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Search Results for " advanced "

Targets Recommended: advanced glycation end products PARP

137

抑制剂 & 化合物

22

天然产物

7

化合物库

28

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2192	抗胰腺癌化合物库		2238 compounds
	2238 种与胰腺癌相关的化合物，可以用于高通量和高内涵筛选；
L9200	药物功能重定位化合物库		4630 compounds
	4630 种全球上市药物和临床药物的独特集合，可用于高通量筛选和高内涵筛选，是老药新用、新的药物靶点筛选和细胞诱导的有效工具。
L6710	中药抗炎分子库		1246 compounds
	1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合，是药物开发、药理研究的有效工具；
L1000	上市药物库		2808 compounds
	2808 个上市药物化合物集合，可用于高通量筛选和高内涵筛选；
L1010	FDA上市及药典收录分子库		3158 compounds
	3158 个上市及药典分子集合，可用于高通量筛选和高内涵筛选；
L2194	抗结直肠癌化合物库		1545 compounds
	1545 种与结直肠癌相关的化合物，可以用于高通量和高内涵筛选；
L2196	抗卵巢癌化合物库		1867 compounds
	1867 种与卵巢癌相关的化合物，可以用于抗卵巢癌药物研发和药理研究

化合物库

抗胰腺癌化合物库

Cat.No: L2192

Compounds: 2238

药物功能重定位化合物库

Cat.No: L9200

Compounds: 4630

中药抗炎分子库

Cat.No: L6710

Compounds: 1246

上市药物库

Cat.No: L1000

Compounds: 2808

FDA上市及药典收录分子库

Cat.No: L1010

Compounds: 3158

抗结直肠癌化合物库

Cat.No: L2194

Compounds: 1545

抗卵巢癌化合物库

Cat.No: L2196

Compounds: 1867

Cat. No.	Product Name	Target	Signaling Pathways
T12695	RBN-2397	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RBN-2397 是一种有效的、选择性的、具有口服活性的跨物种 NAD+ 竞争性 PARP7 抑制剂，IC50 小于 3 nM。它选择性结合 PARP7 ，Kd 为0.001 μM，可恢复干扰素 I 型信号转导，有用于晚期或转移性实体肿瘤的研究潜力。
T38050	CP-609754	Transferase	Metabolism
	CP-609754 是高效的、可逆的法尼基转移酶抑制剂，对重组人 H-Ras 和重组 K-Ras 法尼基化的 IC50分别为 0.57 ng/mL 和 46 ng/mL。CP-609754有潜在的抗癌作用。
T9756	AZD-9574	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	AZD-9574 是 SSB 位点的 PARP1 特异性抑制剂。 AZD-9574 具有抗癌活性，可用于 HRD+ 乳腺癌和晚期实体恶性肿瘤的研究。
T8327	ONO-7475	Trk receptor; TAM Receptor	Tyrosine Kinase/Adaptors
	ONO-7475 是一种选择性的、有效的、具有口服活性的Axl/Mer 抑制剂。它使 AXL 过表达的EGFR 突变型 NSCLC 细胞对 EGFR-TKIs 敏感，抑制耐药细胞的产生和耐药性的维持。它与 Osimertinib 联合使用，具有用于 EGFR 突变非小细胞肺癌的潜力。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T26889	Borofalan(10B) L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸	Others	Others
	Borofalan(10B) (L-4-Boronophenylalanine) 具有抗肿瘤作用，可用于研究复发性或局部晚期头颈癌。
T7369L	Gemigliptin Tartrate(911637-19-9 free base) 吉格列汀酒石酸盐,LC15-0444 tartrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的，可逆的，竞争性的二肽基肽酶 4 (DPP-4) 抑制剂，对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性，能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
T30190	Ataquimast	Others	Others
	Ataquimast 用于治疗晚期受体阳性乳腺癌。
T26978	CEP-40125 RXDX-107	DNA Alkylation	DNA Damage/DNA Repair
	CEP-40125 (RXDX-107) 是一种 DNA 烷基剂，可用于研究晚期实体瘤。
T24818	Sparfosic Acid NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131	Apoptosis	Apoptosis
	Sparfosic Acid (Acide sparfosique) 是一种天门冬氨酸氨甲酰转移酶抑制剂，具有抗肿瘤活性，可用于研究晚期肾细胞癌。
T2669	Berzosertib VX-970,VE-822	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Berzosertib (VE-822) 已用于研究卵巢肿瘤、卵巢浆液性肿瘤、成人实体瘤、晚期实体瘤和晚期实体瘤等治疗的试验。
T2361	LY2874455 LY 2874455,LY-2874455	VEGFR; FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	LY2874455 是pan-FGFR 抑制剂，能够抑制FGFR1 (IC50:2.8 nM)，FGFR2 (IC50:2.6 nM)，FGFR3 (IC50:6.4 nM)，FGFR4 (IC50:6 nM)。
