Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

BCL-XL:0.5-0.6 μM (Ki), BCL2:0.2-0.3 mM (Ki)

Gossypol，一种已知的源自棉属植物的抗精子生成剂，在体外抑制黄鲈鱼精子的活力，并且当按剂量依赖的方式使用时，能够抑制精子中的乳酸脱氢酶活性[1]。此外，Gossypol 在体外对某些癌细胞系显示出了抗增殖和诱导凋亡的效果[2]。

MM(Multiple myeloma) cells are plated in 24-cell culture clusters at a density of 1x105 viable cells/l per well. Triplicate wells are treated with 1, 5, 10, 25 and 50 µmol/l gossypol acetate, and the negative control group is supplemented with 0.1% DMSO. Then, cell numbers at different treatment time points (0, 24, 48 and 72 h) are determined by using a hemocytometer and the trypan blue dye-exclusion method. The trypan blue dye-exclusion method is used to evaluate the cell viability. The cells are examined in a counting chamber under a light microscope. Only viable cells are recorded. (Only for Reference)