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Omberacetam

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产品编号 T7108Cas号 157115-85-0
别名 SGS-111, Noopept, GVS-111

Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。

Omberacetam
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Omberacetam

Rating icon 很棒
产品编号 T7108 别名 SGS-111, Noopept, GVS-111Cas号 157115-85-0

Omberacetam (Noopept) 是一种可作为膳食补充剂的合成二肽,有促智和提高认知作用。

规格价格库存数量
1 mg
¥ 147
现货
5 mg
¥ 313
现货
10 mg
¥ 413
现货
25 mg
¥ 745
现货
50 mg
¥ 1,230
现货
100 mg
¥ 1,980
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200 mg
¥ 2,970
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1 mL x 10 mM (in DMSO)
¥ 345
现货
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产品介绍

生物活性
产品描述
Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
体外活性
Omberacetam(以10 μM浓度加入培养基,于Аβ 25-35前72小时)对Аβ 25-35(5 μM,24小时)诱导的PC12细胞损伤的神经保护作用进行了研究。考察了化合物对由Аβ 25-35引起的细胞活性、钙稳态、ROS水平、线粒体功能、tau蛋白磷酸化以及神经突起生长损伤的保护能力。PC12细胞暴露于Аβ 25-35后,观察到ROS水平、细胞内钙和Ser396处tau蛋白磷酸化水平的增加;这些改变伴随着细胞活性下降和凋亡增加。Omberacetam处理改善了PC12细胞的存活率,降低了早期和晚期凋亡细胞的数量,减少了细胞内活性氧和钙的水平,提高了线粒体膜电位。此外,Omberacetam预处理显著减轻了Аβ25-35引起的tau蛋白在Ser396处的过度磷酸化,并改善了神经突起生长的变化。
体内活性
Noopept在长期(21天)治疗后通过提高受训动物的百分比[2],消除了学习性无助的表现。
细胞实验
PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1].
动物实验
Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2].
别名SGS-111, Noopept, GVS-111
化学信息
分子量318.37
分子式C17H22N2O4
CAS No.157115-85-0
SmilesCCOC(=O)CNC(=O)C1CCCN1C(=O)CC1=CC=CC=C1
密度1.202g/cm3
储存&溶解度
存储keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 100 mg/mL (314.1 mM), Sonication is recommended.
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM3.1410 mL15.7050 mL31.4100 mL157.0500 mL
5 mM0.6282 mL3.1410 mL6.2820 mL31.4100 mL
10 mM0.3141 mL1.5705 mL3.1410 mL15.7050 mL
20 mM0.1570 mL0.7852 mL1.5705 mL7.8525 mL
50 mM0.0628 mL0.3141 mL0.6282 mL3.1410 mL
100 mM0.0314 mL0.1570 mL0.3141 mL1.5705 mL

SCI 文献

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

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