T1103	Aminoglutethimide DL-Aminoglutethimide,氨鲁米特,BA-16038,NSC-330915	Aromatase	Endocrinology/Hormones
	Aminoglutethimide (BA-16038) 是一种芳香酶抑制剂，IC50=10 μM，用于治疗晚期 BREAST Y。
T17216	Valspodar PSC 833	P-gp	Membrane transporter/Ion channel; Neuroscience
	Valspodar (PSC 833) 是一种特异性的 P-糖蛋白抑制剂和MDR调节剂，常被用作化学增敏剂，可用于研究晚期上皮卵巢癌。
T76706	Varlilumab CDX-1127	TNF	Apoptosis
	Varlilumab (CDX-1127) 是一种新型的人 IgG1 抗 CD27 单克隆抗体。Varlilumab 具有抗肿瘤活性，可用于研究晚期实体肿瘤。
T77149	Cobolimab TSR-022,GSK4069889	Others	Others
	Cobolimab (TSR-022) 是一种有效的 TIM-3 单克隆抗体。Cobolimab 诱导 TIM-3 的内化，IC50 值为 0.4464 nM。Cobolimab 具有抗肿瘤活性，可用于研究晚期/转移性黑色素瘤和晚期肝细胞癌。
T15390	Glufosfamide D 19575,Glucosylifosfamide mustard	Others	Others
	Glufosfamide 是一种新型噁唑磷胺化合物，具有抗癌活性，可用于研究晚期非小细胞肺癌。
T71924L	AC 7739	Microtubule Associated	Cytoskeletal Signaling
	AC 7739 是一种微管蛋白结合剂，具有抗癌抗肿瘤活性，抑制晚期实体瘤和原位移植肿瘤。
T27259	Emitefur BOFA2,BOF A2,BOF-A2	Others	Others
	Emitefur (BOF-A 2)是一种有口服活性和有效性的 5-氟尿嘧啶衍生物，具有抗癌和抗肿瘤活性。Emitefur 可用于研究晚期胃癌、乳腺癌和代谢相关疾病。
T11237	Camizestrant Estrogen receptor antagonist 2	Estrogen Receptor/ERR	Endocrinology/Hormones
	Camizestrant (Estrogen receptor antagonist 2) 是一种雌激素受体拮抗剂，可用于 ER+ HER2 晚期乳腺癌的研究[1]。
T79157	Pimicotinib ABSK021,ABSK-021	c-Fms; Others	Others; Tyrosine Kinase/Adaptors
	Pimicotinib (ABSK021) 为一种有效的 CSF1R 抑制剂，具抗肿瘤活性，可用于研究晚期实体瘤。
T2145	Temsirolimus NSC 683864,CCI-779,西罗莫司脂化物	Apoptosis; mTOR; Autophagy	Apoptosis; Autophagy; PI3K/Akt/mTOR signaling
	Temsirolimus (CCI-779) 是一种mTOR 抑制剂，IC50值为 1.76 μM。它能激活自噬，可防止心脏功能恶化。
T68065	Enloplatin	Others	Others
	Enloplatin 是一种卡铂类似物，在治疗晚期卵巢癌有部分作用。
T40199	Tulmimetostat CPI-0209	Histone Methyltransferase	Chromatin/Epigenetic
	Tulmimetostat (CPI-0209) 是一种具有口服活性的 EZH1/EZH2 抑制剂。Tulmimetostat 有抗肿瘤活性，用于研究卵巢癌和晚期实体瘤。
T39403	Avotaciclib BEY1107,Avotaciclib	CDK	Cell Cycle/Checkpoint
	Avotaciclib (BEY1107) 是一种有效和具有口服活性的 cyclin dependent kinase 1 (CDK1) 抑制剂。Avotaciclib 可用于研究局部晚期或转移性胰腺癌。
T77006	Felzartamab TJ-202,MOR-03087,MOR-202	CD38	Immunology/Inflammation
	Felzartamab(MOR-202) 是一种人源靶向 CD38 的单克隆抗体，可用于研究多发性骨髓瘤和晚期抗体介导的同种异体肾移植排斥反应。
T0078	Lapatinib GSK572016,GW572016,拉帕替尼	EGFR; Ferroptosis; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Lapatinib (GW572016) 是一种 ErbB2 和 EGFR 的抑制剂 (IC50=9.2/10.8 nM)，具有口服活性。Lapatinib 具有抗肿瘤活性，可以用于治疗 HER2 过表达的晚期或转移性乳腺癌。
T11877	LR-90	Others	Others
	LR-90, 作为一种高级糖基化终产品(AGE)抑制剂，在糖尿病动物模型研究中被广泛使用。LR-90 有效地抑制了人类单核细胞中的炎症反应。
T8583	Tenilsetam 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone	Others	Others
	Tenilsetam (Piperazinone) 是一种核酸内切酶调节剂；一种促智剂和晚期糖基化终产物 (AGE) 抑制剂，具有治疗阿尔茨海默病 (AD) 的潜力。
T2073	GSK2636771 GSK 2636771,GSK-2636771	PI3K	PI3K/Akt/mTOR signaling
	GSK2636771 是选择性的、口服有效的PI3Kβ抑制剂，Ki=0.89 nM，IC50=5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。
T74698	RMC-6236 RMC6236	Ras	GPCR/G Protein; MAPK
	RMC-6236 是一种 RAS(ON)MULTI 抑制剂，具有抗癌活性，可用于研究晚期恶性实体瘤和结直肠癌。
T77359	Tezepelumab Tezepelumab-ekko,MEDI 19929,AMG 157	Others	Others
	Tezepelumab (AMG 157) 是一种人源化靶向 TSLP 的单克隆抗体 (IgG2λ)，阻止TSLP 与其异二聚体受体相互作用。Tezepelumab 可用于研究晚期哮喘疾病。
T1962	ASP3026 ASP 3026	Apoptosis; ALK	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ASP3026 是一种选择性的，具有口服活性的间变性淋巴瘤激酶抑制剂，可诱导肿瘤细胞凋亡，可研究非小细胞肺癌。
