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Targets Recommended: Histone Methyltransferase

87

抑制剂 & 化合物

4

天然产物

36

化合物库

2

同位素标记化合物

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Cat. No.	Product Name
L2900	氧化还原化合物库		1264 compounds
	1264 个活性化合物，已经验证具有一定的抗氧化活性，包括 ROS 清除剂、iNOS、eNOS、及抗氧化的天然产物，是研究疾病机理以及药物研究的优良载体
L4520	抗菌活性库		904 compounds
	904 种具有抗菌活性的化合物，是抗菌药物研发的有力工具；
L4200	FDA 上市药物库		1729 compounds
	1729 个FDA 批准药物的独特集合，可用于高通量筛选和高内涵筛选；
L3400	临床期小分子药物库		3404 compounds
	3404 个临床期化合物集合，可用于高通量筛选和高内涵筛选；
L1380	转录因子库		695 compounds
	695 种转录因子靶向、结构新颖的化合物；
L4510	抗寄生虫库		419 compounds
	419 种具有抗寄生虫活性的小分子化合物；
L3100	造血毒性小分子库		101 compounds
	101 种生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2910	抗氧化化合物库		1314 compounds
	氧化应激（Oxidative Stress，OS）是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧（ROS）大量积累，氧化程度超出抗氧化物的清除能力，从而引起氧化损伤，氧化应激损伤是许多疾病发生的基础，不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激，降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合，是研究氧化应激的有用工具，可以用于高通量筛选和高内涵筛选。
L6100	天然多酚类化合物库		635 compounds
	635 个天然多酚化合物的独特集合，可用于高通量、高内涵筛选；
L1700	抗病毒库		1040 compounds
	1040 种具有抗病毒活性的化合物的特有集合，是筛选新型抗病毒药的有效工具；可用于高通量筛选和高内涵筛选；
L4500	抗真菌库		252 compounds
	252 个抗真菌活性化合物的独特集合，包含作用于真菌相关靶点的化合物和临床中用于真菌类疾病的药物，是相关疾病药物筛选的有效工具。
L8110	细胞重编程化合物库		1813 compounds
	1813 种重编程信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选
L2180	抗肿瘤库Plus		1468 compounds
	1468 种抗肿瘤相关、结构新颖的化合物；
L9200	药物功能重定位化合物库		4630 compounds
	4630 种全球上市药物和临床药物的独特集合，可用于高通量筛选和高内涵筛选，是老药新用、新的药物靶点筛选和细胞诱导的有效工具。
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
L3200	自噬库		1248 compounds
	1248 种细胞自噬相关的生物活性小分子化合物的特有集合，用于自噬相关的研究，用于高通量、高内涵筛选；
L6710	中药抗炎分子库		1246 compounds
	1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合，是药物开发、药理研究的有效工具；
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；
L6300	药食同源库		1290 compounds
	1290 个药食同源化合物的独特集合，可用于高通量筛选和高内涵筛选；
L8200	抗衰老化合物库		3279 compounds
	3279 个抗衰老化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2195	抗前列腺癌化合物库		2070 compounds
	2070 种与前列腺癌相关的化合物，可以用于高通量和高内涵筛选
L2193	抗肝癌化合物库		1787 compounds
	1787 种与肝癌相关的化合物，可以用于抗肝癌药物研发和药理研究；
L6800	中国药典收录天然产物库		2051 compounds
	2051 种中国药典收录的天然产物，是药物开发、药理研究等领域的有力工具；
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；
L4020	NO PAINS 化合物库		9384 compounds
	TargetMol NO PAINS 化合物库包含 9384 个剔除了PAINS 的小分子活性化合物，可用于新药研发，信号通路研究，老药新用等研究。
L2520	糖代谢化合物库		702 compounds
	702 种糖代谢相关的化合物，可用于高通量和高内涵筛选；
L2510	脂代谢化合物库		492 compounds
	492 个脂代谢相关的化合物集合，可用于高通量和高内涵筛选；
L9500	表型筛选靶点鉴定库		1796 compounds
	1796 种靶点明确的已知活性化合物，适合表型筛选；
L9700	内质网应激化合物库		193 compounds
	193 个内质网应激相关的化合物集合，可用于高通量和高内涵筛选；
L6740	抗结直肠癌中药单体化合物库		382 compounds
	382 种抗结直肠癌相关的中药单体集合，是药物开发、药理研究的有效工具；
L2194	抗结直肠癌化合物库		1545 compounds
	1545 种与结直肠癌相关的化合物，可以用于高通量和高内涵筛选；
L2170	肿瘤免疫治疗小分子化合物库		449 compounds
	449 种靶向肿瘤免疫治疗靶点的小分子，可用于高通量和高内涵筛选，是研究肿瘤免疫治疗的有力工具；
L6200	瑶药化合物库		221 compounds
	221 种瑶药来源的天然产物分子集合，可以用于高通量和高内涵筛选；
L2560	代谢化合物库		2320 compounds
	2320 种代谢途径相关的化合物，可用于高通量和高内涵筛选。
L2550	谷氨酰胺代谢化合物库		565 compounds
	565 种谷氨酰胺代谢相关的分子，可以用于高通量和高内涵筛选；
L2196	抗卵巢癌化合物库		1867 compounds
	1867 种与卵巢癌相关的化合物，可以用于抗卵巢癌药物研发和药理研究

