132
18
1
56
Cat. No. | Product Name | ||
---|---|---|---|
L8710 | 铜死亡化合物库 | 400 compounds | |
TargetMol 铜死亡化合物库集合了 400 种与铜死亡相关的化合物,可以用于铜死亡机制及相关疾病研究 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7693 |
Thiorphan
|
Neprilysin | Metabolism |
Thiorphan 是选择性neprilysin 抑制剂 (IC50:6.9 nM) 。 | |||
T2340 |
AC1NS4RE
|
Tyrosinase | Proteases/Proteasome |
是一种化学合成中的砌块 | |||
T9210 |
CD73-IN-4
|
CD73 | Immunology/Inflammation |
CD73-IN-4 是高选择性的亚甲基膦酸 CD73抑制剂,对人 CD73 作用的 IC50值为 2.6 nM,在癌症免疫学中具有研究潜力。 | |||
T1938 |
FLT3-IN-2
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-2 是 FLT3 抑制剂(IC50<1 μM)。 | |||
T1176 |
Racecadotril
Acetorphan,消旋卡多曲 |
Neprilysin; Proteasome | Metabolism; Proteases/Proteasome; Ubiquitination |
Racecadotril (Acetorphan) 是一种中性内肽酶 (NEP) 抑制剂,具有止泻作用。Racecadotril 及其活性代谢物 Thiorphan 抑制小鼠脑中纯化的NEP 活性,Ki 分别为 4500 和 6.1 nM。 | |||
T3079 |
GSK1838705A
|
IGF-1R; JNK; S6 Kinase; ALK | Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
GSK1838705A 是一种高效的、可逆的IGF-IR (IC50:2.0 nM) 和胰岛素受体 (IC50:1.6 nM)抑制剂,也可抑制ALK (IC50:0.5 nM)。 | |||
T11298 |
FLT3-IN-3
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
FLT3-IN-3 是 FLT3抑制剂,能够抑制 FLT3 WT (IC50:13 nM) 和 FLT3 D835Y (IC50:8 nM) 。 | |||
T4428 |
CCT241736
|
FLT; Aurora Kinase | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂,还抑制临床相关的 FLT3 耐药突变体,包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物,是治疗人类恶性肿瘤的临床前开发候选物。 | |||
TQ0106 |
Sacubitrilat
LBQ-657 |
Neprilysin | Metabolism |
Sacubitrilat (LBQ-657) 是活性的脑啡肽酶 (NEP) 抑制剂。 | |||
T15612 |
JH-VIII-157-02
|
Microtubule Associated; ALK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
JH-VIII-157-02 是一种 ALK 抑制剂,可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK),对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。 | |||
T15335 |
FN-1501
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
FN-1501 是一种有效的 FLT3 和 CDK 抑制剂,具有抗肿瘤的活性,对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。 | |||
T2272 |
BPR1J-097
BPR1J097 |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
BPR1-J097 是新型的、强效的FLT3抑制剂 (IC50:11 nM)。 | |||
T6756 |
AMG 925
|
FLT; CDK | Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
AMG 925 是一种选择性FLT3/CDK4双重抑制剂,IC50分别为 1 nM 和 3 nM。 | |||
T16153 |
MS4078
|
ALK; PROTACs | Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors |
MS4078 是一种基于 Cereblon 配体的间变性淋巴瘤激酶 PROTAC ,结合 ALK 的 Kd 为 19 nM。 | |||
T11254 |
F-1
|
ROS; ALK; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
F-1 是 ALK 和 ROS1 的双重抑制剂,抑制 ALK 的磷酸化及下游通路,可作用于对 ALKWT (IC50:2.1 nM),ROS1WT (IC50:2.3 nM),ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。 | |||
T6138 |
TCS 359
FLT3 Inhibitor |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
TCS 359 (FLT3 Inhibitor) 是 2-酰基氨基噻吩-3-甲酰胺,是选择性FLT3抑制剂(IC50:42 nM),能够抑制 MV4-11 细胞增殖(IC50:340 nM)。 | |||
T6020 |
Pacritinib
SB1518 |
FLT; Tyrosine Kinases; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂,IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y,IC50分别为 22 和 6 nM。 | |||
T3065 |
TG101209
|
Apoptosis; FLT; c-RET; JAK; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
TG101209 是一种选择性有效的 JAK2抑制剂,IC50值为 6 nM。它能抑制 Flt3和RET 的活性,IC50值分别为 25 nM 和 17 nM。 | |||
T9473 |
4SC-203
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
4SC-203 是一种具有潜在的抗肿瘤活性的多激酶抑制剂。它对 FLT3/STK1、 FLT3 的突变形式以及 VEGFRs 具有选择性抑制作用。 | |||
T1962 |
ASP3026
ASP 3026 |
Apoptosis; ALK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ASP3026 是一种选择性的,具有口服活性的间变性淋巴瘤激酶抑制剂,可诱导肿瘤细胞凋亡,可研究非小细胞肺癌。 | |||
T7673 |
ATH686
ATH 686 |
Apoptosis; FLT | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ATH686 是一种选择性的,ATP 竞争性的FLT3抑制剂,具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性,并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。 | |||
