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Search Results for " minimal "

Targets Recommended: Progesterone Receptor

169

抑制剂 & 化合物

12

天然产物

9

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7537	Norgestimate 炔诺肟酯,诺孕酯	Progesterone Receptor	Others
	Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素，是一种合成的孕激素类似物。它可用作口服的避孕药。
T2324	Darunavir 地瑞那韦,达芦那韦,TMC114	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂，用于治疗艾滋病和 HIV 感染。由于单独使用时会出现抗病毒药物耐药性，因此与其他抗 HIV 药物联合使用。
T5500	DORA-22	OX Receptor	GPCR/G Protein; Neuroscience
	DORA-22 是一种双食欲素受体拮抗剂，可改善轻度压力引起的失眠，对记忆的影响很小。
T6187	TDZD-8 GSK-3β Inhibitor I,NP 01139	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	TDZD-8 (NP 01139) 是抑制GSK-3β的抑制剂，其 IC50=2 μM。它对 Cdk-1/cyclin B，CK-II，PKA 和 PKC 的作用较弱，IC50值均 >100 μM。
T13721	Homo-PROTAC cereblon degrader 1	Others; PROTACs	Others; PROTAC
	Homo-PROTAC cereblon degrader 1 (compound 15a) 是一种高效 cereblon 降解剂，对 IKZF1 和 IKZF3 的影响很小。
T61518	TAK-653	iGluR	Membrane transporter/Ion channel; Neuroscience
	TAK-653是一种选择性AMPA受体正向异构调节剂(PAM)，表现出极低的激动剂活性，在大鼠模型中引发类抗抑郁反应，同时保持良好的安全性。
T11211	EP4 receptor antagonist 1	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	EP4 receptor antagonist 1 是一种有效的特异性前列腺素 EP4受体拮抗剂，对人和小鼠 EP4受体的 IC50分别为6.1 nM 和16.2 nM。 EP4 receptor antagonist 1 可用于癌症免疫治疗的研究。
T6029	ONX-0914 ONX0914,PR-957,ONX 0914	Proteasome; HIV Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome; Ubiquitination
	ONX-0914 (PR-957) 是选择性的低分子量多肽-7(LMP7)的抑制剂，LMP7 是免疫蛋白酶体的类糜蛋白酶亚单位。它是分枝杆菌蛋白酶体的非竞争性不可逆抑制剂，Ki 值为5.2 μM。它通过 HSF-1 介导的 p-TEFb 活化激活潜伏的 HIV-1。
T73040	CYP1B1-IN-4	P450	Metabolism
	CYP1B1-IN-4为选择性CYP1B1抑制剂（IC50=0.2 nM），属2,4-二芳基噻唑类化合物。其对细胞的毒性低，且在人类及大鼠肝微粒体中表现出稳定性。
TP1760L	AMARA peptide acetate(163560-19-8 free base)	Others	Others
	AMARA peptide acetate(163560-19-8 free base) 是 SIK 和 AMPK 的底物。AMARA 肽是蛋白激酶家族几个成员的底物。它由 AMP 激活的蛋白激酶 (AMPK) 的磷酸化位点组成。
T4664	ML 297 ML297	Potassium Channel	Membrane transporter/Ion channel
	ML 297 是选择性的 GIRK1/2激活剂，EC50为 0.16 μM。ML 297 在癫痫病的研究中具有价值。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T9698	UC2288	Mdm2; p53	Apoptosis
	UC2288 是新型的、细胞通透性、口服有效的p21衰减试剂，基于索拉非尼的结构合成。在不依赖于p53的情况下，它可以下调 p21 mRNA 的表达，降低 p21 蛋白水平，对 p21 蛋白的稳定性影响很小。它对VEGFR2 和 Raf 激酶没有抑制作用，即使在 10 μM。
T13102	TCMDC-135051	Others	Others
	TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂，具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变，破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。
T2534	Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104	Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。
T17197	UCL 2077	Others	Others
	UCL 2077 是癫痫相关 KCNQ 通道的亚型选择性阻滞剂，也是一种选择性慢后超极化通道阻滞剂，在培养的海马神经元中 IC50 为 500 nM，对 Ca2+ 通道、动作电位、输入电阻的影响小，以及超极化后的介质。
T15576	Indibulin 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Indibulin (D 24851) 是一种口服有效的微管蛋白合成抑制剂，具有抗有丝分裂和抗肿瘤活性，且神经毒性小。它降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。
T15410	GNF351	Aryl Hydrocarbon Receptor	Immunology/Inflammation
	GNF351 是芳烃受体 (AhR) 的完全拮抗剂，具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争，IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。
T32039	HADA Hydrochloride HCC-Amino-D-alanine hydrochloride,HADA HCl	Autophagy	Autophagy
