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Search Results for " immunosuppressive "
Targets Recommended: Glucocorticoid Receptor

97

抑制剂 & 化合物

39

天然产物

9

重组蛋白

4

同位素标记化合物

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Cat. No. Product Name Target Signaling Pathways
T2548 Diflorasone

Glucocorticoid Receptor Endocrinology/Hormones
Diflorasone 是一种皮质类固醇激素受体激动剂,具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞,并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T9744 MP07-66

Phosphatase Metabolism
MP07-66 是 FTY720 的一种类似物,没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T7776 ADH-503

GB1275

Complement System Immunology/Inflammation
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。
T12399 Peldesine

BCX 34

Nucleoside Antimetabolite/Analog; HIV Protease Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖,IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。
T22697 CS 2100

1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid

S1P Receptor GPCR/G Protein
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) 是口服有活性 S1P3-sparingS1P1选择性激动剂,对人 S1P1的EC50值为 4.0 nM,对 HvGR 的ID50值为 0.407 mg/kg。它在大鼠体内具有免疫抑制作用。
T13379 (Z)-Leukadherin-1

ADH-503 free base

Complement System Immunology/Inflammation
(Z)-Leukadherin-1 (ADH-503 free base) 是 CD11b 的变构激动剂。
T9603 MNITMT

Others Others
MNITMT 是一种有效的免疫抑制剂 (immunosuppressive agent),没有骨髓毒性。
T7527 Frentizole

Beta Amyloid Neuroscience
Frentizole 是一种 FDA 批准的免疫抑制剂,是一种新型 Aβ-ABAD 相互作用抑制剂。
T1237 Azathioprine

硫唑嘌呤,BW 57-322

Apoptosis; GPR; Rho Apoptosis; Cell Cycle/Checkpoint; Endocrinology/Hormones; GPCR/G Protein
Azathioprine (BW 57-322) 是一种免疫抑制剂。
T7202 ITE

AhR; Aryl Hydrocarbon Receptor Immunology/Inflammation; Metabolism
ITE 是一种有效的芳烃受体 (AhR) 内源性激动剂,Ki 值为 3 nM。它具有免疫抑制作用。
T0707 Cyclophosphamide hydrate

环磷酰胺一水物,Cyclophosphamide monohydrate,环磷酰胺水合物

DNA Alkylator/Crosslinker; DNA; MRP DNA Damage/DNA Repair; Immunology/Inflammation
Cyclophosphamide hydrate 是一种 DNA 烷化剂,一种 DNA 合成抑制剂。Cyclophosphamide hydrate 具有抗肿瘤活性、免疫抑制活性等。
T26046 Razoxane

Topoisomerase DNA Damage/DNA Repair
Razoxane 是拓扑异构酶 II 的有效抑制剂,具有抗血管生成的作用,在肾细胞癌中具有研究价值。
T11941 Manitimus

FK778

Dehydrogenase Metabolism
Manitimus (FK778) 是一种 dehydroorotate dehydrogenase 的抑制剂,也是一种免疫抑制剂,具有免疫抑制和抗增殖活性,防止机械性内膜损伤后的血管重塑,可用于研究免疫功能异常。
T1550 Thiamphenicol

甲砜霉素,Dextrosulphenidol,Thiophenicol

Antibacterial; Antibiotic Microbiology/Virology
Thiamphenicol (Dextrosulphenidol) 是 Chloramphenicol 的甲基磺酰基衍生物,是一种广谱抗菌类抗生素。它与 50S 核糖体亚基结合,抑制蛋白质合成并具有抑菌作用 ,特别针对革兰氏阴性,革兰氏阳性需氧和厌氧菌。
T20511 6-Thioguanosine

6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422

Others Others
6-Thioguanosine (6-Mercaptoguanosine) 是一种活性核苷,是 Azathioprine 的代谢物,是低分子量凝胶剂。6-Thioguanosine 具有免疫抑制作用,可用于研究RNA 双螺旋结构的形成。
T39615L P8RI acetate

Integrin Cytoskeletal Signaling
P8RI acetate 是 CD31 的仿生肽和 CD3 的激动剂。 P8RI acetate 通过恢复 CD31 抑制途径显示出免疫抑制作用。
T14953 Chloroquinoxaline sulfonamide

NSC-339004,Chloroquinoxaline

Topoisomerase DNA Damage/DNA Repair
Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是拓扑异构酶 II alpha/beta 毒物,具有抗肿瘤活性和免疫抑制特性,可抑制小鼠 B16 黑色素瘤细胞的增殖,可用于研究转移性结直肠癌。
T73698 Basiliximab

CHI 621

Interleukin Immunology/Inflammation
Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性,可用于研究肾移植。
T1163 Betamethasone valerate

Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq

Glucocorticoid Receptor Endocrinology/Hormones
Betamethasone valerate (Luxiq) 的 17 戊酸酯,是一种具有抗炎活性的局部皮质类固醇。它能够抑制放射标记的糖皮质激素地塞米松与人表皮(IC50:5 nM)及小鼠皮肤(IC50:6 nM)的结合。它可用于研究复发性口疮。
T24793 SIRT6-IN-5

SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5

Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair
SIRT6-IN-5(SIRT6 inhibitor 5) 是一种具有有效性和选择性的 SIRT6 抑制剂 ,IC50 值为 34 μM。SIRT6-IN-5 具有免疫抑制和化疗增敏作用,可增加 H3K9 的乙酰化并增加培养细胞中的葡萄糖摄取,减少 T 细胞增殖。
T1076 Dexamethasone

MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性,可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T76699 Sabatolimab

MBG453,NVP-MBG453

Others Others
Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体,是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性,可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。
T20168 Aurothiomalate sodium

金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate

Others; PKC Chromatin/Epigenetic; Cytoskeletal Signaling; Others
Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂,可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂,也是一种抗风湿剂。
T1485 Methotrexate

NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377

Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Methotrexate (WR19039) 是一种叶酸类似物,一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性,常用于类风湿关节炎和多种肿瘤的研究。
T6120 Pralatrexate

Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙

Apoptosis; DHFR; Antifolate; TAM Receptor Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。
T1559 Betamethasone dipropionate

Diprolene AF,SCH 11460,二丙酸倍他米松,Betamethasone 17,21-dipropionate,Diprolene,倍他米松二丙酸酯,Diprosone

Glucocorticoid Receptor Endocrinology/Hormones
Betamethasone dipropionate (SCH 11460) 是糖皮质激素类固醇,具有免疫抑制、抗炎作用。
T11134 DZ2002

Others Others
DZ2002 是一种口服有效的、可逆的、低细胞毒性的 III 型 SAHH 抑制剂 (Ki=17.9 nM),具有较好的免疫抑制活性。DZ2002 能通过逆转各种细胞类型的促纤维化表型来防止实验性皮肤纤维化的发展。DZ2002 可用于自身免疫性疾病,如狼疮综合征和系统性硬化症的研究。
T41303 Isoflupredone

Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone

Others Others
Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇,通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用, 可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。
T1784 Everolimus

依维莫司,RAD001,SDZ-RAD

Apoptosis; Others; mTOR; Autophagy Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling
Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物,是一种 mTOR1 抑制剂,具有选择性和口服活性。Everolimus 具有免疫抑制和抗肿瘤活性,可以抑制肿瘤细胞增殖、诱导细胞凋亡和自噬。
T34952 Trinactin

Akd1D,Akd 1D,Akd-1D

Others Others
Trinactin is a nonactin homolog that has Immunosuppressive effects.
T14964 CI 972 anhydrous

CI 972 (anhydrous)

Others Others
CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.
T30136 Armepavine hydrochloride, (+/-)-

DL-Armepavine hydrochloride

Others Others
Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.
T34361 Ro 4-6824

AI3-50843

Others Others
Ro 4-6824 is a biochemical with immunosuppressive action.
T21192 Diflorasone Diacetate

Apexicon E,Psorcon,Maxiflor,醋酸双氟拉松,Florone E

Others Others
Diflorasone Diacetate, a topical glucocorticoid, has immunosuppressive and anti-inflammatory properties.
T32113 Hydrocortamate Hydrochloride

UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort

Others Others
Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.
T38720 SR-31747 free base

Others Others
SR-31747 free base is an immunosuppressive and anti-inflammatory sigma ligand that efficiently inhibits cell proliferation through the inhibition of sterol isomerase activity.
T25620 Lankacidinol

Antibiotic T 2636F,T2636 F,T-2636 F,T 2636 F

Others Others
Lankacidinol is an antibiotic that has antitumor and immunosuppressive activities.
T24815 Sotrastaurin acetate

Others Others
Sotrastaurin acetate is a pan-protein kinase C inhibitor. It also has potential immunosuppressive and antineoplastic activities.
T26457 A 85 4777

A85-4777,A 8547777

Others Others
A 85 4777, a homoperazine derivative, is an anti-inflammatory agent with nonclassical immunosuppressive properties.
T16926 SR-31747

Others Others
SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.
T27368 FR 901235

FR901235,FR-901235

Others Others
FR-901235 is an immunoactive substance produced by an imperfect fungus, Paecilomyces carneus F-4882. FR-901235 restores the mitogen-induced lymphocyte proliferation to a normal level, which has been suppressed by addition of immunosuppressive factor.
T27661 JNJ-10329670

Others Others
JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
T11430 Glycosidase-IN-1

Others Others
Glycosidase-IN-1 is a glycosidase inhibitor synthesized from D-mannose with hypoglycemic activity. It can be used to synthesize some immunosuppressive agents and β-glucosidase inhibitors.
T76228 ASP5286

ASP5286 是一种新型的非免疫 cyclophilin 抑制剂,用于研究 HCV。
T25980 Pralatrexate, (R)-

Others Others
Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr
T33883 Paramethasone Acetate

NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP

Others Others
Paramethasone Acetate 是一种合成的糖皮质激素,具有抗炎和免疫抑制作用,可用于治疗系统性红斑狼疮。
T39767 AR-C141990 hydrochloride

AR-C141990 hydrochloride

Others Others
AR-C141990 hydrochloride is a potent inhibitor of lactate transporters known as monocarboxylate transporters (MCTs). It has pK i values of 7.6 and 6.6 for MCT-1 and MCT-2, respectively. Additionally, this compound exhibits immunosuppressive properties and effectively inhibits the graft versus host response.
T39615 P8RI

D-P8RI

P8RI (D-P8RI) is a CD31 biomimetic peptide and agonist that specifically targets the juxtamembrane amino acid sequence of the ectodomain of CD31. By restoring the CD31 inhibitory pathway, P8RI exhibits immunosuppressive properties.
T7730L Aminopterin sodium

NSC739,NSC 739 [as the base],NSC-739

Others Others
Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe
T71048 Tacrolimus anhydrous 8-epimer

Others Others
Tacrolimus anhydrous 8-epimer is a new l-pipecolic acid macrolide lactone, an important immunosuppressive drug that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

化合物

Diflorasone
Cat.No: T2548
Synonym:
Target: Glucocorticoid Receptor
MP07-66
Cat.No: T9744
Synonym:
Target: Phosphatase
ADH-503
Cat.No: T7776
Synonym: GB1275
Target: Complement System
Peldesine
Cat.No: T12399
Synonym: BCX 34
Target: Nucleoside Antimetabolite/Analog, HIV Protease
CS 2100
Cat.No: T22697
Synonym: 1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid
Target: S1P Receptor
(Z)-Leukadherin-1
Cat.No: T13379
Synonym: ADH-503 free base
Target: Complement System
MNITMT
Cat.No: T9603
Synonym:
Target: Others
Frentizole
Cat.No: T7527
Synonym:
Target: Beta Amyloid
Azathioprine
Cat.No: T1237
Synonym: 硫唑嘌呤,BW 57-322
Target: Apoptosis, GPR, Rho
ITE
Cat.No: T7202
Synonym:
Target: AhR, Aryl Hydrocarbon Receptor
Cyclophosphamide hydrate
Cat.No: T0707
Synonym: 环磷酰胺一水物,Cyclophosphamide monohydrate,环磷酰胺水合物
Target: DNA Alkylator/Crosslinker, DNA, MRP
Razoxane
Cat.No: T26046
Synonym:
Target: Topoisomerase
Manitimus
Cat.No: T11941
Synonym: FK778
Target: Dehydrogenase
Thiamphenicol
Cat.No: T1550
Synonym: 甲砜霉素,Dextrosulphenidol,Thiophenicol
Target: Antibacterial, Antibiotic
6-Thioguanosine
Cat.No: T20511
Synonym: 6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422
Target: Others
P8RI acetate
Cat.No: T39615L
Synonym:
Target: Integrin
Chloroquinoxaline sulfonamide
Cat.No: T14953
Synonym: NSC-339004,Chloroquinoxaline
Target: Topoisomerase
Basiliximab
Cat.No: T73698
Synonym: CHI 621
Target: Interleukin
Betamethasone valerate
Cat.No: T1163
Synonym: Betnovate,倍他米松戊酸酯,Betaderm,Betamethasone 17-valerate,Luxiq
Target: Glucocorticoid Receptor
SIRT6-IN-5
Cat.No: T24793
Synonym: SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5
Target: Sirtuin
Dexamethasone
Cat.No: T1076
Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松
Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System, ADC Cytotoxin
Sabatolimab
Cat.No: T76699
Synonym: MBG453,NVP-MBG453
Target: Others
Aurothiomalate sodium
Cat.No: T20168
Synonym: 金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate
Target: Others, PKC
Methotrexate
Cat.No: T1485
Synonym: NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate, ADC Cytotoxin
Pralatrexate
Cat.No: T6120
Synonym: Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙
Target: Apoptosis, DHFR, Antifolate, TAM Receptor
Betamethasone dipropionate
Cat.No: T1559
Synonym: Diprolene AF,SCH 11460,二丙酸倍他米松,Betamethasone 17,21-dipropionate,Diprolene,倍他米松二丙酸酯,Diprosone
Target: Glucocorticoid Receptor
DZ2002
Cat.No: T11134
Synonym:
Target: Others
Isoflupredone
Cat.No: T41303
Synonym: Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone
Target: Others
Everolimus
Cat.No: T1784
Synonym: 依维莫司,RAD001,SDZ-RAD
Target: Apoptosis, Others, mTOR, Autophagy
Trinactin
Cat.No: T34952
Synonym: Akd1D,Akd 1D,Akd-1D
Target: Others
CI 972 anhydrous
Cat.No: T14964
Synonym: CI 972 (anhydrous)
Target: Others
Armepavine hydrochloride, (+/-)-
Cat.No: T30136
Synonym: DL-Armepavine hydrochloride
Target: Others
Ro 4-6824
Cat.No: T34361
Synonym: AI3-50843
Target: Others
Diflorasone Diacetate
Cat.No: T21192
Synonym: Apexicon E,Psorcon,Maxiflor,醋酸双氟拉松,Florone E
Target: Others
Hydrocortamate Hydrochloride
Cat.No: T32113
Synonym: UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort
Target: Others
SR-31747 free base
Cat.No: T38720
Synonym:
Target: Others
Lankacidinol
Cat.No: T25620
Synonym: Antibiotic T 2636F,T2636 F,T-2636 F,T 2636 F
Target: Others
Sotrastaurin acetate
Cat.No: T24815
Synonym:
Target: Others
A 85 4777
Cat.No: T26457
Synonym: A85-4777,A 8547777
Target: Others
SR-31747
Cat.No: T16926
Synonym:
Target: Others
FR 901235
Cat.No: T27368
Synonym: FR901235,FR-901235
Target: Others
JNJ-10329670
Cat.No: T27661
Synonym:
Target: Others
Glycosidase-IN-1
Cat.No: T11430
Synonym:
Target: Others
ASP5286
Cat.No: T76228
Synonym:
Target:
Pralatrexate, (R)-
Cat.No: T25980
Synonym:
Target: Others
Paramethasone Acetate
Cat.No: T33883
Synonym: NCGC00185748-01,Monocortin,CHEBI:31963,8X50N88ZDP,UNII-8X50N88ZDP
Target: Others
AR-C141990 hydrochloride
Cat.No: T39767
Synonym: AR-C141990 hydrochloride
Target: Others
P8RI
Cat.No: T39615
Synonym: D-P8RI
Target:
Aminopterin sodium
Cat.No: T7730L
Synonym: NSC739,NSC 739 [as the base],NSC-739
Target: Others
Tacrolimus anhydrous 8-epimer
Cat.No: T71048
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
TQ0248 Alisol F

