A 68930 hydrochloride

Name: A 68930 hydrochloride
Brand: TargetMol
SKU: T21680
Rating: 4.5 (1 reviews)

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产品编号 T21680Cas号 130465-39-3

A68930 hydrochloride 是一种多巴胺D1受体激动剂，可用于支气管扩张的研究。

A 68930 hydrochloride

还可以

产品编号 T21680Cas号 130465-39-3

A68930 hydrochloride 是一种多巴胺D1受体激动剂，可用于支气管扩张的研究。

规格	价格	库存	数量
10 mg	¥ 3,530	35日内发货

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产品介绍

生物活性

产品描述

A68930 hydrochloride is a dopamine D1 receptor agonist which can be used for the research of bronchiectasis [1].

体外活性

The dopamine D1 receptor protein was detected in native human airway epithelium and three sources of cultured human airway epithelial cells. A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein [1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression [1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels [1]. Western Blot Analysis [1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence [1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.