T8317 |
5'-Fluoroindirubinoxime
5'-FIO |
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物,是一种 FLT3 的抑制剂(IC50:15 nM)。 | |||
T16561 |
Polyoxyethylene stearate
POES,聚氧乙烯硬脂酸酯 |
Antibacterial; P-gp | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Polyoxyethylene stearate (POES) 是一种非离子乳化剂。 | |||
T12341 |
P-gp inhibitor 1
|
Others; P-gp | Membrane transporter/Ion channel; Neuroscience; Others |
P-gp inhibitor 1 抑制逆转 P-糖蛋白介导的多药耐药性,EC50 为 57.9 nM(K562/A02 细胞)。 | |||
T6115 |
Fostamatinib
R788,福他替尼 |
FLT; Syk; Monoamine Transporter; Adenosine Receptor | Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的,有效的,ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM,IC50:41 nM),也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。 | |||
TQ0235 |
AC710
|
FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AC710是一种 PDGFR 抑制剂,能够作用于 FLT3 (Kd:0.6),CSF1R (Kd:1.57),KIT (Kd:1),PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。 | |||
T2640 |
Rebastinib
DCC2036,DCC 2036,DCC-2036 |
Apoptosis; FLT; Bcr-Abl; Src | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Rebastinib (DCC-2036) 是一种口服有效的,非 ATP 竞争性的 Bcr-Abl 抑制剂,作用于 Abl1WT 和 Abl1T315I,IC50分别为 0.8 nM 和 4 nM,还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2,对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。 | |||
T3071 |
Olverembatinib
GZD 824 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Olverembatinib (GZD 824) 是一种高效的、口服具有活性的pan-Bcr-Abl 抑制剂,具有抗肿瘤活性。它能广泛而有效地抑制突变型 Bcr-Abl。它对天然的 Bcr-Abl 和 Bcr-AblT315I 作用的IC50值分别为 0.34 nM 和 0.68 nM。 | |||
T6287 |
Tariquidar
XR9576,他立喹达 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Tariquidar (XR9576) 是一种特异性有效的P-糖蛋白抑制剂,Kd 为 5.1 nM。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T4015 |
HG-14-10-04
|
ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
HG-14-10-04 是一种特异的 ALK 抑制剂,IC50=20 nM。 | |||
T11071 |
Dofequidar fumarate
MS-209 |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Dofequidar fumarate (MS-209) 是口服活性的喹啉化合物,通过抑制 ABCB1/P-gp 和 ABCC1/MDR 相关蛋白 1 来克服 MDR。 | |||
T8426 |
Encequidar
HM30181,HM30181A |
P-gp | Membrane transporter/Ion channel; Neuroscience |
Encequidar (HM30181A) 是一种选择性 P-糖蛋白抑制剂。 | |||
T4409 |
Gilteritinib
吉列替尼,ASP2215 |
FLT; TAM Receptor; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50=0.29 nM),也是一种 AXL 抑制剂 (IC50=0.73 nM),具有 ATP 竞争性、选择性和口服活性。Gilteritinib 具有抗肿瘤活性,可以用于治疗 FLT3 突变阳性的 AML。 | |||
T3621 |
Brigatinib
布格替尼,AP-26113 |
EGFR; FLT; ROS; IGF-1R; ALK | Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Brigatinib (AP-26113) 是一种有效,选择性的ALK 抑制剂 (IC50:0.6 nM)。 | |||
T6350 |
CHIR-124
CHIR124,CHIR 124 |
Apoptosis; GSK-3; FLT; Chk; PDGFR; Src | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
CHIR-124 是一种选择性 Chk1抑制剂,IC50值为 0.3 nM,可有效抑制 PDGFR 和 FLT3,IC50值分别为 6.6 nM 和 5.8 nM。 | |||
T16144 |
MRX-2843
UNC2371 |
Others; FLT | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
MRX-2843 (UNC2371) 是ATP 竞争性的、具有口服活性的MERTK 和FLT3酪氨酸激酶抑制剂 (TKI),它们的IC50分别为 1.3 nM 和 0.64 nM。 | |||
T2341 |
KW-2449
KW2449 |
Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
KW-2449是一种多靶点激酶抑制剂,对FLT3,ABL,ABLT315I 和极光激酶的IC50值分别为6.6,14,4 和 48 nM。 | |||
T3455 |
Merestinib
LY2801653 |
Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。 | |||
T2620 |
G-749
G749 |
Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。 | |||
T7007 |
UNC2025
mrx-6313,UNC-2025,UNC 2025 |
FLT; TAM Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
UNC2025 (mrx-6313) 是高效的、具有口服活性的、ATP 竞争性的Mer/Flt3双抑制剂,IC50值分别为 0.74 nM 和 0.8 nM。它对MERTK 的选择性比 Axl 高 45 倍(IC50:122 nM;Ki:13.3 nM)。它具有良好的 PK 特性,可用于研究急性白血病。 | |||
T1791 |
Ceritinib
色瑞替尼,LDK378 |