	HADA Hydrochloride (HCC-Amino-D-alanine hydrochloride) 是一种具有蓝色荧光的D 氨基酸 (λem~450 nm)。FDAAs 在肽聚糖 (PG) 合成位点有效地与多种细菌的 PGs 结合。HADA Hydrochloride 而用于在最小干扰下特异性和共价探测细菌的生长。
T21537L	TMC647055 Choline Hydroxide Salt TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂，可用于治疗 HCV 感染。它具有纳摩尔级细胞效力（EC(50) 为 82 nM），相关细胞毒性较小（CC(50)>20 μM），在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
T1483	Citalopram hydrobromide Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr	5-HT Receptor; Serotonin Transporter; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂，可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取，从而增强中枢神经系统中的 5-羟色胺能活性，也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取，IC50为 14 nM。
T28377	PF-06827443 PF6827443,PF 6827443,PF-6827443	Others	Others
	PF-06827443 is a orally bioavailable, CNS-penetrant M1-selective PAM with minimal agonist activity.
T24206	JNJ-28330835 JNJ 28330835,JNJ28330835	Others	Others
	JNJ-28330835 is a selective androgen receptor modulator with minimal prostate hypertrophic activity.
T29175	YKAs3003 YKAs-3003	Others	Others
	YKAs3003, a potent inhibitor of pathogenic KAS III, displays minimal inhibitory concentration (MIC) values in the range 128-256 microg/mL against various bacteria.
T39502	Lipid 5	Others	Others
	Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.
T26395	6-Benzylthioinosine 6-BT,6Benzylthioinosine,6-Bn-thioinosine	Others	Others
	6-Benzylthioinosine, a broad-spectrum metabolic inhibitor, inhibits glucose uptake, decreases glycolysis and ATP concentration with minimal changes in ROS and mitochondrial respiration.
T29209	ZD4190 HCl ZD-4190,ZD-4190 HCl,ZD 4190,ZD4190,ZD-4190 hydrochloride	Others	Others
	ZD-4190, a potent VEGFR inhibitor, prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues.
T38226	TSHR antagonist S37b	Others	Others
	TSHR antagonist S37b, the less potent enantiomer of TSHR antagonist S37a, exhibits minimal efficacy in inhibiting the thyrotropin receptor (TSHR). It is utilized in thyroid function research[1].
T11912	LY3154207	Others	Others
	LY3154207 is a subtype selective, potent, and orally available human dopamine D1 receptor positive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM).
T40658	[D-Asn5]-Oxytocin [D-Asn5]-Oxytocin
	[D-Asn5]-Oxytocin exhibits minimal specific oxytocic and vasodepressor effects. Comparative cumulative dose-response investigations reveal that [D-Asn5]-Oxytocin demonstrates a similar intrinsic activity to oxytocin in terms of oxytocic activity.
T11716	JH-LPH-33	Others	Others
	JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. It exhibits remarkable antibiotic activity, reflected by a minimal inhibitory concentration (MIC) value of 0.66 μg/mL.
T28852	SRI-31040 SRI 31040	Others	Others
	SRI-31040 is a potent DAT allosteric modulator. It partially inhibits DAT uptake without altering DAT-mediated reverse transport and with minimal inhibition of DAT binding.
T38870	Antibacterial agent 45	Others	Others
	Antibacterial Agent 45 (AA45) exemplifies a potent antibacterial compound that effectively reduces the minimal inhibitory concentration (MIC) value of Ceftazidime, another antibacterial agent.
T61425	Tyrosinase-IN-5	Others	Others
	Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1].
T62588	TCMDC-136230	Others	Others
	TCMDC-136230 是一种疟原虫钙动力学的新型抑制剂，但对血红素结晶的抑制作用较小。
T84574	Prostaglandin F2α 1,9-lactone PGF2α 1,9-lactone	Others	Others
	Prostaglandin F2α (PGF2α) 1,9-lactone, a lipid-soluble internal ester of PGF2α, demonstrates resistance to hydrolysis by human plasma esterases, maintaining its structure even after 20 hours of incubation under physiological conditions. Unlike PGF2α, this compound exhibits minimal antifertility and vasoactivity.
T70760	NVP018	Others	Others
	NVP018, also known as BC 556, is a potent inhibitor of hepatitis B virus, hepatitis C virus (HCV), and HIV-1 replication, shows minimal inhibition of major drug transporters, and has a high barrier to generation of both HCV and HIV-1 resistance..
T73127	C16-K-cBB1	Others	Others
	C16-K-cBB1 是一种对 MRSA(甲氧西林耐药金黄色葡萄球菌)有效且选择性的抗菌剂，其 MIC 为 1 μg/mL。C16-K-cBB1 具有很好的选择性，由于其溶血活性较弱。在 12.5 μg/mL 浓度下，C16-K-cBB1 能够在 120 分钟内杀死 MRSA 细胞。
T61773	Keap1-Nrf2-IN-4	Others	Others
	Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1].
TP1760	AMARA peptide
	AMARA peptide is a substrate for SIK and AMPK.AMARA peptide is a minimal substrate of several members of the protein kinases family. It consists of the phosphorylation site for AMP-activated Protein Kinase (AMPK).
T38831	Endoplasmic reticulum dye 1
	Endoplasmic reticulum dye 1 is a highly effective live cell imaging agent used for detecting exocytotic events occurring at the plasma membrane. This compound exhibits minimal cytotoxicity and is resistant to photobleaching, making it an ideal choice for visualizing both short and long-term processes.
T84756	C14-4 C14-494	Others	Others
	C14-4为一种高转染效率、低细胞毒性的可电离脂质，主要用于合成脂质纳米颗粒。
T83006	Antitumor agent-29	Others	Others
	Antitumor agent-29为新型肝细胞靶向抗肿瘤前体，表现出优异抗肿瘤活性及低毒性副作用。
T62440	TCMDC-125431	Others	Others
	TCMDC-125431 是一种新型的疟原虫钙动力学抑制剂，而对血红素结晶的抑制作用较低。
T68356	AM-3189	Others	Others
	AM-3189 is a potent and selective GPR40 Agonist with minimal CNS penetration, superior pharmacokinetic properties and in vivo efficacy comparable to AMG 837. AM-3189 maintains the in vivo efficacy of AMG 837 while displaying a superior pharmacokinetic profile and minimal CNS exposure. Similar to AMG 837, while highly potent on GPR40, AM-3189 was highly selective over the closely related GPCRs, GPR41 and GPR43. 13kdemonstrated low clearance, moderate volume of distribution, and good oral bioavai...
T36178	Aspalatone	Others	Others
	Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.
T39259	Arzoxifene LY353381,Arzoxifene,SERMIII	Others	Others
	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer and endometrium while displaying minimal side effects. Additionally, Arzoxifene elicits favorable estrogenic effects on bone health and lipid profile.
T84460	Pentadecanoyl ethanolamide	Others	Others
	Pentadecanoyl ethanolamide，一种N-acylethanolamine的内源性脂质酰胺衍生物，对电击休克的小鼠展现出抗惊厥效果，同时无明显毒性。
T80444	Phlo1b μ-TrTx-Phlo1b	Sodium Channel	Membrane transporter/Ion channel
	Phlo1b（μ-TrTx-Phlo1b）为含35个氨基酸残基的肽毒素，特异性抑制Nav1.7通道。相较之下，其对Nav1.2与Nav1.5的抑制作用较弱。
T83025	Antiparasitic agent-19	Others	Others
	Antiparasitic agent-19 (compound 40) 是一种化合物，具备广泛的抗寄生虫活性，且对布氏锥虫、婴儿利什曼原虫和克氏锥虫具有较低的毒性。

