425
70
3
53
8
Cat. No. | Product Name | ||
---|---|---|---|
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; | |||
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20365 |
Monopotassium glutamate
L-谷氨酸钾盐,Potassium glutamate,Potassium L-glutamate |
Others | Others |
Monopotassium glutamate (Potassium glutamate) 可在食品中用作增味剂。 | |||
T20266 |
Tetrasodium glutamate diacetate
Glutamate diacetate tetrasodium,GLDA |
Others | Others |
Tetrasodium glutamate diacetate (Glutamate diacetate tetrasodium) 是一种可降解螯合剂,可用作膳食成分,可从废活性污泥 (WAS) 絮凝体中提取多价金属离子,可增强废活性污泥中挥发性脂肪酸的产生。 | |||
T7658 |
Dimethyl DL-Glutamate (hydrochloride)
|
Others | Others |
Dimethyl DL-Glutamate (hydrochloride) 是一种细胞渗透性谷氨酸衍生物,可在孤立的胰岛和糖尿病动物模型中增强胰岛素释放以响应葡萄糖。 | |||
T20331 |
Sodium lauroyl glutamate
Hostapon CLG,Amisoft LS 11,Sodium N-lauroylglutamate,月桂酰谷氨酸钠,Acylglutamate LS-11 |
Others | Others |
Sodium lauroyl glutamate (Acylglutamate LS-11) 是一种氨基酸去污剂,可增加长链没食子酸烷基酯(如没食子酸烷基酯)的溶解度。 | |||
T72460 |
Dimethyl L-glutamate
Dimethyl glutamate |
||
Dimethyl L-glutamate (Dimethyl glutamate), 一种可透膜的谷氨酸类似物,可刺激葡萄糖诱导的胰岛素 (insulin) 释放。Dimethyl L-glutamate 抑制KATP 通道的活性。Dimethyl L-glutamate 抑制E. gracilis 生长并导致细胞异常分裂。Dimethyl L-glutamate 可用于糖尿病、葡萄糖转运、磷酸化和进一步代谢的研究。 | |||
T40973 |
MDNI-caged-L-glutamate
MDNI-caged-L-glutamate,MDNI-glu |
Others | Others |
MDNI-glu is a photosensitive derivative of L-glutamate, a major excitatory amino acid, that is biologically inert. It demonstrates improved utilization of incident light. | |||
T35369 |
L(+)-Monosodium glutamate monohydrate
L(+)-Monosodium glutamate monohydrate,MSG monohydrate,L-Glutamic acid monosodium salt monohydrate,Monosodium L-glutamate monohydrate |
Others | Others |
L(+)-Monosodium glutamate monohydrate (MSG monohydrate, L-Glutamic acid monosodium salt monohydrate, Monosodium L-glutamate monohydrate, Monosodium L-glutamate monohydrate)是一种广泛使用的营养添加剂和调味剂。L(+)-Monosodium glutamate monohydrate 可导致氧化应激介导的 DNA 损伤和细胞凋亡。 | |||
T34938 |
Triethanolamine linoleoyl glutamate
TEA-linoleoyl glutamate |
Others | Others |
Triethanolamine linoleoyl glutamate is a bioactive chemical. | |||
T34677 |
Sodium palmitoyl glutamate
Sodium N-palmitoyl-L-glutamate,Monosodium N-palmitoyl-L-glutamate |
Others | Others |
Sodium palmitoyl glutamate is a amino acid. | |||
T73616 |
Glutamate dehydrogenase (NAD(P))
GLDH |
Mitochondrial Metabolism | Metabolism |
Glutamate dehydrogenase NAD(P) (GLDH)是一种线粒体酶,广泛存在于生物体内,催化谷氨酸可逆的氧化脱氨生成 α-酮戊二酸 (α-KG),可用于研究谷氨酸代谢异常引起的疾病。 | |||
T23278 |
RuBi-Glutamate
|
Others | Others |
Ruthenium-bipyridine-trimethylphosphine caged glutamate | |||
T31266 |
Deanol glutamate
|
Others | Others |
Deanol glutamate is a central stimulant. | |||
T31941 |
Glutamate cobalt
|
Others | Others |
Glutamate cobalt is a bioactive chemical. | |||
T33724 |
Norfloxacin glutamate
|
Others | Others |
Norfloxacin glutamate is a bioactive chemical. | |||
T34937 |
Triethanolamine glutamate
|
Others | Others |
Triethanolamine glutamate is a bioactive chemical. | |||
T24043 |
Erythromycin glutamate
|
Others | Others |
Erythromycin glutamate is a macrolide bacteriostatic antibiotic. This antibiotic is metabolized through the liver and inhibits cytochrome enzyme P450A 3A41. | |||
T34675 |
Sodium linoleoyl glutamate
|
Others | Others |
Sodium linoleoyl glutamate is salt obtained from linoleoyl glutamate. | |||
T33326 |
Methotrexate-alpha glutamate
Meapa-glu-glu |
Others | Others |
Methotrexate-alpha glutamate is a chemotherapy agent and immune system suppressant. It is used to treat cancer, autoimmune diseases, ectopic pregnancy, and medical abortions. | |||
T31518 |
Dipinacoline glutamate
L-Glutamic acid dipinacoline ester,DiPG |
Others | Others |
Dipinacoline glutamate is a bioactive chemical. | |||
T31497 |
Dineopentyl glutamate
L-Glutamic acid bis(2,2-dimethylpropyl) ester,DNPE |
Others | Others |
Dineopentyl glutamate is a bioactive chemical. | |||
T33911 |
PENB-L-Glutamate
|
Others | Others |
PENB-L-Glutamate is a caged glutamate. | |||
T31709 |
Ethyl glutamate
NSC-156977,NSC156977,Alpha-ethylglutamic acid,gamma-Ethylglutamate,NSC 156977 |
Others | Others |
Ethyl glutamate 可用于生命科学领域的相关研究。其产品编号为 T31709,CAS号为 1119-33-1。 | |||
TP2397 |
Ornithine glutamate dipeptide
Orn-glu |
||
Ornithine glutamate dipeptide is a amino acid. | |||
T21053 |
L-Lysine L-glutamate
|
Others | Others |
L-Lysine L-glutamate is a bioactive chemical. | |||
T23013 |