T2507	Azeliragon TTP488,阿齐瑞格	Beta Amyloid; advanced glycation end products	Neuroscience; Others
	Azeliragon (TTP488) 是一种生物可利用的、可穿过血脑屏障 (BBB)的晚期糖基化终产物 (RAGE) 受体抑制剂，可缓解轻度阿尔茨海默病 (AD) 的发展。
T77750	Rosmantuzumab OMP-131R10	Others	Others
	Rosmantuzumab (OMP-131R10) 是一种人源化抗 R-spondin 3 (RSPO3)单克隆抗体。Rosmantuzumab 具有潜在的抗肿瘤活性，可用于研究晚期复发难治性实体瘤。
T8875	CD73-IN-3 EX-A4254,LY-3475070	CD73	Immunology/Inflammation
	CD73-IN-3 (LY-3475070) 是一种有效的选择性 CD73 抑制剂，IC50 为 28 nM，具有癌症的研究潜力。
T36395	Trotabresib CC-90010	Epigenetic Reader Domain	Chromatin/Epigenetic
	Trotabresib (CC-90010) 是一种具有口服活性的 BET 抑制剂，可用于晚期实体瘤的研究。
T16723	Ranirestat AS3201,SX3030,SX-3030,AS 3201,AS-3201	Reductase	Endocrinology/Hormones; Metabolism
	Ranirestat (AS-3201) 是一种具有口服活性和高效性的醛糖还原酶 (AR) 抑制剂，具有神经保护作用，可改善晚期糖尿病多发性神经病大鼠的周围神经功能障碍。Ranirestat 抑制高葡萄糖暴露内皮细胞的炎症反应，可用于研究糖尿病感觉运动性多发性神经病。
T7143	Alagebrium chloride 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物,ALT711,阿拉氯胺	Others; Endogenous Metabolite	Metabolism; Others
	Alagebrium chloride (ALT711) 是晚期糖基化终产物(AGE) 抑制剂。
T2709	TAK-901 TAK901	JAK; CDK; Src; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAK-901是一种多靶点的极光激酶抑制剂，对极光激酶 A 和 B 的 IC50值分别为 21 和 15 nM。它用于研究淋巴瘤、骨髓纤维化、多发性骨髓瘤、骨髓化生和晚期实体瘤等治疗的试验。
T40292	Opnurasib NVP-JDQ443,JDQ-443,Opnurasib	Ras	GPCR/G Protein; MAPK
	Opnurasib (JDQ-443) 是一种可口服且具有选择性和有效性的共价 KRAS G12C 抑制剂，具有抗肿瘤活性，可用于研究晚期非小细胞肺癌。
T38846	Vevorisertib trihydrochloride ARQ 751 trihydrochloride	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vevorisertib trihydrochloride(ARQ 751 trihydrochloride) 是一种具有选择性和有效性的 pan-AKT 和 AKT1-E17K 突变抑制剂，抑制 AKT1 、AKT2 和 AKT3 。 Vevorisertib trihydrochloride 可用于研究肝癌和晚期实体瘤。
T13389	ZD-0892	Serine Protease	Proteases/Proteasome
	ZD-0892是一种具有选择性和高效的中性粒细胞弹性蛋白酶抑制剂，抑制人嗜中性粒细胞弹性蛋白酶和猪胰弹性蛋白酶，可以逆转大鼠产生的晚期肺血管疾病，可用于研究慢性阻塞性肺疾病（COPD）和外周血管疾病（PVD）。
T60976	Bezuclastinib CGT9486,PLX 9486	c-Kit	Tyrosine Kinase/Adaptors
	Bezuclastinib (CGT9486) 是一种新型有效且具有很高选择性的酪氨酸激酶和c-kit D816V 抑制剂，可用于研究晚期肥大细胞增多症。
T7598	Calcium N5-methyltetrahydrofolate 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328	Others; Antifolate	Cell Cycle/Checkpoint; Others
	Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐，用于治疗心血管疾病、乳腺癌和结肠直肠癌。
T2113	PHA-793887 PHA 793887,PHA793887	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	PHA-793887 是一种ATP 竞争性的CDK 抑制剂，可抑制 Cdk2、Cdk1、Cdk4 和 Cdk9 的活性，IC50值分别为 8 nM、60 nM、62 nM 和 138 nM，同时可抑制糖原合酶激酶 3β，IC50值为 79 nM。
T17028	Tefinostat CHR-2845	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性，可用于研究白血病和晚期血液系统恶性肿瘤。
T76696	Onvatilimab JNJ-61610588	Others	Others
	Onvatilimab (JNJ-61610588) 是一种人 IgG1κ 抗 VISTA (T 细胞激活的 V 域 Ig 抑制剂) 单克隆抗体。Onvatilimab 具有抗肿瘤活性，可用于治疗晚期头颈癌。。
T2381	Abemaciclib CDK4/6 dual inhibitor,LY2835219	CDK	Cell Cycle/Checkpoint
	Abemaciclib (LY2835219) 是一种 CDK4/6 的双重抑制剂 (IC50=2/10 nM)，具有选择性和特异性。Abemaciclib 具有抗肿瘤活性，被用于治疗晚期或转移性乳腺癌。
T6084	Rabusertib LY2603618,IC-83	Chk; PDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
	Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂，IC50为 7 nM。它有潜在的化学增强活性，用于各种癌症和肿瘤治疗的试验。