化合物

Cat.No: T7537

Synonym: 炔诺肟酯,诺孕酯

Target: Progesterone Receptor

Cat.No: T2324

Synonym: 地瑞那韦,达芦那韦,TMC114

Target: HIV Protease

Cat.No: T5500

Target: OX Receptor

Cat.No: T6187

Synonym: GSK-3β Inhibitor I,NP 01139

Target: GSK-3

Homo-PROTAC cereblon degrader 1

Cat.No: T13721

Target: Others, PROTACs

Cat.No: T61518

Target: iGluR

EP4 receptor antagonist 1

Cat.No: T11211

Target: Prostaglandin Receptor

Cat.No: T6029

Synonym: ONX0914,PR-957,ONX 0914

Target: Proteasome, HIV Protease, Antibacterial

Cat.No: T73040

Target: P450

AMARA peptide acetate(163560-19-8 free base)

Cat.No: TP1760L

Target: Others

Cat.No: T4664

Synonym: ML297

Target: Potassium Channel

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T9698

Target: Mdm2, p53

Cat.No: T13102

Target: Others

Pitavastatin calcium

Cat.No: T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Cat.No: T17197

Target: Others

Cat.No: T15576

Synonym: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851

Target: Apoptosis, Microtubule Associated

Cat.No: T15410

Target: Aryl Hydrocarbon Receptor

HADA Hydrochloride

Cat.No: T32039

Synonym: HCC-Amino-D-alanine hydrochloride,HADA HCl

Target: Autophagy

TMC647055 Choline Hydroxide Salt

Cat.No: T21537L

Synonym: TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

Target: HCV Protease

Citalopram hydrobromide

Cat.No: T1483

Synonym: Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr

Target: 5-HT Receptor, Serotonin Transporter, Autophagy

Cat.No: T28377

Synonym: PF6827443,PF 6827443,PF-6827443

Target: Others

Cat.No: T24206

Synonym: JNJ 28330835,JNJ28330835

Target: Others

Cat.No: T29175

Synonym: YKAs-3003

Target: Others

Cat.No: T39502

Target: Others

6-Benzylthioinosine

Cat.No: T26395

Synonym: 6-BT,6Benzylthioinosine,6-Bn-thioinosine

Target: Others

Cat.No: T29209

Synonym: ZD-4190,ZD-4190 HCl,ZD 4190,ZD4190,ZD-4190 hydrochloride

Target: Others

TSHR antagonist S37b

Cat.No: T38226

Target: Others

Cat.No: T11912

Target: Others

[D-Asn5]-Oxytocin

Cat.No: T40658

Synonym: [D-Asn5]-Oxytocin

Cat.No: T11716

Target: Others

Cat.No: T28852

Synonym: SRI 31040

Target: Others

Antibacterial agent 45

Cat.No: T38870

Target: Others

Tyrosinase-IN-5

Cat.No: T61425

Target: Others

Cat.No: T62588

Target: Others

Prostaglandin F2α 1,9-lactone

Cat.No: T84574

Synonym: PGF2α 1,9-lactone

Target: Others

Cat.No: T70760

Target: Others

Cat.No: T73127

Target: Others

Keap1-Nrf2-IN-4

Cat.No: T61773

Target: Others

Cat.No: TP1760

Endoplasmic reticulum dye 1

Cat.No: T38831

Cat.No: T84756

Synonym: C14-494

Target: Others

Antitumor agent-29

Cat.No: T83006

Target: Others

Cat.No: T62440

Target: Others

Cat.No: T68356

Target: Others

Cat.No: T36178

Target: Others

Cat.No: T39259

Synonym: LY353381,Arzoxifene,SERMIII

Target: Others

Pentadecanoyl ethanolamide

