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Search Results for " antiviral activity against "

Targets Recommended: HCV Protease

125

抑制剂 & 化合物

34

天然产物

4

化合物库

6

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L6730	抗病毒中药单体化合物库		268 compounds
	268 种具有抗病毒活性的中药单体集合，是药物开发、药理研究的有效工具；
L1710	抗COVID-19化合物库		1133 compounds
	1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合，可用于高通量和高内涵筛选；
L9300	大环化合物库		210 compounds
	210 种活性已知的大环化合物，用于高通量、高内涵筛选；
L6610	抗感染天然产物库		1060 compounds
	1060 个抗感染相关的天然产物集合，是药物开发、药理研究的有效工具；

化合物库

抗病毒中药单体化合物库

Cat.No: L6730

Compounds: 268

抗COVID-19化合物库

Cat.No: L1710

Compounds: 1133

大环化合物库

Cat.No: L9300

Compounds: 210

抗感染天然产物库

Cat.No: L6610

Compounds: 1060

Cat. No.	Product Name	Target	Signaling Pathways
T15573	Inarigivir soproxil SB9200	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中， HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。
T40276	GS-621763	SARS-CoV	Microbiology/Virology
	GS-621763 是具有口服活性的 GS-441524 前药，在小鼠体内具有抗SARS-CoV-2病毒活性。
T1649	Tenofovir 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂，可研究 HIV 和慢性乙型肝炎。
T16911	Sorivudine BV-araU,索立夫定	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Sorivudine (BV-araU) 是口服有效的，嘧啶核苷抗代谢药物。它的抗病毒活性来自某些 DNA 病毒中存在的特定胸苷激酶选择性转化为核苷酸，从而反过来会干扰病毒 DNA 合成。
T16702	QL47	Virus Protease; BTK	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	QL47 是一种宿主靶向的小分子抗病毒剂，具有抗病毒活性，对登革热病毒和其他 RNA 病毒有抑制作用。QL47 可作为病毒翻译的抑制抑制剂和 BTK 的共价抑制剂，可用于研究淋巴瘤。
T8328	STING agonist-1 G10	Virus Protease; STING	Immunology/Inflammation; Microbiology/Virology
	STING agonist-1 (G10)是一种人类特异性 STING 激动剂，可引发针对新兴甲病毒的抗病毒活性。它抑制甲病毒属 VEEV 复制，IC90值为 24.57 μM。
T2330	Rilpivirine TMC278,R278474,利匹韦林,DB08864	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Rilpivirine (R278474) 是一种二芳基嘧啶衍生物和非核苷逆转录酶抑制剂，具有抗 HIV-1 的抗病毒活性，用于治疗 HIV 感染。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T77555	3-Methoxycatechol 1,2-Dihydroxy-3-methoxybenzene	Antiviral	Immunology/Inflammation
	3-Methoxycatechol 是一种木质素衍生的可再生化学品，可促进食管发生癌变。1,2-Dihydroxy-3-methoxybenzen 对脑脊髓炎病毒（EMCV）表现出很强的抗病毒活性.
T9249	ITMN4077	Antiviral	Immunology/Inflammation
	ITMN4077 对感染人类 HuH7 细胞的丙型肝炎病毒具有抗病毒活性，评估为抑制 HCV 亚基因组复制子复制，EC50 为 2.131μM。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T26726	AzddMeC Azidodideoxymethylcytidine,CS-92,Az-Dcme	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	AzddMeC (Az-Dcme) 是一种具有抗病毒活性的核苷类似物，是一种具有口服活性和选择性的 HIV-1 逆转录酶和 HIV-1 复制的抑制剂。AzddMeC 对感染 HIV-1 的人类 PBM 细胞和感染 HIV-1 的人类巨噬细胞的 EC50 值分别为 9 nM 和 6 nM。
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T9672	GRL-0496	SARS-CoV	Microbiology/Virology
	GRL-0496 是氯吡啶酯衍生物，是有效的 SARS-CoV 3CLpro 抑制剂，IC50为 30 nM。GRL-0496显示出抗 SARS-CoV 病毒活性，EC50为 6.9 μM。
T7766	Remdesivir 瑞德西韦,GS-5734	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Remdesivir (GS-5734) 是一种核苷类似物，一种广谱的抗病毒化合物，通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性，对 COVID-19 有潜在治疗价值。
T11760	KIN101 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene,3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯	HCV Protease; Influenza Virus; RSV; Antifection	Microbiology/Virology; Proteases/Proteasome
	KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene) 是 IRF-3 依赖性信号传导的异黄酮激动剂，可诱导 IRF-3 核易位。它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。
T9394	CHIKV-IN-2	Dehydrogenase	Metabolism
	CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂，具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。
