71
16
2
8
2
Cat. No. | Product Name | ||
---|---|---|---|
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T19438 |
Myristyl nicotinate
Tetradecyl nicotinate,肉豆蔻醇烟酸酯 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
Myristyl nicotinate (Tetradecyl nicotinate) 是 Nicotinic acid 的亲脂衍生物,是一种酯前药。它能够刺激光损伤的皮肤中的表皮分化,增加皮肤 NAD 含量并增强人皮肤屏障。它被开发用于将烟酸输送到皮肤中,以防止光化性角化病及其发展为皮肤癌。 | |||
T22012 |
7BIO
|
FLT; DYRK; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
7BIO 是靛玉红的衍生物,抑制细胞周期蛋白依赖性激酶5 和糖原合酶激酶-3β。它抑制 Aβ 寡聚体诱导的神经炎症、突触损伤、tau 过度磷酸化、星形胶质细胞和小胶质细胞的活化,并减轻 Aβ 寡聚体诱导的小鼠认知障碍。 | |||
T19659 |
Annaosanchun
雄甾-3,5,6三醇,YC6,YC-6,YC 6 |
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
Annaosanchun (YC-6) 有可能用于治疗急性缺血性中风(AIS)。 | |||
T7530 |
PD146176
NSC168807 |
Ferroptosis; Lipoxygenase; Autophagy | Apoptosis; Autophagy; Metabolism |
PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂,抑制兔网织红细胞 15-LO,Ki 为 197 nM,IC50 为 0.54 μM。 它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。 | |||
T28368 |
PF-04859989 HCl
PF 04859989,PF04859989,PF-04859989HCl,PF-04859989 |
Others | Others |
PF-04859989 HCl 是不可逆的犬尿氨酸转氨酶 KAT II 抑制剂,可透过血脑屏障,抑制 hKATⅡ 和 rKATⅡ 的 IC50分别为 23 和 263 nM。它对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50分别为22、11和 >50 μM)。 | |||
T1406 |
Amantadine hydrochloride
盐酸金刚烷胺,1-adamantanamine HCl,1-Adamantanamine hydrochloride,Symmetrel,CI-719,Amantadine HCl,1-Adamantylamine hydrochloride |
Dopamine Receptor; Influenza Virus | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Amantadine hydrochloride (CI-719) 是一种抗病毒药物,用于预防或对症治疗甲型流感和帕金森病。它阻断质子流通过 M2 离子通道,从而阻止病毒 RNA 释放到感染细胞的细胞质中。 | |||
T34435 |
RU 47213
RU-47213,Itameline,RU47213 |
Others | Others |
RU 47213 可用于抑制东莨菪碱诱导的大鼠工作记忆障碍。 | |||
T13151L |
THK5351
|
Others | Others |
THK5351 是一种参与PET成像的示踪剂,参与阿尔茨海默病和认知障碍的电子发射断层扫描成像。 | |||
T31079 |
CP-810123
CP 810123,UNII-E6G4550EC4,CP810123 |
AChR | Neuroscience |
CP-810123 是一种新的α 7 nAChR 激动剂,可用于治疗与精神分裂症和阿尔茨海默病等精神或神经疾病相关的认知障碍。 | |||
T16881 |
SIB-1553A hydrochloride
|
AChR | Neuroscience |
SIB-1553A hydrochloride 是一种可口服且具有选择性的烟碱乙酰胆碱受体激动剂,还是一种选择性神经元 nAChR 配体。SIB-1553A hydrochloride 可增强认知,可用于研究阿尔茨海默病和认知障碍。 | |||
T7193 |
Encenicline
EVP-6124 |
AChR | Neuroscience |
Encenicline (EVP-6124) 是一种新型α7神经元烟碱乙酰胆碱受体 (nAChRs)激动剂,用于治疗精神分裂症和阿尔茨海默病的认知障碍。 | |||
T19812 |
Propentofylline
HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285 |
PDE | Metabolism |
Propentofylline (Hextol) 是一种甲基黄嘌呤衍生物,具有神经保护、抗增殖和抗炎活性,可增强的突触腺苷信号传导,可用于研究阿尔茨海默病、血管性痴呆、认知障碍、痴呆和慢性疼痛。 | |||
T21417 |
Dihydrotachysterol
HSDB 3314,Parterol,Hytakerol,HSDB3314,HSDB-3314 |
Others | Others |
Dihydrotachysterol (HSDB 3314) 是维生素 D 类似物。Dihydrotachysterol 可用于研究手术切除甲状旁腺后的低钙血症性甲状旁腺功能减退症和慢性肾功能不全儿童生长障碍。 | |||
T1884 |
CX516
Ampakine CX516,BDP 12,Ampalex,安帕来斯 |
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
CX516 (Ampalex) 是AMPA 受体正向调节剂,可用于研究阿尔茨海默病,精神分裂等。 | |||
T37184 |
CX08005
2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid |
Phosphatase | Metabolism |
CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂,可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。 | |||
T26834 |
BL-1020 Mesylate
CYP-1020 Mesylate |
Dopamine Receptor; GABA Receptor | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