MNI-caged-L-glutamate
|
Others | Others |
rapidly and efficiently releases glutamate | |||
T20362 |
Glutamyl-glutamic acid
Glu-glu,Dipotassium glutamyl-glutamate,N-L-alpha-Glutamyl-L-glutamic acid |
Amino Acids and Derivatives | Metabolism |
Glutamyl-glutamic acid (Glu-glu) 是一些微球菌和节杆菌属菌的胞壁中的肽桥。 | |||
T34676 |
Sodium oleoyl glutamate
N-Oleoyl-L-glutamic acid monosodium salt,Acylglutamate OS-11 |
Others | Others |
Sodium oleoyl glutamate is a sodium salt oleoyl glutamate. | |||
T20264L |
Alanine glutamate acetate(13187-90-1 Free base)
|
||
Alanine glutamate acetate(13187-90-1 Free base) 是一种二肽,在生命科学相关研究中具有广泛的应用。 | |||
T78350 |
Glutamate dehydrogenase
|
Others | Others |
Glutamate dehydrogenase为存在于原核生物与真核生物线粒体中的酶类,适用于氨、α-酮戊二酸、L-谷氨酸及脲酶的酶促反应检测。 | |||
T2A2497L |
Glutamic acid diethyl ester
L-Glutamate diethylester,Diethyl glutamate,Glutamyl diethyl ester |
Others | Others |
Glutamic acid diethyl ester is a glutamic acid antagonist. | |||
T66113 |
1-Methyl L-Glutamate
|
||
1-Methyl L-Glutamate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66113,CAS号为 6384-08-3。 | |||
T60645 |
Glutamate-5-kinase-IN-2
|
Others | Others |
Glutamate-5-kinase-IN-2 (compound 54) 通过促进 L-谷氨酸结合位点的构象变化,从而抑制 G5K 活性,它是谷氨酸 5-激酶 (G5K)的有效抑制剂,MIC 为 4.2 μM。Glutamate-5-kinase-IN-2 具有用于抗结核药物研究的潜力。 | |||
T60693 |
Glutamate-5-kinase-IN-1
|
Others | Others |
Glutamate-5-kinase-IN-1 (compound 50) 是谷氨酸-5-激酶 (G5K)的有效抑制剂 ,它通过改变 ATP 结合位点构象发挥抑制作用,其抑制浓度为 4.1 μM。Glutamate-5-kinase-IN-1 具有研究抗结核的潜力 | |||
T84390 |
MNI-caged-L-glutamate TFA
|
Others | Others |
MNI-caged-L-glutamate, a derivative of glutamate conjugated with a 4-methoxy-7-nitroindolinyl (MNI) photoprotective group, remains pharmacologically inactive at neuronal glutamate receptors at concentrations up to mM. Upon light exposure (300 - 380 nm excitation), it rapidly releases L-glutamate by cleaving the MNI group within submicroseconds. This characteristic enables the investigation of fast synaptic glutamate receptor mechanisms in situ. | |||
T22641 |
CDPPB
|
GluR | Neuroscience |
CDPPB 是选择性和脑渗透性的代谢型谷氨酸受体亚型5 (mGluR5) 阳性变构的调节剂,在表达人类 mGluR5 的中国仓鼠卵巢细胞中的 EC50值为 27 nM。它为开发抗精神病药提供了一种可能性。 | |||
T21747 |
VU0483605
|
GluR | Neuroscience |
VU0483605 是一种有效的特异性 mGluR1 正变构调节剂,对人和大鼠的 EC50 分别为 390 和 356 nM。 | |||
T14971 |
CIQ
|
NMDAR | Neuroscience |
CIQ 是亚基选择性NMDA 受体增强剂,可作用于NR2C 或NR2D 亚基。 | |||
T3482 |
CFMTI
|
GluR | Neuroscience |
CFMTI 是选择性代谢型谷氨酸受体 1 变构拮抗剂,IC50为2.6 nM。它对 mGluR1 的选择性比 mGluR5 高 2000 倍。 | |||
T6598 |
MPEP
|
GluR | Neuroscience |
MPEP 是一种选择性 mGlu5 受体拮抗剂,IC50 为 36 nM,有抗焦虑和抗抑郁活性。 | |||
T3483 |
FTIDC
|
GluR | Neuroscience |
FTIDC 是非竞争性和选择性的口服变构代谢型谷氨酸受体 1 拮抗剂,对人 mGluR1a 的IC50为 5.8 nM。 | |||
T8779 |
HBT1
|
GluR | Neuroscience |
HBT1 是一种 AMPA 受体增强剂,可诱导脑源性神经营养因子 (BDNF) 的产生,并且在原代神经元中几乎没有激动作用。 HBT1 以谷氨酸依赖的方式与 AMPA-R 的配体结合结构域结合。 | |||
T12406 |
PEPA
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
PEPA 是一种变构 AMPA 受体调节剂,可与 GluA2o 和 GluA3o LBD 结合,可用作 AMPA 受体异质性的指标。 | |||
T35319 |
Zy 15109
N-Acetyl-aspartyl magnesium glutamate,Zy15109,Magnesium N-acetyl-aspartylglutamate |
Others | Others |
Zy 15109 can be used as inhaled mast cell stabilizer. | |||
T60112 |
H-Glu(OEt)-OEt.HCl
Diethyl L-glutamate hydrochloride,(S)-Diethyl 2-aminopentanedioate hydrochloride,L-谷氨酸二乙酯盐酸盐,Diethyl glutamate hydrochloride |
Amino Acids and Derivatives | Metabolism |
H-Glu(OEt)-OEt.HCl (Diethyl L-glutamate hydrochloride) 是一种谷氨酸衍生物。 | |||
T16402 |
Org-26576
|
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Org-26576 是 AMPA 受体的一种正变构调节剂。 | |||
T6022 |
LY404039
pomaglumetad |
Glucocorticoid Receptor; GluR | Endocrinology/Hormones; Neuroscience |
LY404039 (pomaglumetad) 是可口服的mGluR2和mGluR3选择性激动剂,有抗精神病和抗焦虑的作用。它对重组人mGluR2和mGluR3的Ki 分别为 149 和 92 nM,比对其他受体/转运蛋白的抑制性高 100 倍以上。 | |||
T3477 |
E4CPG
|
GluR | Neuroscience |
E4CPG 是一种 I/II 组代谢型谷氨酸受体的拮抗剂,可抑制单突触后机制中突触后电流 (IPSC) 增强的成对脉冲比。 | |||
T3464 |
PHCCC
(-) PHCCC |
GluR | Neuroscience |
PHCCC ((-) PHCCC) 是 I 组代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。 它对 mGluR2 和 mGluR8 也有很强的拮抗作用,具有抗帕金森病作用。 | |||
T20264 |
Ala-Glu-OH
L-Glutamic acid, N-L-alanyl-,Alanine glutamate,Alanylglutamic acid |
||
Alanine glutamate is an agent of the dipeptide. | |||
T9133 |
Caroverine hydrochloride
Caroverine HCL |
GluR; NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Caroverine hydrochloride (Caroverine HCL) 是竞争性可逆的NMDA 和AMPA 谷氨酸受体拮抗剂。它也是抗氧化和钙阻滞剂,具有血管舒张作用,可用于内耳耳鸣的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T20262 |
