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Search Results for " nitric "

Targets Recommended: Others

218

抑制剂 & 化合物

161

天然产物

1

化合物库

17

重组蛋白

10

同位素标记化合物

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Cat. No.	Product Name
L5400	抗心血管疾病化合物库		1408 compounds
	1408 种心血管疾病相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

抗心血管疾病化合物库

Cat.No: L5400

Compounds: 1408

Cat. No.	Product Name	Target	Signaling Pathways
TP2195	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell	Others	Others
	Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the production of NO. Because of the invol
T79981	Nitric oxide production-IN-1	NO Synthase	Immunology/Inflammation
	Nitric oxide production-IN-1（Compound 1）是从Tupistra chinensis中提取的一种NO产生抑制剂，能够抑制脂多糖诱导的大鼠腹腔巨噬细胞NO产量。
T7474	7-Nitroindazole	NOS	Immunology/Inflammation
	7-Nitroindazole 是一种具有抗损伤及心血管作用的选择性nNOS 抑制剂，也是评价一氧化氮在中枢神经系统中生物学效应的有效工具。
T10107	3-Bromo-7-nitroindazole	NOS	Immunology/Inflammation
	3-Bromo-7-nitroindazole 是有效的、选择性的神经元型一氧化氮合酶抑制剂，对 eNOS 或诱导型一氧化氮合酶的效果相对较弱。3-Bromo-7-nitroindazole 对全身和大脑中的细胞间信使一氧化氮的合成都有影响。
T1322	Bendazol 地巴唑,Dibazol,Dibazole	Dopamine Receptor; NO Synthase	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bendazol (Dibazol) 是降压药物，能够提高 NO 合成酶在肾小球和集合小管中的活性。
T22724	Dimaprit dihydrochloride	NOS; NO Synthase; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dimaprit dihydrochloride 是组胺H2受体的一种选择性激动剂，可刺激胃酸的分泌。它还抑制nNOS，IC50值为 49 μM。
T21712	BAY 41-8543	Others; Guanylate cyclase	GPCR/G Protein; Others
	BAY 41-8543 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 刺激剂，具有抗血小板作用。它在大鼠的肺和全身血管床中具有血管舒张活性，有用于心血管疾病的研究潜力。
T15697	L-NMMA acetate Tilarginine acetate,Methylarginine acetate	NOS	Immunology/Inflammation
	L-NMMA acetate (Tilarginine acetate) 是一氧化氮合酶抑制剂, 对其所有亚型均有抑制作用，包括 NOS1，NOS2和 NOS3。与 nNOS (大鼠), eNOS (人), 和 iNOS (小鼠)结合的 Ki 值分别为0.18，0.4，6 µM。
T3491	1400W dihydrochloride 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine	NOS; NO Synthase	Immunology/Inflammation
	1400W dihydrochloride (N-(3-(Aminomethyl)benzyl)acetamidine) 是高效选择性的诱导型一氧化氮合成酶抑制剂(Ki:7 nM)。
T21507	7-Ethoxyresorufin Resorufin ethyl ether,乙氧基试卤灵	P450; NO Synthase	Immunology/Inflammation; Metabolism
	7-Ethoxyresorufin (Resorufin ethyl ether) 是细胞色素 P450 (尤其是CYP1A1) 的荧光底物和竞争性抑制剂，同时对 NO 合酶具有抑制作用。
T19853	Dimethoxycurcumin Veratrylcurcuminoid,二甲氧基姜黄素	Others	Others
	Dimethoxycurcumin (Veratrylcurcuminoid) 是 curcumin 衍生物，拥有抗氧化及抗炎作用。
T21700	NOS-IN-1 2-Imino-4-methylpiperidine (acetate)	NOS	Immunology/Inflammation
	NOS-IN-1 (2-Imino-4-methylpiperidine acetate) 是有效的、具有口服活性的一氧化氮合酶 (NOS) 的抑制剂。NOS-IN-1抑制人 iNOS (hiNOS)，hnNOS 和 heNOS 的 IC50 分别为 0.1 μM，0.2 μM 和1.1 μM。
T2334	Avanafil 阿伐那非,TA1790	PDE	Metabolism
	Avanafil (TA1790) 是一种高活性PDE-5抑制剂，IC50=5.2 nM，对PDE1，PDE6和PDE11活性较低。
T12808	S-Nitroso-N-acetyl-DL-penicillamine N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP	NO Synthase	Immunology/Inflammation
	S-Nitroso-N-acetyl-DL-penicillamine (SNAP) 是一种稳定的血小板聚集抑制剂，是一氧化氮的供体。
T1479	Isosorbide dinitrate 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate	Others; NO Synthase	Immunology/Inflammation; Others
	Isosorbide dinitrate (Isordil) 是 NO 供体，可预防心肌梗死 (MI) 引起的左室重构及心功能退化。
T7461	2,4-Diamino-6-hydroxypyrimidine DAHP,2,4-二氨基-6-羟基嘧啶	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	2,4-Diamino-6-hydroxypyrimidine (DAHP) 是GTP cyclohydrolase I(蛋白从头合成中的限速酶) 的选择性抑制剂。它能够抑制NO 的产生以及阻断 Tetrahydrobiopterin (BH4) 的合成。
T7206L	2-Iminobiotin hydrobromide 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐	NOS; NO Synthase	Immunology/Inflammation
	2-Iminobiotin hydrobromide (Guanidinobiotin) 是生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，可作用于小鼠 iNOS(Ki:21.8 μM)和大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
T19916	TRIM 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑	NOS	Immunology/Inflammation
	TRIM (1-(2-Trifluoromethylphenyl)imidazole) 是一氧化氮合酶抑制剂。它在体外能够抑制小鼠小脑 nNOS (IC50:28.2 µM)，以及大鼠肺 iNOS (IC50:27.0 µM)。它拥有抗焦虑以及抗抑郁的能力。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T1102	Mifepristone C-1073,RU486,RU 38486,米非司酮	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; NO Synthase; Autophagy	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Others
	Mifepristone (C-1073) 是一种黄体酮受体和糖皮质激素受体拮抗剂，在体外实验中的 IC50值分别为 0.2 nM 和 2.6 nM。
T22419	S-Methylisothiourea sulfate (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐	NOS; NO Synthase; HSV	Immunology/Inflammation; Microbiology/Virology
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) 是一种选择性 iNOS 抑制剂，在感染性休克的啮齿动物模型中发挥有益作用。
T0006	Methylene Blue trihydrate 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶，单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药，在医疗中通常用作染料。它具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
