein, S. cerevisiae, Recombinant (His)
Ubiquitin-like protein SMT3,SMT3
|
Saccharomyces cerevisiae
|
P. pastoris (Yeast)
|
|
Not known; suppressor of MIF2 mutations. |
|
TMPH-03463
|
SMT3 Protein, S. cerevisiae, Recombinant (His & SUMO)
SMT3,Ubiquitin-like protein SMT3
|
Saccharomyces cerevisiae
|
E. coli
|
|
Not known; suppressor of MIF2 mutations. |
|
TMPY-04303
|
FAM20C Protein, Human, Recombinant (His)
GEF-CK,DMP4,RNS,DMP-4,family with sequence similarity 20, me...
|
Human
|
Baculovirus Insect Cells
|
|
The Family with sequence similarity 20 member C (FAM20C) catalyzes the phosphorylation of secreted proteins, and participates in a variety of biological processes, including cell proliferation, migration, mineralization, and phosphate homeostasis. FAM20C is an evolutionarily reserved molecule highly expressed in mineralized tissues. Mutations in the Family with sequence similarity (FAM) 20 gene family are associated with mineralized tissue phenotypes in humans. Among these genes, FAM20A mutation... |
|
TMPY-03310
|
Frizzled 4 Protein, Rat, Recombinant (hFc)
frizzled class receptor 4
|
Rat
|
HEK293 Cells
|
|
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9QZH0. |
|
TMPY-00197
|
Frizzled 4 Protein, Human, Recombinant (hFc)
Fz-4,hFz4,EVR1,FEVR,Fz4,GPCR,CD344,FzE4,frizzled class recep...
|
Human
|
HEK293 Cells
|
|
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.3 kDa and the accession number is Q9ULV... |
|
TMPY-00313
|
Frizzled 4 Protein, Rat, Recombinant (His)
frizzled class receptor 4
|
Rat
|
HEK293 Cells
|
|
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is A6I5Z8. |
|
TMPY-04302
|
Frizzled 4 Protein, Human, Recombinant (His)
frizzled class receptor 4,Fz-4,FEVR,hFz4,Fz4,GPCR,FzE4,EVR1,...
|
Human
|
HEK293 Cells
|
|
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9ULV... |
|
TMPY-04311
|
RAB11B Protein, Human, Recombinant (His)
H-YPT3,RAB11B, member RAS oncogene family
|
Human
|
HEK293 Cells
|
|
The two recurrent dominant mutations in RAB11B leading to a neurodevelopmental syndrome, likely caused by altered GDP/GTP binding that inactivate the protein and induce GEF binding and protein mislocalization. |
|
TMPK-00050
|
Leptin Protein, Mouse, Recombinant (hFc)
LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB
|
Mouse
|
HEK293 Cells
|
|
Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. |
|
TMPY-05067
|
Fibrinogen Gamma Chain Protein, Mouse, Recombinant
3010002H13Rik,fibrinogen γ chain,fibrinogen gamma chain,Fibr...
|
Mouse
|
P. pastoris (Yeast)
|
|
Loss of function mutations in FGG have been associated with fibrinogen deficiency. FGG mRNA was expressed abnormally in HCC and elevated plasma fibrinogen may serve as a useful predictor of clinical progression of HCC patients. Fibrinogen Gamma Chain Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 30.5 kDa and the accession number is Q3UEM7. |
|
TMPY-04732
|
Fibrinogen Gamma Chain Protein, Human, Recombinant
fibrinogen gamma chain,fibrinogen γ chain,Fibrinogen γ Chain
|
Human
|
P. pastoris (Yeast)
|
|
Loss of function mutations in FGG have been associated with fibrinogen deficiency. FGG mRNA was expressed abnormally in HCC and elevated plasma fibrinogen may serve as a useful predictor of clinical progression of HCC patients. Fibrinogen Gamma Chain Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 32.2 kDa and the accession number is P02679-1. |
|
TMPY-04765
|
PKLR Protein, Human, Recombinant (His)
PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC
|
Human
|
E. coli
|
|
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl... |
|
TMPY-00320
|
APOA1BP Protein, Human, Recombinant (His)
YJEFN1,apolipoprotein A-I binding protein,AIBP
|
Human
|
HEK293 Cells
|
|
APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites.Pathogenic biallelic mutations in NAXE in children from four families with (sub-) acute-onset ataxia, cerebellar edema, spinal myelopathy, and skin lesions. |
|
TMPY-00569
|
B3GAT3 Protein, Human, Recombinant (His)
beta-1,3-glucuronyltransferase 3,glcUAT-I,GLCATI,β-1,3-glucu...