Arginine glutamate
Modumate,NSC-122009,NSC 122009,NSC122009,NCI-C02120,Argimate |
Others | Others |
Arginine glutamate is an agent of ammonia Detoxicant. | |||
T6871 |
L-Glutamic acid monosodium salt
Monosodium glutamate,谷氨酸单钠盐,Glutacyl,Glutavene,L-谷氨酸单钠盐,Ajinomoto,MSG |
Apoptosis; Ferroptosis; GluR; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
L-Glutamic acid monosodium salt (MSG) 作为兴奋性氨基酸神经递质,是谷氨酸盐受体所有亚型的激动剂,对多巴胺从神经末梢释放的过程有激动作用。 | |||
T3379 |
Decanoic Acid
Decoic acid,CAPRIC ACID,Caprynic acid,癸酸 |
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Decanoic Acid (Caprynic acid) 是中链甘油三酯中的成分,是非竞争性和可透过血脑屏障的 AMPA 受体抑制剂,具有抗癫痫作用。 | |||
T1186 |
Ifenprodil Tartrate
|
Potassium Channel; NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂,抑制 GIRK (Kir3),通过基底 GIRK 活性减少内向电流,有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。 | |||
T2S2264 |
Linalool
Linalol,(±)-Linalool,Phantol,沉香醇 |
Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物,是竞争性NMDA 受体拮抗剂,具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤,具有镇痛、抗菌和抗炎的特性。 | |||
T8394 |
D-Serine
(R)-Serine,D-丝氨酸 |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸,是 NMDA 谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用,包括 NMDAR 介导的神经传递,神经毒性,突触可塑性和细胞迁移。 | |||
T6S1653 |
Albiflorin
Alibiflorin,芍药内酯苷 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分,是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。 | |||
T20191 |
(-)-Camphoric acid
(-)-樟脑酸,L-Camphoric acid,Camphoric acid, (-)- |
GluR | Neuroscience |
(-)-Camphoric acid (L-Camphoric acid) 是一种活性较低的樟脑酸对映异构体,樟脑酸可诱导 GluR 表达。 | |||
T6608 |
NMDA
N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸,作为 D-异构体,是谷氨酸受体的 NMDA 受体亚型的定义激动剂。 | |||
TQ0027 |
Transcrocetinate disodium
Disodium trans-crocetinate,藏红花,藏红花酸二钠盐 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Transcrocetinate disodium (Disodium trans-crocetinate) 从藏红花中提取的一种天然产物,是高亲和力NMDA 受体拮抗剂。 | |||
T4096 |
Quinolinic acid
喹啉酸,pyridine-2,3-dicarboxylic acid,QUIN |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Quinolinic acid (QUIN) 是一种内源性 N-甲基-D-天冬氨酸 (NMDA) 受体激动剂,由 L-色氨酸通过犬尿氨酸途径合成,具有调节 NMDA 神经元损伤和功能障碍的潜力。 | |||
T1589 |
D-Cycloserine
RO-1-9213,D-环丝氨酸 |
Others; Antibacterial; Antibiotic; iGluR | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others |
D-Cycloserine (RO-1-9213) 是一种抗生素,靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂,可以改善认知功能,可研究耐多药结核病。 | |||
T4S0171 |
Transcrocetin
trans-Crocetin,藏红花酸,藏红花,8,8'-Diapocarotenedioic Acid,Crocetin |
Others; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience; Others |
Transcrocetin (8,8'-Diapocarotenedioic Acid) 是来源于藏红花 (Crocus sativus L.) 的活性化合物,是一种能够透过血脑屏障的,高亲和力的NMDA 受体拮抗剂。 | |||
T2O2728 |
glycine
2-Aminoacetic acid,Glycolixir,Aminoacetic acid,Glycosthene,Glycocoll,甘氨酸 |
MT Receptor; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
glycine (2-Aminoacetic acid) 是中枢神经系统的抑制性神经递质,也是谷氨酸的联合激动剂,有促进谷氨酸能NMDA 受体兴奋的潜力。它主要存在于明胶和丝素蛋白中,并在治疗上用作营养物质。 | |||
T3010 |
Xanthurenic Acid
8-Hydroxykynurenic acid,黄尿酸,4,8-Dihydroxyquinaldic acid,xanthurenate |
Apoptosis; Endogenous Metabolite; GluR | Apoptosis; Metabolism; Neuroscience |
Xanthurenic Acid (8-Hydroxykynurenic acid) 是通过 3-羟基犬尿氨酸转氨而由色氨酸代谢产生的分子,可激活 mGlu2/3 代谢型谷氨酸受体。在下丘脑的感觉传输过程中,它被认为是Group II 代谢型谷氨酸受体的激动剂。 | |||
T0326L |
L-Glutamine
L-Glutamic acid 5-amide,L-谷氨酰胺 |
Ferroptosis; Endogenous Metabolite; GluR | Apoptosis; Metabolism; Neuroscience |
L-Glutamine (L-Glutamic acid 5-amide) 是在人体中大量存在的一种非必需氨基酸,由谷氨酸和氨合成。它为某些细胞中的氧化提供了碳源。 | |||
T3026 |
(-)-Huperzine A
HupA,石杉碱,Huperzine A,石杉碱甲 |
Apoptosis; AChR; AChE; iGluR | Apoptosis; Membrane transporter/Ion channel; Neuroscience |
(-)-Huperzine A (HupA) 是从中国梅花苔中分离得到的一种生物碱,具有神经保护活性。它是高特异性可逆的,具有血脑屏障渗透性的一种乙酰胆碱酯酶抑制剂, 其IC50值为 82 nM。 它也是 N-甲基-D-天冬氨酸受体的非竞争性拮抗剂,可研究神经退行性疾病,如阿尔茨海默病。 | |||
T1324 |
O-Phospho-L-serine
L-Serine O-phosphate,磷酸化丝氨酸,Phosphoserine,Dexfosfoserine,L-SOP |
Amino Acids and Derivatives; Endogenous Metabolite; GluR; NMDAR | Metabolism; Neuroscience |
O-Phospho-L-serine (Phosphoserine) 是 L-serine 合成过程中的直接前体物质,是 mGluR 激动剂。 | |||
T2A2497 |
L-Glutamic acid
谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol |
Apoptosis; Ferroptosis; Endogenous Metabolite; iGluR | Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Glutamic acid (Glutaminol) 作为一种兴奋性氨基酸神经递质,为谷氨酸盐受体所有亚型的激动剂,对多巴胺从神经末梢释放的过程有激动作用。 | |||
T4885 |
(-)-Aspartic acid
