160
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4
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Cat. No. | Product Name | ||
---|---|---|---|
L8400 | 血液病分子库 | 514 compounds | |
514 种造血系统疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 | |||
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L6740 | 抗结直肠癌中药单体化合物库 | 382 compounds | |
382 种抗结直肠癌相关的中药单体集合,是药物开发、药理研究的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12317 |
Orelabrutinib
ICP-022 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Orelabrutinib (ICP-022) 是一种口服活性的、强效的、不可逆的 Bruton 酪氨酸激酶(BTK)抑制剂,具有潜在的抗肿瘤作用。它能够阻止 B 细胞抗原受体 (BCR) 信号通路的激活和 BTK 介导的下游生存通路的激活,抑制过度表达 BTK 的恶性 B 细胞的生长。 | |||
T12367 |
Parsaclisib
INCB050465 |
PI3K | PI3K/Akt/mTOR signaling |
Parsaclisib (INCB050465) 是有效的、选择性的、具有口服活性的PI3Kδ抑制剂,其 IC50=1 nM。它相对于其他 PI3K I 类同工型的选择性约为 20000 倍。它可用于复发或难治性 B 细胞恶性肿瘤的研究。 | |||
T6055 |
Quisinostat
奎诺司他,JNJ-26481585 |
Apoptosis; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Quisinostat (JNJ-26481585) 是一种高效的,具有口服活性的 pan-HDAC 抑制剂,对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬,具有广泛的抗肿瘤活性。 | |||
T6761 |
Ossirene
AS101 |
IL Receptor; Caspase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Ossirene (AS101) 是一种免疫调节抑制剂,是一种新型 IL-1beta 转化酶抑制剂,可用于自身免疫性疾病和某些恶性肿瘤。它通过抑制IL-10消除 STAT3 的磷酸化,有效抑制Caspase-1。 | |||
T22349 |
JNJ-38158471
CS-2660 |
VEGFR; c-RET; c-Kit | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
JNJ-38158471 (CS-2660) 是一种耐受性好的,有口服活性的、高效的、选择性的 VEGFR-2抑制剂 (IC50:40 nM),还能抑制 Ret (IC50:180 nM) 和 Kit (IC50:500 nM)。 | |||
T12477 |
Uzansertib phosphate
INCB053914 phosphate |
Pim | Chromatin/Epigenetic; JAK/STAT signaling |
Uzansertib phosphate (INCB053914 phosphate) 是一种可口服的 ATP 竞争性泛-PIM 激酶抑制剂,对多种血液肿瘤细胞系具有广泛的抗增殖活性,对 PIM1、PIM2 和 PIM3 的 IC50分别为 0.24 、30 和 0.12 nM。 | |||
T0975 |
Chlorambucil
CB-1348,Chloroambucil,苯丁酸氮芥,WR-139013 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Chlorambucil (CB-1348) 是一种口服活性的氮芥类双功能烷基化剂,具有抗肿瘤活性,可用于研究淋巴细胞白血病、卵巢癌和乳腺癌以及霍奇金病。 | |||
T4976 |
Umbralisib
TGR-1202,RP5264,TGR 1202,TGR1202 |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂,IC50=22.2 nM,EC50=24.3 nM。它同时可抑制CK1ε,EC50=6.0 μM。 | |||
T12311 |
Tirabrutinib hydrochloride
ONO-4059 (hydrochloride),GS-4059 (hydrochloride) |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Tirabrutinib hydrochloride (GS-4059 (hydrochloride)) 是一种有选择性的、新颖的抑制剂 (IC50:2.2 nM)。 在 B 细胞中 ONO-4059 结合 BTK,因此阻止 B 细胞受体信号和阻碍 B 细胞的发展。 | |||
T1038 |
Fludarabine
NSC 118218,Fludarabinum,氟达拉宾,氟达拉滨,F-ara-A |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Stem Cells |
Fludarabine (Fludarabinum) 是一种氟化嘌呤类似物,一种核酸合成抑制剂和 STAT1 激活抑制剂。Fludarabine 具有抗肿瘤活性,可以用于治疗白血病和淋巴瘤。 | |||
T6079 |
NVP-ADW742
ADW742,ADW,GSK 552602A |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
NVP-ADW742 (ADW) 是一种具有口服活性,选择性的IGF-1R 酪氨酸激酶抑制剂,IC50为 0.17 μM。它抑制胰岛素受体,IC50为 2.8 μM,在肿瘤细胞中诱导多效性抗增殖/促凋亡。 | |||
T12574 |
PTC299
Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate |
VEGFR; Dehydrogenase | Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors |
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂,可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂,可研究血液系统恶性肿瘤。 | |||
T6865 |
Quisinostat dihydrochloride
Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl |
Apoptosis; HDAC; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair |
Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性,高效的 pan-HDAC 抑制剂,具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。 | |||
T6104 |
Cerdulatinib hydrochloride
Cerdulatinib,PRT2070,PRT062070 hydrochloride,PRT062070,PRT2070 hydrochloride |