|
Human
|
E. coli
|
|
B3GAT3, encoding beta-1,3-glucuronyltransferase 3, has an important role in proteoglycan biosynthesis. Homozygous B3GAT3 mutations have been associated with short stature, skeletal deformities, and congenital heart defects. There is a novel B3GAT3-related disorder with craniosynostosis and bone fragility, due to a unique homozygous mutation in B3GAT3. |
|
TMPY-02003
|
FH/Fumarate Hydratase Protein, Human, Recombinant (His)
fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC
|
Human
|
E. coli
|
|
Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func... |
|
TMPY-00131
|
Niemann Pick C1/NPC1 Protein, Human, Recombinant (His & FLAG)
NPC,Niemann-Pick disease, type C1
|
Human
|
HEK293 Cells
|
|
Niemann-Pick C1 (NPC1), a host receptor involved in the envelope glycoprotein (GP)-mediated entry of filoviruses into cells, is believed to be a major determinant of cell susceptibility to filovirus infection. Niemann-Pick C1 (NPC1), a membrane protein of lysosomes, is required for the export of cholesterol derived from receptor-mediated endocytosis of LDL. The NPC1 protein is a multipass transmembrane protein whose deficiency causes the autosomal recessive lipid storage disorder Niemann-Pick ty... |
|
TMPK-00927
|
ALK Protein, Mouse, Recombinant (hFc)
CD246,Anaplastic lymphoma kinase,ALK tyrosine kinase recepto...
|
Mouse
|
HEK293 Cells
|
|
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. |
|
TMPY-04414
|
MUSK Protein, Human, Recombinant (aa 433-783, His & GST)
FADS,CMS9,muscle, skeletal, receptor tyrosine kinase
|
Human
|
Baculovirus Insect Cells
|
|
Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ... |
|
TMPY-01120
|
VPAC2 Protein, Human, Recombinant (mFc)
VPCAP2R,PACAP-R-3,VIP-R-2,vasoactive intestinal peptide rece...
|
Human
|
HEK293 Cells
|
|
VIP and PACAP receptor 2, or VIPR2 encodes the VPAC2 receptor, which binds both VIP and PACAP. VPAC2 is expressed throughout the central nervous system and the periphery. Mutations in the VIPR2 homolog in the mouse cause hypoactivity, as well as disruptions in circadian rhythm. Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. |
|
TMPY-04773
|
TPK1 Protein, Human, Recombinant (His)
THMD5,PP20,HTPK1,thiamin pyrophosphokinase 1
|
Human
|
E. coli
|
|
Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism dysfunction (OMIM 614458) due to TPK1 mutations is a recently described rare disorder. The genomic variations in the fetal and maternal TPK1 gene could contribute to the variability of birth weight in normal humans. |
|
TMPY-05099
|
GBA/glucocerebrosidase Protein, Human, Recombinant (His)
glucosidase, β, acid,GLUC,GCB,GBA1,glucosidase, beta, acid
|
Human
|
HEK293 Cells
|
|
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). ASAH1 (acid ceramidase 1) and GBA2 (glucocerebrosidase 2) enzymes that mediate glucosylsphingosine production and metabolism are attractive therapeutic targets for treating mutant GBA-associated PD. |
|
TMPY-00483
|
Parvalbumin/PVALB Protein, Human, Recombinant (His)
parvalbumin,D22S749
|
Human
|
E. coli
|
|
Parvalbumins (PVALBs) are particularly abundant in the fast-contracting muscles and correlate positively with muscle relaxation speed in amphibians and fishes. The loss of PVALB plays a role in the pathogenesis of thyroid tumors. The mutations in the PVALB gene are not involved in GS patients who harbour a single or no mutant SLC12A3 allele. |
|
TMPY-03353
|
CEL Protein, Mouse, Recombinant (His)
1810036E18Rik,carboxyl ester lipase,BAL
|
Mouse
|
Baculovirus Insect Cells
|
|
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL c... |
|
TMPJ-01383
|
Serpin A10 Protein, Human, Recombinant (His)
PZI,Protein Z-Dependent Protease Inhibitor,Serpin A10,ZPI,PZ...