(R)-Aspartic acid,Asp,D-(-)-Aspartic acid,D-天门冬氨酸,Aminosuccinic acid,asparagic acid,L-Homoproline,D-Aspartic acid |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
(-)-Aspartic acid (L-Homoproline) 是一种存在于无脊椎动物和脊椎动物中的内源性氨基酸,是 NMDA 受体激动剂,可调节睾酮合成。 | |||
T0948L |
Corticosterone
皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants) |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇,有盐皮质激素和糖皮质激素的活性,具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。 | |||
T3377 |
L-Phenylalanine
L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸,是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂,用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂,Ki 为 980 nM。 | |||
T12016 |
Methyl L-pyroglutamate
L-Pyroglutamic acid methyl ester,L-焦谷氨酸甲酯,(S)-Methyl 5-oxopyrrolidine-2-carboxylate |
Others | Others |
Methyl L-pyroglutamate (L-Pyroglutamic acid methyl ester) 分离自甘蓝中分离,显示出抗炎活性。 | |||
T4920 |
2-Ketoglutaric acid Sodium
Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt |
Tyrosinase; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
2-Ketoglutaric acid Sodium (AKG) 是一种三羧酸循环的中间产物,它可以由谷氨酸通过谷氨酸脱氢酶氧化脱氨产生,也可以作为磷酸吡哆醛依赖的转氨化反应的产物(由支链氨基酸转氨酶介导),其中谷氨酸是常见的氨基供体。 | |||
T4913 |
Maleic acid
|
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
Maleic Acid 是大肠杆菌和单核细胞增生李斯特菌的谷氨酸脱羧酶抑制剂。 | |||
T4752 |
1-Aminocyclopropane-1-carboxylic acid
1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC |
Endogenous Metabolite; NMDAR | Metabolism; Neuroscience |
1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。 | |||
T10191L |
7-Chlorokynurenic acid
7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA |
GluR; NMDAR | Neuroscience |
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂,对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中,Ki 为 0.59 μM,并在神经轴输送后显示出镇痛作用。 | |||
T65135 |
Kynurenic acid
Fibrostop 2,Quinurenic acid |
GPR; GluR; NMDAR | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Kynurenic acid (Quinurenic acid) 是一种内源性色氨酸活性代谢物,是一种 NMDA, glutamate, α7 nicotinic acetylcholine receptor 三重拮抗剂,也是 GPR35/CXCR8 激动剂,具有神经保护和抗惊厥特性,可用于研究神经分裂和与代谢相关的疾病。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
T4813 |
L-Citrulline
|
Endogenous Metabolite | Metabolism |
L-Citrulline 是一种氨基酸,源自于精氨酸-瓜氨酸途径获得的 l-精氨酸,或脯氨酸、谷氨酰胺和谷氨酸盐的分解代谢过程中产生的鸟氨酸。 | |||
T6S0659 |
Rhynchophylline
钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin |
Calcium Channel; NF-κB | Membrane transporter/Ion channel; Metabolism; NF-κB |
Rhynchophylline (Mitrinermine) 是一种生物碱类化合物,从钩藤中分离得到,具有很高的生物活性,被广泛用于抗炎、神经保护等方面的研究。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T6S0654 |
Isocorynoxeine
7-Isocorynoxeine,异去氢钩藤碱 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Isocorynoxeine (7-Isocorynoxeine) 是钩藤中的一种生物碱,剂量依赖性抑制5-HT2A 受体介导的电流反应,IC50为 72.4 μM。 | |||
TN1449 |
Brandioside
2'-O-Acetylpoliumoside,2'-Acetylpoliumoside |
Antioxidant | oxidation-reduction |
Brandioside (2'-Acetylpoliumoside) 是可从马鞭草科植物 Callicarpa dichotoma Raeuschel 提取得到的苯丙素类糖苷,具有抗氧化活性,可削弱谷氨酸诱导的神经毒性,可用于研究糖尿病。 | |||
T5692 |
Pyrroloquinoline quinone
|
Others; Endogenous Metabolite | Metabolism; Others |
Pyrroloquinoline quinone 是氧化还原辅助因子,一种阴离子型氧化还原循环原醌。它是哺乳动物的必需营养素,对免疫功能很重要。它是从嗜甲基细菌的培养物中分离的,也存在于哺乳动物的组织。 | |||
T1131 |
Ivermectin
MK-933,伊维菌素 |
Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂,具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入,还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。 | |||
T2596 |
N-Acetyl-β-Asp-Glu
|
Others | Others |
N-Acetyl-β-Asp-Glu 是一种肽类神经递质,是哺乳动物神经系统中第三常见的神经递质。 NAAG 由通过肽键偶联的 N-乙酰天冬氨酸 (NAA) 和谷氨酸组成。 | |||
TN1196 |
17-Hydroxyisolathyrol
|
Others | Others |
17-Hydroxyisolathyrol 是一种大环千金子二萜醇衍生物,分离自Euphorbla luthyrrs种子。17-Hydroxyisolathyrol 抑制蛋白质-蛋白质相互作用。 | |||
TN1677 |
Gartanin
1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷 |
BCL; Caspase; JNK | Apoptosis; MAPK; Proteases/Proteasome |
Gartanin 是山竹果中的一种天然黄酮,具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬,抑制其迁移。 | |||
TN1905 |
Magnolioside
七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷 |
Antifection | Microbiology/Virology |
Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中,对谷氨酸诱导的毒性有显著的神经保护作用。 它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性,对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。 | |||
T6102 |
2'-acetylacteoside
|
Antioxidant; Reductase | Endocrinology/Hormones; Metabolism; oxidation-reduction |
2'-Acetylacteoside 是一种苯乙醇苷类化合物,分离自来江藤中,可抑制自由基诱导的红细胞溶血,具有清除自由基的作用。 | |||
