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TMPY-02587
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Tyrosine Hydroxylase Protein, Mouse, Recombinant (His)
tyrosine hydroxylase
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Mouse
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Baculovirus Insect Cells
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Tyrosine Hydroxylase Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is P24529. |
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TMPY-02707
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PAH Protein, Human, Recombinant (415 Asn/Asp, His)
phenylalanine hydroxylase,PH,PKU1,PKU
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Human
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Baculovirus Insect Cells
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PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg... |
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TMPY-02401
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Tyrosine Hydroxylase Protein, Human, Recombinant (His)
tyrosine hydroxylase,DYT14,TYH,DYT5b
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Human
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Baculovirus Insect Cells
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Tyrosine Hydroxylase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is P07101-3. |
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TMPY-03852
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Dopamine beta-Hydroxylase Protein, Human, Recombinant (His)
dopamine β-hydroxylase (dopamine β-monooxygenase),D...
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Human
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HEK293 Cells
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DBH is a 29 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated ... |
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TMPY-01959
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Tryptophan Hydroxylase 1/TPH-1 Protein, Human, Recombinant (His)
TPRH,tryptophan hydroxylase 1,TRPH
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Human
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E. coli
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Tryptophan 5-hydroxylase 1, also known as Tryptophan 5-monooxygenase 1, Tryptophan hydroxylase 1, TPH1, TPH and TPRH, is an enzyme that belongs to the biopterin-dependent aromatic amino acid hydroxylase family. TPH1 contains one ACT domain. Tryptophan hydroxylase catalyzes the biopterin-dependent monooxygenation of tryptophan to 5-hydroxytryptophan (5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. It is the rate-limiting enzyme in the biosynthesis of serotonin. ... |
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TMPH-02958
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Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO)
Tryptophan 5-monooxygenase 1,Tryptophan 5-hydroxylase
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Mouse
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E. coli
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Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. Tryptophan Hydroxylase 1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 67.3 kDa and the accession number is P17532. |
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TMPY-01012
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P4HB Protein, Human, Recombinant (His)
DSI,prolyl 4-hydroxylase, β polypeptide,PDIA1,PDI,G...
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Human
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HEK293 Cells
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P4HB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.4 kDa and the accession number is A0A024R8S5. |
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TMPH-00563
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3-demethoxyubiquinol 3-hydroxylase Protein, E. coli, Recombinant (His)
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxyl...
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E. coli
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E. coli
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Catalyzes the hydroxylation of 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis. |
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TMPK-00945
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ASPH Protein, Human, Recombinant (His)
Aspartate beta-hydroxylase,ASP beta-hydroxylase...
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Human
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E. coli
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Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis. ASPH... |
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TMPK-01083
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ASPH Protein, Mouse, Recombinant (His)
Aspartate β-hydroxylase,ASP β-hydroxylase,...
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Mouse
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E. coli
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Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis. ASPH... |
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TMPH-03606
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P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc)
Proline 3-hydroxylase type I,L-proline cis-3-hy...
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Streptomyces
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E. coli
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Dioxygenase that catalyzes the 2-oxoglutarate-dependent selective hydroxylation of free L-proline to cis-3-hydroxy-L-proline (cis-3-Hyp). D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, and 3,4-dehydro-DL-proline are not substrates. P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.0 kDa and the accession number is P96010. |
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TMPY-01795
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P4HB Protein, Mouse, Recombinant (His)
ERp59,Pdia1,prolyl 4-hydroxylase, beta polypeptide,...
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Mouse
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HEK293 Cells
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P4HB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.2 kDa and the accession number is P09103. |
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TMPH-01525
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CMAHP Protein, Human, Recombinant (His & Myc)
CMAHP,Inactive cytidine monophosphate-N-acetylneuraminic aci...
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Human
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E. coli
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Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates. However, it may play a role in Wnt signaling. |
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TMPH-02233
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P4HTM Protein, Human, Recombinant (His & SUMO)
Transmembrane prolyl 4-hydroxylase,P4HTM,Hypoxia-in...
