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Search Results for " hypertensive "

Targets Recommended: Others

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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T10511	Anti-hypertensive sulfonanilide 1	Others	Others
	Anti-hypertensive sulfonanilide 1 is an antihypertensive compound.
T3474	RO 46-8443	Endothelin Receptor	GPCR/G Protein
	Ro 46-844 是选择性非肽内皮素受体拮抗剂。它对ETB(IC50: 34-69 nM) 的选择性比ETA 受体 (IC50: 6800 nM) 高的100倍以上。
T0993	Methoxamine hydrochloride Methoxamine HCl,盐酸甲氧明	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出，但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。
T22398	Phenidone 菲尼酮,1-phenyl-3-pyrazolidinone	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Phenidone (1-phenyl-3-pyrazolidinone) 是可口服发环氧化酶和脂氧合酶双重抑制剂，可改善实验性自身免疫性脑脊髓炎大鼠的瘫痪，降低自发性高血压大鼠的血压，可用作照片显像剂。
T0287	Hexamethonium Bromide Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide	Apoptosis; Dopamine Receptor; AChR	Apoptosis; GPCR/G Protein; Neuroscience
	Hexamethonium Bromide (Hexamethonium Dibromide) 是神经节中神经元型烟碱型 AChR 的特异性拮抗剂。在自发性高血压动物模型中，它能降低其交感神经活动和血压。
T28482	Firibastat QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150	Aminopeptidase	Metabolism
	Firibastat (RB150) 是一种具有口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A(APA) 抑制剂 (Ki=200 nM)，选择性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III，降低血压。
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T4560	Alprenolol Alpheprol,阿普洛尔,(RS)-Alprenolol,dl-Alprenolol	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Alprenolol (Alpheprol) 是一种非选择性β受体阻滞剂，也是5-HT1A 受体拮抗剂。
T22236	Alprenolol hydrochloride 阿普洛尔盐酸盐,盐酸阿普洛尔	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alprenolol hydrochloride 是一种非选择性β受体阻滞剂，也是5-HT1A 受体拮抗剂。
T9097	Guanadrel	Others	Others
	Guanadrel 是一种抗高血压药。
T3046	BMY 7378 dihydrochloride BMY7378 HCl	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	BMY 7378 dihydrochloride (BMY7378 HCl) 是选择性 α1D 肾上腺素受体拮抗剂，也是5-HT1A 受体部分激动剂。它同表达克隆大鼠 α1D-AR 的膜结合的亲和力 (Ki=2 nM) 是同克隆大鼠 α1A-AR (Ki=800 nM) 或仓鼠 α1B-AR (Ki=600 nM) 结合的亲和力的100 以上。
T1615	Irbesartan 厄贝沙坦,SR-47436,BMS-186295	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Irbesartan (SR-47436) 是一种 1 型血管紧张素 II 受体拮抗剂，IC50为1.3 nM。
T23044	N,N'-Dicyclohexylurea DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲	Epoxide Hydrolase	Metabolism
	N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。
T6835	Fenoldopam mesylate Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fenoldopam mesylate (Corlopam mesylate) 是一种多巴胺受体D1选择性激动剂。
T79267	Antihypertensive agent 3	Others	Others
	Antihypertensive agent 3 (compound 4a) 是一种针对血管紧张素 II 受体 1(AT1) 的拮抗剂，其在自发性高血压大鼠(SHRs)的模型中表现出显著的降压效果。
T79266	Antihypertensive agent 2	Others	Others
	Antihypertensive agent 2 (Compound 4g) 为一种有效的血管紧张素 II 受体 1 拮抗剂，其降血压效能可与Losartan媲美或更胜一筹。
T80661	Antihypertensive sulfonanilide XVII	Others	Others