泽泻醇 F,泽泻醇F

HBV Microbiology/Virology
Alisol F 是从泽泻中分离得到的一种三萜,具有免疫抑制和抗病毒功能。
T3603 Sodium lauryl sulfoacetate

月桂醇磺基乙酸酯钠,鱼腥草,新鱼腥草素钠,Sodium houttuyfonate

NF-κB; MAPK MAPK; NF-κB
Sodium lauryl sulfoacetate (Sodium houttuyfonate) 是一种植物来源的固体阴离子表面活性剂,也是一种具有抗免疫抑制作用的免疫佐剂。
T7730 Aminopterin

APGA,氨基蝶呤,4-Aminofolic acid

Antifolate Cell Cycle/Checkpoint
Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物,是叶酸拮抗剂,具有抗癌和免疫抑制活性,用于研究儿童白血病。它催化叶酸还原为四氢叶酸,竞争性抑制二氢叶酸还原酶,Ki 值为 3.7 pM。
T1335 Mycophenolic acid

霉酚酸,Mycophenolate,RS-61443

Apoptosis; Dehydrogenase; Endogenous Metabolite; Antibacterial; Antibiotic; UGT; Antifungal Apoptosis; Metabolism; Microbiology/Virology
Mycophenolic acid (Mycophenolate) 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂,EC50为 0.24 µM。它对多种 RNA 病毒具有抗病毒作用。它也是一种免疫抑制剂,具有抗血管生成和抗肿瘤作用。
TN1697 Glucosyringic acid

葡萄糖基丁香酸

Immunology/Inflammation related Immunology/Inflammation
Glucosyringic acid 具有免疫抑制作用,在体外能抑制鼠 B 淋巴细胞的增殖。
T1243 Hydrocortisone acetate

Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松

Glucocorticoid Receptor; Annexin A; Endogenous Metabolite Endocrinology/Hormones; GPCR/G Protein; Metabolism
Hydrocortisone acetate (Cortisol 21-acetate) 是皮质类固醇,能够减少轻微皮肤刺激或痔疮引起的肿胀、搔痒和疼痛。
T5736 1,3-Dicaffeoylquinic acid

CYNARIN,1,3-二咖啡酰奎宁酸,Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1S,​3R,​4R,​5R)​-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid

Reactive Oxygen Species; Akt; PI3K Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
1,3-Dicaffeoylquinic acid (CYNARIN) 是一种咖啡酰奎宁酸衍生物,具有抗氧化、自由基清除作用。
T2179 Triptolide

PG490,NSC 163062,雷公藤甲素

Apoptosis; Mdm2; HSP; NF-κB Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
Triptolide (PG490) 属于三环二萜类天然产物,是一种 NF-κB 活化的抑制剂。Triptolide 具有免疫抑制、抗风湿、抗炎、抗增殖和抗肿瘤活性。
T20879 Tacrolimus monohydrate

FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Phosphatase; Others; Antibacterial; Antibiotic; Autophagy Autophagy; Metabolism; Microbiology/Virology; Others
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
TN1110 Shanziside