Serine Protease; IGF-1R; ALK | Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Ceritinib (LDK378) 是一种选择性,具有口服活性的、ATP 竞争性的 ALK 酪氨酸激酶抑制剂,IC50=200 pM。 它还抑制 IGF-1R (IC50:8 nM),InsR (IC50:7 nM) 和 STK22D (IC50:23 nM)。它显示出良好抗肿瘤效力。 | |||
T6174 |
R406
R-406 besylate |
Apoptosis; FLT; Syk | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
R406 (R-406 besylate) 是一种具有口服活性的 ATP 竞争性 Syk/FLT3抑制剂,Ki 为 30 nM。它有效抑制 Syk 激酶活性,IC50为 41 nM。它还抑制 Lyn 和 Lck,IC50值分别为 63 nM 和 37 nM。它可减轻免疫复合物介导的炎症。 | |||
T4257 |
Belizatinib
TSR-011 |
Trk receptor; ALK | Angiogenesis; Tyrosine Kinase/Adaptors |
Belizatinib (TSR-011) 是可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂,对野生型重组 ALK 的IC50值为0.7 nM。 | |||
T3059 |
ALK-IN-1
AP26113,Brigatinib,AP26113-analog |
EGFR; IGF-1R; ALK | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
ALK-IN-1 (AP26113) 是一种高效的、选择性的 ALK 激酶抑制剂。 | |||
T1836 |
AZD2932
|
VEGFR; FLT; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
AZD2932是一种多靶点激酶抑制剂,细胞试验中能够抑制 VEGFR2 (IC50:8 nM),PDGFβ (IC50:4 nM),PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。 | |||
T2638 |
Gandotinib
LY2784544 |
VEGFR; FGFR; FLT; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Gandotinib (LY2784544) 是一种JAK2抑制剂,IC50为 3 nM。它也抑制FLT3、FLT4、FGFR2、TYK2 和 TRKB,IC50分别为 4、25、32、44 和 95 nM。 | |||
T0093L |
Sorafenib
索拉非尼,Bay 43-9006 |
Apoptosis; Raf; VEGFR; FLT; Ferroptosis; PDGFR; c-Kit; Autophagy | Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors |
Sorafenib (Bay 43-9006) 是一种多激酶抑制剂,抑制 Raf-1、B-Raf、VEGFR2、VEGFR3、VEGFR4、PDGFRβ、FLT3、c-Kit 等 (IC50=6/22/90/15/20/20/57/58 nM),具有口服活性。Sorafenib 具有抗肿瘤活性,可以诱导细胞自噬和凋亡,也可以激动铁死亡。 | |||
T4574 |
Sacubitril
AHU 377,AHU377,沙库必曲,AHU-377 |
Neprilysin | Metabolism |
Sacubitril (AHU-377) 是一种有效的NEP 抑制剂,IC50=5 nM。它是研究心力衰竭药物 LCZ696 的组分之一。 | |||
T3068 |
AT9283
J-504568 |
Apoptosis; FLT; JAK; Bcr-Abl; Aurora Kinase; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
AT9283 (J-504568) 是一种多靶点激酶抑制剂,抑制多种实体瘤在体内外的生长和存活,有效抑制Aurora A/B,JAK2/3,Abl (T315I),和Flt3,IC50值范围为 1-30 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1651 |
Furanodiene
|
Apoptosis; PARP; Reactive Oxygen Species; Caspase; CDK; P-gp | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB; Proteases/Proteasome |
Furanodiene 是从姜黄中提取的一种萜类天然产物,可抑制外排转运蛋白Pgp 功能并降低 Pgp 蛋白水平。它通过抗血管生成和诱导ROS 产生,DNA 链断裂和细胞凋亡发挥抗癌作用。 | |||
T8152 |
6-Demethoxytangeretin
|
MAPK; ALK | Angiogenesis; MAPK; Tyrosine Kinase/Adaptors |
6-Demethoxytangeretin 是一种从柑橘分离的黄酮。它能够促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。它具有抗炎和抗过敏作用,通过间变性淋巴瘤激酶和丝裂原活化蛋白激酶途径抑制人肥大细胞中 IL-6 的产生和基因表达。 | |||
T3S0012 |
coniferyl ferulate
|
P-gp; GST | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Coniferyl ferulate 是从川芎中提取的一种天然产物,是强效的谷胱甘肽 S-转移酶抑制剂,强抑制人胎盘型谷胱甘肽 S-转移酶,IC50为 0.3 μM。它还可逆转多药耐药性并下调 P-糖蛋白。 | |||
T2S0223 |
Isosinensetin
异橙黄酮,6-Demethoxynobiletin |
Antioxidant; HIV Protease; Antibacterial; P-gp | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; oxidation-reduction; Proteases/Proteasome |
Isosinensetin (6-Demethoxynobiletin) 是从青皮中提取的一种甲氧基黄酮,具有抗氧化和抑制 HIV-1 蛋白酶的活性。 | |||
TN4761 |
Phellamurin
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Phellamurin 是一种来自黄檗叶的黄酮糖苷,可诱导细胞凋亡,具有抗肿瘤活性。它抑制肠道 P-糖蛋白,还抑制凤蝶的产卵。 | |||
T3002 |
Piperine
胡椒碱,1-Piperoylpiperidine,Bioperine |
P450; Endogenous Metabolite; P-gp; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Piperine (Bioperine) 是从胡椒中分离的一种生物碱,可以抑制P-糖蛋白和 CYP3A4 的活性,在HeLa 细胞中的IC50值为61.94±0.054 μg/mL。它已用于研究治疗多发性骨髓瘤和吞咽障碍的试验。 | |||
TJS1159 |
Chrysosplenetin
猫眼草黄素,Chrysosptertin B |
P450; Ferroptosis; P-gp | Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Chrysosplenetin 是青蒿和其他几种中草药中的一种多甲氧基化黄酮类天然产物,抑制 P-gp 活性并逆转由青蒿素诱导的上调的 P-gp 和 MDR1 水平。 | |||
T2S0271 |
Voacamine
老刺木胺,Voacanginine |
Cannabinoid Receptor; P-gp | GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience |
Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱,可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用,具有强效的大麻素 CB1受体拮抗活性。 | |||
T6S0033 |
Crotonoside
巴豆苷;异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE |
Others; FLT; HDAC | Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors |
Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。 它抑制 FLT3 和 HDAC3/6,有治疗急性髓性白血病 (AML)的研究潜力。 | |||
T2S1200 |
Sinapine
|
Antioxidant; P-gp; AChE | Membrane transporter/Ion channel; Neuroscience; oxidation-reduction |
Sinapine 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
T4034 |
Solamargine
Solamargin,δ-Solanigrine,澳洲茄边碱 |
Apoptosis; p38 MAPK; P-gp; STAT | Apoptosis; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Neuroscience; Stem Cells |
Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。 | |||
T3392 |
Sinapine thiocyanate
|
P-gp; AChE | Membrane transporter/Ion channel; Neuroscience |
Sinapine thiocyanate 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
TN1757 |
Hypophyllanthin
叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂 |
Potassium Channel; Calcium Channel; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Hypophyllanthin 是珠子草中的一种木脂素,能直接抑制 P-gp 的活性,具有很强的抗炎活性。 | |||
TN1525 |
Convallatoxin
K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷 |
NF-κB; P-gp; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Convallatoxin 是从铃兰分离得到的一种强心苷。它是 P-糖蛋白底物,并识别 Val982 是参与其转运的重要氨基酸。它是配体诱导的 MOR 胞吞作用的增强剂,通过激活PPARγ和抑制NF-κB 改善结肠炎,具有抗炎和抗增殖特性。 | |||
T2799 |
(20S)-Protopanaxadiol
20-Epiprotopanaxadiol,20(S)-APPD,20 (S)-原人参二醇,原人参二醇 |
Apoptosis; Reactive Oxygen Species; P-gp | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) 是人参皂甙的代谢产物,是一种凋亡诱导剂,抑制Akt 活性并诱导多种肿瘤细胞凋亡。 | |||
TCS2336 |
Evodine
|
P-gp | Membrane transporter/Ion channel; Neuroscience |
Evodine 是吴茱萸中的主要柠檬苦素,是P-gp 有效抑制剂,可通过保留抗氧化剂防御系统,针对谷氨酸诱导的毒性具有保护作用。 | |||
T4085 |
Paris saponin VII
重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII |
Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位,增加凋亡相关蛋白的表达,并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬,可研究白血病。 | |||
T6627 |
Phosphoramidon Disodium
Phosphoramidon Disodium Salt,磷酰胺二钠 |
RAAS; Neprilysin; Others | Endocrinology/Hormones; Metabolism; Others |
Phosphoramidon Disodium (Phosphoramidon Disodium Salt) Salt 是一种金属蛋白酶 (metalloprotease) 抑制剂 。Phosphoramidon Disodium Salt 抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50分别为 3.5 ,0.034 和 78 μM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02521 |
HIST3H2A Protein, Human, Recombinant
histone cluster 3, H2a,MGC3165 |
Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. There are subtype diversities: H1, H2A, H2B, and H3 or H4. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enzymatic machinery that set them are crucial regulators that can control cellular proliferation, differentiation,... | |||
TMPY-01332 |
HIST1H3A Protein, Human, Mouse, Recombinant
Histone H3.1,histone cluster 1, H3a,Histone H3 |
Human,Mouse | E. coli |
Histone H3.1, also known as HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, is a member of the histone H3 family which is a core component of nucleosome. It is expressed during the S phase, then expression strongly decreases as cell division slows down during the process of differentiation. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby pla... | |||
TMPH-00930 |
Anamorsin Protein, Human, Recombinant (His & SUMO)
CIAPIN1,Fe-S cluster assembly protein DRE2 homolog,... |
Human | E. coli |
Anamorsin Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q6FI81. | |||
TMPH-00641 |
YTFE Protein, E. coli, Recombinant (GST)