T6888	Methylene Blue 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶，是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用，可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂，用作色素内窥镜检查中的染料。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T1244	Celiprolol hydrochloride Selecor,Selectrol,盐酸塞利洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
T0358	Aminoguanidine hydrochloride Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine	NOS; NO Synthase	Immunology/Inflammation
	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) 是二胺氧化酶抑制剂，也是一氧化氮合酶抑制剂，可用于糖尿病肾病的研究。
T6570	L-NAME hydrochloride L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride	NOS; NO Synthase	Immunology/Inflammation
	L-NAME hydrochloride (L-NAME HCl) 是NOS 抑制剂(IC50:70 μM)。
T9537	N'-Nitro-D-arginine N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸	Others	Others
	N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。
T7206	2-Iminobiotin 2-IMINOBIOTIN HYDROBROMIDE,2-亚氨基生物素,Guanidinobiotin	NOS; NO Synthase	Immunology/Inflammation
	2-Iminobiotin (Guanidinobiotin) 是一种生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，能够作用于小鼠 iNOS(Ki:21.8 μM)及大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
T31448	Diethylamine dinitric oxide adduct DEANO	Others	Others
	Diethylamine dinitric oxide adduct is a nitric oxide generator.
T19032	Nitro blue tetrazolium chloride NBT,氯化硝基四氮唑兰	NO Synthase	Immunology/Inflammation
	Nitro blue tetrazolium chloride (NBT) 是一种脱氢酶底物，能够与碱性磷酸酶底物 BCIP 一起用于 western blotting 和免疫组化染色。
T9442	4-Chloro-3-nitrobenzoic acid	Others	Others
	4-Chloro-3-nitrobenzoic acid 是一氧化氮清除剂，已被用于研究一氧化氮对心血管系统的影响，以及一氧化氮对免疫系统的影响。
T11518L	GW274150	NOS	Immunology/Inflammation
	GW274150 是一种具有口服活性，选择性和高效性的 NADPH 依赖型人一氧化氮合成酶 (iNOS) (Kd=40 nM) 和大鼠诱导型一氧化氮合酶 (iNOS) 双重抑制剂。GW274150 对人和大鼠的内皮一氧化氮合酶 (eNOS) 和神经元一氧化氮合酶 (nNOS) 活性较低。在急性肺损伤炎症模型中，GW274150 表现出保护作用。
T21546	NG,NG-dimethyl-L-Arginine dihydrochloride	NO Synthase	Immunology/Inflammation
	NG,NG-dimethyl-L-Arginine dihydrochloride 是一种内源性一氧化氮合酶抑制剂。由 L-精氨酸合成的一氧化氮 (NO) 有助于调节血压和宿主防御。
T28497	RA-839 RA 839,RA839	Nrf2	Immunology/Inflammation
	RA-839 是一种有效的小分子 Keap1 的结合剂和选择性 Nrf2 信号传导激活剂，也是 Keap1/Nrf2 相互作用的抑制剂，具有抗癌活性。RA-839 抑制诱导型一氧化氮合酶表达，抑制一氧化氮释放。
T19480	NO-prednisolone NCX-1015	IL Receptor	Immunology/Inflammation
	NO-prednisolone (NCX-1015) 是一种有效刺激体内IL-10产生的化合物，是一种释放一氧化氮(NO)的Prednisolone 衍生物。
T39020	Carboxyebselen Carboxyebselen,HOOC-Ebs	NOS	Immunology/Inflammation
	Carboxyebselen (HOOC-Ebs) 是一种内皮型一氧化氮合酶 (eNOS) 抑制剂，具有有效性和选择性。
T9826	GDC-0214	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	GDC-0214 是一种吸入式小分子 JAK1 抑制剂，可降低呼出一氧化氮 (Feno) 的分数。
T3147	Pyrrolidinedithiocarbamate ammonium PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵	NF-κB	NF-κB
	Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt) 是一种选择性的、能透过血脑屏障的NF-κB 抑制剂。
T7201	Nelociguat N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552	Guanylate cyclase	GPCR/G Protein
	Nelociguat (BAY60-4552) 是一种一氧化氮敏感的可溶性鸟苷酸环化酶刺激剂。
T31795	FK-330 LS-192510,FR-260330,FK330,FK 330	NOS	Immunology/Inflammation
	FK-330（FR-260330）是一种新型口服活性诱导型一氧化氮合酶抑制剂，具有潜在的抗癌和抗肿瘤活性，可预防大鼠肝移植缺血和再灌注损伤。
T11805	L-NIL	NOS	Immunology/Inflammation
	L-NIL 是选择性一氧化氮合成酶 (iNOS) 抑制剂，可逆转大鼠骨骼肌中烧伤诱导的糖原合酶激酶-3β激活，可延缓鳞状细胞癌肺的进程。
T25865	NG-Nitroarginine methyl ester ω-Nitroarginine methyl,L-NAME	NO Synthase	Immunology/Inflammation
	NG-Nitroarginine methyl ester (ω-Nitroarginine methyl) 是一种非选择性一氧化氮合酶抑制剂。它已在实验中用于诱发高血压。
T4381	Lificiguat 利非西呱,YC-1	Others; Guanylate cyclase; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Others
	Lificiguat (YC-1) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶激活剂和低氧诱导因子 1α 的抑制剂。
T83625	iNOS-IN-14 3-bromo-1H-indazole-7-carbonitrile	NOS	Immunology/Inflammation
	iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) 是一种有效的一氧化氮合酶(NOS)抑制剂，抑制nNOS的NADPH氧化酶活性。
T9376	Nitroarginine N'-硝基-L-精氨酸,N'-Nitro-L-arginine	NO Synthase	Immunology/Inflammation
	Nitroarginine (N'-Nitro-L-arginine) 是一氧化氮合酶的竞争性抑制剂，可选择性减少流向肿瘤细胞的血流。
TP2057L	Camstatin acetate	NO Synthase	Immunology/Inflammation
	Camstatin acetate 结合钙调蛋白并抑制神经元一氧化氮合酶。它是 PEP-19 的单一钙调蛋白结合 IQ 基序的具有功能活性的 25 个残基片段。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T21443	Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D	Others	Others
	Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。
T20684	2',7'-Dichlorofluorescein diacetate Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,双氯荧光黄乙酸乙酯,DCFDA	Others	Others
	2',7'-Dichlorofluorescein diacetate (Diacetyldichlorofluorescein) 是一种可渗透细胞的荧光探针，可用于检测一氧化氮和活性氧以及确定总体氧化应激的程度。