山栀苷,Shanzhiside

IL Receptor Immunology/Inflammation
Shanziside (Shanzhiside) 是一种分离自福洛美属植物中的环烯醚萜苷类化合物。
T6293 Mycophenolate Mofetil

TM-MMF,吗替麦考酚酯,RS 61443

Apoptosis; Dehydrogenase; Drug Metabolite Apoptosis; Metabolism
Mycophenolate Mofetil (TM-MMF) 是 Mycophenolic acid 的吗啉乙酯前药。它通过抑制肌苷一磷酸脱氢酶抑制从头嘌呤合成,显示出选择性淋巴细胞抗增殖作用。
T1537 Rapamycin

Sirolimus,AY 22989,雷帕霉素,NSC-2260804

Others; Endogenous Metabolite; Antibiotic; mTOR; Autophagy; Antifungal Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
Rapamycin (AY 22989) 属于大环内酯类天然产物,是一种 mTOR 抑制剂,具有特异性(HEK293 细胞:IC50=0.1 nM)。Rapamycin 具有免疫抑制活性,并能诱导自噬。
T5S1285 (+)-(3R,8S)-Falcarindiol

Falcarindiol,镰叶芹二醇

Others Others
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
TN1507 Clematichinenoside AR

TNF; Autophagy Apoptosis; Autophagy
Clematichinenoside AR 是从中药威灵仙中提取的一种天然产物,具有抗炎和免疫抑制特性,对 PI3K/Akt 信号通路和与胶原诱导的关节炎相关的 TNF-α± 具有抗关节炎作用。
T36914 2-Hydroxyanthraquinone

Others Others
2-Hydroxyanthraquinone 是一种天然产物,显示出抗肿瘤和免疫抑制活性。
T3418 Demethylzeylasteral

去甲泽拉木醛,Demethylzeylasteral (T-96)

Apoptosis; UGT Apoptosis; Metabolism
Demethylzeylasteral (Demethylzeylasteral (T-96)) 分离自雷公藤,具有抗炎、免疫抑制和抗肿瘤活性。它通过阻断 TGF-β 信号通路,抑制三阴性乳腺癌的侵袭,它能显著减轻动脉粥样硬化。
T13808 p-Coumaric Acid Ethyl Ester

对香豆酸乙酯,Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate

Others; Drug Metabolite Metabolism; Others
p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate) 是 p-Coumaric acid 的乙酯形式。p-Coumaric Acid 是一种免疫抑制剂, 能够用于自身免疫性炎性疾病 (如类风湿关节炎) 的研究。
T2996 Tetrandrine

NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素

Potassium Channel; Calcium Channel Membrane transporter/Ion channel; Metabolism
Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱,可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。
T1188 Mizoribine

Bredinin,NSC 289637,咪唑立宾,HE 69

HCV Protease; SARS-CoV; Tyrosinase Microbiology/Virology; Proteases/Proteasome
Mizoribine (NSC-289637) 是一种免疫抑制剂,抑制HCVRNA 复制,有抗 HCV 活性,IC50约为 100 μM。它抑制SARS-CoV 复制,对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。
T4S0867 Pogostone

DHELWANGIN,广藿香酮

Apoptosis; Antibacterial; Autophagy Apoptosis; Autophagy; Microbiology/Virology
Pogostone (DHELWANGIN) 是从薄荷中分离出,对革兰氏阴性菌、革兰氏阳性菌、大肠埃希菌等具有强效抗菌、抗真菌活性。它诱导细胞凋亡和自噬。
T6S2140 β-Anhydroicaritin

Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

MMP; Others; TNF; Interleukin Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
β-Anhydroicaritin 是从乳香提取的一种天然产物,具有重要的生物学和药理学作用,如抗骨质疏松症,雌激素调节和抗肿瘤特性。它改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高,并显著降低 iNOS 蛋白的表达。
T5S2357 Acetylcorynoline

(+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵

Antifungal Microbiology/Virology
Acetylcorynoline (O-Acetylcorynoline) 是提取自 Corydalis bungeana 中的一种主要生物碱成分,具有抗炎活性。
T3824 Jaceosidin

Apoptosis; BCL; COX; UGT Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。
TMA2235 Triptobenzene H

Triptobenzene H shows the significant immunosuppressive activity.
TN4841 Ptaquiloside

Ptaquiloside shows genotoxicity, it also has carcinogenic effects. Ptaquiloside has immunosuppressive effects, it reduces NK cell activities by enhancing metallothionein expression, which is prevented by selenium.
T75465 Mycestericin G

Others Others
Mycestericin G 是一种鞘氨醇样真菌代谢产物,具有免疫抑制活性。
TN5187 Triptoquinone B

IL Receptor Immunology/Inflammation
Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells, it shows the significant immunosuppressive activity.
T8303 Cimicifugoside

Others Others
Cimicifugoside 是一种三萜类化合物,提取自升麻单胞菌Cimicifuga simplex 中。它具有免疫抑制活性,其优先针对 B 细胞功能,需要较大剂量来抑制 T 细胞功能。它是新型特异性核苷转运抑制剂,协同增强甲氨蝶呤细胞毒性作用。
T40643 Prodigiosin hydrochloride