T5558 |
Chelidonic acid
Jervaic acid,Jerva acid,白屈菜酸,γ-Pyrone-2,6-dicarboxylic acid |
NF-κB; Caspase | Apoptosis; NF-κB; Proteases/Proteasome |
Chelidonic acid (Jervaic acid) 是从白屈菜中分到的酸类物质,用作温和的镇痛剂、抗菌剂和中枢神经系统镇静剂。它是谷氨酸脱羧酶抑制剂,Ki 值为 1.2 μM。它可能通过抑制 NF-κB 和caspase-1来降低 IL-6 的产生抗炎作用。 | |||
T5083 |
L-Cysteic acid monohydrate
L-磺基丙氨酸 一水合物,3-Sulfo-L-alanine Monohydrate |
Endogenous Metabolite; GluR | Metabolism; Neuroscience |
L-Cysteic acid monohydrate (3-Sulfo-L-alanine Monohydrate) 是内源性代谢产物的一种。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T4705 |
Aminoadipic acid
DL-2-Aminoadipic acid,DL-2-氨基己二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Aminoadipic acid (DL-2-Aminoadipic acid) 是赖氨酸主要生化途径中的代谢物。 它是赖氨酸和糖碱代谢的中间体。 它拮抗由谷氨酸受体 N-甲基-D-天冬氨酸调节的神经兴奋特性。 | |||
TN3808 |
Dehydroheliobuphthalmin
|
Others | Others |
Dehydroheliobuphthalmin has significant neuroprotective activities against glutamate- induced neurotoxicity. | |||
TN1581 |
Dihydroguaiaretic acid
二氢愈创木酸 |
COX; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. | |||
T38054 |
Avenaciolide
|
Others | Others |
Avenaciolide is a water-insoluble fungal metabolite originally isolated from A. avenaceus. It inhibits glutamate transport in isolated rat liver mitochondria (Ki = 8 μM). | |||
TN5169 |
Traxillaside
香榧 |
Others | Others |
Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells . | |||
TN3473 |
Axillarin
|
||
Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress. | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00795 |
Glutamate racemase Protein, Helicobacter pylori, Recombinant (His & Myc)
murI,Glutamate racemase |
Helicobacter pylori | E. coli |
Provides the (R)-glutamate required for cell wall biosynthesis. Glutamate racemase Protein, Helicobacter pylori, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 35.9 kDa and the accession number is B5Z6S2. | |||
TMPY-04699 |
GAD65 Protein, Human, Recombinant (GST)
glutamate decarboxylase 2 (pancreatic islets and br... |
Human | Baculovirus Insect Cells |
GAD65 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 92.6 kDa and the accession number is Q05329. | |||
TMPJ-00855 |
GLUL Protein, Human, Recombinant (His)
GLUL,GS,Glutamine Synthetase,Glutamate-Ammonia Liga... |
Human | E. coli |
Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part in cell prolifetation, inhibition of apoptosis, and cell signaling. Glutamine Synthetase is expressed during early fetal stages, and has a role in maintaining body PH by removing ammonia from circulation. Mutations in the GLUL gene are related to congenital glutamine deficiency. | |||
TMPH-00627 |
GAD-alpha Protein, E. coli, Recombinant (His)
Glutamate decarboxylase alpha,gadA |
E. coli | E. coli |
Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria. | |||
TMPH-01392 |
GRIA2 Protein, Human, Recombinant (His & Myc)
GRIA2,Glutamate receptor ionotropic, AMPA 2,Glu... |
Human | E. coli |
GRIA2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 63.3 kDa and the accession number is P42262. | |||
TMPH-01393 |
GRIA3 Protein, Human, Recombinant (His & SUMO)
AMPA-selective glutamate receptor 3,GRIA3,Gluta... |
Human | E. coli |
GRIA3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.0 kDa and the accession number is P42263. | |||
TMPH-00416 |
NAD-GDH Protein, Clostridium difficile, Recombinant (His)
gluD,NAD-specific glutamate dehydrogenase |
Peptoclostridium difficile | E. coli |
NAD-GDH Protein, Clostridium difficile, Recombinant (His) is expressed in E. coli. | |||
TMPH-01663 |
GRM5 Protein, Human, Recombinant (His & Myc)
Metabotropic glutamate receptor 5,GRM5 |
Human | E. coli |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. | |||
TMPH-00438 |
GLUL Protein, Cricetulus griseus, Recombinant (His)
Glutamine synthetase,GLUL,Glutamate--ammonia ligase... |
Chinese hamster | E. coli |
GLUL Protein, Cricetulus griseus, Recombinant (His) is expressed in E. coli. | |||
TMPH-00628 |
GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO)
gltI,Glutamate/aspartate import solute-binding prot... |
E. coli | E. coli |
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 47.2 kDa and the accession number is P37902. | |||
TMPH-01394 |
GRIN1 Protein, Human, Recombinant (His)
N-methyl-D-aspartate receptor subunit NR1,Glutamate... |
Human | E. coli |
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)... | |||