BL-1020 Mesylate (CYP-1020 Mesylate) 是一种可口服的 GABA A 受体激动剂和 D2 拮抗剂,可降低多巴胺活性并增强GABAA活性。BL-1020 Mesylate 可用于研究神经分裂、阿尔茨海默症和双向认知障碍。 | |||
T77678 |
TZ3O
|
AChR | Neuroscience |
TZ3O是一种具有神经保护活性的抗胆碱能化合物。TZ3O 在Scopolamine诱导的阿尔茨海默型模型中改善大鼠记忆障碍与认知衰减,可用于研究阿兹海默症。 | |||
T6552 |
Istradefylline
伊曲茶碱,KW-6002 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Istradefylline (KW-6002) 是选择性的可口服的腺苷 A2A 受体拮抗剂,可用于研究药物滥用、睡眠障碍、肝损伤、帕金森病和不安腿综合征等的治疗和基础科学的试验。 | |||
T77054 |
Lecanemab
BAN-2401 |
Beta Amyloid | Neuroscience |
Lecanemab (BAN-2401) 是一种靶向可溶性聚集性 β 淀粉样蛋白 (Abeta)的 IgG1 单克隆抗体,对寡聚体、原纤维和不溶性原纤维具有活性,可用于研究阿尔茨海默病 (AD) 引起的轻度认知障碍和轻度 AD 痴呆。 | |||
TP1570 |
Cortistatin-14
|
Somatostatin | GPCR/G Protein |
Cortistatin-14 是一种与生长抑素-14结构相似的神经肽,具有抗惊厥和神经保护作用,通过激活 sst(2)、生长素释放肽和 GABA(A/B) 受体损害小鼠的识别记忆巩固,可用于研究脓毒症引发的认知障碍。 | |||
T8532 |
IM156
|
OXPHOS | Apoptosis |
IM156 (HL156A; HL271 acetate) 是衍生自二甲双胍的化合物,是一种强效的,具有口服活性的AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知下降。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂,可用于实体肿瘤的研究。 | |||
T67729 |
UCM-1306
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
UCM-1306 是具有口服活性的人多巴胺 D1 受体变构调节剂 (PAM)。UCM-1306 增加结合在人和小鼠 D1 受体的内源性多巴胺 (DA) 效应。UCM-1306可以改善运动症状,解决与长期帕金森病(PD) 相关的关键共病认知障碍。 | |||
T62899 |
Tau-aggregation and neuroinflammation-IN-1
|
Microtubule Associated; NO Synthase | Cytoskeletal Signaling; Immunology/Inflammation |
Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂, 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。 | |||
T21792 |
CGP 3466B maleate
马来酸CGP3466B,Omigapil (Maleate),Omigapil maleate |
Apoptosis | Apoptosis |
CGP 3466B maleate (Omigapil maleate) 是一种口服有效的 GAPDH 亚硝基化抑制剂,可消除 Aβ1-42 诱导的小鼠 tau 乙酰化,记忆障碍和运动功能障碍,Omigapil maleate 具有研究阿尔茨海默症的潜力。Omigapil maleate (CGP3446B maleate) 是一种有效的凋亡 (apoptosis) 抑制剂。Omigapil maleate 可用于研究先天性肌营养不良 (CMD)。 | |||
T32191 |
Irdabisant
CEP-26401,CEP 26401,CEP26401 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中,Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。 | |||
T11570 |
HL271
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment. | |||
T69314 |
T-82
|
Others | Others |
T-82 is an acetylcholinesterase inhibitor that may ameliorate the impairment of memory induced by acetylcholinergic dysfunction. | |||
T14334 |
ASP2535
|
GlyT | Neuroscience |
ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1]. | |||
T38659 |
mGluR5 modulator 1
|
Others | Others |
mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research. | |||
T39384 |
Exendin (5-39)
|
||
Exendin (5-39) is a powerful antagonist of the glucagon-like peptide 1 (GLP-1) receptor with the ability to ameliorate memory impairment in rats treated with β-amyloid protein. | |||
T33424 |
MK-0952
MK 0952 |
Others | Others |
MK-0952 is a selective PDE4 inhibitor used to treat long-term memory loss and mild cognitive impairment. It is an intrinsically potent inhibitor and has shown limited whole blood activity. | |||
T38192 |
Unifiram
|
Others | Others |
Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。 | |||
T68881 |
OL-135
|
Others | Others |
OL-135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. OL-135 exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. | |||
T25757 |
Lorcainide hydrochloride
