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Search Results for " microtubule-associated "

16

抑制剂 & 化合物

1

天然产物

2

化合物库

20

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L1110	微管靶向化合物库		142 compounds
	142 种靶向微管的分子集合，用于高通量筛选和高内涵筛选；
L1310	细胞骨架化合物库		759 compounds
	759 种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；

化合物库

微管靶向化合物库

Cat.No: L1110

Compounds: 142

细胞骨架化合物库

Cat.No: L1310

Compounds: 759

Cat. No.	Product Name	Target	Signaling Pathways
TP1420	Microtubule-associated protein tau (26-44)
	Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.
T9504	MAP4343	Microtubule Associated	Cytoskeletal Signaling
	MAP4343 是孕烯醇酮的 3-甲基醚衍生物。它在体外与微管相关蛋白 2 (MAP2) 结合并刺激微管蛋白聚合，从而增强神经突延伸和保护神经元免受神经毒剂的侵害。
T15612	JH-VIII-157-02	Microtubule Associated; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	JH-VIII-157-02 是一种 ALK 抑制剂，可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK)，对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。
T76726	Zagotenemab LY33003560	Microtubule Associated	Cytoskeletal Signaling
	Zagotenemab 是一种人源化抗微管相关蛋白 tau 抗体，能选择性地调节大脑中的 tau 沉积物。Zagotenemab 可用于研究阿尔兹海默症等神经系统疾病。
T11184	EML4-ALK kinase inhibitor 1 EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) 是有效的、具有口服活性的类棘皮细胞微管相关蛋白4-间变性淋巴瘤激酶 (EML4-ALK) 的抑制剂，其 IC50 值为 1 nM。
T60688	MKI-1 MASTL Kinase Inhibitor-1	Others	Others
	MKI-1 (MASTL Kinase Inhibitor-1) 是微管相关丝氨酸/苏氨酸样激酶 (MASTL) 抑制剂 (IC50= 9.9 μM)。MKI-1 通过激活乳腺癌中的PP2A 发挥放射增敏和抗肿瘤活性。
T80616	Posdinemab
	Posdinemab为一种针对微管相关蛋白tau (MAPT)的人源化IgG1κ抗体。
T25043	Alestramustine	Others	Others
	Alestramustine is a cytostatic antineoplastic agent. The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby suppressing cell division. Due to its estrogen moiety, Ales
T81850	MASTL-IN-2	Others	Others
	MASTL-IN-2为MASTL（microtubule-associated Ser/Thr kinase-like）抑制剂，能够抑制人上皮MIA PaCa癌细胞的增殖，其IC50值为2.8 nM。
T68873	Cornigerine	Others	Others
	Cornigerine is a natural product analog of colchicine produced by Colchicum cornigerum that inhibited tubulin polymerization both with and without microtubule-associated proteins, inhibited the binding of radiolabeled colchicine to tubulin, and stimulated tubulin-dependent GTP hydrolysis.
T81851	MASTL-IN-1	Others	Others
	MASTL-IN-1是一款针对MASTL(微管相关丝氨酸/苏氨酸样激酶)的抑制剂，起到调控细胞增殖、迁移及侵袭的作用。它显示出在癌症研究中的应用潜力。
T78552	PB118	Others	Others
	PB118是一种新型组蛋白去乙酰化酶 6（HDAC6）抑制剂，具备穿越血脑屏障的能力，可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。
T71217	MPT0B214	Others	Others
	MPT0B214 is a novel and potent microtubule inhibitor with potential anticancer activity. MPT0B214 inhibited tubulin polymerization through strongly binding to the tubulin's colchicine-binding site and had cytotoxic activity in a variety of human tumor cell lines. After treatment with MPT0B214, KB cells were arrested in the G2-M phase before cell death occurred, which were associated with upregulation of cyclin B1, dephosphorylation of Cdc2, phosphorylation of Cdc25C and elevated expression of th...
T68743	AZD4877 HCl	Others	Others
	AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T69305	Milataxel	Others	Others
	Milataxel is an orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) ...
T85301	ABO hydrochloride	Others	Others
	ABO acts as an annexin A7 modulator, specifically binding to Thr286 to inhibit its phosphorylation on threonine (not on serine or tyrosine) residues within human umbilical vein endothelial cells (HUVECs). This compound furthers the annexin A7 interaction with the EF-hand protein GCA, leading to reduced GCA phosphorylation, lowered intracellular calcium levels, and enhanced autophagy in COS-7 cells. Moreover, ABO lessens phosphorylation of the microtubule-associated protein 1 light chain (LC3) in...

化合物

Microtubule-associated protein tau (26-44)

Cat.No: TP1420

Cat.No: T9504

Target: Microtubule Associated

Cat.No: T15612

Target: Microtubule Associated, ALK

Cat.No: T76726

Synonym: LY33003560

Target: Microtubule Associated

EML4-ALK kinase inhibitor 1

Cat.No: T11184

Synonym: EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1

Target: ALK

Cat.No: T60688

Synonym: MASTL Kinase Inhibitor-1

Target: Others

Cat.No: T80616

Cat.No: T25043

Target: Others

Cat.No: T81850

Target: Others

Cat.No: T68873

Target: Others

Cat.No: T81851

Target: Others

Cat.No: T78552

Target: Others

Cat.No: T71217

Target: Others

Cat.No: T68743

Target: Others

Cat.No: T69305

Target: Others

ABO hydrochloride

Cat.No: T85301

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 属于生物碱类天然产物，可与微管蛋白结合并抑制微管的形成，从而抑制肿瘤细胞的有丝分裂。Vincristine 可用作微管去稳定剂，用于研究治疗血液系统肿瘤，如白血病和淋巴瘤以及儿童肉瘤的相关研究。