TMPY-02091 |
GAD67 Protein, Human, Recombinant (His)
SCP,CPSQ1,glutamate decarboxylase 1 (brain, 67kDa),... |
Human | Baculovirus Insect Cells |
Glutamate decarboxylase 1, also known as 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform and GAD1, is a member of thegroup II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 isoform3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Tissue-specific markers are useful for identification of tumour type ... | |||
TMPH-03304 |
GRIN1 Protein, Rat, Recombinant (His)
Glutamate [NMDA] receptor subunit zeta-1,Glutam... |
Rat | E. coli |
GRIN1 Protein, Rat, Recombinant (His) is expressed in E. coli. | |||
TMPH-00629 |
Gamma-GCS Protein, E. coli, Recombinant (His & SUMO)
Glutamate--cysteine ligase,Gamma-ECS,gshA,Gamma-glu... |
E. coli | E. coli |
N/A. Gamma-GCS Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.3 kDa and the accession number is P0A6W9. | |||
TMPH-00796 |
gltX1 Protein, Helicobacter pylori, Recombinant (His)
Glutamyl-tRNA synthetase 1,gltX1,Glutamate--tRNA li... |
Helicobacter pylori | P. pastoris (Yeast) |
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | |||
TMPJ-01393 |
Carboxypeptidase Q Protein, Mouse, Recombinant (His)
Plasma glutamate carboxypeptidase,Hls2,Hematopoieti... |
Mouse | HEK293 Cells |
Carboxypeptidase Q (Cpq) is a member of the peptidase M28 family. PGCP is involved in a number of fundamental biological processes such as the hydrolysis of circulating peptides, catalyzing the hydrolysis of dipeptides with unsubstituted terminals into amino acids. Carboxypeptidase may play an important role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor. The monomeric form is inactive while the homodimer is active. | |||
TMPH-00626 |
GPR Protein, E. coli, Recombinant (His)
proA,Glutamyl-gamma-semialdehyde dehydrogenase,Gamma-glutamy... |
E. coli | E. coli |
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. GPR Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.7 kDa and the accession number is P07004. | |||
TMPY-04318 |
GRIK2 Protein, Human, Recombinant (hFc)
GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic... |
Human | HEK293 Cells |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl... | |||
TMPY-01590 |
GAD65 Protein, Mouse, Recombinant (His & GST)
glutamate decarboxylase 2 (pancreatic islets and br... |
Mouse | Baculovirus Insect Cells |
GAD65 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 93 kDa and the accession number is P48320. | |||
TMPY-03515 |
GAD65 Protein, Mouse, Recombinant
glutamate decarboxylase 2 (pancreatic islets and br... |
Mouse | Baculovirus Insect Cells |
GAD65 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 65.4 kDa and the accession number is P48320. | |||
TMPH-03190 |
CPG2 Protein, Pseudomonas sp., Recombinant (GST)
Folate hydrolase G2,Pteroylmonoglutamic acid hydrolase G2, |
Pseudomonas | E. coli |
Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity. CPG2 Protein, Pseudomonas sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.7 kDa and the accession number is P06621. | |||
TMPH-00911 |
GPT Protein, Human, Recombinant (His)
Glutamic--alanine transaminase 1,Glutamate pyruvate... |
Human | E. coli |
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. GPT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.5 kDa and the accession number is P24298. | |||
TMPH-03750 |
SLC7A11 Protein, Human, Recombinant (His)
SLC7A11,Calcium channel blocker resistance protein CCBR1,Sol... |
Human | E. coli |
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. | |||
TMPH-03400 |
SLC17A6 Protein, Rat, Recombinant (His)
Slc17a6,Vesicular glutamate transporter 2,Solute ca... |
Rat | P. pastoris (Yeast) |
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Involved in the regulation of retinal hyaloid vessel regression during postnatal development. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. SLC17A6 Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 11.1 kDa an... | |||
TMPH-01314 |
SLC1A3 Protein, Human, Recombinant (His & KSI)
Excitatory amino acid transporter 1,Solute carrier family 1 ... |
Human | E. coli |
SLC1A3 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 25.5 kDa and the accession number is P43003. | |||
TMPH-01199 |
CNDP2 Protein, Human, Recombinant (E. coli, His)
HEL-S-13,CPGL,Threonyl dipeptidase,PEPA,CNDP dipeptidase 2,C... |
Human | E. coli |