Regulator of cell morphogenesis and NO signaling,Iron-sulfur... |
E. coli | E. coli |
Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions. YTFE Protein, E. coli, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 51.9 kDa and the accession number is P69506. | |||
TMPY-02510 |
HIST2H2BE Protein, Human, Recombinant
MGC129734,H2BGL105,H2B.1,histone cluster 2, H2be,H2... |
Human | E. coli |
Histones are a complex family of highly conserved basic proteins responsible for packaging chromosomal DNA into nucleosomes. Histone proteins exhibit two levels of diversity: 1. evolutionary diversity between species and 2. subtype diversity in a class(H1, H2A, H2B, H3 or H4) within a species. It has become more and more evident that histone modifications are key players in the regulation of chromatin states and dynamics as well as in gene expression. Therefore, histone modifications and the enz... | |||
TMPJ-00339 |
ALCAM Protein, Mouse, Recombinant (hFc)
CD6 ligand,CD166 antigen,CD6L,activated leucocyte cell adhes... |
Mouse | HEK293 Cells |
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 molecule but weaker homotypic (ALCAM–ALCAM) interactions have also been described. ALCAM–CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between an... | |||
TMPH-01561 |
ISCU Protein, Human, Recombinant (His & Myc)
NifU-like protein,ISCU,Iron-sulfur cluster assembly... |
Human | Baculovirus Insect Cells |
Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic Functions as a cytoplasmic scaffold protein for the de novo synthesis of iron-sulfur clusters in the cytoplasm. | |||
TMPJ-00775 |
CD74 Protein, Mouse, Recombinant (mFc & His)
HLA class II histocompatibility antigen γ chain,HLA-DR antig... |
Mouse | HEK293 Cells |
Mouse HLA class II histocompatibility antigen gamma chain (CD74), is a single-pass type II membrane protein that in humans is encoded by the CD74 gene. It contains 1 thyroglobulin type-1 domain. CD74 Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. | |||
TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,APO-J,SP-40,CLU1,cluster<... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-01694 |
Clusterin Protein, Mouse, Recombinant (His)
SP-40,AI893575,Sgp-2,clusterin,Sugp-2,Cli,ApoJ,D14U... |
Mouse | HEK293 Cells |
Clusterin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 50.8 kDa and the accession number is Q06890. | |||
TMPY-06211 |
Clusterin Protein, Chinese hamster, Recombinant (His)
clusterin |
Chinese hamster | CHO Cells |
Clusterin Protein, Chinese hamster, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 50.9 kDa and the accession number is G3HNJ3-1. | |||
TMPJ-00278 |
Clusterin Protein, Human, Recombinant (hFc & His)
CLU,NA1/NA2,TRPM-2,40,Apo-J,Clusterin,Complement Cy... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (hFc & His) is expressed in HEK293 mammalian cells with C-Fc-6xHis tag. The predicted molecular weight is (33-45) and (60-85) KDa and the accession number is P10909. | |||
TMPY-06908 |
Clusterin Protein, Human, Recombinant (sCLU, His)
KUB1,SP-40,TRPM-2,SGP2,CLI,TRPM2,APOJ,NA1/NA2,CLU1,AAG4,CLU2... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (sCLU, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.51 kDa and the accession number is NP_001822.3. | |||
TMPJ-00279 |
Clusterin Protein, Human, Recombinant (His)
Clusterin,Ku70-Binding Protein 1,Apo-J,Testosterone... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-40 KDa and the accession number is P10909. | |||
TMPY-01085 |
VLDLR Protein, Human, Recombinant (His)
VLDLRCH,CAMRQ1,CHRMQ1,very low density lipoprotein receptor,... |
Human | HEK293 Cells |
The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar sdomain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is ... | |||