天然产物

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03425	Tau Protein, Human, Recombinant (His) PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-	Human	E. coli
	MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP...
TMPH-01685	MAST4 Protein, Human, Recombinant (His & Myc) Microtubule-associated serine/threonine-pr...	Human	E. coli
	MAST4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-03749	LC3B Protein, Human, Recombinant (His) microtubule-associated protein 1 light cha...	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal...
TMPY-03340	MAP1LC3A Protein, Human, Recombinant (His) LC3,ATG8E,microtubule-associated protein 1...	Human	E. coli
	LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and r...
TMPH-02785	Tau Protein, Mouse, Recombinant (His) Microtubule-associated protein tau,Mapt,Pa...	Mouse	HEK293 Cells
	Tau Protein, Mouse, Recombinant (His) is expressed in HEK293.
TMPH-03335	Tau Protein, Rat, Recombinant (E. coli, His) Mapt,Neurofibrillary tangle protein,Microtubule-	Rat	E. coli
	Tau Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.4 kDa and the accession number is P19332.
TMPH-01683	Tau-F Protein, Human, Recombinant (HEK293, His) Microtubule-associated protein tau,Paired ...	Human	HEK293 Cells
	Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ...
TMPJ-00828	Tau-F Protein, Human, Recombinant Neurofibrillary tangle protein,Paired helical filament-tau,M...	Human	E. coli
	Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def...
TMPH-02443	Tau Protein, Rhesus macaque, Recombinant (His & SUMO) Neurofibrillary tangle protein,MAPT,Microtubule-	Rhesus	E. coli
	Tau Protein, Rhesus macaque, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.8 kDa and the accession number is P57786.
TMPH-03336	Tau Protein, Rat, Recombinant (His) Neurofibrillary tangle protein,Mapt,Paired helical filament-...	Rat	HEK293 Cells
	Tau Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 81.2 kDa and the accession number is P19332.
TMPH-02444	Tau Protein, Rhesus macaque, Recombinant (His) Microtubule-associated protein tau,MAPT,Pa...	Rhesus	HEK293 Cells
	Tau Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P57786.
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Microtubu...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant Autophagy-related ubiquitin-like modifier LC3 B,MAP1A/MAP1B ...	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat...
TMPY-03865	EB3 Protein, Human, Recombinant (His) microtubule-associated protein, RP/EB fami...	Human	E. coli
	MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role i...
TMPH-01684	MAP1LC3C Protein, Human, Recombinant (His) MAP1A/MAP1B light chain 3 C,Microtubule-associa...	Human	E. coli
	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins. MAP1LC3C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.7 kDa and the accession number is Q9BXW...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...
TMPH-01254	DNM1 Protein, Human, Recombinant (His) DNM,Dynamin,Dynamin-1,DNM1,Dynamin I	Human	E. coli
	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. DNM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.2 kDa and the accession number is Q05193.
TMPH-02275	Lck Protein, Human, Recombinant (His) Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,T...	Human	E. coli
	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules...
TMPY-02718	Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST) XLIS,doublecortin,LISX,DBCN,DC,SCLH	Human	E. coli
	DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion an...
TMPH-01621	BRCC3 Protein, Human, Recombinant (His & SUMO) BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...	Human	E. coli
	Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta...

重组蛋白

Tau Protein, Human, Recombinant (His)

Cat.No: TMPY-03425

Species: Human

Expression System: E. coli

MAST4 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01685

Species: Human

Expression System: E. coli

LC3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03749

Species: Human

Expression System: E. coli

MAP1LC3A Protein, Human, Recombinant (His)

Cat.No: TMPY-03340

Species: Human

Expression System: E. coli

Tau Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02785

Species: Mouse

Expression System: HEK293 Cells

Tau Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03335

Species: Rat

Expression System: E. coli

Tau-F Protein, Human, Recombinant (HEK293, His)

Cat.No: TMPH-01683

Species: Human

Expression System: HEK293 Cells

Tau-F Protein, Human, Recombinant

Cat.No: TMPJ-00828

Species: Human

Expression System: E. coli

Tau Protein, Rhesus macaque, Recombinant (His & SUMO)

Cat.No: TMPH-02443

Species: Rhesus

Expression System: E. coli

Tau Protein, Rat, Recombinant (His)

Cat.No: TMPH-03336

Species: Rat

Expression System: HEK293 Cells

Tau Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPH-02444

Species: Rhesus

Expression System: HEK293 Cells

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

MAP1LC3B Protein, Human, Recombinant

Cat.No: TMPJ-01321

Species: Human

Expression System: E. coli

EB3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03865

Species: Human

Expression System: E. coli

MAP1LC3C Protein, Human, Recombinant (His)

Cat.No: TMPH-01684

Species: Human

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

DNM1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01254

Species: Human

Expression System: E. coli

Lck Protein, Human, Recombinant (His)

Cat.No: TMPH-02275

Species: Human

Expression System: E. coli

Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)

Cat.No: TMPY-02718

Species: Human

Expression System: E. coli

BRCC3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01621

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...

同位素标记化合物

Cat.No: T70808

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