T7911	Arbidol Umifenovir	Antiviral; SARS-CoV	Immunology/Inflammation; Microbiology/Virology
	Arbidol (Umifenovir) 是一种具有口服活性广谱抗病毒化合物，属于融合抑制剂，可与 SARS-CoV-2 刺突蛋白相互作用。Arbidol 对多种冠状病毒显示出抑制活性。Arbidol 具有抗炎抗氧化活性，可用于研究浓度感染。
T8591	RNase L-IN-2 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one	Others	Others
	RNase L-IN-2 是 RNase L 的激活剂，EC50 为 22 uM；对多种类型的 RNA 病毒（包括人类病原体人类副流感病毒 3 型）具有广谱抗病毒活性，在有效浓度下没有细胞毒性。
T9103	BVDV-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BVDV-IN-1 是一种牛病毒性腹泻病毒 (BVDV) 的非核苷抑制剂 (NNI)，EC50 为 1.8 μM。它直接与 BVDV RdRp 的疏水口袋结合，对耐 NNI 氨基硫脲 (TSC) 的 BVDV 具有抗病毒活性。
TNU0060	3’-O-Methyladenosine	Antiviral; Adenosine deaminase	Immunology/Inflammation; Metabolism
	3’-O-Methyladenosine 是一种抗病毒化合物，对西尼罗河病毒具有抑制作用，可用于治疗病毒感染。3’-O-Methyladenosine 对腺苷脱氨酶VII型具有抑制作用，Ki 值为 493 µM。
T36433	A2ti-2 A2ti-2	Virus Protease; Antiviral	Immunology/Inflammation; Microbiology/Virology
	A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂（IC50 : 230 μM)。A2ti-2 具有抗病毒活性，可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用，可防止人乳头瘤病毒 16 型 (HPV16) 感染。
T26873	BMY-27709 BMY 27709,BMY27709	Influenza Virus	Microbiology/Virology
	BMY-27709 是一种流感病毒生长抑制剂，对 A/WSN/33 病毒生长的 IC50 值为 3-8 μM，对流感病毒的部分亚型也展现出抑制活性。BMY-27709 对 H1 和 H2 病毒感染的早期起作用，通过抑制血凝素蛋白展现其抗病毒活性。然而，BMY-27709 对 H3 亚型病毒以及 B 型/Lee/40 流感病毒没有作用。
T60951	Molnupiravir EIDD-2801,Lagevrio,MK-4482	SARS-CoV; Influenza Virus	Microbiology/Virology
	Molnupiravir (MK-4482) (EIDD-2801) 是核糖核苷类似物 EIDD-1931 的异丙酯前体药物，具有口服生物利用度。Molnupiravir 可用于 COVID-19 ，季节性和流行性流感的研究，对多种冠状病毒和流感病毒具有广谱的抗病毒活性，例如，SARS-CoV-2，MERS-CoV，SARS-CoV。
T60095	CCF0058981	SARS-CoV	Microbiology/Virology
	CCF0058981 (CCF981) 是3-氯苯基类似物，是一种非共价 SARS-CoV-2 3CLpro(SC2)抑制剂，IC50为 68 nM。CCF0058981 抑制 SC1 (SARS-CoV-1 3CLpro)，IC50为 19 nM。CCF0058981 具有抗病毒功效，具有用于 COVID-19 研究的潜力。
T8501	3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide	Influenza Virus	Microbiology/Virology
	3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide 具有抗埃博拉病毒的抗病毒活性靶向表面暴露的糖蛋白并抑制病毒进入宿主细胞。 Vero 细胞的体外研究表明，该化合物抑制病毒复制，EC50 为 0.38 μM。
T3614	Inosine pranobex Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun	IL Receptor; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。
T0684	Ribavirin Tribavirin,ICN-1229,NSC-163039,利巴韦林,RTCA	Dehydrogenase; HCV Protease; DNA/RNA Synthesis; Antibiotic; AChR; RSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ribavirin (Tribavirin) 是一种合成的呋喃核苷类似物，一种抗病毒剂。Ribavirin 具有抗丙型肝炎病毒和其他 RNA 病毒的活性。
T17026	Tecovirimat ST-246,特考韦瑞	Cysteine Protease	Proteases/Proteasome
	Tecovirimat 是一种核心蛋白半胱氨酸蛋白酶抑制剂，可能用于治疗天花感染。Tecovirimat 是一种新型抗病毒药物，对多种正痘病毒具有有效和选择性的活性（EC50：约 10 nM）。通过靶向病毒 p37 蛋白直系同源物来抑制正痘病毒的排出。迄今为止，Tecovirimat 已在所有小动物和非人类灵长类动物预防和治疗痘病毒引起的疾病模型中显示出功效。
T1303	Auranofin 醋硫葡金,SKF-39162	Others; SARS-CoV; Antibacterial	Microbiology/Virology; Others
	Auranofin (SKF-39162) 是一种硫氧还蛋白还原酶 TrxR 抑制剂 (IC50=0.2 μM)。Auranofin 是一种抗风湿剂，用于治疗类风湿性关节炎，改善关节炎症状。Auranofin 也具有对 SARS-CoV21 的抗病毒活性。
T24234	JX040 JX 040,JX-040	Others	Others
	JX040 is an enterovirus replication inhibitor. JX040 has strong antiviral activity against non-polio enteroviruses and it has weak antiviral activity against polioviruses.
T24385	L-Acosamine nucleoside	Others	Others
	L-Acosamine nucleoside has antiviral activity against HIV and HSV-1.
T24103	GS-9148	Others	Others
	GS-9148 is a dAMP analog. It also maintains its antiviral activity against drug-resistant HIV.
T70710	M2WJ332	Others	Others