Ro 13-1042,EINECS 261-504-6,Lorcainide HCl,Lopantrol,R 15889 |
Others | Others |
Lorcainide hydrochloride is an antiarrhythmic drug with local anesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Lorcainide appears effective in suppressing reentry phenomena and ectopic | |||
T33918 |
Pentanochlor
Hortox,Niagara 4512,Solane,Dutom,FMC 4512 |
Others | Others |
Pentanochlor can be used in agricultural use and biological study of herbicide composition containing a pyrazolyl pyrazole derivative. The impairment of mobility and development in freshwater snails (Physa fontinalis and Lymnaea stagnalis) caused by herbi | |||
T34752 |
Samelisant dihydrochloride
SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl |
Others | Others |
Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain. | |||
T61684 |
S 17092
|
Others | Others |
S 17092 (S 17092-1) is a highly effective inhibitor of cerebral prolyl-endopeptidase (PEP), displaying an IC50 value of 1.2 nM. It is utilized in research focused on understanding memory impairment and cognitive disorders associated with cerebral aging [1]. | |||
T61540 |
F15845
|
Others | Others |
F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1]. | |||
T28313 |
PD 117302
PD-117302,PD117302 |
Others | Others |
PD 117302 is a nonpeptide opioid compound. It is a selective kappa-opioid agonist. PD 117302 causes naloxone-reversible locomotor impairment and diuresis. It is an Anti-Arrhythmia Agent, an Anticonvulsants, a Cardiovascular Agent, and a Central Nervous Sy | |||
T80071 |
PKCζ/ι pseudosubstrate inhibitor
|
||
PKCζ/ι偽基質抑制劑對PKC酶家族表現廣譜抑制作用,並可能促成記憶功能障礙。 | |||
T75884 |
ZIP TFA
|
Others | Others |
ZIP TFA为选择性PKMζ肽抑制剂,能够抑制因吗啡条件性位置偏好所诱导的神经损伤。 | |||
T12416L |
PF 03654746 FA
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
PF 03654746 FA 是人组胺受体H(3)拮抗剂,可用于研究认知障碍和阿尔茨海默病。 | |||
T69513 |
(–)-IHCH7041
|
Others | Others |
(–)-IHCH7041 is a optical rotation negative isomer of IHCH7041. (–)-IHCH7041 is a DRD2 partial agonist. (–)-IHCH7041 showed EC50 = 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment. (–)-IHCH7041 exhibited a inhibition constant (Ki) of 22.44 nM binding affinity at DRD2. (–)-IHCH7041 has antidepressant properties and reverses cognitive impairment. | |||
T70646 |
Deltarasin HCl
|
Others | Others |
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/RAF signaling in human pancreatic ductal adenocarcinoma cell lines. The anti-cancer cell activity of deltarasin can be enhanced by simultaneously blocking tumor protective" autophagy | |||
T72859 |
11β-HSD1-IN-10
|
Others | Others |
11β-HSD1-IN-10 (化合物 c3a) 是一种针对11β-HSD1的有效抑制剂,具有对人IC50值为1.8 µM。可应用于肥胖、高血糖和认知障碍研究。 | |||
T21470 |
Davunetide
AL-208,AL 208,AL 108,AL-108 |
||
Davunetide is an eight amino acid peptide (NAPVSIPQ) with potent neuroprotection in vitro and in vivo. Davunetide has been shown to enhance functional daily behaviors in schizophrenia patients and to increase memory scores in patients suffering from amnes | |||
T75689 |
Mumefural
|
Others | Others |
Mumefural,Prunus mumeSieb 加工果实中的一种生物活性成分,具有抑制血小板聚集、显示抗血栓作用及改善认知障碍的功能。 | |||
T37012 |
(±)-PPCC oxalate
|
Others | Others |