化合物库

氧化还原化合物库

Cat.No: L2900

Compounds: 1264

抗菌活性库

Cat.No: L4520

Compounds: 904

FDA 上市药物库

Cat.No: L4200

Compounds: 1729

临床期小分子药物库

Cat.No: L3400

Compounds: 3404

转录因子库

Cat.No: L1380

Compounds: 695

抗寄生虫库

Cat.No: L4510

Compounds: 419

造血毒性小分子库

Cat.No: L3100

Compounds: 101

抗氧化化合物库

Cat.No: L2910

Compounds: 1314

天然多酚类化合物库

Cat.No: L6100

Compounds: 635

Cat.No: L1700

Compounds: 1040

Cat.No: L4500

Compounds: 252

细胞重编程化合物库

Cat.No: L8110

Compounds: 1813

抗肿瘤库Plus

Cat.No: L2180

Compounds: 1468

药物功能重定位化合物库

Cat.No: L9200

Compounds: 4630

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

Cat.No: L3200

Compounds: 1248

中药抗炎分子库

Cat.No: L6710

Compounds: 1246

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

药食同源库

Cat.No: L6300

Compounds: 1290

抗衰老化合物库

Cat.No: L8200

Compounds: 3279

抗前列腺癌化合物库

Cat.No: L2195

Compounds: 2070

抗肝癌化合物库

Cat.No: L2193

Compounds: 1787

中国药典收录天然产物库

Cat.No: L6800

Compounds: 2051

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

NO PAINS 化合物库

Cat.No: L4020

Compounds: 9384

糖代谢化合物库

Cat.No: L2520

Compounds: 702

脂代谢化合物库

Cat.No: L2510

Compounds: 492

表型筛选靶点鉴定库

Cat.No: L9500

Compounds: 1796

内质网应激化合物库

Cat.No: L9700

Compounds: 193

抗结直肠癌中药单体化合物库

Cat.No: L6740

Compounds: 382

抗结直肠癌化合物库

Cat.No: L2194

Compounds: 1545

肿瘤免疫治疗小分子化合物库

Cat.No: L2170

Compounds: 449

瑶药化合物库

Cat.No: L6200

Compounds: 221

代谢化合物库

Cat.No: L2560

Compounds: 2320

谷氨酰胺代谢化合物库

Cat.No: L2550

Compounds: 565

抗卵巢癌化合物库

Cat.No: L2196

Compounds: 1867

Cat. No.	Product Name	Target	Signaling Pathways
T4314	EPZ020411 EPZ020411 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ020411是一种特异性有效的 PRMT6 抑制剂， IC50 为 10 nM，比作用于 PRMT1 和 PRMT8 的选择性高10倍多。
T40350	HPK1-IN-4 HPK1-IN-4	MAPK	MAPK
	HPK1-IN-4是一种HPK1（MAPK41）抑制剂，IC 50为0.061 nM。HPK1-IN-4常被作为临床前免疫治疗工具化合物。
T63788	PCLX-001	Others	Others
	PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2].
T22180	3F8 3F 8,3F-8	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	3F8 是一种具有选择性的 GSK-3β抑制剂，可用作 GSK3 相关疾病的新工具和潜在治疗候选化合物，可用于研究神经系统疾病和癌症。
T9314	CC214-1	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	CC214-1 是一种 mTOR 抑制剂，具有潜在的抗癌活性，抑制蛋白翻译，可诱导自噬 (autophagy)。 CC214-1 是探索 mTOR 激酶生物学的体外工具化合物，可用于研究骨髓瘤。
T9361	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	Others	Others
	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) 是一种合成化合物。它已被用作催化剂以及酶动力学研究中的工具；还被用于酶抑制的研究，以及药物受体相互作用的研究。
T64355	TDI-10229	cAMP	GPCR/G Protein
	TDI-10229 是一种口服有效的可溶性腺苷酸环化酶 (sAC, ADCY10) 抑制剂 (IC50 值为 195 nM)。TDI-10229 在生化和细胞分析中都显示出对 sAC 的纳摩尔级抑制，并表现出足以保证其用作体内工具化合物的小鼠药代动力学特性。
T38955	β-Lactamase-IN-4	Others	Others
	β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.
T39270	2-NP-AMOZ	Others	Others
	2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ, which is a metabolite of the antibiotic Furaltadone. This chemical compound specifically serves as a reliable tool for protein bound AMOZ detection.
T38938	Antibacterial agent 37	Others	Others
	Antibacterial agent 37 is an effective antimicrobial compound. It holds potential as a valuable tool for researching bacterial infections.
T30216	AV-105 AV105,AV 105	Others	Others
	Av-105 is the precursor of florbetapir (18F). It is a radiopharmaceutical compound scanned by pet, which can be used as a diagnostic tool for Alzheimer's disease.
T61868	Antitumor agent-66	Others	Others
	Antitumor agent-66 (Compound 4) is a derivative of (-)-cleistenolide, showcasing potential as a research tool for cancer diseases [1].