	M2WJ332 is a novel M2-S31N inhibitor, showing antiviral activity against Influenza A virus.
T70246	PD159206	Others	Others
	PD-159206 is a nucleocapsid inhibitor. It exhibits good antiviral activity against HIV.
T39334	Remdesivir nucleoside monophosphate	Others	Others
	Remdesivir nucleoside monophosphate, a metabolite of Remdesivir, is a potent antiviral compound with nucleoside analogue characteristics. It exhibits effective antiviral activity against both SARS-CoV and MERS-CoV.
T24773	SCH-43478 SCH 43478	Others	Others
	SCH-43478 is a non-nucleoside agent of antiviral. It has an effective and selective activity against herpes simplex virus type 2 (HSV-2).
T24563	Nummularine B N-Demethylamphibine H,Daechuine S27	Others	Others
	Nummularine B is a cyclopeptide alkaloid. It has antiviral activity against the porcine epidemic diarrhea virus. It also has potent inhibitory effects on PEDV replication.
T10677	Carbodine	Others	Others
	Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent and targets CTP synthetase that converts UTP to CTP. It possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro.
T41013	Ganciclovir mono-O-acetate	Others	Others
	Ganciclovir mono-O-acetate is a derivative of Ganciclovir, an orally active antiviral agent with activity against CMV. It belongs to the group of nucleoside analogues.
T41177	Galidesivir dihydrochloride BCX 4430	Others	Others
	Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.
T40120	FNC-TP	Others	Others
	FNC-TP, the intracellular active form of FNC, is a potent nucleoside reverse transcriptase inhibitor (NRTI) with broad-spectrum antiviral activity against HIV, HBV, and HCV.
T16576	Pritelivir mesylate BAY 57-1293 mesylate,AIC316 mesylate	Others	Others
	Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models
T16439	PC786	Others	Others
	PC786 shows effective antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM). PC786 is an inhaled respiratory syncytial virus L protein polymerase inhibitor.
T15028	Cyclopropavir MBX-400,Filociclovir,ZSM-I-62	Others	Others
	Cyclopropavir (Filociclovir; MBX-400) is a compound of broad-spectrum anti-herpesvirus. It has good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8 (EC50s: 0.7 μM to 8 μM).
T37277	2-Amino-6-chloropurine	Others	Others
	2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).1 1.Qiu, Y.-L., Ksebati, M.B., Ptak, R.G., et al.(Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activityJ. Med. Chem.41(1)10-23(1998)
T16575	Pritelivir mesylate hydrate BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate	Others	Others
	Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vit
T21456	Grazoprevir hydrate Grazoprevir,MK5172,MK 5172,MK-5172	Others	Others
	Grazoprevir, a second generation hepatitis C virus protease inhibitor acting at the NS3/4a protease targets, has good activity against a range of hepatitis C virus genotype variants, including some that are resistant to most currently used antiviral medic
T33282	Memotine HCl UK-237101,UK-2371,UK 237101,UK 2371,UK2371	Others	Others
	Memotine HCl has antiviral activity against respiratory tract infection and is used as a therapeutic agent for acute respiratory diseases. It is also a memo fracture in the form of hydrochloride, an isoquinoline, with anti-myxovirus and paramyxovirus acti
T67784	6-fluorinated-aristeromycin2c	Others	Others
	6-fluorinated-aristeromycin2c 具有抗病毒感染活性，对热病毒、寨卡病毒和Sars 冠状病毒具有抑制作用。