化合物

Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell

Cat.No: TP2195

Target: Others

Nitric oxide production-IN-1

Cat.No: T79981

Target: NO Synthase

7-Nitroindazole

Cat.No: T7474

Target: NOS

3-Bromo-7-nitroindazole

Cat.No: T10107

Target: NOS

Cat.No: T1322

Synonym: 地巴唑,Dibazol,Dibazole

Target: Dopamine Receptor, NO Synthase

Dimaprit dihydrochloride

Cat.No: T22724

Target: NOS, NO Synthase, Histamine Receptor

Cat.No: T21712

Target: Others, Guanylate cyclase

Cat.No: T15697

Synonym: Tilarginine acetate,Methylarginine acetate

Target: NOS

1400W dihydrochloride

Cat.No: T3491

Synonym: 1400W 2HCl,N-(3-(Aminomethyl)benzyl)acetamidine

Target: NOS, NO Synthase

7-Ethoxyresorufin

Cat.No: T21507

Synonym: Resorufin ethyl ether,乙氧基试卤灵

Target: P450, NO Synthase

Dimethoxycurcumin

Cat.No: T19853

Synonym: Veratrylcurcuminoid,二甲氧基姜黄素

Target: Others

Cat.No: T21700

Synonym: 2-Imino-4-methylpiperidine (acetate)

Target: NOS

Cat.No: T2334

Synonym: 阿伐那非,TA1790

Target: PDE

S-Nitroso-N-acetyl-DL-penicillamine

Cat.No: T12808

Synonym: N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸,SNAP

Target: NO Synthase

Isosorbide dinitrate

Cat.No: T1479

Synonym: 硝酸异山梨酯,Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate

Target: Others, NO Synthase

2,4-Diamino-6-hydroxypyrimidine

Cat.No: T7461

Synonym: DAHP,2,4-二氨基-6-羟基嘧啶

Target: Reactive Oxygen Species, NO Synthase

2-Iminobiotin hydrobromide

Cat.No: T7206L

Synonym: 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐

Target: NOS, NO Synthase

Cat.No: T19916

Synonym: 1-(2-Trifluoromethylphenyl)imidazole,1-(2-三氟甲基苯基)咪唑

Target: NOS

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

Cat.No: T1102

Synonym: C-1073,RU486,RU 38486,米非司酮

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, NO Synthase, Autophagy

S-Methylisothiourea sulfate

Cat.No: T22419

Synonym: (S)-Methylisothiourea sulfate,S-甲基异硫脲硫酸盐,S-甲基异硫脲半硫酸盐

Target: NOS, NO Synthase, HSV

Methylene Blue trihydrate

Cat.No: T0006

Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Cat.No: T6888

Synonym: 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

Celiprolol hydrochloride

Cat.No: T1244

Synonym: Selecor,Selectrol,盐酸塞利洛尔

Target: Adrenergic Receptor

Aminoguanidine hydrochloride

Cat.No: T0358

Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine

Target: NOS, NO Synthase

L-NAME hydrochloride

Cat.No: T6570

Synonym: L-NAME HCl,N'-硝基-L-精氨酸甲酯盐酸盐,N(G)-Nitro-L-arginine methyl ester,NG-Nitroarginine methyl ester hydrochloride

Target: NOS, NO Synthase

N'-Nitro-D-arginine

Cat.No: T9537

Synonym: N'-Nitro-D-arginine,H-D-Arg(NO2)-OH,(R)-2-Amino-5-(3-nitroguanidino)pentanoic acid,N'-硝基-D-精氨酸

Target: Others

Cat.No: T7206

Synonym: 2-IMINOBIOTIN HYDROBROMIDE,2-亚氨基生物素,Guanidinobiotin

Target: NOS, NO Synthase

Diethylamine dinitric oxide adduct

Cat.No: T31448

Synonym: DEANO

Target: Others

Nitro blue tetrazolium chloride

Cat.No: T19032

Synonym: NBT,氯化硝基四氮唑兰

Target: NO Synthase

4-Chloro-3-nitrobenzoic acid

Cat.No: T9442

Target: Others

Cat.No: T11518L

Target: NOS

NG,NG-dimethyl-L-Arginine dihydrochloride

Cat.No: T21546

Target: NO Synthase

Cat.No: T28497

Synonym: RA 839,RA839

Target: Nrf2

NO-prednisolone

Cat.No: T19480

Synonym: NCX-1015

Target: IL Receptor

Cat.No: T39020

Synonym: Carboxyebselen,HOOC-Ebs

Target: NOS

Cat.No: T9826

Target: JAK

Pyrrolidinedithiocarbamate ammonium

Cat.No: T3147

Synonym: PDTC,Pyrrolidinedithiocarbamate,吡咯烷二硫代氨基甲酸铵,APDC,1-Pyrrolidinedithiocarboxylic acid ammonium salt,Ammonium pyrrolidinedithiocarbamate,吡咯烷二硫代甲酸铵

Target: NF-κB

Cat.No: T7201

Synonym: N-[4,6-二氨基-2-[1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-B]吡啶-3-基]-5-嘧啶]-氨基甲酸甲酯,BAY60-4552