CNDP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. | |||
TMPH-02807 |
NPTXR Protein, Mouse, Recombinant (His & Myc)
Neuronal pentraxin receptor,Nptxr |
Mouse | Baculovirus Insect Cells |
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | |||
TMPK-00798 |
IGSF11 Protein, Mouse, Recombinant (His)
Bt-IGSF,BtIGSF,IgSF11,VSIG3,Bt IGSF,CXADRL1,CT119 |
Mouse | HEK293 Cells |
Immunoglobulin superfamily member 11 (IgSF11), a homophilic adhesion molecule that preferentially expressed in the brain, is a dual-binding partner of the postsynaptic scaffolding protein PSD-95 and AMPA glutamate receptors (AMPARs). | |||
TMPH-02808 |
NPTX1 Protein, Mouse, Recombinant (His)
Nptx1,Neuronal pentraxin-1,Neuronal pentraxin I |
Mouse | E. coli |
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. | |||
TMPH-02882 |
NQO2 Protein, Mouse, Recombinant (His)
Ribosyldihydronicotinamide dehydrogenase [quinone],Quinone r... |
Mouse | P. pastoris (Yeast) |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | |||
TMPH-01862 |
PFAS Protein, Human, Recombinant (His & Myc & SUMO)
Phosphoribosylformylglycinamidine synthase,Formylglycinamide... |
Human | E. coli |
Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. PFAS Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 45.4 kDa and the accession number is O15067. | |||
TMPH-02616 |
CSAD Protein, Mouse, Recombinant (His & SUMO)
Csad,Cysteine sulfinic acid decarboxylase,Cysteine-sulfinate... |
Mouse | E. coli |
Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3-sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate. | |||
TMPH-02797 |
NQO1 Protein, Mouse, Recombinant (His)
Quinone reductase 1,NAD(P)H dehydrogenase [quinone] 1,NAD(P)... |
Mouse | P. pastoris (Yeast) |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. NQO1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is Q64669. | |||
TMPH-03604 |
Phosphinothricin N-acetyltransferase Protein, Streptomyces hygroscopicus, Recombinant (His)
Phosphinothricin-resistance protein,Phosphinothricin N-acety... |
Streptomyces hygroscopicus | E. coli |
Inactivates phosphinothricin (PPT) by transfer of an acetyl group from acetyl CoA. Can also acetylate demethylphosphinothricin but not PTT or glutamate. This enzyme is an effector of phosphinothricin tripeptide (PTT or bialaphos) resistance. Phosphinothricin N-acetyltransferase Protein, Streptomyces hygroscopicus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.6 kDa and the accession number is P16426. | |||
TMPH-00863 |
5-oxoprolinase/OPLAH Protein, Human, Recombinant (His & Myc)
5-oxo-L-prolinase,5-OPase,Pyroglutamase,OPLAH |
Human | E. coli |
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. 5-oxoprolinase/OPLAH Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.4 kDa and the accession number is O14841. | |||
TMPH-01596 |
AADAT Protein, Human, Recombinant (His & SUMO)
2-aminoadipate transaminase,Glycine transaminase AADAT,Alpha... |
Human | E. coli |
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). | |||
TMPJ-00489 |
NTAQ1 Protein, Human, Recombinant (GST)
Nt(Q)-amidase,C8orf32,NTAQ1,Protein NH2-terminal glutamine d... |
Human | E. coli |
Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it do... | |||
TMPY-01100 |
GPT2 Protein, Rat, Recombinant (His)
glutamic pyruvate transaminase (alanine aminotransferase) 2 |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ... | |||
TMPH-01609 |
LGI1 Protein, Human, Recombinant (His & Myc)
Leucine-rich glioma-inactivated protein 1,Epitempin-1,LGI1 |
Human | E. coli |
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. | |||
TMPY-03257 |
Calumenin Protein, Human, Recombinant (His)
calumenin |
Human | HEK293 Cells |
Calumenin belongs to the CREC family. It contains 6 EF-hand domains. Calumenin is expressed in skeletal muscle (at protein level). Calumenin interacts with GGCX and RYR1 in the presence of calcium ions, but not in the presence of EDTA. Calumenin is Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. It seems to inhibit gamma-carboxylase GGCX. Calumenin also binds 7 calcium ions with a low affinity and may modulate calcium release from the sarcop... | |||
TMPH-02716 |
HADH Protein, Mouse, Recombinant (His & SUMO)
Short-chain 3-hydroxyacyl-CoA dehydrogenase,Hydroxyacyl-coen... |
Mouse | E. coli |
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. HADH Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