化合物

Cat.No: T12695

Target: PARP

Cat.No: T38050

Target: Transferase

Cat.No: T9756

Target: PARP

Cat.No: T8327

Target: Trk receptor, TAM Receptor

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T26889

Synonym: L-4-Boronophenylalanine,4-10硼酸-L-苯丙氨酸

Target: Others

Gemigliptin Tartrate(911637-19-9 free base)

Cat.No: T7369L

Synonym: 吉格列汀酒石酸盐,LC15-0444 tartrate

Target: Proteasome, DPP-4

Cat.No: T30190

Target: Others

Cat.No: T26978

Synonym: RXDX-107

Target: DNA Alkylation

Cat.No: T24818

Synonym: NSC224131,NSC-224131,Acide sparfosique,N-Phosphonacetyl-L-aspartate,NSC 224131

Target: Apoptosis

Cat.No: T2669

Synonym: VX-970,VE-822

Target: ATM/ATR

Cat.No: T2361

Synonym: LY 2874455,LY-2874455

Target: VEGFR, FGFR

Aminoglutethimide

Cat.No: T1103

Synonym: DL-Aminoglutethimide,氨鲁米特,BA-16038,NSC-330915

Target: Aromatase

Cat.No: T17216

Synonym: PSC 833

Target: P-gp

Cat.No: T76706

Synonym: CDX-1127

Target: TNF

Cat.No: T77149

Synonym: TSR-022,GSK4069889

Target: Others

Cat.No: T15390

Synonym: D 19575,Glucosylifosfamide mustard

Target: Others

Cat.No: T71924L

Target: Microtubule Associated

Cat.No: T27259

Synonym: BOFA2,BOF A2,BOF-A2

Target: Others

Cat.No: T11237

Synonym: Estrogen receptor antagonist 2

Target: Estrogen Receptor/ERR

Cat.No: T79157

Synonym: ABSK021,ABSK-021

Target: c-Fms, Others

Cat.No: T2145

Synonym: NSC 683864,CCI-779,西罗莫司脂化物

Target: Apoptosis, mTOR, Autophagy

Cat.No: T68065

Target: Others

Cat.No: T40199

Synonym: CPI-0209

Target: Histone Methyltransferase

Cat.No: T39403

Synonym: BEY1107,Avotaciclib

Target: CDK

Cat.No: T77006

Synonym: TJ-202,MOR-03087,MOR-202

Target: CD38

Cat.No: T0078

Synonym: GSK572016,GW572016,拉帕替尼

Target: EGFR, Ferroptosis, Autophagy

Cat.No: T11877

Target: Others

Cat.No: T8583

Synonym: 替尼西坦,3-(2-thienyl)- (9CI),Piperazinone

Target: Others

Cat.No: T2073

Synonym: GSK 2636771,GSK-2636771

Target: PI3K

Cat.No: T74698

Synonym: RMC6236

Target: Ras

Cat.No: T77359

Synonym: Tezepelumab-ekko,MEDI 19929,AMG 157

Target: Others

Cat.No: T1962

Synonym: ASP 3026

Target: Apoptosis, ALK

Cat.No: T2507

Synonym: TTP488,阿齐瑞格

Target: Beta Amyloid, advanced glycation end products

Cat.No: T77750

Synonym: OMP-131R10

Target: Others

Cat.No: T8875

Synonym: EX-A4254,LY-3475070

Target: CD73

Cat.No: T36395

Synonym: CC-90010

Target: Epigenetic Reader Domain

Cat.No: T16723

Synonym: AS3201,SX3030,SX-3030,AS 3201,AS-3201

Target: Reductase

Alagebrium chloride

Cat.No: T7143

Synonym: 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物,ALT711,阿拉氯胺

Target: Others, Endogenous Metabolite

Cat.No: T2709

Synonym: TAK901

Target: JAK, CDK, Src, Aurora Kinase

Cat.No: T40292

Synonym: NVP-JDQ443,JDQ-443,Opnurasib

Target: Ras

Vevorisertib trihydrochloride

Cat.No: T38846

Synonym: ARQ 751 trihydrochloride

Target: Akt

Cat.No: T13389

Target: Serine Protease

Cat.No: T60976

Synonym: CGT9486,PLX 9486

Target: c-Kit

Calcium N5-methyltetrahydrofolate

Cat.No: T7598

Synonym: 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328

Target: Others, Antifolate

Cat.No: T2113

Synonym: PHA 793887,PHA793887

Target: Apoptosis, CDK

Cat.No: T17028

Synonym: CHR-2845

Target: HDAC

Cat.No: T76696

Synonym: JNJ-61610588

Target: Others

Cat.No: T2381

Synonym: CDK4/6 dual inhibitor,LY2835219

Target: CDK

Cat.No: T6084

Synonym: LY2603618,IC-83

Target: Chk, PDK, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
T6S2384	Poliumoside	Reductase	Endocrinology/Hormones; Metabolism
	Poliumoside 是从 Brandisia hancei 的茎和叶中分离出来的咖啡酰化的苯丙烷糖苷。Poliumoside 能够抑制晚期糖基化终产物的形成和大鼠晶状体醛糖还原酶，IC50分别为 19.69 和 8.47 μM。Poliumoside 具有抗炎和抗氧化特性。
T8242	Sabinene	Others	Others
	Sabinene 是香料添加剂，具有成为下一代飞机燃料成分的成分。