T61423	Transthyretin-IN-1	Others	Others
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T69922	EPZ020411 HCl	Others	Others
	EPZ020411 is a potent and selective PRMT6 inhibitor tool compound. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies. EPZ020411 suppresses RCC1 arginine methylation and improves the cytotoxic activity of radiotherapy against GSC brain tumor xenografts.
T61592	Thalidomide-piperazine hydrochloride	Others	Others
	Thalidomide-piperazine hydrochloride is a chemical compound with potential applications in the research of leprosy and multiple myeloma. It serves as a valuable tool in developmental biology, facilitating significant discoveries in the biochemical pathways of limb development [1].
T39729	HIV Protease Substrate 1
	HIV Protease Substrate 1 is a fluorogenic compound that offers insights into the enzymatic activity of HIV protease, making it a valuable tool for studying this aspect.
T39629	BRD4 ligand-Linker Conjugate 1 BRD4 ligand-Linker Conjugate 1	Others	Others
	BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules utilized for targeted protein degradation.
T18373	N-(Amino-PEG4)-N-Biotin-PEG4-acid	Others	Others
	N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker that incorporates biotin for labeling purposes. This compound serves as a versatile tool in the synthesis of PROTACs[1].
T61341	A-908292	Others	Others
	A-908292 is a highly potent and selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), displaying an impressive IC50 of 38 nM. This compound serves as a valuable tool in the investigation of fatty acid metabolism [1].
T61073	KH-259	Others	Others
	KH-259 (compound 1) is a highly potent, selective, and CNS-penetrant HDAC6 inhibitor, demonstrating an IC50 of 0.26 μM. It exerts its antidepressant effects in mice by inhibiting HDAC6 within the brain. Therefore, KH-259 holds promise as a valuable tool for neurodegenerative diseases research [1].
T40452	N-Acetylpsychosine N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)	Others	Others
	N-Acetylpsychosine, also known as α-galactosylated C2-ceramide (d18:1/2:0), exhibits immunostimulatory properties. This compound, N-Acetylpsychosine, holds potential as a valuable tool for studying the mechanisms of apoptosis and immune responses activated by dendritic cells (DCs).
T74959	Antifungal agent 41	Others	Others
	Antifungal agent 41 (compound B01) 是一种抗真菌剂。Antifungal agent 41 在体内外表现出对白假丝酵母菌的抗性。Antifungal agent 41 可以用于侵袭性真菌感染的研究。
T61796	MtTMPK-IN-1	Others	Others
	MtTMPK-IN-1 (compound 3) is a highly effective inhibitor of Mycobacterium tuberculosis thymidylate kinase (Mt TMPK), exhibiting an IC50 value of 2.5 μM. It displays moderate to weak activity against Mtb H37Rv while demonstrating low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 is a valuable tool for tuberculosis research [1].
T17884	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	Others	Others
	cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].
T18552	Pomalidomide-amido-C1-Br	Others	Others
	Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].
T61502	Antifungal agent 32	Others	Others
	Antifungal agent 32 (compound 1a) is a highly effective antifungal compound. It displays strong inhibitory activity against Candida albicans filamentation and biofilm formation, as well as inhibiting the morphological switching of Candida albicans and its adherence to epithelial cells. This makes Antifungal agent 32 a valuable tool for research on Candida albicans infections [1].