	Antihypertensive sulfonanilide XVII 是一种可口服的抗高血压磺酰苯胺类小分子化合物，可用于研究高血压。
T28009	ME-3221 ME 3221,ME3221	RAAS	Endocrinology/Hormones
	ME-3221是一种血管紧张素AT1受体拮抗剂，可预防老年中风易发性高血压大鼠的高血压并发症。
T17111	Todralazine hydrochloride Ecarazine hydrochloride,盐酸托屈嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Todralazine hydrochloride (Ecarazine hydrochloride) 是一种 β2AR 阻滞剂，具有抗氧化和自由基清除活性。 Todralazine hydrochloride 可用于抗高血压的研究。
T16329	Nitroflurbiprofen NO-flurbiprofen,Nitroxybutyl flurbiprofen,硝基氟比洛芬,HCT 1206	COX	Immunology/Inflammation; Neuroscience
	Nitroflurbiprofen (Nitroxybutyl flurbiprofen) 是一种释放 NO 的环氧合酶抑制剂，可调节门脉高压性肝硬化大鼠肝内血管张力的增加。
T10595	BQ-788 BQ788	Endothelin Receptor	GPCR/G Protein
	BQ-788 是一种具有选择性和有效性的 ETB 受体拮抗剂，具有潜在的高血压活性，抑制 ET-1 与 ETB 受体结合，抑制外源性 ET-1 诱导的冠状动脉灌注压升高。
T0126	Diazoxide 氯甲苯噻嗪,二氮嗪,SRG-95213,Sch-6783,Proglycem	ATPase; Potassium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel
	Diazoxide (Proglycem) 是一种 ATP 敏感性的钾离子通道激活剂，是一种苯并噻二嗪衍生物，是一种用于高血压急症的外周血管扩张剂。
T2528	Latanoprost Xalatan,PHXA41,拉坦前列腺素,拉坦前列素	GPR; Prostaglandin Receptor; RAR/RXR	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Latanoprost (Xalatan) 是前列腺素 F2α 类似物，是一种前列腺素受体激动剂，能够降低眼内压。
T36506	Tempone 4-Oxo-tempo	Others	Others
	Tempone 是一种氨基氧烷，具有自由基清除剂的作用，会与活性氧（ROS）发生反应。静脉注射 Tempone 可降低自发性高血压大鼠的平均动脉。
T37496L	Alamandine TFA	RAAS	Endocrinology/Hormones
	Alamandine TFA 是肾素-血管紧张素系统 (RAS) 的成员，是一种血管活性肽，是 G 蛋白偶联受体 MrgD 的内源性配体。它通过抗高血压作用来保护肾脏和心脏。
T1275	Phentolamine mesylate Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。
T12596	(4E)-SUN9221	5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(4E)-SUN9221 是一种有效的 α1-adrenergic 受体和 5-HT2 受体双重拮抗剂，在高血压大鼠中显示出抗高血压和抗血小板聚集活性。
T24932	Vatanidipine AE-0047,AE 0047,AE0047	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Vatanidipine (AE0047) 是一种新型的双氢吡啶(DHP)型钙通道阻滞剂，具有缓慢起效的药理作用。在各种实验性高血压模型中观察到缓慢起效和持久的降压作用。
T20570	Labetalol Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Labetalol (Apo-Labetalol) 是一种抗高血压药物，可用于心血管疾病的研究，如妊娠期高血压。它是一种口服具有活性的选择性 α1- 和非选择性 β-肾上腺素能受体 (adrenergic receptor) 竞争性拮抗剂。
T22948	LY 272015 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	LY 272015 hydrochloride 是一种具有口服活性的和选择性的 5-HT2B 受体拮抗剂，在DOCA-盐高血压大鼠中显示出抗高血压作用。LY 272015 hydrochloride 抑制 5-HT 或 BW723C86 诱导的 ERK2 磷酸化，可减轻 MVIC 和组织中 5HT 信号传导的下游细胞效应，可用于研究肝癌。
T24478	MK-8141 MK 8141,ACT 077825,ACT077825,ACT-077825	Others	Others
	MK-8141 is a renin inhibitor. It displays some antihypertensive efficacy in hypertensive patients.
T34945	Trimazosin hydrochloride CP19106-1,CP 19106-1,Trimazosin HCl,CP-19106-1	Others	Others
	Trimazosin hydrochloride is used in the treatment of hypertensive patients failing to respond to thiazides.
T31598	Ecadotril S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049	Others	Others
	Ecadotril is a neutral endopeptidase (NEP) inhibitor, which plays an anti hypertensive role.
T71396	FCE-24379	Others	Others
	FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats.
T28039	Milfasartan LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081	Others	Others
	Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats.
T21416	Hydroflumethiazide Diurometon,Glomerulin,Diuredemina,Flutizide,Hidroflumetiazid	Others	Others
	Hydroflumethiazide is a thiazide diuretic. It has also shown the activity of anti-hypertensive.
T17112	Todralazine Ecarazine	Others	Others
	Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity.
T27743	KRH-594 free acid WK14922K,WK-1492,WK-14922K,WK1492	Others	Others
	KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm ra
T13328	AE0047 Hydrochloride	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
T38424	(R)-Fadrozole FAD286,(R)-CGS 16949A free base,(R)-Fadrozole	Others	Others
	(R)-Fadrozole ((R)-CGS 16949A; FAD286) is a potent nonsteroidal inhibitor. (R)-Fadrozole also inhibits human placental aromatase (pIC 50 = 6.17) and aldosterone biosynthesis. (R)-Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats..
T14942	CGP48369	RAAS	Endocrinology/Hormones
	CGP48369 是一种有效的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂，具有降血压作用，可增强自发性高血压大鼠冠状动脉的内皮依赖性松弛。
T40688	Fulvine	Others	Others
	Fulvine, a pyrrolizidine alkaloid extracted from Crotalaria fulva seeds, exhibits hepatotoxic properties and can be employed for inducing hypertensive pulmonary vascular disease in vivo.
T11642	Imidaprilate Imidaprilat,6366A	RAAS	Endocrinology/Hormones
	Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin-converting enzyme (ACE) inhibitor (IC50: 2.6 nM). It is used in the research of the hypertensive disease.
T27306	Fasidotril BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137	Others	Others
	Fasidotril is a NEP/ACE inhibitor. Fasidotril was an effective oral antihypertensive agent during chronic treatment in high-renin renovascular rats, normal-renin SHR, and low-renin DOCA-salt hypertensive rats and in patients with essential hypertension.
T26802	BIBS-222 BIBS 222	Others	Others
	BIBS-222, a nonpeptide angiotensin II (Ang II) receptor antagonist, appears to be an effective antihypertensive in the model of the renal hypertensive rat.
T78063	Endothelin-1 (1-31) (Human) TFA	ERK	MAPK
	Endothelin-1 (1-31) (Human) TFA 是源自chymase对大ET-1选择性水解的一种有效血管收缩剂和血压升高剂。
TP2126	R 892
	Potent and selective bradykinin B1 receptor antagonist (ID50 values are 2.8 and > 600 nM at B1 and B2 receptors respectively). Exhibits no intrinsic agonist activity and is resistant to aminopeptidase and kininase II (ACE) cleavage. Displays hypertensive
T15680	L-159282 MK 996	Others	Others
	L-159282 is an orally active and nonpeptide angiotensin II receptor antagonist. It also has anti-hypertensive activity.
T81681	Neuromedin U-25 (porcine)
	Neuromedin U-25 (porcine) 是一类具有子宫刺激和升高血压作用的肽。
T14672	BMS-248360	Others	Others
	BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].