TMPY-02258 |
Kallikrein 3/KLK3 Protein, Human, Recombinant (His)
APS,KLK2A1,PSA,kallikrein related peptidase 3,Hk3 |
Human | HEK293 Cells |
KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific Antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases.... | |||
TMPY-01850 |
CEACAM3 Protein, Human, Recombinant (His)
W282,W264,CEA,CD66D,CGM1,MGC119875,carcinoembryonic antigen ... |
Human | HEK293 Cells |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexp... | |||
TMPY-00217 |
KIR3DL3 Protein, Human, Recombinant (His)
KIR44,KIR3DL7,CD158Z,KIRC1,killer cell immunoglobulin like r... |
Human | HEK293 Cells |
KIR3DL3 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3) is a Protein Coding gene. KIR3DL3 is a framework gene of the Leukocyte Receptor Complex, present in all individuals and haplotypes analyzed to date.KIR3DL3 alleles were characterized by two families and one unrelated individual. The most centromeric gene in the human KIR cluster is KIR3DL3. The encoded protein belongs to the immunoglobulin superfamily. KIR3DL3 has only one immunoreceptor tyrosine-bas... | |||
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPY-01806 |
CD9 Protein, Human, Recombinant (His)
BTCC-1,DRAP-27,TSPAN29,MRP-1,CD9 molecule,MIC3,TSPAN-29 |
Human | HEK293 Cells |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins d... | |||
TMPH-03705 |
NfuA Protein, Vibrio vulnificus, Recombinant
nfuA,Fe/S biogenesis protein NfuA |
Vibrio vulnificus | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, Vibrio vulnificus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.0 kDa and the accession number is Q8DDU2. | |||
TMPH-00621 |
NfuA Protein, E. coli, Recombinant (His)
Fe/S biogenesis protein NfuA,nfuA |
E. coli | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.1 kDa and the accession number is B1X760. | |||
TMPH-03746 |
NfuA Protein, E. coli, Recombinant (Avi & His & MBP), Biotinylated
Fe/S biogenesis protein NfuA,nfuA |
ENT-Escherichia coli | E. coli |
Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. NfuA Protein, E. coli, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 68.8 kDa and the accession number is B1X760. | |||
TMPY-02961 |
PANP/C12orf53 Protein, Human, Recombinant (hFc)
C12orf53,UNQ828/PRO1755,PILR α associated neural protein,PAN... |
Human | HEK293 Cells |
C12orf53 is mainly expressed in adult brain and cerebellum. It also can be detected in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain. C12orf53 acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation. Chromosome 12 encodes over 1,100 genes within 132 million bases. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan... | |||
TMPH-00267 |
GJD2 Protein, Bovine, Recombinant (His & SUMO)
Gap junction alpha-9 protein,Gap junction delta-2 protein,Co... |
Bovine | E. coli |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJD2 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.1 kDa and the accession number is Q866T7. | |||
TMPK-01323 |
CEACAM1 Protein, Canine, Recombinant (His)
CEACAM1,BGP1,BGP,CD66a,BGPI |
Canine | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1 on the growth of human colorectal cancer (CRC) cells in vitro. CEACAM1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 43.62 kDa and the accession number is XP_038509497.1. | |||
TMPK-00178 |
B7-1 Protein, Human, Recombinant (His & Avi)
B71,CD80,BB1,LAB7,B7-1,B7.1,B7,CD28LG1,CD80 molecule |
Human | HEK293 Cells |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. B7-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.8 kDa and the accession number is P33681-1. | |||
TMPK-00179 |
B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated
B7.1,CD80,B7,CD80 molecule,CD28LG1,B7-1,BB1,LAB7,B71 |
Human | HEK293 Cells |
Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. B7-1 Protein, Human, Recombinant (aa 35-242, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 26.8 kDa and the accession number is P33681-1. | |||
TMPH-01373 |
GJA5 Protein, Human, Recombinant (His)
Gap junction alpha-5 protein,GJA5,Connexin-40 |
Human | E. coli |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJA5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 21.6 kDa and the accession number is P36382. | |||
TMPK-00644 |
CD47 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
CD47,OA3,IAP,CD47 molecule,CD47 glycoprotein,MER6 |
Cynomolgus,Rhesus | HEK293 Cells |
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. | |||
TMPY-04124 |
LPAL2 Protein, Human, Recombinant (mFc)
APOARGC,APOAL,lipoprotein, Lp(a)-like 2, pseudogene,LPAL2,AP... |
Human | HEK293 Cells |
LPAL2 (Lipoprotein(A) Like 2, Pseudogene) is a Pseudogene. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Lipoprotein(a) [Lp(a)] level is an established risk factor for coronary artery disease and has been implicated in carotid artery disease (CAAD). Mutations in the solute carrier family 22 member 3 (SLC22A3), lipoprotein (a)-like 2 (LPAL2), and the lipoprotein ... | |||
TMPH-02669 |
GJA1 Protein, Mouse, Recombinant (His & Myc)
Gap junction 43 kDa heart protein,Gja1,Gap junction alpha-1 ... |
Mouse | Baculovirus Insect Cells |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibi... | |||
TMPK-00095 |
CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi)
CD3-epsilon,IMD18,T3E,CD3-ε,CD3E/CD3 ε 1-27 peptide Protein,... |
Human | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The p... | |||
TMPK-00869 |
CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His)
BGP,CEACAM1,BGP1,CD66a,BGPI |
Mouse | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1 on the growth of human colorectal cancer (CRC) cells in vitro. CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 44.7 kDa and the accession number is P31809-1. | |||
TMPK-01136 |
CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
TCRE,CD3e,CD3-epsilon,FLJ18683,CD3-ε,CD3E/CD3 ε,IMD18,T3E |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells ... | |||
TMPK-01350 |
CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi)
CD3E,T3E,FLJ18683,CD3-ε,CD3E/CD3 ε 1-27 peptide Protein,IMD1... |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. ... | |||
TMPY-04321 |
CHRNA5 Protein, Human, Recombinant (His)
cholinergic receptor, nicotinic, α5 (neuronal),cholinergic r... |
Human | HEK293 Cells |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increa... | |||
TMPJ-00419 |
CD16b Protein, Human, Recombinant (hFc & His)
Fc-γ RIII-beta,FCG3,FcR-10,Fc-gamma RIII-β,FCGR3,FCGR3B,Low ... |
Human | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of infl... | |||
TMPJ-00394 |
LDLR Protein, Human, Recombinant (Avi & His), Biotinylated
Low-Density Lipoprotein Receptor,LDL Receptor,LDLR |
Human | HEK293 Cells |
Low-density lipoprotein receptor 9 (LDL receptor) is a single-pass type I membrane protein which belongs to the LDLR family. It contains 3 EGF-like domains, 7 LDL-receptor class A domains, and 6 LDL-receptor class B repeats. This protein binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, it functions as a r... | |||
TMPK-01135 |
CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His)
T3E,CD3-ε,FLJ18683,CD3e,IMD18,CD3-epsilon,TCRE,CD3E/CD3 ε |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular... | |||
TMPJ-00202 |
CD157 Protein, Human, Recombinant (hFc)
Cyclic ADP-ribose hydrolase 2,cADPr hydrolase 2,ADP-ribosyl ... |