盐酸灵菌红素,Prodigiosine hydrochloride

Others Others
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
TN4778 Physalin H

gp120/CD4; Antifection; Autophagy Autophagy; Immunology/Inflammation; Microbiology/Virology
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both
T75502 Brazilein

Others Others
Brazilein为从Caesalpinia sappan L.中提取的关键免疫抑制成分,能够诱导小鼠脾淋巴细胞(apoptosis)。
TN3403 Djalonensone

交链孢霉甲基醚,Alternariol monomethyl ether

Immunology/Inflammation related Immunology/Inflammation
Djalonensone (Alternariol monomethyl ether) 具有强大的 DPPH 自由基清除作用。
T72857 Maydispenoid A

Others Others
Maydispenoid A, 作为一种有效的免疫抑制剂,能够抑制抗CD3/抗CD28单抗和脂多糖激活的小鼠脾细胞增殖。
T82565 Diayangambin

Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether

Diayangambin (Syringaresinol dimethyl ether; Lirioresinol C dimethyl ether) 作为一种细胞增殖抑制剂,其对人单核细胞的IC50值为1.5 μM。此外,Diayangambin 还表现出免疫抑制与抗炎特性。
T35761 Carviolin

Others Others
Carviolin is an anthraquinone fungal metabolite that has been found inZ. longicaudatawith immunosuppressive and antitrypanosomal activities.1,2It inhibits LPS- or concanavalin A-induced proliferation of mouse splenocytes (IC50s = 4 and 4.5 μg/ml, respectively).1Carviolin is active againstT. b. brucei(MIC = 41.66 μM).2 1.Fujimoto, H., Nakamura, E., Okuyama, E., et al.Six immunosuppressive features from an ascomycete, Zopfiella longicaudata, found in a screening study monitored by immunomodulatory...
T19886 Cirsilineol

Fastigenin,SPM 927,Eupatrin

Apoptosis; COX; STAT Apoptosis; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
Cirsilineol (Eupatrin) 是从 Artemisia vestita Wall 的草本植物中分离出来的,具有免疫抑制、抗增殖和抗肿瘤特性。 Cirsilineol 通过线粒体途径选择性诱导细胞凋亡。
T80777 Withaphysalin R

Withaphysalin R (化合物 5),一种可从茄科植物中提取的睡茄内酯 (Withanolide),具有麦角固醇框架的甾体内酯。其活性包括细胞毒性、免疫抑制、抗肿瘤、抗炎、抗惊厥及抗氧化等显著生物活性。
TN4838 Pseurotin A

Antifection Microbiology/Virology
Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), r
T73925 α-D-Glucose-1-phosphate disodium hydrate

Others Others
α-D-Glucose-1-phosphate disodium hydrate 为合成葡萄糖醛酸的初始原料之一,同时,在心脏病研究领域,亦被广泛应用作为细胞抑制剂、抗生素、免疫抑制剂与循环系统研究的关键材料。