化合物

Anti-hypertensive sulfonanilide 1

Cat.No: T10511

Target: Others

Cat.No: T3474

Target: Endothelin Receptor

Methoxamine hydrochloride

Cat.No: T0993

Synonym: Methoxamine HCl,盐酸甲氧明

Target: Adrenergic Receptor

Cat.No: T22398

Synonym: 菲尼酮,1-phenyl-3-pyrazolidinone

Target: Lipoxygenase, COX

Hexamethonium Bromide

Cat.No: T0287

Synonym: Gangliostat,溴化六甲铵,Simpatoblock,六甲溴铵,Hexamethonium Dibromide

Target: Apoptosis, Dopamine Receptor, AChR

Cat.No: T28482

Synonym: QGC 001,QGC-001,RB-150,RB150,QGC001,RB 150

Target: Aminopeptidase

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Cat.No: T4560

Synonym: Alpheprol,阿普洛尔,(RS)-Alprenolol,dl-Alprenolol

Target: 5-HT Receptor, Adrenergic Receptor

Alprenolol hydrochloride

Cat.No: T22236

Synonym: 阿普洛尔盐酸盐,盐酸阿普洛尔

Target: 5-HT Receptor

Cat.No: T9097

Target: Others

BMY 7378 dihydrochloride

Cat.No: T3046

Synonym: BMY7378 HCl

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T1615

Synonym: 厄贝沙坦,SR-47436,BMS-186295

Target: Apoptosis, RAAS

N,N'-Dicyclohexylurea

Cat.No: T23044

Synonym: DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲

Target: Epoxide Hydrolase

Fenoldopam mesylate

Cat.No: T6835

Synonym: Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐

Target: Dopamine Receptor

Antihypertensive agent 3

Cat.No: T79267

Target: Others

Antihypertensive agent 2

Cat.No: T79266

Target: Others

Antihypertensive sulfonanilide XVII

Cat.No: T80661

Target: Others

Cat.No: T28009

Synonym: ME 3221,ME3221

Target: RAAS

Todralazine hydrochloride

Cat.No: T17111

Synonym: Ecarazine hydrochloride,盐酸托屈嗪

Target: Adrenergic Receptor

Nitroflurbiprofen

Cat.No: T16329

Synonym: NO-flurbiprofen,Nitroxybutyl flurbiprofen,硝基氟比洛芬,HCT 1206

Target: COX

Cat.No: T10595

Synonym: BQ788

Target: Endothelin Receptor

Cat.No: T0126

Synonym: 氯甲苯噻嗪,二氮嗪,SRG-95213,Sch-6783,Proglycem

Target: ATPase, Potassium Channel, Autophagy

Cat.No: T2528

Synonym: Xalatan,PHXA41,拉坦前列腺素,拉坦前列素

Target: GPR, Prostaglandin Receptor, RAR/RXR

Cat.No: T36506

Synonym: 4-Oxo-tempo

Target: Others

Cat.No: T37496L

Target: RAAS

Phentolamine mesylate

Cat.No: T1275

Synonym: Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate

Target: Adrenergic Receptor

Cat.No: T12596

Target: 5-HT Receptor, Adrenergic Receptor

Cat.No: T24932

Synonym: AE-0047,AE 0047,AE0047

Target: Calcium Channel

Cat.No: T20570

Synonym: Apo-Labetalol,Albetol,Trandate,Dilevalol,拉贝洛尔,Normodyne

Target: Adrenergic Receptor

LY 272015 hydrochloride

Cat.No: T22948

Target: 5-HT Receptor

Cat.No: T24478

Synonym: MK 8141,ACT 077825,ACT077825,ACT-077825

Target: Others

Trimazosin hydrochloride

Cat.No: T34945

Synonym: CP19106-1,CP 19106-1,Trimazosin HCl,CP-19106-1

Target: Others

Cat.No: T31598

Synonym: S.049,BAY-y 7432,BAY y 7432,BP 1.02,S049

Target: Others

Cat.No: T71396

Target: Others

Cat.No: T28039

Synonym: LR-B081,LRB-081,LR-B-081,LRB 081,LR-B 081

Target: Others

Hydroflumethiazide

Cat.No: T21416

Synonym: Diurometon,Glomerulin,Diuredemina,Flutizide,Hidroflumetiazid

Target: Others

Cat.No: T17112

Synonym: Ecarazine

Target: Others

KRH-594 free acid

Cat.No: T27743

Synonym: WK14922K,WK-1492,WK-14922K,WK1492

Target: Others

AE0047 Hydrochloride

Cat.No: T13328

Target: Calcium Channel

Cat.No: T38424

Synonym: FAD286,(R)-CGS 16949A free base,(R)-Fadrozole

Target: Others

Cat.No: T14942

Target: RAAS

Cat.No: T40688

Target: Others

Cat.No: T11642

Synonym: Imidaprilat,6366A

Target: RAAS

Cat.No: T27306

Synonym: BP 1137,BP1137,BP-1.137,BP1.137,BP-1137,BP 1.137

Target: Others

Cat.No: T26802

Synonym: BIBS 222

Target: Others

Endothelin-1 (1-31) (Human) TFA

Cat.No: T78063

Target: ERK

Cat.No: TP2126

Cat.No: T15680

Synonym: MK 996

Target: Others

Neuromedin U-25 (porcine)

