adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH) 是一种由垂体前叶分泌的促肾上腺皮质激素(tropic hormone)，能够调节皮质醇和雄激素的产生。

Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) 是一种有效的黑皮质素 (MC4R) 受体激动剂。

Adrenocorticotropic Hormone (ACTH) (4-10), human 是黑皮质素 4 型受体 (melanocortin 4 receptor, MC4R) 激动剂。

Adrenocorticotropic Hormone (ACTH) (1-39), rat, is a potent melanocortin 2 (MC2) receptor agonist. During in vitro incubation with membrane preparations, peptide fragments of ACTH (1-39) were formed and subsequently isolated by high-pressure methods.

Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist.

Adrenocorticotropic Hormone (ACTH) (1-10), human is a fragment of the adrenocorticotropin hormone. It exhibits a weak potency of α-melanocyte stimulating hormone (α-MSH), but only at high doses (100 and 1000 nM).

Adrenocorticotropic hormone (ACTH) TFA，是由垂体前叶分泌，用于调节皮质醇和雄激素产生的促肾上腺皮质激素。

Adrenocorticotropic Hormone (ACTH) (1-39), rat acetate(77465-10-2 Free base) 是一种有效的黑皮质素 2 (MC2) 受体激动剂。ACTH (1-39) 的肽片段是在体外孵育过程中形成的 肽与膜制剂。

Adrenocorticotropic Hormone (ACTH) (18-39), also known as the Corticotropin-like Intermediate Lobe Peptide, stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to secretin and carbamylcholine.

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 是促肾上腺皮质激素的一个片段。 Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 仅在 100 和 1000 nM 时具有较弱的 α-MSH 效力。

ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) 是促肾上腺皮质激素的片段，可诱导皮质醇释放。 ACTH (11-24) 已被确定为分离的肾上腺细胞中 ACTH (1-39) 和 ACTH (1-10) 的竞争性拮抗剂。

ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。

Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) 是黑皮质素受体激动剂。

ACTH (1-14), a fragment of adrenocorticotropin, governs the production of cortisol and androgens.

ACTH (22-39) is a fragment of the adrenocorticotropic hormone (ACTH), specifically comprising the 22-39 sequence of ACTH.

ACTH (6-24) (human)（腎上腺皮質激素（6-24））是腎上腺皮質激素的片段。該化合物作為ACTH (1-39) 和 ACTH (5-24) 引起的類固醇生成的競爭性抑制劑，具有相應的Kd值分別為13.4和3.4nM。此外，ACTH (6-24) (human) 能夠抑制 hPTH 1-34 所誘導的皮質酮產生以及cAMP的累積。

ACTH (4-11) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.

Adrenocorticotropic Hormone (ACTH) (1-39) human (TFA), a member of the melanocortin family, is a melanocortin receptor agonist that stimulates corticosteroid (CS) production by the adrenals and is also found in the central nervous system (CNS).

ACTH (1-13) is a 13-amino acid peptide that exhibits cytoprotective effects in a rat model of ethanol-induced gastric lesions. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.

ACTH (1-14) (TFA) is a polypeptide of corticotrophin, which promotes the release of cortisol.

ACTH (11-24) is a fragment of adrenocorticotrophin, induces cortisol release. ACTH (11-24) has been identified as a competitive antagonist of ACTH (1-39) and ACTH (1-10) in isolated adrenal cells.

ACTH (22-39) acetate 是促肾上腺皮质激素 (ACTH) 的片段，在 N 末端的第 3 位和第 15 位含有两个脯氨酸残基。

Tildacerfont 是 CRF1 的拮抗剂，可降低促肾上腺皮质激素和肾上腺雄激素的水平。 Tildacerfont 可用于先天性肾上腺增生的研究。

Tetracosactide (Tetracosactrin) 是一种肾上腺皮质激素 (ACTH) 的类似物，能够刺激肾上腺皮质激素分泌。

Semax acetate(80714-61-0 free base) 是一种合成的促肾上腺皮质激素 (ACTH) 肽类似物，具有神经保护、镇痛和抗焦虑特性。

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) 是一种似皮质促素中叶肽，由垂体中叶的促黑素细胞产生。

20α-Dihydro Prednisolone, a prednisolone metabolite, is detected in cattle urine post-adrenocorticotropic hormone (ACTH) administration but absent in both naturally stressed and non-stressed cattle.