化合物

Inarigivir soproxil

Cat.No: T15573

Synonym: SB9200

Target: HCV Protease

Cat.No: T40276

Target: SARS-CoV

Cat.No: T1649

Synonym: 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278

Target: HBV, HIV Protease, Reverse Transcriptase

Cat.No: T16911

Synonym: BV-araU,索立夫定

Target: DNA/RNA Synthesis

Cat.No: T16702

Target: Virus Protease, BTK

STING agonist-1

Cat.No: T8328

Synonym: G10

Target: Virus Protease, STING

Cat.No: T2330

Synonym: TMC278,R278474,利匹韦林,DB08864

Target: HIV Protease, Reverse Transcriptase

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

3-Methoxycatechol

Cat.No: T77555

Synonym: 1,2-Dihydroxy-3-methoxybenzene

Target: Antiviral

Cat.No: T9249

Target: Antiviral

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Cat.No: T26726

Synonym: Azidodideoxymethylcytidine,CS-92,Az-Dcme

Target: HIV Protease

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

Cat.No: T9672

Target: SARS-CoV

Cat.No: T7766

Synonym: 瑞德西韦,GS-5734

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: T11760

Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene,3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯

Target: HCV Protease, Influenza Virus, RSV, Antifection

Cat.No: T9394

Target: Dehydrogenase

Cat.No: T7911

Synonym: Umifenovir

Target: Antiviral, SARS-CoV

Cat.No: T8591

Synonym: 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one

Target: Others

Cat.No: T9103

Target: DNA/RNA Synthesis

3’-O-Methyladenosine

Cat.No: TNU0060

Target: Antiviral, Adenosine deaminase

Cat.No: T36433

Synonym: A2ti-2

Target: Virus Protease, Antiviral

Cat.No: T26873

Synonym: BMY 27709,BMY27709

Target: Influenza Virus

Cat.No: T60951

Synonym: EIDD-2801,Lagevrio,MK-4482

Target: SARS-CoV, Influenza Virus

Cat.No: T60095

Target: SARS-CoV

3-Phenyl-N-[1-(phenylmethyl)-4-piperidinyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide

Cat.No: T8501

Target: Influenza Virus

Inosine pranobex

Cat.No: T3614

Synonym: Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Cat.No: T0684

Synonym: Tribavirin,ICN-1229,NSC-163039,利巴韦林,RTCA

Target: Dehydrogenase, HCV Protease, DNA/RNA Synthesis, Antibiotic, AChR, RSV

Cat.No: T17026

Synonym: ST-246,特考韦瑞

Target: Cysteine Protease

Cat.No: T1303

Synonym: 醋硫葡金,SKF-39162

Target: Others, SARS-CoV, Antibacterial

Cat.No: T24234

Synonym: JX 040,JX-040

Target: Others

L-Acosamine nucleoside

Cat.No: T24385

Target: Others

Cat.No: T24103

Target: Others

Cat.No: T70710

Target: Others

Cat.No: T70246

Target: Others

Remdesivir nucleoside monophosphate

Cat.No: T39334

Target: Others

Cat.No: T24773

Synonym: SCH 43478

Target: Others

Cat.No: T24563

Synonym: N-Demethylamphibine H,Daechuine S27

Target: Others

Cat.No: T10677

Target: Others

Ganciclovir mono-O-acetate

Cat.No: T41013

Target: Others

Galidesivir dihydrochloride

Cat.No: T41177

Synonym: BCX 4430

Target: Others

Cat.No: T40120

Target: Others

Pritelivir mesylate

Cat.No: T16576

Synonym: BAY 57-1293 mesylate,AIC316 mesylate

Target: Others

Cat.No: T16439

Target: Others

Cat.No: T15028

Synonym: MBX-400,Filociclovir,ZSM-I-62

Target: Others

2-Amino-6-chloropurine

Cat.No: T37277

Target: Others

Pritelivir mesylate hydrate

Cat.No: T16575

Synonym: BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate

Target: Others

Grazoprevir hydrate

Cat.No: T21456

Synonym: Grazoprevir,MK5172,MK 5172,MK-5172

Target: Others

Cat.No: T33282

Synonym: UK-237101,UK-2371,UK 237101,UK 2371,UK2371

Target: Others

6-fluorinated-aristeromycin2c

Cat.No: T67784

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7972	Gallic aldehyde 3,4,5-三羟基苯甲醛,五倍子醛	HSV	Microbiology/Virology
	Gallic aldehyde 对 HSV-1 显示出有效的抗病毒活性。
T8263	3,4'-Dihydroxyflavone	Influenza Virus	Microbiology/Virology
	3,4'-Dihydroxyflavone 是一种口服活性黄酮类化合物，具有抗甲型流感病毒的抗病毒活性。
TN1693	Glabrone	Influenza Virus; PPAR	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Glabrone 是从甘草根中分离的一种异黄酮，可与 PPAR-γ 配体结合，具有抗流感活性。
T8205	Norwogonin 5,7,8-Trihydroxyflavone,去甲汉黄芩素	Virus Protease	Microbiology/Virology
	Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的，对肠道病毒 71 具有抗病毒活性，IC50为 31.83 μg/ ml。
TN1453	Bruceantinol	Anti-infection	Microbiology/Virology
	Bruceantinol 是一种quassinol 化合物，分离自Brucea javanica 的 CH3OH 提取物。它能够将系统性寄主植物中灭活。有效的抑制浓度为 10 μM。
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。
T10164	5,6-Dihydroxyindole Dopamine lutine	Endogenous Metabolite	Metabolism
	5,6-Dihydroxyindole (Dopamine lutine) 是黑色素的前体，显示出广谱的抗菌，抗真菌，抗病毒，抗寄生虫活性。5,6-Dihydroxyindole 也显示出细胞毒性作用。
T75643	Isoxanthohumol	HSV	Microbiology/Virology
	Isoxanthohumol 是一种从啤酒花和啤酒中提取的一种前黄酮类化合物，对几种人类癌细胞株具有抗增殖活性。Isoxanthohumol对肿瘤细胞肺转移灶的转移或侵袭有抑制作用。Isoxanthohumol具有抗病毒活性，对疱疹病毒（HSV1和HSV2）和牛病毒性腹泻病毒（BVDV）具有抑制作用。
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T3149	Salvianolic Acid C 丹酚酸C,丹酚酸 C	Others; P450	Metabolism; Others
	Salvianolic acid C 属于天然产物，是一种细胞色素 P4502C8(CYP2C8) 和细胞色素 P4502J2(CYP2J2) 的抑制剂 (Ki=4.82/5.75 μM)，具有非竞争性。Salvianolic Acid C 具有抗新冠病毒活性。
TN2395	Epirengynic acid	Antiviral	Immunology/Inflammation
	Epirengynic acid has antiviral activity against RSV
TN6420	Sikokianin A