TN1471	Cassiaside C 决明子苷C,Toralactone 9-O-β-D-gentiobioside	Others; Endogenous Metabolite	Metabolism; Others
	Cassiaside C (Toralactone 9-O-β-D-gentiobioside) 是一种萘酚类化合物，从决明子种子中分离得到，对晚期糖基化终产物 (AGE) 的形成具有抑制作用。
T12588	Pyridoxylamine pyridoxamine,吡多胺	Endogenous Metabolite	Metabolism
	Pyridoxylamine (pyridoxamine) 是脂质化终产物和糖基化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T10183	6-Methoxytricin	Reductase	Endocrinology/Hormones; Metabolism
	6-Methoxytricin 是从积雪草中分离的黄酮类化合物，是醛糖还原酶 (AR) 和晚期糖基化终产物 (AGE) 的抑制剂，抑制生物细胞中的T细胞增殖和活化。
T5565	Undecanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	Undecanedioic acid 是存在于人体主动脉的部分区域中，其中晚期动脉粥样硬化病变与细胞间基质大分子相关，特别是与弹性蛋白相关。
TN2122	Quercetin 3-gentiobioside Quercetin-3-gentiobioside	Reductase	Endocrinology/Hormones; Metabolism
	Quercetin 3-gentiobioside (Quercetin-3-gentiobioside) 是一种AR 和 AGE 形成的抑制剂，可从 A. iwayomogi 中提取。Quercetin 3-gentiobioside 对醛糖还原酶 (AR) 的生物活性和晚期糖基化终产物 (AGEs) 的形成具有抑制作用。
T21502	Aclacinomycin A Aclarubicin	Topoisomerase	DNA Damage/DNA Repair
	Aclacinomycin A (Aclarubicin) 是一种从加利莱链霉菌中分离出的新型蒽环类抗生素，具有抗肿瘤活性。Aclacinomycin A 是拓扑异构酶 I 和 II 的抑制剂，抑制 RNA 活性。Aclacinomycin A 可用于研究复发性白血病和晚期恶性淋巴瘤。
TN2165	Rubrofusarin gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷	ERK; NF-κB; TGF-beta/Smad	MAPK; NF-κB; Stem Cells
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) 一种分离自决明子的、具有清除自由基作用的化合物。
T13741	Isoviolanthin 异佛莱心苷,异佛来心苷	Others	Others
	Isoviolanthin 是一种黄酮类苷类化合物，提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力，对正常细胞没有毒性影响，对转移性肝癌晚期具有潜在的研究价值。
T2805	Chlorogenic Acid NSC-407296,3-O-Caffeoylquinic acid,Heriguard,绿原酸	Others; Influenza Virus; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Antibacterial	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others
	Chlorogenic acid 作为金银花中的主要酚类化合物，具有潜在的抗氧化，抗菌抗炎和抗癌活性，可用于晚期癌症和葡萄糖耐量受损治疗等相关研究。
T10619	Bromelain	Apoptosis; Others	Apoptosis; Others
	Bromelain 是来源于菠萝茎的一种抗炎药，可诱导细胞凋亡，具有纤维蛋白溶解、抗癌、抗水肿和抗血栓形成活性。它通过下调血浆激肽原，抑制前列腺素 E2 表达，降解晚期糖基化终产物受体，在COX 途径上游发生抗氧化作用以及调节血管生成生物标志物而发挥作用。
TN1042	Chebulic acid	Others	Others
	Chebulic acid 是一种分离自Terminalia chebula 中的酚羧酸化合物，具有显著的抗氧化作用，它能够打破由晚期糖基化终产物 (AGEs) 诱导的蛋白质交联，阻碍 AGEs 的形成。它能够有效控制代谢参数升高、氧化应激和肾损害，支持其在糖尿病肾病中的有益作用。
T4843	2,2-Dihydroxyacetic acid Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物	Others; Endogenous Metabolite	Metabolism; Others
	2,2-Dihydroxyacetic acid (Formylformic acid) 是乙醛酸循环的中间体，使某些生物体能够将脂肪酸转化为碳水化合物。2,2-Dihydroxyacetic acid 被发现与原发性高草酸尿有关，这是一种先天性代谢错误。作为一种醛，乙醛酸酯也具有高活性，可以修饰蛋白质形成晚期糖基化产物(AGEs)。
T19117	3-Deoxyglucosone 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX; Glucagon Receptor	GPCR/G Protein; oxidation-reduction
	3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活，可与低葡萄糖协同作用以增强 GLP-1 分泌，可以作为糖尿病生物学检测的标志物。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
TN2894	3,5-Di-O-caffeoylquinic acid methyl ester 金银花	HSV	Microbiology/Virology
	3,5-Di-O-caffeoylquinic acid methyl ester exhibits potent inhibitory activities against the formation of advanced glycation end products (AGEs); it exhibits cytotoxicity actions against human cervix carcinoma HeLa cells. 3,5-Di-O-caffeoylquinic acid methyl ester shows high efficiency and low toxicity with antivirus activity against RSV.
T81905	Lucidin-ω-Me ether
	Lucidin-ω-Me ether（化合物2），一种自Knoxia valerianoides的根中分离得到的化合物，具有抑制体外晚期糖基化终末产物（AGE）形成的活性，其IC50为62.79 μM。
T80950	Tricetin 7-O-glucoside
	Tricetin 7-O-glucoside (compound 33)为一种黄酮类单-O-糖苷。
TN6059	Demethoxyfumitremorgin C
	Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex
TN6198	Mahanine
	Mahanine has effects on the activation of the apoptotic pathway in human leukemia U937 cells, causes the mitochondrial membranes to lose their permeability, resulting in caspase-3 activation and apoptosis. Mahanine can reverse an epigenetically silenced g