(±)-PPCC (oxalate) 是 sigma-1 激动剂,能与 sigma-1 受体相互作用(Ki=1.5 nM)。(±)-PPCC (oxalate) 在有认知障碍的大鼠中具有抗遗忘作用,可以改善大鼠的认知能力。 | |||
T28653 |
S-8510 free base
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
Others | Others |
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ameliorated memory impairment induced | |||
T74195 |
4′-Demethylnobiletin
|
Others | Others |
4′-Demethylnobiletin 是一种生物活性代谢物,可以激活PKA/ERK/CREB 信号通路,增强海马神经元中 CRE 介导的转录,并通过刺激ERK 信号逆转与 NMDA 受体拮抗相关的记忆障碍。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3S0195 |
Nootkatone
诺卡酮,努特卡酮,诺卡酮 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Nootkatone 是一种神经保护剂,来自于Alpiniae OxyphyllaeFructus ,具有抗氧化和抗炎活性。它能够改善脂多糖诱导的阿尔茨海默氏病小鼠模型的认知障碍。 | |||
TN2100 |
Pratensein
红车轴草素,三叶草 |
Others; NF-κB | NF-κB; Others |
Pratensein 是黄酮类化合物,能够减少氧化损伤和恢复突触和 BDNF 水平,改善 β-淀粉样蛋白诱导的大鼠认知障碍。 | |||
T2230 |
Paeoniflorin
芍药苷,Peoniflorin |
HSP; COX | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience |
Paeoniflorin (Peoniflorin) 是从芍药根中提取的一种蒎烷单萜糖苷,具有抗癌作用、抗氧化应激、抗血小板聚集、血管扩张、降低血液粘度和抗炎活性等多种生物活性。它是一种热休克蛋白诱导剂,通过自噬途径保护 PC12 细胞免受 MPP+和酸性损伤。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
T4956 |
Tetrahydroxystilbene-2-O-β-D-glucoside
tetrahydroxyl diphenylethylene-2-o-gluco,何首乌苷,EH-201 |
Others | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) 是一种低分子量的促红细胞生成素诱导剂。 | |||
TN2230 |
Soyasaponin Ba
大豆皂苷 BA,大豆皂苷Ba |
Others | Others |
Soyasaponin Ba 是一种大豆皂苷,分离自菜豆类,可用作醛糖还原酶抑制剂。 | |||
TN1420 |
Bacopaside I
|
Others | Others |
Bacopaside I 是一种皂苷,分离自 Bacopa monniera 中,具有抗氧化活性和清除自由基的功能,有抗抑郁作用。 | |||
T3902 |
Atractylenolide III
白术内酯 III,ICodonolactone,8β-Hydroxyasterolide |
Apoptosis | Apoptosis |
Atractylenolide III (ICodonolactone) 是白术根茎主要成分,通过诱导细胞色素 c 的释放、上调 Bax 的表达和易位凋亡诱导因子,是治疗人肺癌的潜力。 | |||
T5702 |
Tenuifoliside B
|
Dehydrogenase | Metabolism |
Tenuifoliside B 是一种分离自Polygalae Radix 中的成分,能够抑制氰化钾引起的缺氧和东莨菪碱引起的记忆障碍。它有成为 AD 先导化合物的潜力。它具有潜在的认知改善和脑保护作用。 | |||
T6S2227 |
Spinosin
斯皮诺素,Flavoayamenin |
Others | Others |
Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮,从 Zizyphus jujube 种子分离得到,能够激活 Nrf2/HO-1 通路,并抑制 Aβ1-42的产生和聚合。 | |||
T3767 |
Polygalacic acid
Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸 |
MMP; AChR; AChE | Neuroscience; Proteases/Proteasome |
Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜,可抑制 MMP 表达。它对认知障碍有显著的神经保护作用,PA 通过抑制乙酰胆碱酯酶活性,增加胆碱乙酰转移酶活性,提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。 它可以用于骨关节炎相关研究。 | |||
T5S0896 |
Loureirin A
龙血素 A,龙血素A |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Loureirin A 是一种黄酮类物质,从龙血树中分离得到,能够降低Akt 的磷酸化,具有抗血小板聚集作用。 | |||
T6S0659 |
Rhynchophylline
钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel; NF-κB | Membrane transporter/Ion channel; Metabolism; NF-κB |
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。 | |||
T4S0969 |
Obtusifolin
决明蒽醌,决明蒽醌;美决明子素 |
Antioxidant; NF-κB | NF-κB; oxidation-reduction |
Obtusifolin 是分离自决明子的种子中,能够抑制NF-kB 通路,调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。 | |||
T40866 |
8-Methylsulfinyloctyl isothiocyanate
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Others | Others |
8-Methylsulfinyloctyl isothiocyanate is a compound with antimicrobial activity and notable inhibitory effects on plant growth. It also exhibits COX-2-mediated inflammatory response impairment in LPS-stimulated raw macrophages. | |||