T61565	KDM5B-IN-3	Others	Others
	KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valuable tool in gastric cancer research [1].
T79131	KAT modulator-1	Histone Acetyltransferase	Chromatin/Epigenetic
	KAT modulator-1 (Compound 3)为一种KAT调节剂, 能够与全长p300进行相互作用，但不影响催化结构域。该化合物主要应用于表观遗传学研究领域。
T74339	DNA crosslinker 3 dihydrochloride	Others	Others
	DNA crosslinker 3 (dihydrochloride) (compound 1) 为一种与DNA结合的小沟结合剂，其结合亲和力(ΔTm)达1.4°C，常用于抗癌研究。
T38980	Mg(II) protoporphyrin IX	Others	Others
	Mg(II) protoporphyrin IX is a crucial compound in the synthesis of chlorophyll in Chlorella. It also serves as a negative regulator of nuclear photosynthetic gene expression. Additionally, Mg(II) protoporphyrin IX is employed as a valuable research tool for investigating the signaling molecule involved in plastid-to-nucleus communication.
T39791	Mal-amide-PEG2-oxyamine-Boc Mal-amide-PEG2-oxyamine-Boc	Others	Others
	Mal-amide-PEG2-oxyamineBoc is a polyethylene glycol (PEG)-based linker molecule that possesses a Boc-protected oxyamine functionality. This compound serves as a valuable tool in the efficient synthesis of PROTACs (proteolysis targeting chimeras), offering a versatile and straightforward approach for constructing these targeted protein degradation agents.
T61543	CLK1/4-IN-1	Others	Others
	CLK1/4-IN-1 (compound 31) is a highly potent and selective inhibitor of Clk1 and Clk4, with IC50 values of 9.7 nM and 6.6 nM, respectively. It effectively inhibits the growth of T24 cancer cells, with a GI50 value of 1.1 μM. CLK1/4-IN-1 has shown promising potential as an anticancer research tool [1].
T61573	MtTMPK-IN-5	Others	Others
	MtTMPK-IN-5 (compound 17) is a highly effective inhibitor of M. tuberculosis thymidylate kinase (Mtb TMPK), demonstrating remarkable enzyme inhibitory activity with an IC50 value of 34 μM. Additionally, MtTMPK-IN-5 exhibits notable activity against M. tuberculosis, as evidenced by a minimum inhibitory concentration (MIC) of 12.5 μM. Given its potent properties, MtTMPK-IN-5 serves as a valuable tool for tuberculosis research [1].
T84783	Azidoacetic Acid 2-Azidoacetic acid	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Azidoacetic Acid (2-Azidoacetic acid) (化合物 92-1)，是一种含有叠氮基的点击化学试剂，可用于小分子工具合成PROTAC。
T61777	Anticancer agent 42	Others	Others
	Anticancer agent 42 (compound 10d) is an orally active, potent anticancer agent with demonstrated efficacy against MDA-MB-231 cells, exhibiting an IC50 of 0.07 μM. It exerts its anticancer activity through the activation of apoptotic pathways and p53 expression. Anticancer agent 42 is a valuable tool for investigating metastatic breast cancer [1].
T61785	BChE-IN-6	Others	Others
	BChE-IN-6 (compound 12) is a highly effective inhibitor of BChE, showcasing a Ki value of 0.182 μM. Notably, BChE-IN-6 exhibits significant chelating abilities towards Zn 2+. Due to these characteristics, BChE-IN-6 serves as a valuable tool for researchers in the field of Alzheimer's disease (AD) [1].
T39074	(Rac)-Zevaquenabant (Rac)-MRI-1867,(Rac)-Zevaquenabant	Others	Others
	(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of the cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (Ki) of 5.7 nM specifically for CB1R. Due to its characteristics, (Rac)-Zevaquenabant holds promise as an investigative tool in liver fibrosis research.