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Human
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E. coli
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Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
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TMPH-02259
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TPH2 Protein, Human, Recombinant (His)
Tryptophan 5-hydroxylase 2,TPH2,Tryptophan 5-monoox...
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Human
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E. coli
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N/A. TPH2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 60.1 kDa and the accession number is Q8IWU9. |
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TMPH-03188
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NahG Protein, Pseudomonas putida, Recombinant (His & Myc)
Salicylate 1-monooxygenase,nahG,Salicylate hydroxylase
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Pseudomonas putida
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E. coli
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N/A. NahG Protein, Pseudomonas putida, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 54.3 kDa and the accession number is P23262. |
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TMPH-01595
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KMO Protein, Human, Recombinant (His)
Kynurenine 3-monooxygenase,KMO,Kynurenine 3-hydroxylase<...
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Human
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E. coli
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Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). |
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TMPH-00092
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FLS1 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
FLS 1,FLS1,Flavonol synthase/flavanone 3-hydroxylase
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Arabidopsis thaliana
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E. coli
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Catalyzes the formation of flavonols from dihydroflavonols. It can act on dihydrokaempferol to produce kaempferol, on dihydroquercetin to produce quercitin and on dihydromyricetin to produce myricetin. In vitro catalyzes the oxidation of both enantiomers of naringenin to give both cis- and trans-dihydrokaempferol. FLS1 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.3 kDa and the ac... |
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TMPH-00913
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AOX1 Protein, Human, Recombinant (His)
Aldehyde oxidase,AO,Azaheterocycle hydroxylase,Alde...
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Human
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E. coli
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AOX1 Protein, Human, Recombinant (His) is expressed in E. coli. |
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TMPH-00396
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TrhO Protein, Chlamydophila felis, Recombinant (His)
trhO,tRNA uridine(34) hydroxylase,tRNA hydroxylatio...
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Chlamydia felis
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E. coli
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Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. TrhO Protein, Chlamydophila felis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q252M0. |
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TMPH-01713
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PLOD3 Protein, Human, Recombinant (His)
Multifunctional procollagen lysine hydroxylase and ...
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Human
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HEK293 Cells
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PLOD3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 85.9 kDa and the accession number is O60568. |
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TMPY-03109
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PHYH Protein, Human, Recombinant
PHYH1,RD,PAHX,LN1,phytanoyl-CoA 2-hydroxylase,LNAP1
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Human
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E. coli
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PHYH belongs to the family of iron(II)-dependent oxygenases, which typically incorporate one atom of dioxygen into the substrate and one atom into the succinate carboxylate group. PHYH is expressed in liver, kidney, and T-cells, but not in spleen, brain, heart, lung and skeletal muscle. It converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA. Defects in PHYH can cause Refsum disease (RD). RD is an autosomal recessive disorder characterized clinically by a tetrad of abnormalities: retinitis pigmentos... |
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TMPH-02840
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PLOD2 Protein, Mouse, Recombinant (E. coli, His & Myc)
Lysyl hydroxylase 2,Plod2,Procollagen-lysine,2-oxog...
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Mouse
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E. coli
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Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. |
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TMPY-03756
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BBOX1 Protein, Human, Recombinant (His & GST)
butyrobetaine (γ), 2-oxoglutarate dioxygenase (γ-butyrobetai...
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Human
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Baculovirus Insect Cells
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BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarctio... |
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TMPH-00443
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P4HB Protein, Cricetulus griseus, Recombinant (His)
Protein disulfide-isomerase,Prolyl 4-hydroxylase su...
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Chinese hamster
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P. pastoris (Yeast)
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P4HB Protein, Cricetulus griseus, Recombinant (His) is expressed in Yeast. |
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TMPH-02839
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PLOD2 Protein, Mouse, Recombinant (His & Myc)
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2,Lysyl ...