天然产物

Alisol F
Cat.No: TQ0248
Synonym: 泽泻醇 F,泽泻醇F
Target: HBV
Sodium lauryl sulfoacetate
Cat.No: T3603
Synonym: 月桂醇磺基乙酸酯钠,鱼腥草,新鱼腥草素钠,Sodium houttuyfonate
Target: NF-κB, MAPK
Aminopterin
Cat.No: T7730
Synonym: APGA,氨基蝶呤,4-Aminofolic acid
Target: Antifolate
Mycophenolic acid
Cat.No: T1335
Synonym: 霉酚酸,Mycophenolate,RS-61443
Target: Apoptosis, Dehydrogenase, Endogenous Metabolite, Antibacterial, Antibiotic, UGT, Antifungal
Glucosyringic acid
Cat.No: TN1697
Synonym: 葡萄糖基丁香酸
Target: Immunology/Inflammation related
Hydrocortisone acetate
Cat.No: T1243
Synonym: Cortisol 21-acetate,Hydrocortisone 21-acetate,醋酸氢化可的松
Target: Glucocorticoid Receptor, Annexin A, Endogenous Metabolite
1,3-Dicaffeoylquinic acid
Cat.No: T5736
Synonym: CYNARIN,1,3-二咖啡酰奎宁酸,Cyclohexanecarboxyli​c acid, 1,​3-​bis[[3-​(3,​4-​dihydroxyphenyl)​-​1-​oxo-​2-​propen-​1-​yl]​oxy]​-​4,​5-​dihydroxy-​, (1S,​3R,​4R,​5R)​-,1,3-O-Dicaffeoylquinic acid,1,5-Dicaffeoylquinic acid
Target: Reactive Oxygen Species, Akt, PI3K
Triptolide
Cat.No: T2179
Synonym: PG490,NSC 163062,雷公藤甲素
Target: Apoptosis, Mdm2, HSP, NF-κB
Tacrolimus monohydrate
Cat.No: T20879
Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506
Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy
Shanziside
Cat.No: TN1110
Synonym: 山栀苷,Shanzhiside
Target: IL Receptor
Mycophenolate Mofetil
Cat.No: T6293
Synonym: TM-MMF,吗替麦考酚酯,RS 61443
Target: Apoptosis, Dehydrogenase, Drug Metabolite
Rapamycin
Cat.No: T1537
Synonym: Sirolimus,AY 22989,雷帕霉素,NSC-2260804
Target: Others, Endogenous Metabolite, Antibiotic, mTOR, Autophagy, Antifungal
(+)-(3R,8S)-Falcarindiol
Cat.No: T5S1285
Synonym: Falcarindiol,镰叶芹二醇
Target: Others
Clematichinenoside AR
Cat.No: TN1507
Synonym:
Target: TNF, Autophagy
2-Hydroxyanthraquinone
Cat.No: T36914
Synonym:
Target: Others
Demethylzeylasteral
Cat.No: T3418
Synonym: 去甲泽拉木醛,Demethylzeylasteral (T-96)
Target: Apoptosis, UGT
p-Coumaric Acid Ethyl Ester
Cat.No: T13808
Synonym: 对香豆酸乙酯,Ethyl (E)-p-hydroxycinnamate,Ethyl trans-4-hydroxycinnamate
Target: Others, Drug Metabolite
Tetrandrine
Cat.No: T2996
Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素
Target: Potassium Channel, Calcium Channel
Mizoribine
Cat.No: T1188
Synonym: Bredinin,NSC 289637,咪唑立宾,HE 69
Target: HCV Protease, SARS-CoV, Tyrosinase
Pogostone
Cat.No: T4S0867
Synonym: DHELWANGIN,广藿香酮
Target: Apoptosis, Antibacterial, Autophagy
β-Anhydroicaritin
Cat.No: T6S2140
Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素
Target: MMP, Others, TNF, Interleukin
Acetylcorynoline
Cat.No: T5S2357
Synonym: (+)-Corynoline Acetate,O-Acetylcorynoline,乙酰紫堇灵
Target: Antifungal
Jaceosidin
Cat.No: T3824
Synonym:
Target: Apoptosis, BCL, COX, UGT
Triptobenzene H
Cat.No: TMA2235
Synonym:
Target:
Ptaquiloside
Cat.No: TN4841
Synonym:
Target:
Mycestericin G
Cat.No: T75465
Synonym:
Target: Others
Triptoquinone B
Cat.No: TN5187
Synonym:
Target: IL Receptor
Cimicifugoside
Cat.No: T8303
Synonym:
Target: Others
Prodigiosin hydrochloride
Cat.No: T40643
Synonym: 盐酸灵菌红素,Prodigiosine hydrochloride
Target: Others
Physalin H
Cat.No: TN4778
Synonym:
Target: gp120/CD4, Antifection, Autophagy
Brazilein
Cat.No: T75502
Synonym:
Target: Others
Djalonensone
Cat.No: TN3403
Synonym: 交链孢霉甲基醚,Alternariol monomethyl ether
Target: Immunology/Inflammation related
Maydispenoid A
Cat.No: T72857
Synonym:
Target: Others
Diayangambin
Cat.No: T82565
Synonym: Syringaresinol dimethyl ether,Lirioresinol C dimethyl ether
Target:
Carviolin
Cat.No: T35761
Synonym:
Target: Others
Cirsilineol
Cat.No: T19886
Synonym: Fastigenin,SPM 927,Eupatrin
Target: Apoptosis, COX, STAT
Withaphysalin R
Cat.No: T80777
Synonym:
Target:
Pseurotin A
Cat.No: TN4838
Synonym:
Target: Antifection
α-D-Glucose-1-phosphate disodium hydrate
Cat.No: T73925
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPK-01231 CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated

OCILmember D,LLT1,CLAX,CLEC2D,CLAXLLT-1,LLT-1,OCIL

Human HEK293 Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies.
TMPY-03859 DHRS9 Protein, Human, Recombinant (His)

3α-HSD,RDHTBE,3ALPHA-HSD,RDH-E2,RETSDR8,dehydrogenase/reduct...

Human E. coli
Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in CRC. The human regulatory macrophage (Mreg) has emerged as a promising cell type for use as a cell-based adjunct immunosuppressive therapy in solid organ transplant recipients. DHRS9 is a specific and stable marker of human Mregs.
TMPH-01195 Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog

UL111A,Viral interleukin-10 homolog

HCMV E. coli
Functional viral IL-10 homolog. Can bind to the human IL-10 receptor and compete with human IL-10 for binding sites. Requires both subunits of the human IL-10 receptor complex to induce signal transduction events and biological activities. IL-10 signaling pathway has several immunosuppressive activities that are exploited by the virus. Inhibits TLR-induced type I interferon production in host plasmacytoid dendritic cells. Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog ...
TMPK-01230 CLEC2D Protein, Human, Recombinant (hFc & Avi)

Lectin-like NK cell receptor,LLT-1,OCIL,LLT1,Lectin-like tra...