MLK; c-Fms; Tyrosine Kinases; Hippo pathway; JAK; Syk | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
Cerdulatinib hydrochloride (PRT2070 hydrochloride) 是一种选择性可逆,具有口服活性、 ATP 竞争性的 SYK 和 JAK 的双重抑制剂,抑制 JAK1、2、3、SYK 和 Tyk2的 IC50值分别为12、6、8、32 和 0.5 nM。它可用于研究自身免疫性疾病和B 细胞恶性肿瘤。 | |||
T28297 |
Parsaclisib hydrochloride
Parsaclisib HCl,INCB-50465,INCB 050465,INCB-050465,INCB050465 HCl,INCB 50465,INCB50465 HCl |
PI3K | PI3K/Akt/mTOR signaling |
Parsaclisib hydrochloride (INCB050465 HCl) 是一种选择性的、有效的,具有口服活性的 PI3Kδ抑制剂,IC50=1 nM。它相对于其他 PI3K I 类同工型的选择性约为 20000 倍。它可用于复发或难治性 B 细胞恶性肿瘤的研究。 | |||
T1601 |
Lomustine
CCNU,NSC 79037,洛莫司汀 |
Apoptosis; Others; DNA Alkylator/Crosslinker; DNA Alkylation; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Others |
Lomustine (NSC-79037) 是一种具有抗肿瘤活性的 DNA 烷化剂。 | |||
T23903 |
CM037
CM-037,A-37,CM 037,A37,A 37 |
Dehydrogenase | Metabolism |
CM037 (A-37) 是一种选择性 ALDH1A1 (乙醛脱氢酶 1A1) 的抑制剂(IC50;4.6 µM),具有抗肿瘤活性,可用于研究消除妇科恶性肿瘤。 | |||
T9756 |
AZD-9574
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AZD-9574 是 SSB 位点的 PARP1 特异性抑制剂。 AZD-9574 具有抗癌活性,可用于 HRD+ 乳腺癌和晚期实体恶性肿瘤的研究。 | |||
T10436 |
AZD4573
|
CDK | Cell Cycle/Checkpoint |
AZD4573 是一种有效的选择性 CDK9 抑制剂,IC50值小于 4 nM,可以用于治疗血液系统恶性肿瘤的研究。 | |||
T7221 |
Satraplatin
BMS182751,JM216,顺式-二氯-反式-二乙酸-氨-环己胺合铂,BMY45594 |
DNA Alkylator/Crosslinker; DNA Alkylation | DNA Damage/DNA Repair |
Satraplatin (BMS182751) 是一种烷化剂 ,是一种口服的抗肿瘤铂 (IV) 复合物,具有广泛的抗肿瘤效果。 | |||
TNU0352 |
1-beta-D-Arabinofuranosylthymine
Thymine 1-β-D-arabinofuranoside,Spongothymidine |
Apoptosis | Apoptosis |
1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog. | |||
T1962 |
ASP3026
ASP 3026 |
Apoptosis; ALK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ASP3026 是一种选择性的,具有口服活性的间变性淋巴瘤激酶抑制剂,可诱导肿瘤细胞凋亡,可研究非小细胞肺癌。 | |||
T3069 |
AZD-1480
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
AZD1480 是 ATP 竞争型JAK1和JAK2抑制剂,IC50分别为 1.3 和 0.4 nM。 | |||
T63788 |
PCLX-001
|
Others | Others |
PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2]. | |||
T76705 |
Utomilumab
PF 05082566,PF-2566 |
TNF | Apoptosis |
Utomilumab (PF 05082566) 是一种人源化靶向T 细胞共刺激受体4-1BB/CD137的 IgG2 抗体,也是一种 4-1BB/CD137 激动剂。Utomilumab 具有抗肿瘤活性,可用于研究晚期恶性肿瘤患者。 | |||
T17028 |
Tefinostat
CHR-2845 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性,可用于研究白血病和晚期血液系统恶性肿瘤。 | |||
T35569 |
CTA 056
|
Apoptosis | Apoptosis |
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。 | |||
T63771 |
Golcadomide
CC-99282,CC 99282,CC99282 |
Ligand for E3 Ligase | PROTAC |
Golcadomide (CC-99282) 是一种具有口服活性的 CRBN E3 连接酶调节剂 ,诱导 CRBN 与其新底物之间的相互作用,募集靶致病蛋白和 E3 泛素连接酶。Golcadomide 可用于研究血液系统恶性肿瘤。 | |||
T68316 |
GAC0003A4
GAC0001E5 |
Liver X Receptor | Metabolism |
GAC0003A4 是一种有效的 LXR 反向激动剂,具有抗肿瘤活性,能抑制 LXR 蛋白的转录。GAC0003A4 可降解 LXRβ 蛋白,以剂量依赖性方式抑制PDAC细胞增殖。GAC0003A4 有用于研究晚期胰腺癌和其他顽固性恶性肿瘤。 | |||
T12660L |
BAY1238097
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BAY1238097 是一种具有有效性和选择性的溴结构域和末端外基序(BET)抑制剂,具有抗癌活性,在AML (急性髓性白血病) 和MM (多发性骨髓瘤) 模型中表现出较强的抗增殖活性 。BAY1238097 可用于研究晚期难治性恶性肿瘤。 | |||
T4428 |
CCT241736
|
FLT; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂,还抑制临床相关的 FLT3 耐药突变体,包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物,是治疗人类恶性肿瘤的临床前开发候选物。 | |||
T73381 |
BGB-8035
|
Others | Others |
BGB-8035 是一种口服有效,高选择性BTK 抑制剂,对 BTK、TEC、EGFR 的IC50分别为 1.1 nM、99 nM、621 nM。BGB-8035 具有抗肿瘤和抗关节炎活性。BGB-8035 具有用于 B 细胞恶性肿瘤和自身免疫性疾病研究的潜力。 | |||
TQ0236 |
Tirabrutinib
ONO-4059,GS-4059,Velexbru |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Tirabrutinib (GS-4059) (ONO-4059) 是一种口服有效的高选择性 Bruton’s Tyrosine Kinase (BTK) 抑制剂 (能透过血脑屏障),其 IC50 值为 6.8 nM。Tirabrutinib 不可逆共价结合 BTK 并抑制异常 B 细胞受体信号传导。Tirabrutinib 可用于自身免疫性疾病和血液学恶性肿瘤的研究。 | |||