|
Human
|
HEK293 Cells
|
|
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis. |
|
TMPY-04149
|
RNF43 Protein, Human, Recombinant (hFc)
RNF43,RNF124,URCC,ring finger protein 43
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and t... |
|
TMPJ-00855
|
GLUL Protein, Human, Recombinant (His)
GLUL,GS,Glutamine Synthetase,Glutamate-Ammonia Ligase,GLNS,G...
|
Human
|
E. coli
|
|
Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part in cell prolifetation, inhibition of apoptosis, and cell signaling. Glutamine Synthetase is expressed during early fetal stages, and has a role in maintaining body PH by removing ammonia from circulation. Mutations in the GLUL gene are related to congenital glutamine deficiency. |
|
TMPJ-01111
|
TSTA3 Protein, Human, Recombinant (His)
GDP-L-Fucose Synthase,Short-Chain Dehydrogenase/Reductase Fa...
|
Human
|
E. coli
|
|
GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the substrate of several fucosyltransferase, involving the expression of mamy glycoconjugates, including blood group ABH antigens and development adhesion antigens. Mutations in the TSTA3 gene may cause leukocyte adhesion deficiency type II. |
|
TMPJ-01211
|
EDA2R Protein, Mouse, Recombinant (His)
EDA-A2R,Tumor necrosis factor receptor superfamily member XE...
|
Mouse
|
HEK293 Cells
|
|
Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 ... |
|
TMPY-03282
|
FUCA1 Protein, Human, Recombinant (His)
fucosidase, alpha-L- 1, tissue,fucosidase, α-L- 1, tissue,FU...
|
Human
|
HEK293 Cells
|
|
FUCA1 is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in FUCA1 gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. Different phenotypes include clinical features such as neurologic deterioration, growth retardation, visceromegaly, and seizures in a severe early form; coarse facial features, angiokeratoma corporis diffusum, spasticity and delayed psychomotor development in a longe... |
|
TMPJ-00724
|
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Proliferation-I...
|
Human
|
E. coli
|
|
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. |
|
TMPK-00790
|
Complement factor H/CFH Protein, Human, Recombinant (His)
ARMD4,AHUS1,H factor 1,HF1,AMBP1,FH,FHL1,HUS,CFHL3,ARMS1,HF2...
|
Human
|
HEK293 Cells
|
|
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self)... |
|
TMPK-00418
|
MERTK/Mer Protein, Human, Recombinant (mFc)
MER,Tyro12,MERTK,c-Eyk,MGC133349,c-mer,RP38
|
Human
|
HEK293 Cells
|
|
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 78.9 kDa and the accession ... |
|
TMPK-01022
|
MERTK/Mer Protein, Mouse, Recombinant (His)
Tyro12,c-Eyk,MGC133349,RP38,c-mer,MERTK,MER
|
Mouse
|
HEK293 Cells
|
|
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.38 kDa and the accession... |
|
TMPK-00417
|
MERTK/Mer Protein, Human, Recombinant (His)
Tyro12,MGC133349,c-mer,MERTK,c-Eyk,RP38,MER
|
Human
|
HEK293 Cells
|
|
MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans. MERTK/Mer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.73 kDa and the accession... |
|
TMPJ-00793
|
TPM3 Protein, Human, Recombinant
Tropomyosin α-3 Chain,γ-Tropomyosin,hTM5,Tropomyosin Alpha-3...