Target: Guanylate cyclase

Cat.No: T31795

Synonym: LS-192510,FR-260330,FK330,FK 330

Target: NOS

Cat.No: T11805

Target: NOS

NG-Nitroarginine methyl ester

Cat.No: T25865

Synonym: ω-Nitroarginine methyl,L-NAME

Target: NO Synthase

Cat.No: T4381

Synonym: 利非西呱,YC-1

Target: Others, Guanylate cyclase, HIF

Cat.No: T83625

Synonym: 3-bromo-1H-indazole-7-carbonitrile

Target: NOS

Cat.No: T9376

Synonym: N'-硝基-L-精氨酸,N'-Nitro-L-arginine

Target: NO Synthase

Camstatin acetate

Cat.No: TP2057L

Target: NO Synthase

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Cat.No: T21443

Synonym: Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D

Target: Others

2',7'-Dichlorofluorescein diacetate

Cat.No: T20684

Synonym: Diacetyldichlorofluorescein,Leuco-dcf diacetate,Dcfh-DA,双氯荧光黄乙酸乙酯,DCFDA

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TQ0301	Kuwanon A	NO Synthase	Immunology/Inflammation
	Kuwanon A 抑制一氧化氮的产生 (IC50: 10.5 μM)。Kuwanon A 是从桑树 (Morus alba L.) 中分离出来的黄酮衍生物。
T6S1665	Irisflorentin	Others; NO Synthase	Immunology/Inflammation; Others
	Irisflorentin 是天然存在的异黄酮，是大量存在于 Rhizoma Belamcandae 中的活性成分。它明显抑制了诱导型一氧化氮合酶的转录和翻译以及 NO 产生。
T6S2023	Harpagoside	Others; COX; NO Synthase	Immunology/Inflammation; Neuroscience; Others
	Harpagoside 是从爪钩草中分离出来的一种天然产物，可抑制COX-1和COX-2活性，并抑制 NO 的产生。
TN1058	Pelargonidin chloride	NOS; Reactive Oxygen Species; Nrf2; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Pelargonidin chloride 是一种氧化氮自由基的清除剂，具有抗氧化作用。
T7682	Asymmetric dimethylarginine	Endogenous Metabolite; NO Synthase; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Asymmetric dimethylarginine 是内源性一氧化氮合成酶抑制剂，可以作为内皮功能障碍的标志。
T2S0765	Epibetulinic acid	NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Epibetulinic acid 对细菌内毒素刺激的小鼠巨噬细胞 (RAW 264.7) 中 NO 和前列腺素 E(2) 的产生具有有效的抑制作用，IC50分别为 0.7 和 0.6 μM，具有抗炎活性。
T3847	Asperuloside Asperulosid,车叶草苷	Others; NO Synthase	Immunology/Inflammation; Others
	Asperuloside (Asperulosid) 是一种来源于蛇舌草的环烯醚萜，具有抗炎作用。它可抑制诱导型一氧化氮合酶，抑制 NF-κB 和 MAPK 信号通路。
T5838	L-Canavanine sulfate	NO Synthase; NOD	Immunology/Inflammation; NF-κB
	L-Canavanine sulfate 是一种诱导型 NO 合酶的选择性抑制剂。
T5S0285	Cistanoside A 肉苁蓉苷 A,肉苁蓉苷A	Others	Others
	Cistanoside A 是一种肉苁蓉中的苯丙素类化合物，能够抑制 NO 的聚集，但不影响诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性。它具有抗炎作用。
T4808	Agmatine sulfate Agmatine sulfate salt,硫酸胍基丁胺	Endogenous Metabolite; NO Synthase; Imidazoline Receptor	Immunology/Inflammation; Metabolism; Neuroscience
	Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统，离子通道和一氧化氮合成。
T2791	Pectolinarin 柳穿鱼叶苷,大蓟苷	Apoptosis; Others; NO Synthase; Prostaglandin Receptor; Interleukin	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Others
	Pectolinarin 抑制 IL-6和 IL-8分泌以及 PGE2和 NO 产生，可通过抑制 PI3K/Akt 途径来抑制细胞增殖和炎症反应并诱导凋亡，具有抗炎活性。
T7597	6-Biopterin L-生物喋呤,L-Biopterin	Endogenous Metabolite; NO Synthase; NOD	Immunology/Inflammation; Metabolism; NF-κB
	6-Biopterin (L-Biopterin) 是一种蝶呤衍生物，是一氧化氮合酶 (NO synthase) 辅因子。
T2980	Chondroitin sulfate Chonsurid,Chondroitin polysulfate,硫酸软骨素	MMP; Others; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism; Others; Proteases/Proteasome
	Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖，被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程，并能够减少炎性细胞因子，iNOS 和MMPs 产生。
TN2139	Regaloside B 鸦胆子苦醇,王百合苷 B	NOS; COX; NO Synthase	Immunology/Inflammation; Neuroscience
	Regaloside B 是从麝香百合中分离出来的一种苯丙烷，可抑制iNOS 和COX-2的表达，具有抗炎活性。
T2S2335	Dehydroevodiamine DHED,去氢吴茱萸碱	Others; NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB; Others
	Dehydroevodiamine (DHED) 是从吴茱萸中分离出的一种喹唑啉生物碱，可抑制 LPS 诱导的小鼠巨噬细胞中iNOS、COX-2、PGE2和NF-κB 的表达，对豚鼠心室肌细胞具有抗心律失常作用。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
T1310	2-Thiouracil Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶	Thyroid hormone receptor(THR); NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	2-Thiouracil (Deracil) 是神经型一氧化氮合酶 (nNOS) 的选择性抑制剂(Ki:20 μM)，是一种抗甲状腺化合物，可用作高度特异性的黑色素瘤探测物。
TN1373	α-Humulene Alpha-caryophyllene,ALPHA-律草烯	TNF; NOS; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	α-Humulene (Alpha-caryophyllene) 是 Tanacetum vulgareL. 精油的主要成分，显示出抗炎作用，IC50=15±2 μg/mL。它抑制 iNOS 和COX-2表达。
T5681	ETHYL CAFFEATE 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB; COX; PGE Synthase; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物，在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T5684	Ethyl 3,4-dihydroxybenzoate	Apoptosis; Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others
	Ethyl 3,4-dihydroxybenzoate 是从花生种子的种皮中发现的脯氨酰羟化酶抑制剂，是一种抗氧化剂。它是胶原蛋白合成抑制剂，具有骨骼保护作用。它通过激活 NO 合酶并产生线粒体 ROS 来保护心肌，可诱导 ESCC 细胞自噬和凋亡。
T7786	Tryptanthrin	DNA gyrase	DNA Damage/DNA Repair
	Tryptanthrin 是一种口服具有活性的细胞内Leukotriene (LT) biosynthesis 抑制剂。它能够降低大鼠胸膜炎模型中的 LTB4 水平，并抑制人全血中Leukotriene 的形成 (IC50= 10 µM)。
T3918	Ginsenoside Rb3 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3	NF-κB; COX; NO Synthase	Immunology/Inflammation; Neuroscience; NF-κB
	Ginsenoside Rb3 (Gypenoside IV) 是从三七中提取的一种天然产物。它在 293T 细胞系中抑制 TNFα 诱导的NF-κB 转录活性，IC50为 8.2 μM。它还抑制COX-2和iNOSmRNA 的诱导。
T0983	Penicillamine 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine	Antibiotic	Microbiology/Virology
	Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物，是一种螯合剂，可作用于威尔逊氏病。