[Tyr0] Corticotropin Releasing Factor, ovine 是从绵羊分离的促肾上腺皮质激素释放因子 激素。该因子（CRF）为下丘脑激素，能激发促肾上腺皮质激素（ACTH）及β-内啡肽的释放。

[Asu1,6-Arg8]Vasopressin 是一种加压素 (vasopressin) 激动剂，可增强培养的大鼠垂体前叶细胞中由促肾上腺皮质激素释放因子 (CRF) 诱导的环AMP 积累和ACTH 释放。

α-Helical CRF (9-41) 是一种合成的皮质酮释放因子（CRF）拮抗剂。它在0.5至5 µM浓度范围内，能抑制CRF诱导的大鼠前叶垂体细胞释放促肾上腺皮质激素（ACTH）。在体内研究中，α-Helical CRF (9-41) (0.02-0.6 µmol/kg) 能够抑制未经麻醉的完整大鼠体内CRF诱导的ACTH释放，并在0.6 µmol/kg剂量下抑制大鼠应激诱导的ACTH释放。此外，α-Helical CRF (9-41) 在尼古丁诱导的条件性焦虑大鼠模型中增加社交互动时间，并减少小鼠的类似暴饮暴食的乙醇消费。

Alsactide，一种ACTH激动剂七肽类似物，主要应用于中枢神经系统的研究。

NBI 35965 hydrochloride 是一种选择性、口服活性、能穿过血脑屏障的促肾上腺皮质激素释放因子受体 1 (CRF1) 拮抗剂，Ki 值为 4 nM，pKi 值为 8.5，并且不抑制 CRF2。NBI 35965 hydrochloride 可减少体内 CRF 或应激诱导的促肾上腺皮质激素 (ACTH) 生成，pIC50 值分别为 7.1 和 6.9，具有抗焦虑作用。

CRN04894 (compound 17h) 作为一种口服有效的MC2R拮抗剂，在大鼠的促肾上腺皮质激素（ACTH）刺激皮质酮分泌模型中显示出了体内效力。此化合物在抑制人类与大鼠MC2R方面表现出较高的活性，其KB值分别为0.34 nM和0.23 nM。

ACTH (7-38) (human) 是 ACTH (1-39) 的第7至第38个氨基酸序列构成的片段。该化合物作为ACTH受体的拮抗剂，又称为促肾上腺皮质激素抑制肽（CIP），它不具有皮质类固醇活性。

(Des-His6)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb db mouse model of type 2 diabetes.

ACTH (11-24) (acetate) 为促肾上腺皮质激素(ACTH)受体拮抗剂，属于ACTH片段，具有诱导皮质醇释放的功能，适用于中枢神经系统研究。

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.

ACTH (34-39), an adrenocorticotropic hormone fragment, is a peptide sequence comprising amino acids 34 to 39.

[DPro5] Corticotropin Releasing Factor, human, rat 是人类和大鼠促肾上腺皮质激素释放因子 激素 R2 的选择性激动剂。作为一种下丘脑激素，促肾上腺皮质激素释放因子 (CRF) 能够促进肾上腺皮质激素 (ACTH) 和 β-内啡肽的分泌。值得注意的是，[DPro5] Corticotropin Releasing Factor, human, rat 并不触发典型的焦虑反应，而是能调控大鼠的学习与记忆过程。

R121919 (NBI30775) 是一种高效的促肾上腺皮质激素释放因子受体 1 （CRF1）小分子受体拮抗剂，具有抗抑郁和抗焦虑活性，抑制 CRF1 受体、 CRF2 受体和 CRF 结合蛋白。

ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) 是ACTH的3-24片段，适用于癌症、免疫疾病、心血管疾病等多种疾病的研究。

Stressin I (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA，作为CRF1受体选择性激动剂，具有1.7 nM的Ki值。该化合物能够促使大鼠促肾上腺皮质激素(ACTH)水平提升。

ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland.

(Des-Glu5)-ACTH (1-24) (human, bovine, rat) 是促肾上腺皮质激素 (ACTH) 的类似物。ACTH 是一种由垂体前叶腺产生的多肽激素，调节皮质醇和雄激素的产生。

Efonidipine(NZ-105)盐酸盐是T 型和L 型钙离子通道双重阻断剂。