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Anti-AGER Monoclonal Antibody

产品编号 TMAZ-0128
别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor

Anti-AGER Monoclonal Antibody is a rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody can be used in ELISA, FACS.

Anti-AGER Monoclonal Antibody

Anti-AGER Monoclonal Antibody

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产品编号 TMAZ-0128 别名 Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor

Anti-AGER Monoclonal Antibody is a rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody can be used in ELISA, FACS.

规格价格库存数量
25 μg¥ 1,086.92¥ 1,8747日内发货
50 μg¥ 1,303.84¥ 2,2487日内发货
100 μg¥ 1,825.26¥ 3,1477日内发货
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产品介绍

生物活性
产品描述
Anti-AGER Monoclonal Antibody is a rabbit antibody targeting AGER. Anti-AGER Monoclonal Antibody can be used in ELISA, FACS.
别名Receptor for advanced glycosylation end products, Advanced glycosylation end product-specific receptor
Ig Type
Rabbit monoclonal IgG
交叉反应
Human
验证活性
Flow cytometry analysis of AGER overexpressed 297F cells with TMAZ-0128, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line).
应用
ELISA, FACS
推荐剂量
0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Secreted
构建方式This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AGER protein.
纯化方式Protein A Affinity Purified
性状Liquid
缓冲液0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin.
纯度> 95% as determined by SDS-PAGE.
研究背景Cell surface pattern recognition receptor that senses endogenous stress signals with a broad ligand repertoire including advanced glycation end products, S100 proteins, high-mobility group box 1 protein/HMGB1, amyloid beta/APP oligomers, nucleic acids, phospholipids and glycosaminoglycans (PubMed: 27572515, PubMed: 28515150, PubMed: 34743181). Advanced glycosylation end products are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes (PubMed: 21565706). These ligands accumulate at inflammatory sites during the pathogenesis of various diseases, including diabetes, vascular complications, neurodegenerative disorders, and cancers and RAGE transduces their binding into pro-inflammatory responses. Upon ligand binding, uses TIRAP and MYD88 as adapters to transduce the signal ultimately leading to the induction or inflammatory cytokines IL6, IL8 and TNFalpha through activation of NF-kappa-B (PubMed: 21829704). Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators (PubMed: 19386136). Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons (PubMed: 19906677). ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Participates in endothelial albumin transcytosis together with HMGB1 through the RAGE/SRC/Caveolin-1 pathway, leading to endothelial hyperpermeability (PubMed: 27572515). Mediates the loading of HMGB1 in extracellular vesicles (EVs) that shuttle HMGB1 to hepatocytes by transferrin-mediated endocytosis and subsequently promote hepatocyte pyroptosis by activating the NLRP3 inflammasome (PubMed: 34743181). Promotes also extracellular hypomethylated DNA (CpG DNA) uptake by cells via the endosomal route to activate inflammatory responses (PubMed: 24081950, PubMed: 28515150)
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Biotin/APC/PE/AF488/AF555/AF647
可提供抗体种类
1
抗原信息
免疫原
AGER
抗原种属
Human
基因ID
177
Uniprot ID
研究领域
Cancer Research
化学信息
分子量150 kDa
存储&运输
储存方式For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze.
运输方式For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice.

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