T3779	Crocin II Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B	Caspase; COX; NO Synthase	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Crocin II (Crocetin gentiobiosylglucosyl ester) 是从栀子果实中分离出来的一种天然产物，具有抗氧化、抗癌和抗抑郁活性。它抑制 iNOS 和 COX-2的蛋白质和 m-RNA 的表达，还抑制NO 产生，IC50值为 31.1 μM。
T3811	Ginsenoside C-K 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K	P450; cell cycle arrest; COX; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience
	Ginsenoside C-K (Ginsenoside K) 是 Ginsenoside Rb1 的细菌代谢物，可通过抑制诱生型一氧化氮合酶和COX-2来发挥抗炎作用。它在人肝微粒体中抑制CYP2C9和CYP2A6活性，IC50分别为 32.0±3.6 和 63.6±4.2 μM。
T3805	Prim-O-glucosylcimifugin 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF; COX; JAK; NO Synthase	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。
T3S0401	Piceatannol 3'-O-glucoside 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷	Arginase; NO Synthase	Immunology/Inflammation
	Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) 是大黄的一种活性成分，通过抑制精氨酸酶活性激活内皮细胞一氧化氮合酶，抑制Arginase I 和Arginase II，IC50值分别为 11.22 和 11.06 μM。它可增加肺血氧分压，减少肺间质水肿，从而保护肺损伤。
T2758	Madecassic acid 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose	Others; TNF; COX; NO Synthase; Interleukin	Apoptosis; Immunology/Inflammation; Neuroscience; Others
	Madecassic acid (L-fucopyranose) 是分离自积雪草的一种天然产物，抑制iNOS、COX-2、TNF-α、IL-1beta 和IL-6，可通过在 RAW 264.7 巨噬细胞中下调NF-κB 激活而具有抗炎作用。
T5S0754	Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷	NF-κB; Wnt/beta-catenin; NO Synthase	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; Stem Cells
	Isoquercetin (3-Glucosylquercetin) 是天然存在的多酚，具有抗氧化，抗增殖和抗炎特性。它通过调节核因子-κB 转录调节系统调节一氧化氮合酶 2 的表达。它通过 Nrf2/ARE 抗氧化剂信号传导途径减轻乙醇诱导的肝毒性，氧化应激和炎症反应。它具有高生物利用度和低毒性，是预防糖尿病妊娠出生缺陷的有希望的候选药物。
T0670	L-Arginine hydrochloride (S)-(+)-Arginine hydrochloride,左旋精氨酸单盐酸盐,L-Arginine HCl (L-Arg),L-arginine monohydrochloride	Amino Acids and Derivatives; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine hydrochloride 为合成一氧化氮的氮供体，是血管扩张剂。
TN1102	Physalin L 酸浆苦味素L,酸浆苦味素 L	Others; NO Synthase	Immunology/Inflammation; Others
	Physalin L 抑制巨噬细胞中 LPS 诱导的 NO 生成，平均抑制率是 70.97%。它具有抗炎作用。
TN1109	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸	NOS; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) 是三萜类化合物。它能够作用于 LPS 刺激的 Raw264.7 细胞，减少NO 产生和 iNOS 表达，具有消炎作用。
TN1021	Secologanic acid	NO Synthase	Immunology/Inflammation
	Secologanic acid 是裂环烯醚萜苷的一种。
T2877	Mucic Acid Galactaric acid,Saccharolactic acid,Schleimsaure,粘液酸,D-Glucaric acid,Tetrahydroxyadipic acid	Others; Endogenous Metabolite	Metabolism; Others
	Mucic Acid (Tetrahydroxyadipic acid) 是内源性代谢产物的一种。
T5S1408	Pteryxin 北美芹素,(+)-Pteryxin	Others; AChE	Neuroscience; Others
	Pteryxin ((+)-Pteryxin) 是一种白花前胡叶中的香豆素，是一种有效的丁酰胆碱酯酶(BChE)抑制剂，IC50=12.96 μg/ml，具有抗肥胖作用。
TN2167	Rutaevin	Reactive Oxygen Species; NO Synthase	Immunology/Inflammation; Metabolism; NF-κB
	Rutaevin 从Euodia rutaecarpa 中分离。它对 Raw 264.7 巨噬细胞中 LPS 诱导的NO 产生具有抑制作用。
T7344	SDMA NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine,对称N,N-二甲基精氨酸	Endogenous Metabolite	Metabolism
	SDMA (Symmetric dimethylarginine) 是一氧化氮 (NO) 合酶的内源性抑制剂。
T40388	Methyl 5-hydroxypyridine-2-carboxylate	Others	Others
	Methyl 5-hydroxypyridine-2-carboxylate 是存在于 Mahonia fortune 茎中的一种酚酸，在体外表现出 NO 抑制活性。
T17056	Tetrahydrobiopterin Sapropterin,BH4,(Rac)-Sapropterin	NOS; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Tetrahydrobiopterin (BH4) 是芳香族氨基酸羟化酶的辅因子, 也是一氧化氮合酶 (NOS) 的必需辅因子，可用于研究如高血压、高胆固醇血症、糖尿病等内皮功能障碍。
T1391	4-Methylumbelliferone Hymecromone,4-MU,胆通	Others	Others
	4-Methylumbelliferone (Hymecromone) 是透明质酸生物合成抑制剂，显示出抗肿瘤和抗转移活性。
T5721	Dehydroevodiamine hydrochloride	AChE	Neuroscience
	Dehydroevodiamine hydrochloride 是分离自吴茱萸叶中，能够抑制 AChE。它能够调节一氧化氮的产生，具有降压和神经保护作用。
TN1546	Dactylorhin A	NO Synthase	Immunology/Inflammation
	Dactylorhin A 是一种琥珀酸衍生物酯，分离自 Gymnadenia conopsea 根茎中。它对 RAW 264.7 巨噬细胞产生 NO 有中等程度的抑制作用。
T4890	3-Nitro-L-tyrosine 3-Nitrotyrosine,3-硝基-L-酪氨酸	Endogenous Metabolite	Metabolism
	3-Nitro-L-tyrosine (3-Nitrotyrosine) 在系统自免疫原性条件下，能够作无氮自由基修饰蛋白的生物标记物。
TN1949	Moracin C 桑辛素 C,5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇	ROS; NO Synthase	Immunology/Inflammation
	Moracin C 是一种发现于Morus mesozygia、Morus alba var. multicaulis 中的天然化合物，是一种抗炎剂。Moracin C 可抑制细胞中的一氧化氮（NO）释放和LPS 激活的活性氧（ROS）。
T1716	Echinacoside	Reactive Oxygen Species; Wnt/beta-catenin	Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells
	Echinacoside 是一种从Cistanche salsa 中分离的苯乙醇类化合物，抑制Wnt/β-catenin 信号通路。它能够激活 Trk 受体及其下游信号通路而起到神经保护作用，还具有显著的抗骨质疏松作用。
T13686	Ergolide	NF-κB	NF-κB
	Ergolide, 源自Inula Britannica干燥花朵提取的倍半萜内酯，有效抑制RAW 264.7巨噬细胞中可诱导型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)的表达，其机制为失活NF-κB。
T5309	Dimethylamine hydrochloride N,N-Dimethylamine,二甲胺盐酸盐	Others	Others
	Dimethylamine hydrochloride (N,N-Dimethylamine) 大量存在于人类尿液中。
T24417	Yakuchinone A Yakuchinone-A,益智酮甲	Others	Others
	Yakuchinone A (Yakuchinone-A) 是从 Alpinia oxyphylla Miquel 中分离出来的天然产物。它在体外对前列腺素和白三烯的合成有很强的抑制作用。它抑制 cyclooxygenase-2 和诱导型一氧化氮合酶 (iNOS) 的表达。
TN1222	26-Deoxyactein 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭	NOS; CDK; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation
	23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分，能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR，CYP1A1 和 ERK 的水平升高具有抑制作用。
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天然产物

