|
TMPH-03720
|
YscM Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
Yop proteins translocation protein M,yscM
|
Yersinia enterocolitica
|
E. coli
|
|
Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function. |
|
TMPY-03596
|
JTB Protein, Human, Recombinant (mFc)
PAR,hJT,jumping translocation breakpoint,JTB,HSPC22...
|
Human
|
HEK293 Cells
|
|
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal... |
|
TMPH-03726
|
YscM Protein, Yersinia pseudotuberculosis serotype I, Recombinant (His & SUMO)
Yop proteins translocation protein M,Low calcium re...
|
Yersinia pseudotuberculosis
|
E. coli
|
|
Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function. |
|
TMPH-01330
|
FCRL3 Protein, Human, Recombinant (His)
MAIA,IFGP family protein 3,Fc receptor homolog 3,Immune rece...
|
Human
|
E. coli
|
|
FCRL3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 67.4 kDa and the accession number is Q96P31. |
|
TMPY-02700
|
BCL2 Protein, Human, Recombinant (His)
Bcl-2,PPP1R50,B-cell CLL/lymphoma 2
|
Human
|
E. coli
|
|
BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family and all members contain at least one of four BH (bcl-2 homology) domains. Certain members such as Bcl-2, Bcl-xl and Mcl1 are anti-apoptotic, whilst others are pro-apoptotic. Most Bcl-2 family members contain a C-terminal transmembrane domain that functions to target these proteins... |
|
TMPY-02287
|
Ku70 & Ku80 Heterodimer Protein, Human, Recombinant (His)
KARP1,XRCC5 & XRCC6,KUB2,KU80,KARP-1,Ku86,NFIV
|
Human
|
Baculovirus Insect Cells
|
|
X-ray repair cross-complementing protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 8 kDa subunit, CTC box-binding factor 85 kDa subunit, DNA repair protein XRCC5, Lupus Ku autoantigen protein p86, TLAA and XRCC5, is a nucleus and chromosome which belongs to the ku8 family. XRCC5 is a single-stranded DNA-dependent ATP-dependent helicase. XRCC5 has a role in chromosome translocation. X-ray repair cross-complementing protein... |
|
TMPH-03764
|
YAP1 Protein, Human, Recombinant (His)
YAP1-2gamma,YAP2L,YAP65
|
Human
|
P. pastoris (Yeast)
|
|
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,... |
|
TMPH-03741
|
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F
|
Clostridium botulinum
|
E. coli
|
|
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... |
|
TMPH-03010
|
EsxB Protein, Mycobacterium tuberculosis, Recombinant (His)
ESAT-6-like protein EsxB,10 kDa culture filtrate antigen CFP...
|
Mycobacterium tuberculosis
|
P. pastoris (Yeast)
|
|
A secreted protein. Acts as a strong host T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA. |
|
TMPH-00649
|
LptA Protein, E. coli, Recombinant (His & SUMO)
lptA,Lipopolysaccharide export system protein LptA
|
E. coli
|
E. coli
|
|
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. |
|
TMPH-00694
|
LolA Protein, E. coli O9:H4, Recombinant (His)
Outer-membrane lipoprotein carrier protein,lolA
|
E. coli
|
P. pastoris (Yeast)
|
|
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane). |
|
TMPH-02683
|
GSTP1 Protein, Mouse, Recombinant (His & SUMO)
Gstp1,GST-piB,GST class-pi,Preadipocyte growth factor,GST YF...
|
Mouse
|
E. coli
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. |
|
TMPH-00268
|
GLTP Protein, Bovine, Recombinant (His)
GLTP,Glycolipid transfer protein
|
Bovine
|
P. pastoris (Yeast)
|
|
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. GLTP Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 25.8 kDa and the accession number is P68265. |
|
TMPH-01691
|
TOMM40 Protein, Human, Recombinant (GST)
Mitochondrial import receptor subunit TOM40 homolog,p38.5,Pr...
|
Human
|
E. coli
|
|
Channel-forming protein essential for import of protein precursors into mitochondria. Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria. |
|
TMPH-01690
|
TIM14 Protein, Human, Recombinant (GST)
Mitochondrial import inner membrane translocase subunit TIM1...
|
Human
|
E. coli
|
|
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity. |
|
TMPH-03009
|
EsxB Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)
ESAT-6-like protein EsxB,esxB,10 kDa culture filtrate antige...
|
Mycobacterium tuberculosis
|
E. coli
|
|
A secreted protein. Acts as a strong host T-cell antigen. Involved in translocation of bacteria from the host (human) phagolysosome to the host cytoplasm. Might serve as a chaperone to prevent uncontrolled membrane lysis by its partner EsxA. EsxB Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 14.7 kDa and the accession number is P9WNK4. |
|
TMPH-01398
|
GSTP1 Protein, Human, Recombinant (E. coli, His)
GSTP1,Glutathione S-transferase P,GSTP1-1,GST class-pi
|
Human
|
E. coli
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. GSTP1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted mo... |
|
TMPH-02536
|
BNIP3 Protein, Mouse, Recombinant (Cell-Free, His)
Bnip3,BCL2/adenovirus E1B 19 kDa protein-interacting protein...
