Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.

MOCD:25 µM, TRPV1:6.3 µM , CYP450:23 µM

TETRAHYDROPIPERINE 是一种瞬态受体电位香草酰胺类型1（TRPV1；EC50 = 6.3 μM）的激动剂[1]。它抑制大鼠肝微粒体中的细胞色素P450（CYP）亚型CYP1A1/芳烃羟化酶（AHH；IC50 = 23 μM）及7-甲氧基香豆素O-去甲基酶（MOCD）活性（IC50 = 25 μM）[2]。在白癜风小鼠模型中，通过局部给药100 μl的175 mM溶液，Tetrahydropiperine能增加皮肤色素沉着，紫外线（UVR）辐照后此效果可得到增强[3]。

The test compounds were PIP [5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylpiperidine], tetrahydropiperine [THP, 5-(3,4-methylenedioxyphenyl)-pentanoylpiperidine], a cyclohexyl analogue of piperine [CHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylcyclohexylamine], and reduced CHP [rCHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentanoylcyclohexylamine].?Sparsely pigmented, HRA/Skh-II mice were randomized to receive topical treatment with test compounds or vehicle twice a day for five days a week, with or without ultraviolet (UV) irradiation on 3 days a week.?Treatment was either continuous or interrupted to evaluate fading and repigmentation.?Skin inflammation and pigmentation were evaluated regularly during treatment.?DOPA+ melanocytes were determined histologically at the termination of treatment[3].