Cat.No: TQ0301

Target: NO Synthase

Cat.No: T6S1665

Target: Others, NO Synthase

Cat.No: T6S2023

Target: Others, COX, NO Synthase

Pelargonidin chloride

Cat.No: TN1058

Target: NOS, Reactive Oxygen Species, Nrf2, NO Synthase

Asymmetric dimethylarginine

Cat.No: T7682

Target: Endogenous Metabolite, NO Synthase, NOD

Epibetulinic acid

Cat.No: T2S0765

Target: NO Synthase, Prostaglandin Receptor

Cat.No: T3847

Synonym: Asperulosid,车叶草苷

Target: Others, NO Synthase

L-Canavanine sulfate

Cat.No: T5838

Target: NO Synthase, NOD

Cat.No: T5S0285

Synonym: 肉苁蓉苷 A,肉苁蓉苷A

Target: Others

Agmatine sulfate

Cat.No: T4808

Synonym: Agmatine sulfate salt,硫酸胍基丁胺

Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor

Cat.No: T2791

Synonym: 柳穿鱼叶苷,大蓟苷

Target: Apoptosis, Others, NO Synthase, Prostaglandin Receptor, Interleukin

Cat.No: T7597

Synonym: L-生物喋呤,L-Biopterin

Target: Endogenous Metabolite, NO Synthase, NOD

Chondroitin sulfate

Cat.No: T2980

Synonym: Chonsurid,Chondroitin polysulfate,硫酸软骨素

Target: MMP, Others, Endogenous Metabolite, NO Synthase

Cat.No: TN2139

Synonym: 鸦胆子苦醇,王百合苷 B

Target: NOS, COX, NO Synthase

Dehydroevodiamine

Cat.No: T2S2335

Synonym: DHED,去氢吴茱萸碱

Target: Others, NF-κB, COX, PGE Synthase, NO Synthase

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Cat.No: T1310

Synonym: Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶

Target: Thyroid hormone receptor(THR), NO Synthase

Cat.No: TN1373

Synonym: Alpha-caryophyllene,ALPHA-律草烯

Target: TNF, NOS, COX

Cat.No: T5681

Synonym: 咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Ethyl 3,4-dihydroxybenzoate

Cat.No: T5684

Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy

Cat.No: T7786

Target: DNA gyrase

Ginsenoside Rb3

Cat.No: T3918

Synonym: 人参皂苷 Rb3,Gypenoside IV,人参皂苷Rb3

Target: NF-κB, COX, NO Synthase

Cat.No: T0983

Synonym: 青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine

Target: Antibiotic

Cat.No: T3779

Synonym: Crocin 2,西红花苷II,Crocetin gentiobiosylglucosyl ester,藏红花,Tricrocin,Crocin B