|
Mouse
|
E. coli
|
|
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP... |
|
TMPH-01399
|
GSTP1 Protein, Human, Recombinant (His)
GST class-pi,GSTP1,Glutathione S-transferase P,GSTP1-1
|
Human
|
P. pastoris (Yeast)
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. GSTP1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 25.2 kDa and... |
|
TMPH-01286
|
EEF2 Protein, Human, Recombinant (His)
Elongation factor 2,EEF2,EF2,EF-2
|
Human
|
E. coli
|
|
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. |
|
TMPJ-01106
|
NAD(P) transhydrogenase/NNT Protein, Human, Recombinant (His)
NAD(P) transhydrogenase,NNT
|
Human
|
E. coli
|
|
NAD(P)+transhydrogenase (NNT) is located in the inner mitochondrial membrane and catalyzes a reversible hydride transfer between NAD(H) and NADP(H) that is coupled to proton translocation between the intermembrane space and mitochondrial matrix. NNT activity has an essential role in maintaining the NADPH supply for antioxidant defense and biosynthetic pathways. Structurally, NNT is composed of three domains; domains I and III are hydrophilic and have binding sites for NAD and NADP, respectively,... |
|
TMPJ-00965
|
TIM16 Protein, S. cerevisiae, Recombinant
TIM16,Mitochondrial import inner membrane translocase subuni...
|
S. cerevisiae
|
E. coli
|
|
Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM16 is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. TIM16 may act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase s... |
|
TMPY-03959
|
CHST11 Protein, Human, Recombinant (His)
carbohydrate (chondroitin 4) sulfotransferase 11,HSA269537,C...
|
Human
|
Baculovirus Insect Cells
|
|
CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving CHST11 gene and IgH, t(12;14)(q23;q32), has been reported in a patient with ... |
|
TMPH-03507
|
IpaD Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)
ipaD,36 kDa membrane antigen,Invasin IpaD
|
Shigella flexneri
|
E. coli
|
|
Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore in the host membrane that allows the translocation of the other effectors into the host cytoplasm. Along with IpaB, is essential for both blocking secretion through the Mxi/Spa translocon in the absence of a secretion-inducing signal, and for controlling the level of secretion in... |
|
TMPH-01522
|
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
vpx,Viral protein X,X ORF protein,Protein Vpx
|
HIV-2
|
P. pastoris (Yeast)
|
|
Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by... |
|
TMPJ-01087
|
TIM14 Protein, S. cerevisiae, Recombinant
Mitochondrial import inner membrane translocase subunit TIM1...
|
S. cerevisiae
|
E. coli
|
|
Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM14 is required to stimulate activity of mtHSP70 (SSC1). TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as p... |
|
TMPK-00668
|
IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)
NILR,IL-21 receptor,IL-21R,CD360
|
Cynomolgus
|
HEK293 Cells
|
|
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker i... |
|
TMPH-00541
|
Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc)
Latent membrane protein 1,Protein p63,LMP1
|
EBV
|
E. coli
|
|
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular protein... |
|
TMPY-04406
|
Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)
protein kinase D2,nPKC-D2,PKD2,HSPC187
|
Human
|
Baculovirus Insect Cells
|
|
Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 an... |
|
TMPY-03455
|
FGFR1OP Protein, Human, Recombinant (His & GST)
FGFR1 oncogene partner,FOP
|
Human
|
Baculovirus Insect Cells
|
|
FOP( fibroblast growth factor receptor 1 oncogene partner) is a largely hydrophilic protein postulated to be a leucine-rich protein family member. FOP contains 1 LisH domain. A t(6;8)(q27;p11) chromosomal translocation, fusing FOP gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. FOP g... |
|
TMPJ-00376
|
IL-17RD Protein, Human, Recombinant (hFc)
IL17Rhom,IL17RD,IL-17RD,IL-17 RD,IL17RLM,SEF,interleukin 17 ...
|
Human
|
HEK293 Cells
|
|
Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation ... |
|
TMPH-02194
|
TAB2 Protein, Human, Recombinant (His & Myc)
Mitogen-activated protein kinase kinase kinase 7-interacting...