T61579	BuChE-IN-5	Others	Others
	BuChE-IN-5 (compound 25b) is a highly potent BuChE inhibitor, displaying an IC50 value of 1.94 μM. It effectively inhibits aggregation of Aβ and tau protein in Escherichia coli. Furthermore, BuChE-IN-5 exhibits considerable free radical scavenging capacity and antioxidant activity. Given these properties, it holds promise as a valuable tool for Alzheimer's disease research [1].
T14593	Biotin-PEG3-Mal	Others	Others
	Biotin-PEG3-Mal is a biotinylated polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs). By introducing the biotin moiety, it enables specific recognition and binding to target proteins. Additionally, the PEG spacer contributes to improved solubility and flexibility of the linker. This compound offers a valuable tool for constructing PROTACs, which hold great potential in targeted protein degradation strategies[1].
T61732	EGFR/HER2-IN-6	Others	Others
	EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This compound displays notable anticancer properties in various cancer cell lines, while demonstrating a favorable safety profile and selectivity indices. Consequently, EGFR/HER2-IN-6 holds promise as a valuable tool in cancer research [1].
T40131	SGC-CK2-1 SGC-CK2-1	Others	Others
	SGC-CK2-1 is an ATP-competitive chemical compound that acts as a highly potent and cell-active CK2 inhibitor. It demonstrates excellent selectivity towards both isoforms of human CK2, with IC50 values of 36 nM for CK2α and 16 nM for CK2α′ in the nanoBRET assay. Given its properties, SGC-CK2-1 is a suitable tool for the investigation of neurodegenerative diseases.
T79315	PROTAC TG2 degrader-2	PROTACs	PROTAC
	PROTACTG2 degrader-2（compound 7）是一种针对Transglutaminase 2（TG2）的选择性竞争性降解剂，其Kd值大于100 μM。该化合物能有效抑制卵巢癌细胞的迁移，并降低其TG2表达水平，因此可作为卵巢癌研究的工具。
T39772	BRK inhibitor P21d hydrochloride BRK inhibitor P21d hydrochloride	Others	Others
	BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM. Additionally, it effectively suppresses p-SAM68 with an IC50 value of 52 nM. This compound, BRK inhibitor P21d hydrochloride, serves as a valuable tool for evaluating the efficacy of BRK inhibitors in xenograft breast tumor models, enabling the assessment of their in vivo activity.
T82801	C12 NBD Galactosylceramide
	C12 NBD galactosylceramide，一种荧光染料，作为半乳糖神经酰胺的生物活性衍生物，具有标记的荧光C12硝基苯并恶二唑（C12 NBD）基团。该化合物主要用于成像研究。
T39109	ML338 ML338	Others	Others
	ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuber...
T61739	Dyrk1A-IN-5	Others	Others
	Dyrk1A-IN-5 (compound 5j) is a highly potent and selective inhibitor of DYRK1A, exhibiting an IC50 of 6 nM. It dose-dependently diminishes the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Moreover, Dyrk1A-IN-5 effectively inhibits the phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Given these properties, Dyrk1A-IN-5 is a valuable tool for Down syndrome research [1].
T61601	TLR7/8 antagonist 2	Others	Others
	TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7/8 antagonist 2 represents a valuable tool for research in the field of autoimmune disea...
T24692	QAQ dichloride	Others	Others
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...
T77967	MS159	PROTACs	PROTAC
	MS159为一有效的NSD2 (核受体结合SET结构域蛋白2) PROTAC降解剂，能够抑制肿瘤细胞生长，是探究NSD2在健康与疾病中作用的重要化学工具。
T81233	S-(p-Nitrobenzyl)glutathione	Others	Others
	S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂，能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。