天然产物

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: T6S2384

Target: Reductase

Cat.No: T8242

Target: Others

Cat.No: TN1471

Synonym: 决明子苷C,Toralactone 9-O-β-D-gentiobioside

Target: Others, Endogenous Metabolite

Cat.No: T12588

Synonym: pyridoxamine,吡多胺

Target: Endogenous Metabolite

6-Methoxytricin

Cat.No: T10183

Target: Reductase

Undecanedioic acid

Cat.No: T5565

Target: Others, Endogenous Metabolite

Quercetin 3-gentiobioside

Cat.No: TN2122

Synonym: Quercetin-3-gentiobioside

Target: Reductase

Aclacinomycin A

Cat.No: T21502

Synonym: Aclarubicin

Target: Topoisomerase

Rubrofusarin gentiobioside

Cat.No: TN2165

Synonym: Rubrofusarin-6-O-beta-D-gentiobioside,红链霉素-龙胆二糖苷,芸苔红素龙胆苷

Target: ERK, NF-κB, TGF-beta/Smad

Cat.No: T13741

Synonym: 异佛莱心苷,异佛来心苷

Target: Others

Chlorogenic Acid

Cat.No: T2805

Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard,绿原酸

Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial

Cat.No: T10619

Target: Apoptosis, Others

Cat.No: TN1042

Target: Others

2,2-Dihydroxyacetic acid

Cat.No: T4843

Synonym: Formylformic acid,Glyoxylic acid monohydrate,乙醛酸水合物

Target: Others, Endogenous Metabolite

3-Deoxyglucosone

Cat.No: T19117

Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

Target: GPX, Glucagon Receptor

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

3,5-Di-O-caffeoylquinic acid methyl ester

Cat.No: TN2894

Synonym: 金银花

Target: HSV

Lucidin-ω-Me ether

Cat.No: T81905

Tricetin 7-O-glucoside

Cat.No: T80950

Demethoxyfumitremorgin C

Cat.No: TN6059

Cat.No: TN6198

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02881	RAGE Protein, Human, Recombinant RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35 kDa and the accession number is A0A1U9X785.
TMPY-02927	RAGE Protein, Human, Recombinant (His) RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.5 kDa and the accession number is A0A1U9X785.
TMPY-01675	RAGE Protein, Mouse, Recombinant (His) advanced glycosylation end product-specific recepto...	Mouse	HEK293 Cells
	RAGE Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.3 kDa and the accession number is Q62151-1.
TMPY-01716	RAGE Protein, Human, Recombinant (hFc) RAGE,advanced glycosylation end product-specific re...	Human	HEK293 Cells
	RAGE Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.1 kDa and the accession number is A0A1U9X785.
TMPY-02030	CD82 Protein, Human, Recombinant (His) CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1...	Human	HEK293 Cells
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud...
TMPK-00807	Osteopontin Protein, Mouse, Recombinant (His) ETA-1,SPP1,OPN,Bone sialoprotein 1,BNSP,SPP-1,Osteopontin,Ne...	Mouse	HEK293 Cells
	Secreted phosphoprotein 1 (SPP1) expression in TAMs isolated from lung adenocarcinoma tissues and PMA-treated THP-1 cells were measured. Macrophage polarization was identified by flow cytometric analysis. Cell migration and apoptosis were assessed by Transwell migration assays and flow cytometric analysis, respectively. SPP1 is highly expressed in tumor tissues and TAMs isolated from patients with an advanced TNM stage, and also in PMA-treated THP-1 cells.
TMPH-03401	Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc) Azgp1,Zinc-alpha-2-glycoprotein	Rat	E. coli
	Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.7 kDa and the accession number is Q63678.
TMPK-00172	B7-H4 Protein, Human, Recombinant (His & Avi) B7H4,B7x,VTCN1,PRO1291,B7S1,B7h.5,FLJ22418,B7-H4	Human	HEK293 Cells
	B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status .
TMPK-01045	IL-20RA Protein, Mouse, Recombinant (hFc) IL-20R1,CRF2-8,IL-20R-alpha,IL-20RA,IL-20R-α,FLJ40993,ZcytoR...	Mouse	HEK293 Cells
	IL-20RA was highly expressed in the tumor tissue of CRC and related to the advanced stage.IL-20RA was involved in regulating oncogenic and immune pathways and affecting the expression of genes related to cell proliferation and immune evasion in CRC.Super-enhancer inhibition by JQ-1 or iBET-151 suppressed the growth of tumor cells and inhibited the expression of IL-20RA.
