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Anti-AGER Monoclonal Antibody-Biotin
产品编号 TMAZ-0128B
别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor
Anti-AGER Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FACS.
Anti-AGER Monoclonal Antibody-Biotin
Anti-AGER Monoclonal Antibody-Biotin
产品编号 TMAZ-0128B 别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor
Anti-AGER Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 2,087.42¥ 3,599 | 7日内发货 | |
| 50 μg | ¥ 3,478.84¥ 5,998 | 7日内发货 | |
| 100 μg | ¥ 5,218.26¥ 8,997 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-AGER Monoclonal Antibody-Biotin is a Biotin-conjugated rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody-Biotin can be used in ELISA, FACS. |
| 别名 | Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of AGER overexpressed 297F cells with TMAZ-0128B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Secreted |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AGER protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed: 27572515, PubMed: 28515150, PubMed: 34743181). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed: 21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed: 21829704). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed: 19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed: 19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed: 27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed: 34743181). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed: 24081950, PubMed: 28515150) |
| 偶联 | Biotin |
| 其他可选修饰符 | APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | AGER |
| 抗原种属 | Human |
| 基因ID | 177 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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