Cat.No: T84460

Target: Others

Cat.No: T80444

Synonym: μ-TrTx-Phlo1b

Target: Sodium Channel

Antiparasitic agent-19

Cat.No: T83025

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2S0265	Robinin NSC 9222,刺槐素	TLR	Immunology/Inflammation
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
T6194	Fidaxomicin 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂，具有窄谱活性。它选择性地根除致病性艰难梭菌，对构成正常健康肠道菌群的多种细菌影响很小。
TN4634	Neocyclomorusin	Antifection	Microbiology/Virology
	Neocyclomorusin displays minimal inhibitory concentration (MIC) value of 4 ug/mL against Klebsiella pneumoniae ATCC11296, Enterobacter cloacae BM47.
TN4788	Pierreione B	mTOR	PI3K/Akt/mTOR signaling
	Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cytotoxicity.
TN1852	Lancifodilactone F 披针叶五味子二内酯 F	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.
TN3450	Artanin	Antifection	Microbiology/Virology
	Artanin displays promising inhibition against both MSSA and MRSA with minimal inhibitory concentrations (MICs) of 8-64 ug/ml, but very weak against Gram-negative pathogen and yeast with MICs of 256 to ≥1024 ug/ml.
T75570	Justicidin C	Others	Others
	Justicidin C 是一种抗病毒木脂素，对水泡性口炎病毒展现了较强的抗病毒活性，同时在兔肺细胞(RL-33)中显示较低的细胞毒性。
T36990	Moenomycin Complex	Others	Others
	Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases. [1] The minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.[1]
T81769	Mollicellin I
	Mollicellin I（compound 1）为一种Depsidone类化合物。其对Bre04人乳腺癌细胞系、Lu04人肺癌细胞系以及N04人神经瘤细胞系的生长抑制活性低，GI50s均超过10 μg/mL。
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln	Others	Others
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。
TN3080	5,6,7-Trimethoxycoumarin	P450; Antifection	Metabolism; Microbiology/Virology
	5,6,7-Trimethoxycoumarin shows moderate inhibitory activity against Micrococcus luteus, it also displays an intermediate cytotoxic effects against brine shrimp larvae. 5,6,7-Trimethoxycoumarin can improve gastroprotective effects, and it has low toxicity
TN6674	Cyclo-(Pro-Gly) Cyclo(Pro-Gly)
	Cyclo(Pro-Gly) is an active metabolite of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111), it shows a greater resistance to an enzymatic effect than natural neuropeptides. Cyclo-(Gly-Pro) shows cytotoxicity at the concentration of 10 umol/L, it inhibit

天然产物

Cat.No: T2S0265

Synonym: NSC 9222,刺槐素

Target: TLR

Cat.No: T6194

Synonym: 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic

Neocyclomorusin

Cat.No: TN4634

Target: Antifection

Cat.No: TN4788

Target: mTOR

Lancifodilactone F

Cat.No: TN1852

Synonym: 披针叶五味子二内酯 F

Target: HIV Protease

Cat.No: TN3450

Target: Antifection

Cat.No: T75570

Target: Others

Moenomycin Complex

Cat.No: T36990

Target: Others

Cat.No: T81769

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

Target: Others

5,6,7-Trimethoxycoumarin

Cat.No: TN3080

Target: P450, Antifection

Cyclo-(Pro-Gly)

