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Nifurtimox

Rating icon 很棒
产品编号 T5325Cas号 23256-30-6
别名 硝呋替莫, BAY-A-2502, BAY-2502

Nifurtimox (BAY-A-2502) 是一种用于锥虫病的抗虫剂,可影响乳酸脱氢酶活性。它有潜力研究神经母细胞瘤细胞。

Nifurtimox
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Nifurtimox

Rating icon 很棒
纯度: 99.92%
产品编号 T5325 别名 硝呋替莫, BAY-A-2502, BAY-2502Cas号 23256-30-6

Nifurtimox (BAY-A-2502) 是一种用于锥虫病的抗虫剂,可影响乳酸脱氢酶活性。它有潜力研究神经母细胞瘤细胞。

规格价格库存数量
1 mg¥ 170现货
5 mg¥ 397现货
10 mg¥ 636现货
25 mg¥ 1,390现货
50 mg¥ 2,190现货
100 mg¥ 3,370现货
200 mg¥ 4,650现货
1 mL x 10 mM (in DMSO)¥ 437现货
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产品介绍

生物活性
产品描述
Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi- epimastigotes, respectively).
靶点活性
Taluahuén:9.91μM, T. cruzi Brener strains:10.44 μM, LQ:12.28μM
体外活性
Nifurtimox can produce anion radicals and interfere with oxygen metabolism [1]. On the neuroblastoma cell lines LA-N-1, IMR-32, LS and SK-N-SH, the treatment of nifurtimox shows an increased production of oxidative stress, a reduced lactate dehydrogenase enzyme activity and reduced lactate production. Furthermore, nifurtimox leads to reduced mRNA and protein levels of the proto-oncogene protein N-Myc [2].
细胞实验
To assess the cell viability after incubation with nifurtimox at different concentrations (10 μg/mL up to 50 μg/mL or 34.8 μM to 174 μM, respectively in the supernatant growth medium) or the vehicle control with according concentrations, all neuroblastoma cell lines were subjected to an MTS assay. Stock solutions of MTS were made at 480 μM in sterile filtered deionized water and stored at ?20°C. Cells were grown to approximately 50% confluency, treated with nifurtimox, and incubated for 1 h with fresh media containing 12 μM MTS. The supernatant was subsequently removed and the cells were lysed with DMSO containing 10% (w/v) sodium dodecyl sulfate (SDS) and 1% (v/v) glacial acetic acid (Carl Roth, #3738). Purple formazan contents of each cell lysate were photometrically analyzed in triplicates at 570 nm (630 nm reference wavelength) in 96 microtiter plates [2].
别名硝呋替莫, BAY-A-2502, BAY-2502
化学信息
分子量287.29
分子式C10H13N3O5S
CAS No.23256-30-6
SmilesCC1CS(=O)(=O)CCN1\N=C\c1ccc(o1)[N+]([O-])=O
密度1.56g/cm3
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
H2O: Insoluble
DMSO: 55 mg/mL (191.44 mM)
溶液配制表
1mg5mg10mg50mg
1 mM3.4808 mL17.4040 mL34.8080 mL174.0402 mL
5 mM0.6962 mL3.4808 mL6.9616 mL34.8080 mL
10 mM0.3481 mL1.7404 mL3.4808 mL17.4040 mL
20 mM0.1740 mL0.8702 mL1.7404 mL8.7020 mL
50 mM0.0696 mL0.3481 mL0.6962 mL3.4808 mL
100 mM0.0348 mL0.1740 mL0.3481 mL1.7404 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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