Human HEK293 Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART).
TMPJ-00021 LGALS1 Protein, Human, Recombinant (His)

HPL,S-Lac Lectin 1,Lactose-Binding Lectin 1,14 kDa Lectin,Be...

Human E. coli
Galectin-1 is a member of growing family of evolutionary conserved animal lectins. Galectin-1 is widely expressed in many cells and tissues. Galectins consists of a Galectin domain and two Beta-galactoside binding domains. Galectin-1 can binds LGALS3BP and interacts with CD2, CD3, CD4, CD7, CD43 and CD45. Galectin-1 may act as an autocrine negative growth factor which regulates apoptosis, cell proliferation and cell differentiation. In addition, Galectin-1 plays improtant roles in immunosuppress...
TMPJ-01313 HIV-1 gp120 Protein (His)

Envelope glycoprotein gp120,Surface protein gp120,Glycoprote...

HIV HEK293 Cells
Envelope glycoprotein gp160 is single-pass type I membrane protein. The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. It is cleaved into the following 2 chains: glycoprotein 120 and transmembrane protein gp41. The resulting complex protrudes from the virus surface as a spike. The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequ...
TMPJ-01049 CYPA Protein, Human, Recombinant

Rotamase A,Peptidyl-prolyl cis-trans isomerase A,PPIase A,PP...

Human E. coli
Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressi...
TMPJ-00189 TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)

HAVCR2,Tim-3,TIM3,T cell immunoglobulin and mucin domain3

Cynomolgus HEK293 Cells
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance...
TMPJ-01252 CLEC2D Protein, Mouse, Recombinant (His)

Clec2d,Clr-b,Clrb,Ocil,Osteoclast inhibitory lectin,C-type l...

Mouse HEK293 Cells
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tu...

重组蛋白

CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPK-01231
Species: Human
Expression System: HEK293 Cells
DHRS9 Protein, Human, Recombinant (His)
Cat.No: TMPY-03859
Species: Human
Expression System: E. coli
Human cytomegalovirus (HCMV) (strain Merlin) Viral interleukin-10 homolog
Cat.No: TMPH-01195
Species: HCMV
Expression System: E. coli
CLEC2D Protein, Human, Recombinant (hFc & Avi)
Cat.No: TMPK-01230
Species: Human
Expression System: HEK293 Cells
LGALS1 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00021
Species: Human
Expression System: E. coli
HIV-1 gp120 Protein (His)
Cat.No: TMPJ-01313
Species: HIV
Expression System: HEK293 Cells
CYPA Protein, Human, Recombinant
Cat.No: TMPJ-01049
Species: Human
Expression System: E. coli
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00189
Species: Cynomolgus
Expression System: HEK293 Cells
CLEC2D Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01252
Species: Mouse
Expression System: HEK293 Cells
Cat. No. Product Name Target Signaling Pathways
TMID-0087 Azathioprine-d3

Azathioprine-d3 是 Azathioprine 的氘代化合物。Azathioprine 的 CAS 号为 446-86-6。Azathioprine是一种免疫抑制剂。
TMID-0086 Mycophenolate Mofetil-d4

Mycophenolate Mofetil-d4 是 Mycophenolate Mofetil 的氘代化合物。Mycophenolate Mofetil 的 CAS 号为 128794-94-5。Mycophenolate mofetil 是 Mycophenolic acid 的吗啉乙酯前药。它通过抑制肌苷一磷酸脱氢酶抑制从头嘌呤合成,显示出选择性淋巴细胞抗增殖作用。
TMIJ-0022 Thiamphenicol-Methyl-d3

Thiamphenicol-Methyl-d3 是 Thiamphenicol 的氘代化合物。Thiamphenicol 的 CAS 号为 15318-45-3。Thiamphenicol是 Chloramphenicol 的甲基磺酰基衍生物,是一种广谱抗菌类抗生素。它与 50S 核糖体亚基结合,抑制蛋白质合成并具有抑菌作用 ,特别针对革兰氏阴性,革兰氏阳性需氧和厌氧菌。
TMIJ-0204 Betamethasone-d10 Dipropionate

Betamethasone-d10 Dipropionate 是 Betamethasone Dipropionate 的氘代化合物。Betamethasone Dipropionate 的 CAS 号为 5593-20-4。Betamethasone dipropionate 是糖皮质激素类固醇,具有免疫抑制、抗炎作用。

同位素标记化合物

Azathioprine-d3
Cat.No: TMID-0087
Synonym:
Target:
Mycophenolate Mofetil-d4
Cat.No: TMID-0086
Synonym:
Target:
Thiamphenicol-Methyl-d3
Cat.No: TMIJ-0022
Synonym:
Target:
Betamethasone-d10 Dipropionate
Cat.No: TMIJ-0204
Synonym:
Target:
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