|
Human
|
E. coli
|
|
Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the calcium dependent regulation of vertebrate striated muscle contraction. Defects in TPM3 are the cause of thyroid papillary carcinoma. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are... |
|
TMPJ-01271
|
PIK3IP1 Protein, Human, Recombinant (His)
Kringle domain-containing protein HGFL,PIK3IP1,HGFL
|
Human
|
HEK293 Cells
|
|
Phosphoinositide-3-kinase-interacting protein 1(PIK3IP1) is an enzyme that in humans is encoded by the PIK3IP1 gene.It is a negative regulator of phosphatidylinositol-3-kinase (PI3K), suppresses the development of hepatocellular carcinoma. The gene encoding PIK3IP1 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibrom... |
|
TMPK-00056
|
IL-10 Protein, Human, Recombinant (His & Avi)
MGC126450,白细胞介素,GVHDS,B-TCGF,IL10A,白介素,TGIF,CSIF,IL-10,Inter...
|
Human
|
HEK293 Cells
|
|
Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. IL-10 Protein, Human, Rec... |
|
TMPJ-00457
|
OGG1 Protein, Human, Recombinant
OGH1,N-Glycosylase/DNA Lyase,DNA-(Apurinic or Apyrimidinic S...
|
Human
|
E. coli
|
|
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma. |
|
TMPK-00057
|
IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated
IL-10,GVHDS,Interleukin-10,白介素,白细胞介素,MGC126451,CSIF,MGC12645...
|
Human
|
HEK293 Cells
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Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. IL-10 Protein, Human, Rec... |
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TMPY-03451
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SPF30 Protein, Human, Recombinant (His)
SPF30,SMNR,TDRD16C,survival motor neuron domain containing 1
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Human
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E. coli
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SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis. |
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TMPY-03502
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PAX8 Protein, Human, Recombinant (His)
paired box 8
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Human
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E. coli
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PAX8 gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. PAX8 is involved in thyroid follicular cell development and expression of thyroid-specific genes. Also functions in very early stages of kidney organogenesis. Mutations in PAX8 gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyr... |
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TMPJ-01382
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HSPB8 Protein, Human, Recombinant (His)
Small stress protein-like protein HSP22,CRYAC,E2IG1,Alpha-cr...
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Human
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E. coli
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Heat shock protein beta-8 (HSPB8) belongs to the small heat shock protein (HSP20) family. This protein can be inducted by 17-beta-estradiol, and is predominantly expressed in skeletal muscle and heat, mainly located in the cytoplasm and nucleus. HSPB8 usually exists in monomer, it can interact with HSPB1 and DNAJB6. HSPB8 displays temperature-dependent chaperone activity，appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have bee... |
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TMPJ-01093
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HYAL1 Protein, Human, Recombinant (His)
LUCA1,Hyaluronoglucosaminidase-1,HYAL1,LuCa-1,Hyal-1,Hyaluro...
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Human
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HEK293 Cells
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Hyaluronidase-1 (HYAL1) is a secreted lysosomal hyaluronidase that belongs to the glycosyl hydrolase 56 family. HYAL1 contains one EGF-like domain and is highly expressed in the liver, kidney, and heart, but it is weakly expressed in the lung, placenta, and skeletal muscle. HYAL1 is thought to be involved in cell proliferation, migration, and differentiation. It may play a role in promoting tumor progression and blocking the TGFB1-enhanced cell growth. Mutations in HYAL1 are associated with muco... |
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