	Sikokianin A shows in vitro antiviral activity against HBsAg secretion.
TN2220	Sophoranol 槐醇,(+)-Sophoranol	HBV	Microbiology/Virology
	(+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion.
T25789	Melianone NSC 302037,NSC-302037,NSC302037
	Melianone exhibits antiviral activity (EC50s: 3-11μM) against three important human pathogens, belonging to the Flaviviridae family, West Nile virus, Dengue virus, and Yellow Fever virus.
TN4932	Sageone	PARP; Akt; Caspase; Antifection	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.Sageone also shows antiviral activity.
TN4456	Lucidadiol	AChR; HSV	Microbiology/Virology; Neuroscience
	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against i
TN3559	Cabraleahydroxylactone	HSV	Microbiology/Virology
	Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).
TN1843	Kushenol K	PDE; HSV	Metabolism; Microbiology/Virology
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II.
TN1632	Euparin	Antifection	Microbiology/Virology
	Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP
TN4696	Odorinol	Antifection	Microbiology/Virology
	Odorine and odorinol inhibit both the initiation and promotion stages of two-stage skin carcinogenesis. (+)-Odorinol exhibits strong antiviral activity against Ranikhet disease virus (RVD) in chick embryo.
T75533	Dihydromaniwamycin E	Others	Others
	Dihydromaniwamycin E 是一种热休克代谢物，对influenza 和SARS-CoV-2病毒具有抗病毒活性。
TN3461	Asebotin	Influenza Virus	Microbiology/Virology
	Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells.
TN3925	Eichlerianic acid	HSV	Microbiology/Virology
	Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg/mL. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. Eichlerianic acid shows weak cytotoxicity (IC50 6.87 to >40 μM) against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480).
TN7391	Caffeoylcalleryanin	Others	Others
	Caffeoylcalleryanin demonstrated potent inhibitory activity against 15-lipoxygenase (15-LOX), with an IC50 value of 1.59 μM. Furthermore, ethanol extract from A. pulchra leaves (EEAPL) was found to contain compounds exhibiting antiviral properties, particularly effective against Dengue virus type 2 (DENV-2). Among these compounds, Caffeoylcalleryanin emerged as the most potent anti-DENV-2 agent, achieving a selectivity index (SI) of 20.0.
T37451	Stachybotrysin B	Others	Others
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 \|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).\|2. Ma, X.-h., Zhen...
TN5014	Shoreic acid	Antifection; HSV	Microbiology/Virology
	Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
TN7265	16-epi Latrunculin B	Others	Others
	16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml.
TN5463	Leachianone G
	Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, it also shows inhibitory activities against pancreatic lipase, it may be used as drug candidate to control obesity. Leachianone G shows potent antiviral
TN4402	Labd-13-ene-8,15-diol	Antifection	Microbiology/Virology
	13(E)-Labd-13-ene-8alpha,15-diol shows antiviral and anticancer activity, it shows strong anti-HRV2 and HRV3 activity with a 50% inhibitory concentration (IC50) of 2.68 and 0.87 microg/mL,respectively; it also exhibits antilung and antilaryngeal cancer ac