|
Human
|
Baculovirus Insect Cells
|
|
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to ... |
|
TMPH-00542
|
Epstein-Barr virus (strain Raji) LMP1 Protein (His)
Latent membrane protein 1,LMP1,Protein p63
|
EBV
|
P. pastoris (Yeast)
|
|
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several signaling pathways, including those of the NF-kappa-B family. LMP1 signaling leads to up-regulation of antiapoptotic proteins and provide growth signals in latently infected cells. Interacts with host UBE2I and subsequently affects the sumoylation state of several cellular protein... |
|
TMPY-03500
|
ARL2BP Protein, Human, Recombinant (His)
RP66,ADP-ribosylation factor-like 2 binding protein,BART1,BA...
|
Human
|
E. coli
|
|
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. ARL2BP binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of ARL2BP or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. ARL2BP is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.... |
|
TMPJ-00499
|
GSTP1 Protein, Human, Recombinant
GSTP1,GST3,GST class-pi,Glutathione S-transferase P,FAEES3,G...
|
Human
|
E. coli
|
|
Glutathione S-transferase P (GSTP1) is an enzyme that contains 1 GST C-terminal domain, 1 GST N-terminal domain. GSTP1 belongs to the GST superfamily, the GSTs are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione ... |
|
TMPY-04478
|
IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)
inositol hexakisphosphate kinase 1,IHPK1,PiUS
|
Human
|
Baculovirus Insect Cells
|
|
IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth-suppressive and... |
|
TMPY-02963
|
Calcineurin A/PPP3CA Protein, Human, Recombinant (His)
CALNA1,CNA1,PPP2B,CALNA,CCN1,protein phosphatase 3, catalyti...
|
Human
|
Baculovirus Insect Cells
|
|
PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of th... |
|
TMPH-02538
|
Beclin-1 Protein, Mouse, Recombinant (His & SUMO)
Beclin-1,GT197,Coiled-coil myosin-like BCL2-interacting prot...
|
Mouse
|
E. coli
|
|
Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential f... |
|
TMPJ-00305
|
SIRP alpha Protein, Cynomolgus, Recombinant (aa 31-369, His)
Inhibitory Feceptor SHPS-1,MyD-1 Antig,Brain Ig-Like Molecul...
|
Cynomolgus
|
HEK293 Cells
|
|
Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ... |
|
TMPH-02530
|
ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)
ATP synthase F1 subunit beta,Atp5b,Atp5f1b,ATP synthase subu...
|
Mouse
|
E. coli
|
|
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ... |
|
TMPY-02120
|
XPNPEP2 Protein, Human, Recombinant (His)
AEACEI,X-prolyl aminopeptidase (aminopeptidase P) 2, membran...
|
Human
|
HEK293 Cells
|
|
Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution ... |
|
TMPJ-00271
|
SMAD3 Protein, Human, Recombinant (His & Flag)
SMAD 3,Mothers against DPP homolog 3,hMAD-3,MADH3,JV15-2,SMA...
|
Human
|
E. coli
|
|
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated... |
|
TMPJ-00306
|
SIRP alpha Protein, Human, Recombinant (His & Avi), Biotinylated
Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs...
|
Human
|
HEK293 Cells
|
|
Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking ... |
|
TMPY-02964
|
Calcineurin B/PPP3R1 Protein, Human, Recombinant (His)
protein phosphatase 3, regulatory subunit B, alpha,CNB1,CALN...
|
Human
|
Baculovirus Insect Cells
|
|
PPP3R1 belongs to the calcineurin regulatory subunit family. It is a regulatory subunit of calcineurin. Calcineurin is composed of two subunits: calcineurin A (CnA) and calcineurin B (CnB). Dephosphorylation of the nuclear factor of activated T-cells (NF-AT) by Calcineurin is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. PPP3R1 is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase which takes a vital part in the T cell activatio... |
|
TMPJ-01182
|
SIRP alpha Protein, Mouse, Recombinant (MIgG2a)
SIRP,CD172 Antigen-Like Family Member A,SIRPA,MFR,Signal-Reg...
|
Mouse
|
HEK293 Cells
|
|
SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-l... |
|
TMPH-01280
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EGLN1 Protein, Human, Recombinant (His & Myc)
HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxylase 2,HIF-PH2,C1or...
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Human
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E. coli
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Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti... |
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TMPY-04421
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FES Protein, Human, Recombinant (His & GST)
FPS,FES proto-oncogene, tyrosine kinase
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Human
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Baculovirus Insect Cells
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Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. T... |
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TMPH-02186
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TERT Protein, Human, Recombinant (His)
Telomerase reverse transcriptase,Telomerase catalytic subuni...
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Human
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E. coli
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Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de... |
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TMPY-03435
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NCKIPSD Protein, Human, Recombinant (GST)
NCK interacting protein with SH3 domain,WASLBP,SPIN90,ORF1,V...
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Human
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E. coli
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NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an important role in stress fiber formation. NCKIPSD gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding d... |
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TMPJ-00936
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CCND2 Protein, Human, Recombinant (His)
G1/S-specific cyclin-D2,CCND2
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Human
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E. coli
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CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ... |
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