T3626 |
Acalabrutinib
ACP-196,阿可替尼 |
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 | |||
T38960 |
QL-X-138
|
Virus Protease; MNK; BTK | Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors |
QL-X-138 是一种强效的选择性 BTK和 MNK 双激酶抑制剂,与 BTK 具有共价结合,与 MNK 具有非共价结合。QL-X-138 对 BTK、MNK1 和 MNK2 激酶的 IC 50 s 分别为 9.4 nM、107.4 nM 和 26 nM。QL-X-138 对登革病毒 2 具有抑制作用,其 IC 50 为 3.5 μM。QL-X-138 可用于 B 细胞恶性肿瘤的研究。 | |||
T19661 |
8-Chloroadenosine
NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷 |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂,可能用于治疗慢性淋巴细胞白血病。 它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性;在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。 | |||
T36083 |
DS-7423
|
PI3K; mTOR | PI3K/Akt/mTOR signaling |
DS-7423 是PI3K 和mTOR 的有效抑制剂,抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。 | |||
T11603 |
Ibrutinib-MPEA
|
Others | Others |
Ibrutinib-MPEA is ibrutinib derivative. Ibrutinib is a covalent and irreversible BTK inhibitor that has been used to treat hematological malignancies. | |||
T27274 |
EP009
|
Others | Others |
EP009, a novel, selective, and orally active inhibitor of JAK3, induces therapeutic response in T-cell malignancies. | |||
T20858 |
Metanilic acid
m-Anilinesulfonic acid,m-Sulfanilic acid |
Others | Others |
Metanilic acid, an anti-cancer drug, is used to treat several malignancies including choriocarcinoma and pediatric acute lymphoblastic leukemia. | |||
T27558 |
HT1042
HT 1042,HT-1042 |
Others | Others |
HT1042 is an inhibitor of the β5i component of the 20S proteasome complex, it is used to aid in the treatment of inflammatory diseases, autoimmune and hematologic malignancies. | |||
T68411 |
AT-7519M
|
Others | Others |
AT-7519M is a small molecule inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies. | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T79067 |
PROTAC BTK Degrader-3
|
PROTACs | PROTAC |
PROTACBTK Degrader-3为BTKPROTAC降解剂,具有效力,其在Mino细胞中BTK降解的DC50值为10.9 nM。该降解剂具有应用于研究B细胞恶性肿瘤潜力,包括慢性淋巴细胞恶性肿瘤。 | |||
T21329 |
Gemcitabine monophosphate disodium salt
Gemcitabine monophosphate disodium salt monohydrate,Gemcitabine monophosphate disodium,GemMP |
Others | Others |
R306465 is a novel HDAC inhibitor with broad-spectrum antitumor activity against solid (IC50: 30 to 300 nM) and hematological malignancies. R306465 was found to be a potent inhibitor of HDAC1 and -8 (class I) in vitro. | |||
T22859 |
Imatinib hydrochloride
|
Others | Others |
Imatinib is a multi-target inhibitor of v-Abl, c-Kit, and PDGFR (IC50: 0.6 μM, 0.1 μM, and 0.1 μM, respectively). Imatinib is used to treat chronic myelogenous leukemia (CML), gastrointestinal stromal tumors (GISTs), and a number of other malignancies. | |||
T70759 |
CUDC-907 mesylate
|
Others | Others |
CUDC-907 mesylate is a small molecule inhibitor of histone deacetylase and PI3 kinase developed by Curis. It is investigated in clinical trials for the treatment of relapsed or refractory lymphomas, thyroid cancer, multiple myeloma, breast cancer and other malignancies. | |||
T11544 | HDACs/mTOR Inhibitor 1 | HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα). | |||
T62896 |
EZH2-IN-12
|
Others | Others |
EZH2-IN-12 (Compound 5) 是一种 EZH2 的有效抑制剂。EZH2-IN-12 具有潜力进行中枢神经系统恶性肿瘤的研究。 | |||
T63497 |
PI3Kδ/γ-IN-1
|
Others | Others |
PI3Kδ/γ-IN-1 是选择性的 PI3Kδ/γ 有效抑制剂,能够用于血液系统恶性肿瘤的治疗。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
TNU0052 |
Nebularine
9-(beta-D-Ribofuranosyl)-9H-purine |
Apoptosis | Apoptosis |
Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine),是一种嘌呤核苷类似物,具有广谱的抗肿瘤活性,针对惰性淋巴恶性肿瘤并诱导凋亡。Nebularine的抗癌机制依赖于抑制DNA合成。 | |||
T12403 |
Penitrem A
|
Others | Others |
Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies. | |||
T35000 |
Uproleselan sodium
GMI 1271,GMI1271,GMI-1271 |
Others | Others |
Uproleselan sodium (GGI-1271) is a small molecule E-selector antagonist originally targeted at AML as an adjuvant to standard chemotherapy for hematological malignancies. | |||
TN2299 |
Vindesine
|
Others | Others |
Vindesine is a microtubule inhibitor and widely used to treat malignancies. Vindesine neuropathy seems to be the cause of the patient's neurological symptoms. | |||
T16035 |
Meleagrin
|
Others | Others |
Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00008 |
CCL5 Protein, Mouse, Recombinant (hFc)
D17S136E,RANTES,SCYA5,SIS-δ,Ccl5,SISd,eoCP,MuRantes,TCP228,S... |
Mouse | HEK293 Cells |
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is P30882. | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-03748 |
BCL2L12 Protein, Human, Recombinant (GST)
BCL2-like 12 (proline rich) |
Human | E. coli |
BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog... | |||
TMPK-00618 |
FcRH5/FcRL5 Protein, Human, Recombinant (His)
FcR-like protein 5,CD307,BXMAS1,FcRH5,IFGP5,CD307e,FcRL5 |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. | |||
TMPK-00009 |
CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated
RANTES,SIS-δ,D17S136E,TCP228,eoCP,SIS-delta,SCYA5,CCL5,SISd,... |
Human | E. coli |
The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 10.89 kDa and the accession number is P13501. | |||
TMPK-01039 |
FcRH5/FcRL5 Protein, Mouse, Recombinant (His)
CD307e,FcRL5,BXMAS1MGC119592,IFGP5,FcRH5,BXMAS1,CD307,DKFZp6... |
Mouse | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 53.7 kDa and the accession number is Q68SN8-1. | |||
TMPK-01145 |
FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated
CD307,FcRL5,FcR-like protein 5,FCRH5MGC119593,DKFZp667F216,B... |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi tag. The predicted molecular weight is 94.19 kDa and the accession number is Q96RD9-1. | |||
TMPK-00619 |
FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
IFGP5,CD307,FCRH5MGC119593,FLJ00397,DKFZp667E2019,BXMAS1MGC1... |
Human | HEK293 Cells |
FcRH5 is a cell surface marker enriched on malignant plasma cells when compared to other hematologic malignancies and normal tissues. DFRF4539A is an anti-FcRH5 antibody-drug conjugated to monomethyl auristatin E (MMAE), a potent anti-mitotic agent. FcRH5/FcRL5 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 92.38 kDa and the accession number is AAK93971. | |||
TMPK-00270 |
TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled
WAIF1,TPBG,5T4AG,5T4,M6P1 |
Human | HEK293 Cells |
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession numb... | |||
TMPK-00346 |
CD30/TNFRSF8 Protein, Human, Recombinant (His & Avi)
CD30KI-1,CD30L receptor,TNFRSF8,D1S166EKi-1,CD30 |
Human | HEK293 Cells |
The transmembrane receptor CD30 (TNFRSF8) and its ligand CD30L (CD153, TNFSF8) are members of the tumor necrosis factor (TNF) superfamily and display restricted expression in subpopulations of activated T-and B-cells in nonpathologic conditions. CD30 expression is upregulated in various hematological malignancies, including Reed-Sternberg cells in Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL) and subsets of Non-Hodgkin's lymphomas (NHLs). | |||
TMPK-00271 |
TPBG/5T4 Protein, Human, Recombinant (His & Avi)
M6P1,WAIF1,5T4,TPBG,5T4AG |
