(e/z)-gsk5182

(E Z)-GSK5182 (GSK5182(Z E)) 是 (E)-GSK5182 和 (Z)-GSK5182 的外消旋体。GSK5182 是一种具有高效选择性和口服活性的ERRγ的反向激动剂，其IC50值为 79 nM。GSK5182 还诱导肝癌细胞中活性氧 (ROS)的产生。

(E Z)-Squalen 调节细胞内活性氧化物质 (ROS) 的产生，并呈浓度和时间依赖性引起细胞凋亡和坏死 。(E Z)-Squalene ((E Z)-AddaVax) 在肝脏中积累并降低肝脏胆固醇和甘油三酯。

(E Z)-Polydatin (Polydatin) 是从虎杖的根和根茎中分离得到的一种单晶化合物。它具有抗血小板聚集、心脏保护作用、抗低密度脂蛋白 (LDL) 氧化作用、抗炎和免疫调节功能。

Geranylacetone(Z E) (Dihydropseudoionone) 是一种天然存在的化合物，存在于许多植物的精油中，包括迷迭香、薰衣草和茉莉花。它具有抗氧化、抗炎和抗微生物的特性。

GW406108X(Z/E) 是不同配置的 GW406108X 的混合物，它是 Kinesin-12 和 ULK1 的抑制剂。

(E Z)-Sivopixant ((E Z)-S-600918) 是一种有效的 P2X3 受体拮抗剂(IC50 为 4 nM)。(E Z)-Sivopixant 可用于呼吸系统疾病研究。

(E/Z)-Necrosulfonamide 是一种新型的 MLKL 抑制剂。

(E Z)-4-Hydroxytamoxifen (Afimoxifene) 是一种新的雌激素抑制剂，多用于多种雌激素依赖性疾病的研究，包括周期性乳房疼痛和男性乳房发育症。

(E Z)-BCI (NSC-150117) 是一种DUSP6抑制剂，可通过激活 Nrf2 信号和抑制 NF-κB 通路，减弱 LPS 诱导的巨噬细胞炎症和 ROS 生成，具有抗炎活性。

(E Z)-ZINC09659342 是 Lbc-RhoA 相互作用的抑制剂。

BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM)，也抑制 ERK5 催化活性 (IC50: 810 nM)，并且不抑制密切相关的激酶 MEK1 2、JNK2 和 ERK2。

(E Z)-Teriflunomide (Aubagio) 是一种可口服的嘧啶合成抑制剂，用于治疗复发性多发性硬化症。

ON-01910 是一种非 ATP 竞争性 PLK1 抑制剂（IC50 为 9 nM，在无细胞试验中）。它对 Plk2 的选择性高出 30 倍，对 Plk3 没有活性。 Rigosertib 抑制 PI3K Akt 通路并激活氧化应激信号。 Rigosertib 可诱导多种癌细胞凋亡。它是一种合成的苄基苯乙烯基砜类似物，具有潜在的抗肿瘤活性。

(E/Z)-GO289 是一种选择性酪蛋白激酶 2 抑制剂，IC50值为 7 nM。它可显着延长昼夜节律周期，表现出与细胞时钟功能相关的癌细胞生长的细胞类型依赖性抑制。

THZ1 2HCl (THZ1 Dihydrochloride) 是一种选择性、共价和变构的 CDK7 抑制剂，IC50 为 3.2 nM。 THZ1 2HCl 对多种癌细胞系具有抗增殖作用。

(E Z)-IT-603 是一种c-Rel 抑制剂，其IC50=3 μM。它是 E-IT-603 和 Z-IT-603的混合物。它具有抗癌作用。它有望作为调节剂调节移植物抗宿主病和恶性病中的 T 细胞反应。

(E Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。它是一种糖原合成酶激酶 3β (GSK-3β)的抑制剂，可其对 GSK-3β 的 IC50=4.9 nM，用于糖尿病的研究。

(E Z)-TG003 是一种有效的 ATP 竞争性 Cdc2 样激酶 (Clk) 抑制剂，抑制 Clk1 和 Clk4 的 IC50值分别为 20 和 15 nM。它是 (Z)-TG003 和 (E)-TG003的消旋体。

(Z,E)-7,11-Hexadecadienyl acetate ((7Z,11E)-Gossyplure; (Z7,E11-16:Ac)) 作为一种合成雌性性信息素，对于粉斑螟蛾 (Cadra cautella)、棉红铃虫 (Pectinophoragossypiella) 和甜菜夜蛾 (Spodoptera exigua) 显示出显著的引诱效果。

(E,Z)-3,13-Octadecadienyl acetate (E3,Z13-18:Ac) 能够吸引雄性小桃树螟虫 (Lesser Peachtree Borer)，这种昆虫性信息素可以从雌性小桃树螟虫体内提取。

(Z,E)-9,12-Tetradecadienol 是用于增强雄性粉斑螟 (Ephestia cautella) 引诱剂的合成物质。

10(E),12(Z)-Conjugated linoleic acid methyl ester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254]