Cat.No: T81681

Cat.No: T14672

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8158	Tilianin 香清兰苷,田蓟苷	Others	Others
	Tilianin 是一种广泛存在于多种药用植物中的活性黄酮类苷，具有降压、保护心肌、降血脂、抗糖尿病、抗炎、抗氧化等作用。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T8044	Ajmalicine 阿吗里新,Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ajmalicine (Raubasine) 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，IC50 为 72.3 μM。Ajmalicine 还可用于降压、蛇毒，具有镇静活性。
T5581	6-(γ,γ-Dimethylallylamino)purine N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine	Others	Others
	6-(γ,γ-Dimethylallylamino)purine (Triacanthine) 是植物生长调节剂。
T6S0657	Isorhynchophylline IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline	Others	Others
	Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物，具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。
TCS1704	Artemitin 艾黄素,Artemetin,Artemisetin,Erianthin	Antioxidant	oxidation-reduction
	Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮，具有抗氧化、抗炎、抗病毒活性。
T4S1102	Liensinine diperchlorate 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate	Mitophagy; Others; Autophagy	Autophagy; Others
	Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬，具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T1035	Hesperidin 橙皮甙,Hesperetin 7-rutinoside,Cirantin,橙皮苷	Apoptosis; Reactive Oxygen Species; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Hesperidin (Cirantin) 属于黄烷酮糖苷类天然产物，广泛存在于柑橘类水果中。Hesperidin 具有抗氧化活性、抗肿瘤活性和抗过敏活性。
TN2990	3alpha-dihydrocadambine	Others	Others
	3alpha-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats.
T12789	S-1-Propenyl-L-cysteine	Others	Others
	S-1-Propenyl-L-cysteine, a stereoisomer of S-allyl-l-cysteine, exhibits immunomodulatory effects and has been shown to decrease blood pressure in hypertensive animal models.
T69254	Ajmalicine hydrochloride Raubasine hydrochloride	Others	Others
	Ajmalicine (Raubasine) hydrochloride 是一种有效的抗肾上腺素 (adrenolytic) 剂，优先阻断 α1-肾上腺素受体 (α1-adrenoceptor)。Ajmalicine hydrochloride 是一种可逆性但非竞争性尼古丁受体 (nicotine receptor) 完全抑制剂，其 IC50为 72.3 μM。Ajmalicine hydrochloride 还可用于降压、蛇毒，具有镇静活性。

天然产物

Cat.No: T8158

Synonym: 香清兰苷,田蓟苷

Target: Others

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T8044

Synonym: 阿吗里新,Lamuran,Delta-Yohimbine,Raubasine,Ajmalicin

Target: Adrenergic Receptor

6-(γ,γ-Dimethylallylamino)purine

Cat.No: T5581

Synonym: N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine

Target: Others

Isorhynchophylline

Cat.No: T6S0657

Synonym: IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline

Target: Others

Cat.No: TCS1704

Synonym: 艾黄素,Artemetin,Artemisetin,Erianthin

Target: Antioxidant

Liensinine diperchlorate

Cat.No: T4S1102

Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

Cat.No: TN1065

Target: Apoptosis

Cat.No: T1035

Synonym: 橙皮甙,Hesperetin 7-rutinoside,Cirantin,橙皮苷

Target: Apoptosis, Reactive Oxygen Species, Endogenous Metabolite, Autophagy

3alpha-dihydrocadambine

Cat.No: TN2990

Target: Others

S-1-Propenyl-L-cysteine

Cat.No: T12789

Target: Others

Ajmalicine hydrochloride

Cat.No: T69254

Synonym: Raubasine hydrochloride

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03600	TPM4 Protein, Human, Recombinant (His) tropomyosin 4,HEL-S-108,TPM4	Human	HEK293 Cells
	TPM4, also known as tropomyosin 4, is a member of the tropomyosin family. Members of this family are actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. TPM4 is expressed in cardiac tissue and platelets. It is highly expressed in the platelets of hypertensive patients. TPM4 plays a central role, in association with the troponin complex, in the calcium-dependent regulation of vertebrate striated muscle contraction. Smo...
TMPJ-01061	Nucleobindin-2 Protein, Human, Recombinant NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...	Human	E. coli
	Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ...
TMPJ-01304	C1QTNF1 Protein, Human, Recombinant (His) C1QTNF1,G Protein-Coupled Receptor-Interacting Protein,CTRP1...	Human	HEK293 Cells
	C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framew...

重组蛋白

TPM4 Protein, Human, Recombinant (His)

Cat.No: TMPY-03600

Species: Human

Expression System: HEK293 Cells

Nucleobindin-2 Protein, Human, Recombinant

Cat.No: TMPJ-01061

Species: Human

Expression System: E. coli

C1QTNF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01304

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T70883	Moexipril-d5
	Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) ...
T71328	Theobromine-d6
	Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and has diverse biological activities. It is an adenosine A1 receptor antagonist. Theobromine increases AMPK phosphorylation and inhibits adipocyte differentiation, ERK and JNK phosphorylation, and IL-6 and TNF-α production in 3T3-L1 preadipocytes cultured in differentiation medium....
T69598	Isoproterenol-d7 HCl
	Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom...
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...

同位素标记化合物

Cat.No: T71065

Cat.No: T70883

Cat.No: T71328

Isoproterenol-d7 HCl

Cat.No: T69598

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

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