TMPY-01099 |
GPT Protein, Rat, Recombinant (His)
Gpt1,ALAT,glutamic-pyruvate transaminase (alanine aminotrans... |
Rat | Baculovirus Insect Cells |
Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (GPT), is a pyridoxal enzyme that belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family, Alanine aminotransferase subfamily. Gpt / Gpt1 / ALT catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. Gpt / Gpt1 / ALT is expressed in the liver, kidney, heart, and skeletal musc... | |||
TMPK-00370 |
PSMA Protein, Human, Recombinant (hFc)
NAALAdase,FOLH1,FOLHNAALADase I,FGCP,mGCP,PSMAFGCP,NAALADase... |
Human | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein, Human, Recombinant (hFc) is expressed in HEK293 mamma... | |||
TMPK-00521 |
PSMA Protein, Cynomolgus, Recombinant (His)
PSMA,FOLHNAALADase I,FGCP,GCPII,PSMAFGCP,NAALADase I,PSM,NAA... |
Cynomolgus | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ... | |||
TMPK-00522 |
PSMA Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
PSMAFGCP,PSM,NAALAdase,NAALADase I,FOLHNAALADase I,GCPIImGCP... |
Cynomolgus | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His... | |||
TMPK-00371 |
PSMA Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated
NAALADase I,FOLH1,GCPIImGCP,FGCP,GCP2,PSM,mGCP,NAALAdase,FOL... |
Mouse | HEK293 Cells |
Prostate-specific membrane antigen (PSMA) is an enzyme that in humans is encoded by the FOLH1 (folate hydrolase 1) gene, also known as Glutamate carboxypeptidase II (GCPII). Human PSMA is highly expressed in the prostate, roughly a hundred times greater than in most other tissues. In some prostate cancers, PSMA is the second-most upregulated gene product, with an 8- to 12-fold increase over levels in noncancerous prostate cells. PSMA Protein (Primary Amine Labeling), Mouse, Recombinant (His), Bi... | |||
TMPJ-00871 |
BAR Protein, S. hygroscopicus, Recombinant
bar,PPT N-acetyltransferase,Phosphinothricin-resistance prot... |
Streptomyces hygroscopicus | E. coli |
Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acetylate other L-amino acids or structurally similar molecules. L-PPT is a glutamate analog that can inhibit glutamine synthetase activity in plants, resulting in the accumulation of ammonia to toxic levels and impairment of photosynthesis. The introduction of a PAT gene into a plant... | |||
TMPJ-01130 |
NPTX1 Protein, Human, Recombinant (His)
Neuronal pentraxin-1,NPTX1,NP1 |
Human | HEK293 Cells |
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ... | |||
TMPY-00286 |
Neuropeptide Y Protein, Human, Recombinant (hFc)
PYY4,neuropeptide Y |
Human | HEK293 Cells |
NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne... | |||
TMPY-03445 |
Aspartate Aminotransferase Protein, Human, Recombinant (His)
ASTQTL1,glutamic-oxaloacetic transaminase 1, soluble,cCAT,cA... |
Human | E. coli |
GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. GOT1 belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme that exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. GOT1 is an important regulator of levels of glut... | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
||
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... | |||
T39565 |
L-Glutamic acid-15N
|
||
L-Glutamic acid-15N is the 15N-labeled version of L-Glutamic acid, an excitatory neurotransmitter and an agonist at metabotropic, kainate, NMDA, and AMPA glutamate receptor subtypes. It directly activates the release of dopamine (DA) from dopaminergic terminals. | |||
TMIJ-0160 |
Dextrorphan-d3 Tartrate
Dextromethorphan EP Impurity B-d3 Tartrate |
||
Dextrorphan-d3 Tartrate 是 Dextrorphan Tartrate 的氘代化合物。Dextrorphan Tartrate 的 CAS 号为 77-07-6。Dextrorphan tartrate 是一种非竞争性 NMDA 谷氨酸受体拮抗剂。 | |||
T71305 |
Clofibric Acid-d4
|
||
Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal... | |||
TMIJ-0030 |
1-Aminoadamantane-d15
|
||
1-Aminoadamantane-d15 是 1-Aminoadamantane 的氘代化合物。1-Aminoadamantane 的 CAS 号为 768-94-5。Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
TMIJ-0019 |
Amantadine-d6
|
||
Amantadine-d6 是 Amantadine 的氘代化合物。Amantadine 的 CAS 号为 768-94-5。Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
TMID-0299 |
Zonisamide-d4
|
||
Zonisamide-d4 是 Zonisamide 的氘代化合物。Zonisamide 的 CAS 号为 68291-97-4。Zonisamide 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的Ki值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 |