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-5(Z)-E is a structural analog of 14,15-epoxyeicosatrienoic acids (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. Relaxation of U46619-constricted bovine arteries by 14,15-EET could be inhibited approximately 80% by 14,15-EE-5(Z)-E at a concentration of 10 μM. 14,15-EE-5(Z)-E does not appear to antagonize nitric oxide- or iloprost-mediated vascular relaxation.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration inob/obmice. It also increases body weight gain and body fat in weanling mice.4[Matreya, LLC. Catalog No. 1278] 1.Shultz, T.D., Chew, B.P., Seaman, W.R., et al.Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cellsCancer Lett.63(2)125-133(1992) 2.Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al.Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARαJ. Lipid Res.40(8)1426-1433(1999) 3.Moloney, F., Toomey, S., Noone, E., et al.Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissueDiabetes56(3)574-582(2007) 4.Pariza, M.W., Park, Y., and Cook, M.E.The biologically active isomers of conjugated linoleic acidProg. Lipid Res.40(4)283-298(2001)

(E/Z)-10-Hydroxy-2-decenoic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124254，CAS号为 765-01-5。

9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity and hepatotoxicity.

(E Z)-SIB-1893 (SIB 1893)是 (E)-SIB-1893 和 (Z)-SIB-1893 的消旋体。(E)-SIB-1893 是一种选择性的、非竞争性的 mGluR5 拮抗剂，具有抗惊厥活性 。

(Z,E)-9,12-Tetradecadienal (Z9,E12-14:Ald) 作为一种雌性信息素，能诱发雄性触角的电击反应，可从印度谷螟 (Plodia interpunctella (lepidoptera:pyralidae)) 的性腺素提取物中分离提取。

3-O-(2'E ,4'Z-decadienoyl)-20-deoxyingenol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124424。

8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland microsomes (IC50= 31 μM).4 1.Crombie, L., and Holloway, S.J.The biosynthesis of calendic acid, octadeca-(8E,10E, 12Z)-trienoic, acid, by developing marigold seeds: origins of (E,E,Z) and (Z,E,Z) conjugated triene acids in higher plantsJ. Chem. Soc. Perk. T. 12425-2434(1985) 2.Yasui, Y., Hosokawa, M., Kohno, H., et al.Growth inhibition and apoptosis induction by all-trans-conjugated linolenic acids on human colon cancer cellsAnticancer Res.26(3A)1855-1860(2006) 3.Shinohara, N., Ito, J., Tsuduki, T., et al.Jacaric acid, a linolenic acid isomer with a conjugated triene system, reduces stearoyl-CoA desaturase expression in liver of miceJ. Oleo Sci.61(8)433-441(2012) 4.Nugteren, D.H., and Christ-Hazelhof, E.Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesisProstaglandins33(3)403-417(1987)

(E Z)-AG490 ((E Z)-Tyrphostin AG490) 是异构体 (E)-AG490 和 (Z)-AG490 的外消旋体。(E)-AG490 是一种可抑制EGFR，Stat-3和JAK2 3的酪氨酸激酶抑制剂。

Docosapentaenoic acid (DPA) is a ω-3 fatty acid found in fish oils. 17-oxo-7(Z),10(Z),13(Z),15(E),19(Z)-docosapentaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DPA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

(E Z)-E64FC26 is a mixture complex comprising E-E64FC26 and Z-E64FC26. E-E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50 values of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. Furthermore, E64FC26 demonstrates anti-myeloma activity.

3-O-(2'E,4'Z-Decadienoyl)ingenol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124104。

(E Z)-Elafibranor ((E Z)-GFT505) 是一种 PPARα δ 激动剂，EC50 分别为 45 和 175 nM。

(E,Z)-4,7-Tridecadienyl acetate 为从马铃薯蛾 (Phthorimaea opercucella) 中提取的性信息素。

(Z,E)-10,12-Hexadecadienal 是Conogethes pluto所产生的信息素，它能有效地用作诱导剂。

(E Z)-OSM-SMI-10B，作为OSM-SMI-10的一个衍生物， 当与OSM (Oncostatin M) 共同孵育时，能有效减少OSM引起的癌细胞中STAT3的磷酸化水平。

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

Methyl mycophenolate can be used to synthesize mycophenolic acid β-D-glucuronide and phenolic glycosides. (E/Z)-Methyl mycophenolate is a racemic compound of (Z)-Methyl mycophenolate and (E)-Methyl mycophenolate isomers. Methyl mycophenolate is a methyl e

(E/Z)-BIO-acetoxime 是有效的，选择性的GSK-3α/β 抑制剂。对于GSK-3α/β，CDK5/p25，CDK2/cyclin A 和CDK1/cyclin B 的IC50分别为10nM，2.4μM, 4.3μM, 63μM。

(E Z)-Zotiraciclib ((E Z)-TG02) 是一种 CDK2、JAK2和FLT3的抑制剂，IC50分别为 13、73 和 56 nM。

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator agonist activity in bovine coronary arteries similar to that of 14(15)-EET.

(±)14(15)-EE-8(Z)-E is a potent vasodilator in bovine coronary arteries. The synthesis of this analog involves the formation of the epoxide at the 14,15-double bond, however, epoxidation can also occur at the 8,9-double bond. (±)8(9)-EE-14(Z)-E is a minor product from the synthesis of (±)14(15)-EE-8(Z)-E. This compound has not been reported in the literature, and its biological activity is not known. It may serve as a tool to verify that the parent compound, (±)14(15)-EE-8(Z)-E, is pure and does not contain the 8,9-epoxy regioisomer.

(E)-Cinnamyl-(Z)-p-coumarate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5923，CAS号为 391682-51-2。