化合物

Cat.No: T4314

Synonym: EPZ020411 2HCl

Target: Histone Methyltransferase

Cat.No: T40350

Synonym: HPK1-IN-4

Target: MAPK

Cat.No: T63788

Target: Others

Cat.No: T22180

Synonym: 3F 8,3F-8

Target: GSK-3

Cat.No: T9314

Target: mTOR, Autophagy

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

Cat.No: T9361

Synonym: 5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Target: Others

Cat.No: T64355

Target: cAMP

β-Lactamase-IN-4

Cat.No: T38955

Target: Others

Cat.No: T39270

Target: Others

Antibacterial agent 37

Cat.No: T38938

Target: Others

Cat.No: T30216

Synonym: AV105,AV 105

Target: Others

Antitumor agent-66

Cat.No: T61868

Target: Others

Transthyretin-IN-1

Cat.No: T61423

Target: Others

Cat.No: T69922

Target: Others

Thalidomide-piperazine hydrochloride

Cat.No: T61592

Target: Others

HIV Protease Substrate 1

Cat.No: T39729

BRD4 ligand-Linker Conjugate 1

Cat.No: T39629

Synonym: BRD4 ligand-Linker Conjugate 1

Target: Others

N-(Amino-PEG4)-N-Biotin-PEG4-acid

Cat.No: T18373

Target: Others

Cat.No: T61341

Target: Others

Cat.No: T61073

Target: Others

N-Acetylpsychosine

Cat.No: T40452

Synonym: N-Acetylpsychosine,C2 Galactosylceramide (d18:1/2:0)

