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PDE1-IN-9 (Compound 7a) 为磷酸二酯酶 1 (PDE1) 的选择性抑制剂,其可抑制PDE1C,IC50为11 nM。PDE1-IN-9 能降低IL-1β、IL-6、TNF-α 和 iNOS的mRNA表达,并抑制一氧化氮 (NO) 和活性氧 (ROS) 的产生。此外,该化合物在大鼠肝微粒体中显示出良好的代谢稳定性。
PDE1-IN-9 (Compound 7a) 为磷酸二酯酶 1 (PDE1) 的选择性抑制剂,其可抑制PDE1C,IC50为11 nM。PDE1-IN-9 能降低IL-1β、IL-6、TNF-α 和 iNOS的mRNA表达,并抑制一氧化氮 (NO) 和活性氧 (ROS) 的产生。此外,该化合物在大鼠肝微粒体中显示出良好的代谢稳定性。
产品描述 | PDE1-IN-9 (Compound 7a) is a selective inhibitor of phosphodiesterase 1 (PDE1), targeting PDE1C with an IC50 value of 11 nM. It effectively reduces the mRNA expression of IL-1β, IL-6, TNF-α, and iNOS, while also inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS). Additionally, PDE1-IN-9 demonstrates good metabolic stability in rat liver microsomes. |
靶点活性 | PDE1C:11 nM |
分子量 | 441.57 |
分子式 | C28H31N3O2 |
CAS No. | 2982945-41-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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