TMPJ-01381	ANXA10 Protein, Human, Recombinant Annexin-10,ANX14,Annexin-14,ANXA10,Annexin A10	Human	E. coli
	Annexin A10 (ANXA10) contains four Annexin repeats and is a member of the Annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is reported that ANXA10 may be a clinical relevant marker for predicting outcome in both early and advanced stages of bladder cancer.
TMPK-00479	AGER Protein, Cynomolgus, Recombinant (His) AGER,RAGE,SCARJ1	Cynomolgus	HEK293 Cells
	The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
TMPK-00407	AXL Protein, Human, Recombinant (His & Avi) AXL oncogene,Axl,EC 2.7.10.1,Tyro7,UFO,ARK,EC 2.7.10,AI32364...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi) is e...
TMPK-00472	AXL Protein, Cynomolgus, Recombinant (His) Tyro7,JTK11,AI323647,AXL oncogene,EC 2.7.10.1,EC 2.7.10,UFO,...	Cynomolgus	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Cynomolgus, Recombinant (His) is ex...
TMPY-01584	PR-Set7 Protein, Human, Recombinant SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans...	Human	E. coli
	KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re...
TMPK-00248	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) DCR2,TNFRSF10D,RSF10D,CD264,TRUNDD,TRAILR4	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 19.4 kDa and t...
TMPK-00410	AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated ARK,EC 2.7.10.1,EC 2.7.10,Axl,JTK11,AXL oncogene,UFO,AI32364...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein (Primary Amine Labeling), Human, Rec...
TMPK-00491	IL-18BP Protein, Cynomolgus, Recombinant (His) Igifbp,Interleukin-18-binding protein,IL-18BP	Cynomolgus	HEK293 Cells
	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Cynomolgus, Recombinant (His) is expressed i...
TMPK-00082	IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated Igifbp,IL-18BP,IL-18BPA	Human	HEK293 Cells
	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated...
TMPK-00249	TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated TNFRSF10D,CD264,TRUNDD,DCR2,RSF10D,TRAILR4	Human	HEK293 Cells
	TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is ...
TMPK-00408	AXL Protein, Human, Recombinant (His & Avi), Biotinylated AXL oncogene,EC 2.7.10.1,AI323647,Axl,JTK11,ARK,EC 2.7.10,UF...	Human	HEK293 Cells
	Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. AXL Protein, Human, Recombinant (His & Avi), Bio...
TMPK-00492	IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated Igifbp,Interleukin-18-binding protein,IL-18BP	Cynomolgus	HEK293 Cells
	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombi...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc) FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...	Human	HEK293 Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece...
TMPY-02193	GOLPH2/GOLM1 Protein, Human, Recombinant (His) HEL46,PSEC0257,GOLPH2,bA379P1.3,C9orf155,GP73,golgi membrane...	Human	HEK293 Cells
	Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantl...
TMPY-02091	GAD67 Protein, Human, Recombinant (His) SCP,CPSQ1,glutamate decarboxylase 1 (brain, 67kDa),GAD	Human	Baculovirus Insect Cells
	Glutamate decarboxylase 1, also known as 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform and GAD1, is a member of thegroup II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 isoform3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Tissue-specific markers are useful for identification of tumour type ...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc) SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam...
TMPJ-01137	MIA Protein, Human, Recombinant (His) MIA,Melanoma Inhibitory Activity Protein,Melanoma-Derived Gr...	Human	E. coli
	Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an au...
TMPY-01992	Kallikrein 8/KLK8 Protein, Human, Recombinant (His) kallikrein-related peptidase 8,PRSS19,TADG14,NRPN,NP,HNP	Human	HEK293 Cells
	Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-c...
TMPY-00924	SMAC Protein, Human, Recombinant (His) DFNA64,diablo, IAP-binding mitochondrial protein,SMAC	Human	E. coli
	Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, bot...