Target: Others

Antifungal agent 41

Cat.No: T74959

Target: Others

Cat.No: T61796

Target: Others

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride

Cat.No: T17884

Synonym: E3 ligase Ligand-Linker Conjugates 33 Hydrochloride

Target: Others

Pomalidomide-amido-C1-Br

Cat.No: T18552

Target: Others

Antifungal agent 32

Cat.No: T61502

Target: Others

Cat.No: T61565

Target: Others

KAT modulator-1

Cat.No: T79131

Target: Histone Acetyltransferase

DNA crosslinker 3 dihydrochloride

Cat.No: T74339

Target: Others

Mg(II) protoporphyrin IX

Cat.No: T38980

Target: Others

Mal-amide-PEG2-oxyamine-Boc

Cat.No: T39791

Synonym: Mal-amide-PEG2-oxyamine-Boc

Target: Others

Cat.No: T61543

Target: Others

Cat.No: T61573

Target: Others

Azidoacetic Acid

Cat.No: T84783

Synonym: 2-Azidoacetic acid

Target: Others, ADC Linker

Anticancer agent 42

Cat.No: T61777

Target: Others

Cat.No: T61785

Target: Others

(Rac)-Zevaquenabant

Cat.No: T39074

Synonym: (Rac)-MRI-1867,(Rac)-Zevaquenabant

Target: Others

Cat.No: T61579

Target: Others

Biotin-PEG3-Mal

Cat.No: T14593

Target: Others

Cat.No: T61732

Target: Others

Cat.No: T40131

Synonym: SGC-CK2-1

Target: Others

PROTAC TG2 degrader-2

Cat.No: T79315

Target: PROTACs

BRK inhibitor P21d hydrochloride

Cat.No: T39772

Synonym: BRK inhibitor P21d hydrochloride

Target: Others

C12 NBD Galactosylceramide

Cat.No: T82801

Cat.No: T39109

Synonym: ML338

Target: Others

Cat.No: T61739

Target: Others

TLR7/8 antagonist 2

Cat.No: T61601

Target: Others

Cat.No: T24692

Target: Others

Cat.No: T77967

Target: PROTACs

S-(p-Nitrobenzyl)glutathione

Cat.No: T81233

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T39277	D-Hexamannuronic acid	Others	Others
	D-Hexamannuronic acid, an alginate oligomer, is derived from marine brown algae and a restricted group of Gram negative bacteria. This compound serves as a valuable tool for investigating pain and vascular dementia[4].
T40966	D-Heptamannuronic acid	Others	Others
	D-Heptamannuronic acid, an alginate oligomer, is derived from marine brown algae and a select group of Gram-negative bacteria. This compound serves as a valuable research tool in the study of pain and vascular dementia[4].
T38954	L-Glyceric acid sodium	Others	Others
	L-Glyceric acid sodium is a urinary metabolite predominantly found in individuals with the rare inherited metabolic disorder, L-glyceric aciduria. This compound serves as a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and can be used to differentiate between PH1 and PH2 based on its excretion pattern.
T73068	Mammea A/BA	Others	Others
	Mammea A/BA 对克氏锥虫 (T. cruzi) 显示出有效抗性。通过诱导线粒体功能障碍、产生活性氧 (ROS)、DNA 片段化以及增加酸性液泡数量，Mammea A/BA 触发细胞死亡机制，包括细胞凋亡 (apoptosis)、细胞自噬 (autophagy) 和细胞坏死，对于南美锥虫病的研究具有潜在应用价值。

天然产物

D-Hexamannuronic acid

Cat.No: T39277

Target: Others

D-Heptamannuronic acid

Cat.No: T40966

Target: Others

L-Glyceric acid sodium

Cat.No: T38954

Target: Others

Cat.No: T73068

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0026	2-NP-AMOZ-d5
	2-NP-AMOZ-d5 是 2-NP-AMOZ 的氘代化合物。2-NP-AMOZ 的 CAS 号为 183193-59-1。2-NP-AMOZ 是 AMOZ 的 2-硝基苯基衍生物，AMOZ 是抗生素呋喃他酮的代谢产物。2-NP-AMOZ 专门作为蛋白质结合 AMOZ 检测的可靠工具。
TMID-0075	Reserpine-d9
	Reserpine-d9 是 Reserpine 的氘代化合物。Reserpine 的 CAS 号为 50-55-5。Reserpine 是一种从催吐萝芙木的根中发现的生物碱。它抑制去甲肾上腺素吸收到储存囊泡中，导致中枢和外周轴突末端的儿茶酚胺和血清素耗尽。它可作为抗高血压药和抗精神病药以及研究工具。

同位素标记化合物

Cat.No: TMIJ-0026

Cat.No: TMID-0075

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