Human | HEK293 Cells |
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth. CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities followed with CD38. It plays a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derive... | |||
TMPJ-00958 |
B7-1 Protein, Rabbit, Recombinant (His)
Activation B7-1 antigen,T-lymphocyte activation antigen CD80... |
Rabbit | HEK293 Cells |
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can ... | |||
TMPY-00867 |
Kallikrein 13/KLK13 Protein, Human, Recombinant (His)
KLKL4,kallikrein-related peptidase 13,KLK-L4 |
Human | HEK293 Cells |
Tissue kallikrein 13 (hK13), also known as KLK-L4 (kallikrein-like gene 4), is a member of the human tissue kallikrein family of serine proteases having diverse physiological functions in many tissues. The KLK13 gene resides on chromosome 19q13.3-4 along with other 14 members in a gene cluster and shares a high degree of homology. KLK13 is a trypsin-like, secreted serine protease expressed specifically in the testicular tissue including prostate, salivary gland, breast, and testis. Growing evide... | |||
TMPK-01351 |
CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated
TCRE,FLJ18683,T3E,CD3E,CD3-epsilon,CD3E/CD3 ε 1-27 peptide P... |
Cynomolgus | HEK293 Cells |
CD3E, is a single-pass type I membrane protein.CD3 (cluster of differentiation 3) T cell co-receptor helps to activate both the cytotoxic T cell (CD8 naive T cells) and also T helper cells (CD4 naive T cells). It consists of a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. CD3 epsilon/CD3e epsilon 1-27 peptide Protein, Cynomolgus, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cell... | |||
TMPJ-00991 |
S100A8 Protein, Rat, Recombinant (His)
Leukocyte L1 complex light chain,Migration inhibitory factor... |
Rat | E. coli |
Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. It may function in the inhi... | |||
TMPY-02482 |
Aconitase 1 Protein, Human, Recombinant (His)
HEL60,IRP1,ACONS,aconitase 1, soluble,IREBP,IREBP1,IREB1 |
Human | Baculovirus Insect Cells |
Aconitase 1(ACO1) or IRP1 is one member of the aconitase family that contains a diverse group of iron-sulphur(Fe-S) isomerases and two types of iron regulatory protein. Aconitase exits in two forms: one is soluble and the other is mitochondrial. ACO1 is the soluble existing form, and the mitochondrial form is ACO2. Residues from all three N-terminal domains and the larger C-terminal domain contribute to the active site region. When the enzyme is activated, it gains an additional iron atom. ACO1 ... | |||
TMPJ-00812 |
HBQ1 Protein, Human, Recombinant (His)
Hemoglobin subunit θ-1,Hemoglobin subunit theta-1,Hemoglobin... |
Human | E. coli |
Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene. Theta-globin mRNA is originally found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. Theta-1 is a member of the human alpha-globin gene cluster that includes five functional genes and two pseudogenes. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. Hemoglobin ... | |||
TMPK-01103 |
LILRA3/CD85e Protein, Human, Recombinant (His & Avi)
HM43,LIR-4HM43e3,HM31,ILT-6,LIR4,CD85e,LILRA3,ILT6 |
Human | HEK293 Cells |
Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds b... | |||
TMPY-00004 |
CD28 Protein, Rat, Recombinant (hFc)
CD28 molecule |
Rat | HEK293 Cells |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell r... | |||
TMPJ-00630 |
B7-1 Protein, Cynomolgus, Recombinant (hFc)
B7,CD80,T-lymphocyte activation antigen CD80,Activation B7-1... |
Cynomolgus | HEK293 Cells |
Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the ... | |||
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