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Mouse
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Baculovirus Insect Cells
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Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. PLOD2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with C-6xHis-Myc tag. The predicted molecular weight is 85.2 kDa and the accession number is Q9R0B9. |
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TMPH-02403
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JBP1 Protein, Leishmania infantum, Recombinant (His & V5)
J-binding protein 1,Thymine dioxygenase JBP1,Thymidine h...
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Leishmania infantum
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E. coli
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JBP1 Protein, Leishmania infantum, Recombinant (His & V5) is expressed in E. coli expression system with N-10xHis-V5 tag. The predicted molecular weight is 53.4 kDa and the accession number is A4HU70. |
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TMPH-01512
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HIF1AN Protein, Human, Recombinant (His)
Hypoxia-inducible factor asparagine hydroxylase,Hyp...
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Human
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P. pastoris (Yeast)
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Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and severa... |
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TMPH-01280
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EGLN1 Protein, Human, Recombinant (His & Myc)
HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxylase 2,HIF...
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Human
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E. coli
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Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti... |
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TMPH-01920
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P4HA3 Protein, Human, Recombinant (His & SUMO)
Prolyl 4-hydroxylase subunit alpha-3,Procollagen-pr...
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Human
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E. coli
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P4HA3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
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TMPH-01919
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P4HA1 Protein, Human, Recombinant (His)
P4HA1,Prolyl 4-hydroxylase subunit alpha-1,Procolla...
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Human
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E. coli
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P4HA1 Protein, Human, Recombinant (His) is expressed in E. coli. |
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TMPH-01186
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CYP2C9 Protein, Human, Recombinant (His & Myc)
CYP2C10,Cytochrome P450 2C9,S-mephenytoin 4-hydroxylase<...
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Human
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E. coli
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CYP2C9 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPH-02618
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CYP2E1 Protein, Mouse, Recombinant (His)
Cyp2e1,Cytochrome P450 2E1,Cytochrome P450-J,4-nitrophenol 2...
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Mouse
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E. coli
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A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be invo... |
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TMPH-03170
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PvdA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)
Pyoverdin biosynthesis protein A,L-ornithine N(5)-hydrox...
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Pseudomonas aeruginosa
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E. coli
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PvdA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.5 kDa and the accession number is Q51548. |
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TMPH-01184
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CYP2A6 Protein, Human, Recombinant (His & Myc)
CYP2A3,Coumarin 7-hydroxylase,1,4-cineole 2-exo-mon...
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Human
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E. coli
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CYP2A6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPH-02140
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CYP21A2 Protein, Human, Recombinant (E. coli, His)
Cytochrome P-450c21,Cytochrome P450-C21B,CYP21,21-OHase,Cyto...
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Human
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E. coli
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A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via... |
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TMPH-02141
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CYP21A2 Protein, Human, Recombinant (His)
Cytochrome P450 21,CYP21A2,Cytochrome P450-C21B,Cytochrome P...
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Human
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P. pastoris (Yeast)
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A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via... |
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TMPH-02139
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CYP17A1 Protein, Human, Recombinant (GST)
Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...
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Human
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E. coli
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A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow... |
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TMPJ-01043
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PHS Protein, Human, Recombinant (His)
4-Alpha-Hydroxy-Tetrahydropterin Dehydratase,Pterin-4-α-Carb...
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Human
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E. coli
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Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type ... |
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TMPY-01380
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Cyclophilin B Protein, Human, Recombinant (His)
CYPB,peptidylprolyl isomerase B (cyclophilin B),HEL-S-39,SCY...
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Human
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HEK293 Cells
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PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing. |
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TMPY-03227
|
CISD1 Protein, Human, Recombinant (His)
ZCD1,CDGSH iron sulfur domain 1,C10orf70,mitoNEET,MDS029
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Human
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E. coli
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Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. CDGSH iron sulfur domain 1 (CISD1, also termed mitoNEET), an iron-containing outer mitochondrial membrane protein, negatively regulates ferroptotic cancer cell death. At the ce... |
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