Target: Caspase, COX, NO Synthase

Ginsenoside C-K

Cat.No: T3811

Synonym: 20(S)-人参皂苷 C-K,Ginsenoside compound K,Ginsenoside K,人参皂苷 C-K

Target: P450, cell cycle arrest, COX, NO Synthase

Prim-O-glucosylcimifugin

Cat.No: T3805

Synonym: 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

Piceatannol 3'-O-glucoside

Cat.No: T3S0401

Synonym: 白皮杉醇 3'-O-葡萄糖苷,Piceatannol 3-glycoside,Quzhaqigan,曲札茋苷、白皮杉醇-3'-O-葡萄糖苷

Target: Arginase, NO Synthase

Madecassic acid

Cat.No: T2758

Synonym: 6-Deoxy-L-Galactose,羟基积雪草酸,L-Fucose,Brahmic acid,L-fucopyranose

Target: Others, TNF, COX, NO Synthase, Interleukin

Cat.No: T5S0754

Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,异槲皮苷,Quercetin 3-o-glucopyranoside,槲皮素-3-葡萄糖苷

Target: NF-κB, Wnt/beta-catenin, NO Synthase

L-Arginine hydrochloride

Cat.No: T0670

Synonym: (S)-(+)-Arginine hydrochloride,左旋精氨酸单盐酸盐,L-Arginine HCl (L-Arg),L-arginine monohydrochloride

Target: Amino Acids and Derivatives, Endogenous Metabolite, NO Synthase

Cat.No: TN1102

Synonym: 酸浆苦味素L,酸浆苦味素 L

Target: Others, NO Synthase

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid

Cat.No: TN1109

Synonym: 3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid,3-O-乙酰基-16Α-羟基松苓新酸

Target: NOS, NO Synthase, Prostaglandin Receptor

Secologanic acid

Cat.No: TN1021

Target: NO Synthase

Cat.No: T2877

Synonym: Galactaric acid,Saccharolactic acid,Schleimsaure,粘液酸,D-Glucaric acid,Tetrahydroxyadipic acid

Target: Others, Endogenous Metabolite

Cat.No: T5S1408

Synonym: 北美芹素,(+)-Pteryxin

Target: Others, AChE

Cat.No: TN2167

Target: Reactive Oxygen Species, NO Synthase

Cat.No: T7344

Synonym: NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine,对称N,N-二甲基精氨酸

Target: Endogenous Metabolite

Methyl 5-hydroxypyridine-2-carboxylate

Cat.No: T40388

Target: Others

Tetrahydrobiopterin

Cat.No: T17056

Synonym: Sapropterin,BH4,(Rac)-Sapropterin

Target: NOS, Endogenous Metabolite

4-Methylumbelliferone

Cat.No: T1391

Synonym: Hymecromone,4-MU,胆通

Target: Others

Dehydroevodiamine hydrochloride

Cat.No: T5721

Target: AChE

Cat.No: TN1546

Target: NO Synthase

3-Nitro-L-tyrosine

Cat.No: T4890

Synonym: 3-Nitrotyrosine,3-硝基-L-酪氨酸

Target: Endogenous Metabolite

Cat.No: TN1949

Synonym: 桑辛素 C,5-(6-羟基-2-苯并呋喃基)-2-(3-甲基-2-丁烯基)-1,3-苯二醇

Target: ROS, NO Synthase

Cat.No: T1716

Target: Reactive Oxygen Species, Wnt/beta-catenin

Cat.No: T13686

Target: NF-κB

Dimethylamine hydrochloride

Cat.No: T5309

Synonym: N,N-Dimethylamine,二甲胺盐酸盐

Target: Others

Cat.No: T24417

Synonym: Yakuchinone-A,益智酮甲

Target: Others

Cat.No: TN1222

Synonym: 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭

Target: NOS, CDK, NO Synthase

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01052	DYNLL1 Protein, Human, Recombinant (His) DNCL1,PIN,DLC8,Protein Inhibitor of Neuronal Nitric...	Human	E. coli
	Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, and it regulate numerous biologic processes throughits effects on nitric oxide synthase activity. DYNLL1 is widely expressed, with higher expression in testis and moderate expression in brain.
TMPY-00545	Dermcidin Protein, Human, Recombinant (hFc) AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP	Human	HEK293 Cells
	Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ...
TMPY-03172	Argininosuccinate lyase Protein, Human, Recombinant (His & GST) ASAL,argininosuccinate lyase,ASL	Human	Baculovirus Insect Cells
	The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate ...
TMPH-02161	Synapsin-1 Protein, Human, Recombinant (GST) SYN1,Brain protein 4.1,Synapsin I,Synapsin-1	Human	E. coli
	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
TMPH-01733	DDAH2 Protein, Human, Recombinant (GST & His) Inactive dimethylarginine dimethylaminohydrolase 2,DDAHII,G6...	Human	E. coli
	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 61.2 kDa and the accession number is O95865.
TMPJ-01248	Cytoglobin/CYGB Protein, Human, Recombinant (His) Stellate Cell Activation-Associated Protein,Cytoglobin,CYGB,...	Human	E. coli
	Cytoglobin is a ubiquitously globin protein that belongs to the globin family. The highest expressed in heart, stomach, bladder and small intestine. CYGB acts a protector under conditions of oxidative stress. CYGB may be involved in intracellular oxygen storage or transfer, modulates oxygen and nitric oxide metabolism or scavenging free radicals within a cell.
TMPH-01732	DDAH1 Protein, Human, Recombinant (His & Myc) DDAHI,N(G),N(G)-dimethylarginine dimethylaminohydrolase 1,DD...	Human	E. coli
	Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.4 kDa and the accession number is O94760.
TMPH-02575	PDE5A Protein, Mouse, Recombinant (His & Myc) cGMP-specific 3',5'-cyclic phosphodiesterase,Pde5a,cGMP-bind...	Mouse	E. coli
	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. PDE5A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.1 kDa and the accession number is Q8CG03.
TMPH-02526	Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) Arginase II,Kidney-type arginase,Type II arginase,Arg2,Argin...	Mouse	E. coli
	May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium....
TMPH-02136	SPSB1 Protein, Human, Recombinant (His) SPSB1,SPRY domain-containing SOCS box protein 1	Human	E. coli
	Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
TMPJ-00826	TXN Protein, Human, Recombinant (His) ADF,TXN,TRX1,Thioredoxin,TRX,ATL-Derived Factor,TRDX,Surface...	Human	E. coli
	Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin exists as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contri...
TMPJ-01058	ARG2 Protein, Human, Recombinant (His) ARG2,Kidney-type arginase,Type II arginase,Arginase-2, mitoc...	Human	E. coli
	Arginase-2 (ARG2) is a member of the arginase family. Arginase is a manganese-containing enzyme which catalyzes the hydrolysis of arginine to ornithine and urea. ARG2 is highly expressed in kidney and prostate, not founded in the liver, heart and pancreas. ARG2 has been implicated in the regulation of the arginine/ornithine concentrations in the cell. ARG2 may take part in the regulation of extra-urea cycle arginine metabolism and in down-regulation of nitric oxide synthesis. The extrahepatic ar...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His) PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK...	Human	HEK293 Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,...
TMPJ-00693	EDF1 Protein, Human, Recombinant (His) Multiprotein-Bridging Factor 1,EDF-1,Endothelial Differentia...	Human	E. coli
	Endothelial Differentiation-Related Factor 1 (EDF1) is a 148 amino acid transcriptional coactivator that contains 1 HTH cro/C1-type DNA-binding domain. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. When endothelial cells are induced to differentiate in vitro, EDF1 is downregulated, leading to inhibition o...
TMPJ-00802	THBS1 Protein, Human, Recombinant (His) TSP,TSP1,Thrombospondin-1,THBS1	Human	HEK293 Cells
	Thrombospondin-1 (TSP-1) is a 150-180kDa calcium-sensitive protein that is secreted as a disulfide-linked homotrimer. TSP-1 regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 contains an N-terminal Laminin G-like globular domain, an extended central region with one vWFC domain, 3 TSP type 1domains, 2 EGF-like domains, and 8 TSP type3 domains, and a globular TSP C-terminal domain. Distinct regions of TSP-1 have...
TMPY-02640	FAM3B Protein, Human, Recombinant (hFc) PANDER,ORF9,PRED44,C21orf11,C21orf76,42056,family with seque...	Human	HEK293 Cells
	Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and beta- cells of pancreatic islets, insulin-secreting beta-TC3 cells, and glucagon-secreting alpha-TC cells. FAM3B causes apoptosis of beta-cells as assessed by electron microscopy, annexin Ⅴ fluorescent staining, and flow-cytometric terminal deoxynucleotidyl transferase-mediated dU...
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His) Arginase-1,Type I arginase,Liver-type arginase,Arg1	Mouse	P. pastoris (Yeast)
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i...