Human | HEK293 Cells |
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession number is Q13641-1... | |||
TMPJ-00803 |
CD32B Protein, Mouse, Recombinant (His)
Fcgr2,Fcgr2b,Fc-γ-RIIB,Fc-γ RII,Low affinity immunoglobulin ... |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap... | |||
TMPK-00812 |
Midkine Protein, Mouse, Recombinant (His)
MK1,ARAP,MKARAP,MEK,MK,NEGF2,MDK |
Mouse | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Mo... | |||
TMPK-00933 |
ADAM8/CD156a Protein, Mouse, Recombinant (His)
CD156a,MGC134985,ADAM 8,Ms2,Adam8 |
Mouse | HEK293 Cells |
A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/... | |||
TMPK-00710 |
Claudin-4 Protein-VLP, Human, Recombinant
Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R |
Human | HEK293 Cells |
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in... | |||
TMPK-01306 |
CDH3 Protein, Cynomolgus, Recombinant (His)
PCAD,CDHP,CAD3,Placental cadherin,HJMD,Cadherin-3,CDH3,P-cad... |
Cynomolgus | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.... | |||
TMPK-00800 |
CDH3 Protein, Mouse, Recombinant (His)
HJMD,CDHP,CAD3,P-cadherin,Placental cadherin,PCAD,CDH3,Cadhe... |
Mouse | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The ... | |||
TMPY-02271 |
TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His)
thioredoxin reductase 1,TR1,TXNR,TR,TRXR1,GRIM-12 |
Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor th... | |||
TMPY-03287 |
RRM1 Protein, Human, Recombinant (His & GST)
ribonucleotide reductase M1,R1,RR1,RIR1 |
Human | Baculovirus Insect Cells |
RRM1 is a subunit of ribonucleoside-diphosphate reductase which is constituted by two subunits. Ribonucleoside-diphosphate reductase is an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. RRM1 is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocort... | |||
TMPK-00851 |
CDH3 Protein, Human, Recombinant (aa 108-654, His)
CAD3,Placental cadherin,PCAD,HJMD,CDH3,P-cadherin,Cadherin-3... |
Human | HEK293 Cells |
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Human, Recombinant (aa 108-654, His) is expressed in HEK293 mammalian cells with C-H... | |||
TMPK-00918 |
ADAM8/CD156a Protein, Human, Recombinant (aa 17-655, His)
CD156a,ADAM 8,MGC134985,Adam8,Ms2 |
Human | HEK293 Cells |
A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/... | |||
TMPK-00023 |
Midkine Protein, Human, Recombinant (His & Avi)
MDK,MEK,MK1,MKARAP,ARAP,MK,NEGF2 |
Human | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu... | |||
TMPK-00024 |
Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
MK1,MK,MDK,NEGF2,MKARAP,MEK,ARAP |
Human | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu... | |||
TMPY-03601 |
PDRG1 Protein, Human, Recombinant (His)
PDRG,p53 and DNA-damage regulated 1,C20orf126 |
Human | E. coli |
PDRG1, also known as C2orf126, belongs to the prefoldin subunit beta family. It is predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs. PDRG1 may play a role in chaperone-mediated protein folding. PDRG1 is overexpressed in tumors relative to normal tissues. Its expression is upregulated in multiple malignancies including cancers of the colon, rectum, ovary, lung, stomach, breast and uterus when compared to their respective matched normal tissue... | |||
TMPJ-01113 |
RCN2 Protein, Human, Recombinant (His)
Reticulocalbin-2,ERC55,RCN2,E6BP |
Human | HEK293 Cells |