重组蛋白

RAGE Protein, Human, Recombinant

Cat.No: TMPY-02881

Species: Human

Expression System: HEK293 Cells

RAGE Protein, Human, Recombinant (His)

Cat.No: TMPY-02927

Species: Human

Expression System: HEK293 Cells

RAGE Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01675

Species: Mouse

Expression System: HEK293 Cells

RAGE Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01716

Species: Human

Expression System: HEK293 Cells

CD82 Protein, Human, Recombinant (His)

Cat.No: TMPY-02030

Species: Human

Expression System: HEK293 Cells

Osteopontin Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00807

Species: Mouse

Expression System: HEK293 Cells

Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03401

Species: Rat

Expression System: E. coli

B7-H4 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00172

Species: Human

Expression System: HEK293 Cells

IL-20RA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01045

Species: Mouse

Expression System: HEK293 Cells

ANXA10 Protein, Human, Recombinant

Cat.No: TMPJ-01381

Species: Human

Expression System: E. coli

AGER Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00479

Species: Cynomolgus

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00407

Species: Human

Expression System: HEK293 Cells

AXL Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00472

Species: Cynomolgus

Expression System: HEK293 Cells

PR-Set7 Protein, Human, Recombinant

Cat.No: TMPY-01584

Species: Human

Expression System: E. coli

TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00248

Species: Human

Expression System: HEK293 Cells

AXL Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00410

Species: Human

Expression System: HEK293 Cells

IL-18BP Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00491

Species: Cynomolgus

Expression System: HEK293 Cells

IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00082

Species: Human

Expression System: HEK293 Cells

TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00249

Species: Human

Expression System: HEK293 Cells

AXL Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00408

Species: Human

Expression System: HEK293 Cells

IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Cat.No: TMPK-00492

Species: Cynomolgus

Expression System: HEK293 Cells

CD36 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00292

Species: Human

Expression System: HEK293 Cells

GOLPH2/GOLM1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02193

Species: Human

Expression System: HEK293 Cells

GAD67 Protein, Human, Recombinant (His)

Cat.No: TMPY-02091

Species: Human

Expression System: Baculovirus Insect Cells

AOC3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00379

Species: Human

Expression System: HEK293 Cells

MIA Protein, Human, Recombinant (His)

Cat.No: TMPJ-01137

Species: Human

Expression System: E. coli

Kallikrein 8/KLK8 Protein, Human, Recombinant (His)

Cat.No: TMPY-01992

Species: Human

Expression System: HEK293 Cells

SMAC Protein, Human, Recombinant (His)

Cat.No: TMPY-00924

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。
T71401	Oxaliplatin-d10
	Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2....

同位素标记化合物

Cat.No: TMIH-0413

Oxaliplatin-d10

Cat.No: T71401

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