重组蛋白

DYNLL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01052

Species: Human

Expression System: E. coli

Dermcidin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00545

Species: Human

Expression System: HEK293 Cells

Argininosuccinate lyase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03172

Species: Human

Expression System: Baculovirus Insect Cells

Synapsin-1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02161

Species: Human

Expression System: E. coli

DDAH2 Protein, Human, Recombinant (GST & His)

Cat.No: TMPH-01733

Species: Human

Expression System: E. coli

Cytoglobin/CYGB Protein, Human, Recombinant (His)

Cat.No: TMPJ-01248

Species: Human

Expression System: E. coli

DDAH1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01732

Species: Human

Expression System: E. coli

PDE5A Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02575

Species: Mouse

Expression System: E. coli

Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02526

Species: Mouse

Expression System: E. coli

SPSB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02136

Species: Human

Expression System: E. coli

TXN Protein, Human, Recombinant (His)

Cat.No: TMPJ-00826

Species: Human

Expression System: E. coli

ARG2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01058

Species: Human

Expression System: E. coli

PRKG1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01112

Species: Human

Expression System: HEK293 Cells

EDF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00693

Species: Human

Expression System: E. coli

THBS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00802

Species: Human

Expression System: HEK293 Cells

FAM3B Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02640

Species: Human

Expression System: HEK293 Cells

Arginase-1/ARG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02524

Species: Mouse

Expression System: P. pastoris (Yeast)

Cat. No.	Product Name	Target	Signaling Pathways
T39441	L-Arginine-15N4 hydrochloride L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride
	L-Arginine-15N4 ((S)-(+)-Arginine-15N4) hydrochloride, the 15N-labeled variant of L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as the nitrogen donor in the synthesis of nitric oxide. This potent vasodilator is crucial, especially during a sickle cell crisis where its levels are notably diminished.
TMIH-0361	N,N'-Dimethylarginine-d6
	N,N'-Dimethylarginine-d6 是 N,N'-Dimethylarginine 的氘代化合物。N,N'-Dimethylarginine 的 CAS 号为 30344-00-4。SDMA 是一氧化氮 (NO) 合酶的内源性抑制剂。
T35697	Lauric Acid-13C
	Lauric acid-13C is intended for use as an internal standard for the quantification of lauric acid by GC- or LC-MS. Lauric acid is a medium-chain saturated fatty acid. It has been found at high levels in coconut oil.1Lauric acid induces the activation of NF-κB and the expression of COX-2, inducible nitric oxide synthase (iNOS), and IL-1α in RAW 264.7 cells when used at a concentration of 25 μM.2
TMIJ-0114	Vardenafil-d5
	Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂，IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解，从而提高 cGMP 水平。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T71212	Lornoxicam-d4
	Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously e...
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir6.2 (EC50 = ~10 µM) and a nitric oxide (NO) donor. It is selective for SUR2B/Kir6.2 over the SUR2A/Kir6.2 channel (EC50 = >500 µM). Nicorandil activates soluble guanylate cyclase in a cell-free assay and relaxes partially depolarized isolated bovine coronary artery strips (EC50 =...
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...

同位素标记化合物

L-Arginine-15N4 hydrochloride

Cat.No: T39441

Synonym: L-Arginine-15N4 hydrochloride,(S)-(+)-Arginine-15N4 hydrochloride

N,N'-Dimethylarginine-d6

Cat.No: TMIH-0361

Lauric Acid-13C

Cat.No: T35697

Cat.No: TMIJ-0114

Cat.No: T70990

Cat.No: T71212

Cat.No: T71402

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

Palmitic acid-1-13C

Cat.No: T35789

Palmitic acid-13C

Cat.No: T35791

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上海市静安区江场三路238号8楼