TN1766 |
(-)-Integerrimine
Integerrimine,全緣千里光鹼,全缘千里光碱 |
Others | Others |
Prenatal exposure to Integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delayed in physical and behavioral development of the offspring. Doses of Integerrimine N-oxide here employed did not produce marked immunotoxic effects. |
Cat. No. | Product Name | Species | Expression System |
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TMPY-02769 |
RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2 |
Human | Baculovirus Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... | |||
TMPK-01137 |
FAM3D Protein, Human, Recombinant (hFc)
OIT1,EF7,FAM3D |
Human | HEK293 Cells |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t... | |||
TMPK-00191 |
PILRA Protein, Mouse, Recombinant (hFc)
PILR-α,FDF03,PILRA,PILR-alpha,PILRalpha,PILRα |
Mouse | HEK293 Cells |
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be p... | |||
TMPJ-00871 |
BAR Protein, S. hygroscopicus, Recombinant
bar,PPT N-acetyltransferase,Phosphinothricin-resistance prot... |
Streptomyces hygroscopicus | E. coli |
Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acetylate other L-amino acids or structurally similar molecules. L-PPT is a glutamate analog that can inhibit glutamine synthetase activity in plants, resulting in the accumulation of ammonia to toxic levels and impairment of photosynthesis. The introduction of a PAT gene into a plant... | |||
TMPY-04170 |
DEFB1 Protein, Human, Recombinant (hFc)
DEFB101,defensin, β1,β Defensin 1/DEFB1,defensin, beta 1,DEF... |
Human | HEK293 Cells |
The DEFB1 gene, encoding for the constitutively expressed human beta-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis. To counteract host immunity, Cryptosporidium parvum has evolved multiple strategies to suppress host antimicrobial defense. On... | |||
TMPJ-01083 |
Serpin E2 Protein, Mouse, Recombinant (His)
Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI... |
Mouse | HEK293 Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser... | |||
TMPJ-00796 |
Serpin E2 Protein, Human, Recombinant (His)
PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser... |
Human | HEK293 Cells |
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha... | |||
TMPY-02289 |
CIB2 Protein, Human, Recombinant (His)
DFNB48,calcium and integrin binding family member 2,USH1J,KI... |
Human | E. coli |
Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is genetically heterogeneous. The mutations in CIB2, which encodes a calcium- and integrin-binding protein, are associated with nonsyndromic deafness (DFNB48) and Usher syndrome type 1J (USH1J). Furthermore, in zebrafish and Drosophila melanogaster, CIB2 is essential for the function a... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T71142 |
Tebuconazole-d9
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Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per... | |||
TMIJ-0317 |
Nadolol-d9 (Mixture of Diastereomers)
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Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物,是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂,可用于高血压,心绞痛和血管性头痛的研究。 |