天然产物

Gallic aldehyde

Cat.No: T7972

Synonym: 3,4,5-三羟基苯甲醛,五倍子醛

Target: HSV

3,4'-Dihydroxyflavone

Cat.No: T8263

Target: Influenza Virus

Cat.No: TN1693

Target: Influenza Virus, PPAR

Cat.No: T8205

Synonym: 5,7,8-Trihydroxyflavone,去甲汉黄芩素

Target: Virus Protease

Cat.No: TN1453

Target: Anti-infection

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

5,6-Dihydroxyindole

Cat.No: T10164

Synonym: Dopamine lutine

Target: Endogenous Metabolite

Cat.No: T75643

Target: HSV

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Salvianolic Acid C

Cat.No: T3149

Synonym: 丹酚酸C,丹酚酸 C

Target: Others, P450

Epirengynic acid

Cat.No: TN2395

Target: Antiviral

Cat.No: TN6420

Cat.No: TN2220

Synonym: 槐醇,(+)-Sophoranol

Target: HBV

Cat.No: T25789

Synonym: NSC 302037,NSC-302037,NSC302037

Cat.No: TN4932

Target: PARP, Akt, Caspase, Antifection

Cat.No: TN4456

Target: AChR, HSV

Cabraleahydroxylactone

Cat.No: TN3559

Target: HSV

Cat.No: TN1843

Target: PDE, HSV

Cat.No: TN1632

Target: Antifection

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

Cat.No: TN4696

Target: Antifection

Dihydromaniwamycin E

Cat.No: T75533

Target: Others

Cat.No: TN3461

Target: Influenza Virus

Eichlerianic acid

Cat.No: TN3925

Target: HSV

Caffeoylcalleryanin

Cat.No: TN7391

Target: Others

Stachybotrysin B

Cat.No: T37451

Target: Others

Cat.No: TN5014

Target: Antifection, HSV

Cat.No: T14368

Target: Others

16-epi Latrunculin B

Cat.No: TN7265

Target: Others

Cat.No: TN5463

Labd-13-ene-8,15-diol

Cat.No: TN4402

Target: Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00848	OASL Protein, Human, Recombinant (His) 59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid re...	Human	E. coli
	Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646.
TMPH-01553	GBP2 Protein, Human, Recombinant (E. coli, His) Interferon-induced guanylate-binding protein 2,GBP2,Guanylat...	Human	E. coli
	Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. GBP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.4 kDa and the accession number is P32456.
TMPH-01772	DEFA1 Protein, Human, Recombinant (GST) MRS,HP1,HP-1,DEFA1,DEF1,Defensin, alpha 1,Neutrophil defensi...	Human	E. coli
	Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. DEFA1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 37.2 kDa and the accession number is P59665.
TMPH-01235	APOBEC3A Protein, Human, Recombinant (His & SUMO) A3A,APOBEC3A,DNA dC->dU-editing enzyme APOBEC-3A,Phorbolin-1	Human	E. coli
	DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a rol...
TMPH-01902	DDX60 Protein, Human, Recombinant (His) Probable ATP-dependent RNA helicase DDX60,DEAD box protein 6...	Human	E. coli
	Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). DDX60 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8IY2...
TMPY-06983	IFN gamma Protein, Human, Recombinant (E. coli) Interferon Gamma,IFN γ,IFN gamma,IFG,IFI,干扰素,Interferon γ	Human	E. coli
	IFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activ...

重组蛋白

OASL Protein, Human, Recombinant (His)

Cat.No: TMPH-00848

Species: Human

Expression System: E. coli

GBP2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01553

Species: Human

Expression System: E. coli

DEFA1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01772

Species: Human

Expression System: E. coli

APOBEC3A Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01235

Species: Human

Expression System: E. coli

DDX60 Protein, Human, Recombinant (His)

Cat.No: TMPH-01902

Species: Human

Expression System: E. coli

IFN gamma Protein, Human, Recombinant (E. coli)

Cat.No: TMPY-06983

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0013	Acyclovir-d4
	Acyclovir-d4 是 Acyclovir 的氘代化合物。Acyclovir 的 CAS 号为 59277-89-3。Acyclovir是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。

同位素标记化合物

Cat.No: TMIJ-0013

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