Reticulocalbin-2 (RCN2, also named as ERC-55), is a 55-kDa Ca2+-binding protein containing six EF-hands, which was identified to be localized in endoplasmic reticulum. RCN2 is belonging to Reticulocalbin (RCN) family, the family members could play oncogenic roles in human malignancies and facilitate tumor cell proliferation and metastasis. Recently, studies on RCN2 functions mainly focused on its role in differentiation and endocrine regulation in mouse. Another study has suggested that RCN2 cou... | |||
TMPY-03047 |
Stathmin 1 Protein, Human, Recombinant (His)
SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22 |
Human | E. coli |
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom... | |||
TMPY-00371 |
STC1 Protein, Human, Recombinant (His)
stanniocalcin 1,STC |
Human | HEK293 Cells |
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e... | |||
TMPY-02769 |
RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2 |
Human | Baculovirus Insect Cells |
RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... | |||
TMPY-04270 |
GPR133 Protein, Human, Recombinant (His)
PGR25,GPR133 |
Human | HEK293 Cells |
ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1, an orphan member of the adhesion family of G-protein-coupled receptors, is a critical regulator of the response to hypoxia and tumor growth in Glioblastoma (GBM). ADGRD1 represents a novel molecular target in GBM and possibly other malignancies where hypoxia is fundamental to pathogenesis. Variations in the ADGRD1 locus are linked with... | |||
TMPY-02264 |
LRIG1 Protein, Mouse, Recombinant (His)
LIG-1,D6Bwg0781e,leucine-rich repeats and immunoglobulin-lik... |
Mouse | HEK293 Cells |
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein, which is induce... | |||
TMPY-04267 |
MSH2 Protein, Human, Recombinant (His & GST)
FCC1,COCA1,HNPCC1,HNPCC,LCFS2,mutS homolog 2 |
Human | Baculovirus Insect Cells |
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch r... | |||
TMPJ-00192 |
CD32B Protein, Human, Recombinant (His)
FCG2,IgG Fc Receptor II-b,CDw32,Low Affinity Immunoglobulin ... |
Human | HEK293 Cells |
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)... | |||
TMPY-04547 |
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK |
Human | Baculovirus Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... | |||
TMPY-01856 |
MGAT5 Protein, Human, Recombinant (His)
mannosyl (alpha-1,6-)-glycoprotein β-1,6-N-acetyl-glucosamin... |
Human | HEK293 Cells |
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, also known as Alpha-mannoside beta-1,6-N-acetylglucosaminyl-transferase, Mannoside acetylglucosaminyltransferase 5, N-acetylglucosaminyl-transferase V, MGAT5, and GGNT5, is a single-pass type II membrane protein that belongs to the glycosyltransferase 18 family. MGAT5 / GGNT5 catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of t... | |||
TMPY-04936 |
BCL2A1 Protein, Human, Recombinant (His)
BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protein A1,BCL2... |
Human | E. coli |
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der... | |||
TMPY-02386 |
PTP4A2 Protein, Human, Recombinant (GST)
HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,... |
Human | E. coli |
PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu... | |||
TMPY-03341 |
ASF1B Protein, Human, Recombinant (His)
anti-silencing function 1B histone chaperone,CIA-II |
Human | Baculovirus Insect Cells |
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely... | |||
TMPY-01000 |
BVES Protein, Human, Recombinant (GST)
CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,... |
Human | E. coli |
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0065 |
Acalabrutinib-d4
|
||
Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。 |