Cat.No: TN6674

Synonym: Cyclo(Pro-Gly)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02481	ACOX1 Protein, Human, Recombinant (His) PALMCOX,ACOX,SCOX,acyl-CoA oxidase 1, palmitoyl	Human	Baculovirus Insect Cells
	Peroxisomal acyl-coenzyme A oxidase 1(ACOX1 or AOX) is the first enzyme of the fatty acid beta-oxidation pathway and belongs to the Acyl-CoA oxidase family. Human liver peroxisomes contain two acyl-CoA oxidases, namely, palmitoyl-CoA oxidase (ACOX1/AOX) and a branched chain acyl-CoA oxidase. The palmitoyl-CoA oxidase (ACOX1/AOX) oxidizes the CoA esters of straight chain fatty acids and prostaglandins and donates electrons directly to molecular oxygen, thereby producing H2O2. Human ACOX1/AOX is a...
TMPY-05176	AMH Protein, Human, Recombinant (His) MIS,anti-Mullerian hormone,MIF	Human	HEK293 Cells
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and thi...
TMPY-06416	SARS-CoV-2 NSP8 Protein	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is...
TMPY-05749	SARS-CoV-2 NSP8 Protein (Avi)	SARS-CoV-2	E. coli
	NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num...
TMPJ-01251	POMGNT1 Protein, Human, Recombinant (His) 2-N-Acetylglucosaminyltransferase 1,UDP-GlcNAc:α-D-Mannoside...	Human	HEK293 Cells
	Protein O-Linked-Mannose β-1 2-N-Acetylglucosaminyltransferase 1 (POMGNT1) belongs to the Glycosyltransferase 13 family. Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. It is suggested that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form. Defects in POMGNT1 are the cause of muscular dystr...
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His) AKR1C2,HBAB,SRXY8,AKR1C-pseudo,aldo-keto reductase family 1,...	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. AKR1C2 gene shares high sequence identity with three other gene ...
TMPY-03338	GSTZ1 Protein, Human, Recombinant (His) MAI,GSTZ1-1,glutathione S-transferase ζ 1,MAAI,GSTZ1,glutath...	Human	E. coli
	GSTZ1 (Glutathione S-Transferase Zeta 1) is a Protein Coding gene. 3 alternatively spliced human isoforms have been reported. GSTZ1 gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. GSTZ1 is a bifunctional protein that has minimal glutathione-conjugating activity with ethacrynic acid ...
TMPY-02795	Eotaxin-2 Protein, Human, Recombinant (His) MPIF-2,chemokine (C-C motif) ligand 24,SCYA24,MPIF2,Ckb-6	Human	Baculovirus Insect Cells
	CCL24, also known as Eotaxin-2 and MPIF-2, belongs to the intercrine beta (chemokine CC) family. CCL24 gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. CCL24 displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. CCL24 is als...
TMPY-02810	Ninjurin-1 Protein, Rat, Recombinant (hFc) ninjurin 1	Rat	HEK293 Cells
	Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in some other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified...

重组蛋白

ACOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02481

Species: Human

Expression System: Baculovirus Insect Cells

AMH Protein, Human, Recombinant (His)

Cat.No: TMPY-05176

Species: Human

Expression System: HEK293 Cells

SARS-CoV-2 NSP8 Protein

Cat.No: TMPY-06416

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 NSP8 Protein (Avi)

Cat.No: TMPY-05749

Species: SARS-CoV-2

Expression System: E. coli

POMGNT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01251

Species: Human

Expression System: HEK293 Cells

AKR1C2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03497

Species: Human

Expression System: E. coli

GSTZ1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03338

Species: Human

Expression System: E. coli

Eotaxin-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02795

Species: Human

Expression System: Baculovirus Insect Cells

Ninjurin-1 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02810

Species: Rat

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

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