CL67 is a hypoxia-inducible factor pathway inhibitor. It acts by binding to a G-quadruplex higher-order structure in the HIF promoter sequence in vitro.
Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).
BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).
Telomestatin is an inhibitor of the telomerase, it induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region.
BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
PBP2 is a selective inducer of G-quadruplex structures from the unstructured single-stranded DNA conformations. PBP2 downregulates BCL-2 gene expression in cancer cells.