10(E),12(Z)-Conjugated linoleic acid methylester serves as a standard for quantifying 10(E),12(Z)-conjugated linoleic acid in L. plantarum culture samples. [Matreya, LLC. Catalog No. 1254]
Mead acid, a 20-carbon ω-9 polyunsaturated fatty acid, experiences elevated levels in human plasma under conditions of essential fatty acid deficiency. As 1,25(Z),8(Z),11(Z)-Eicosatrienoic Acid methylester (Mead acid methylester), it frequently serves as a standard for fatty acid analysis, particularly after fatty acids have been transesterified into methylesters.
10-Methyl palmitic acid methylester is a methylated derivative of fatty acid methylester, identified in glycolipid analogs with cyclitol from P. crassa. [Matreya, LLC. Catalog No. 1792]
2-hydroxy Stearic acid is a hydroxylated fatty acid methylester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides.
(+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. It is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF2α. Cloprostenol is also used in veterinary medicine as a luteolytic agent for the induction of estrus and the treatment of reproductive disorders in cattle, swine, and horses. (+)-Cloprostenol methylester is a more lipid soluble form of cloprostenol, which may be more amenable for certain formulations.
(±)4(5)-EpDPA methylester is a derivative of (±)4(5)-EpDPA which is stable enough to ship and handle routinely. The active free acid can be regenerated from the methylester by careful base hydrolysis. (±)4(5)EpDPA is a CYP450 metabolite of DHA which can be further metabolized to the diol metabolite. There are no published reports on the biological activity of (±)4(5)-EpDPA methylester at this time.
Resolvin D3 methylester is a methylester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methylester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid.