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TMPY-00568
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CDNF Protein, Human, Recombinant (His)
cerebral dopamine neurotrophic factor,ARMETL1
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Human
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HEK293 Cells
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CDNF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q49AH0-1. |
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TMPY-01916
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CDNF Protein, Mouse, Recombinant (His)
Armetl1,cerebral dopamine neurotrophic factor,93301...
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Mouse
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HEK293 Cells
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CDNF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8CC36. |
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TMPY-00188
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CDNF Protein, Human, Recombinant (hFc)
cerebral dopamine neurotrophic factor,ARMETL1
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Human
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HEK293 Cells
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CDNF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.2 kDa and the accession number is Q49AH0-1. |
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TMPH-01913
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PDCD10 Protein, Human, Recombinant (His & SUMO)
PDCD10,Cerebral cavernous malformations 3 protein,T...
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Human
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E. coli
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PDCD10 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
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TMPJ-01300
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PDCD10 Protein, Human, Recombinant
TFAR15,Programmed Cell Death Protein 10,PDCD10,TF-1 Cell Apo...
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Human
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E. coli
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Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is required for normal cardiovascular development and normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3. |
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TMPY-05510
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BDNF Protein, Mouse, Recombinant (His)
brain-derived neurotrophic factor
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Mouse
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HEK293 Cells
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BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,... |
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TMPK-00481
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PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
PDGF R beta,PDGFRB,PDGFR-2,PDGF-R-β,PDGF-R-beta,PDGFR-β,PDGF...
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Cynomolgus
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HEK293 Cells
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Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity after cerebral ischemia and therefore represents a novel potential therapeutic target. |
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TMPY-03053
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Ezrin Protein, Human, Recombinant (His)
HEL-S-105,CVL,VIL2,CVIL,ezrin
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Human
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E. coli
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VIL2, also known as villin-2, belongs to the ERM protein family. It is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. VIL2 contains 1 FERM domain and may be involved in connections of major cytoskel |
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TMPJ-01398
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ITM2B Protein, Human, Recombinant (His)
Transmembrane Protein BRI,Protein E25B,BRI2,imBRI2,Immature ...
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Human
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HEK293 Cells
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Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervou... |
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TMPH-01025
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CALCA Protein, Human, Recombinant (GST)
Calcitonin gene-related peptide 1,CGRP-I,CALCA,CALC1,Alpha-t...
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Human
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E. coli
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CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CALCA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.6 kDa and the accession number is P06881. |
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TMPY-04463
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CDKL2 Protein, Human, Recombinant (His)
KKIAMRE,P56,cyclin-dependent kinase-like 2 (CDC2-related kin...
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Human
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Baculovirus Insect Cells
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Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus. |
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TMPJ-00313
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Fumarase Protein, Human, Recombinant
FH,Fumarase,Fumarate Hydratase Mitochondrial
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Human
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E. coli
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Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy... |
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TMPJ-01296
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SULT4A1 Protein, Human, Recombinant
hBR-STL,SULTX3,Nervous System Sulfotransferase,SULT4A1,ST4A1...
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Human
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E. coli
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Sulfotransferase 4A1 (ST4A1) is a member of the Sulfotransferase 1 family. ST4A1 is highly expressed in the cerebral cortex and frontal lobe, but no expression is detected in the pancreas. ST4A1 is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. ST4A1 acts on catecholamines and T4 in a manner that may not involve sulfonation. ST4A1 may have a role in the metabolism of drugs and neurotransmitters in the CNS. In addition, ST4A1 is related to schizo... |
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TMPJ-01022
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SUMO3 Protein, Human, Recombinant (HEK293, His)
SMT3 homolog 1,Smt3A,Small ubiquitin-related modifier 3,Ubiq...
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Human
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HEK293 Cells
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Small ubiquitin-like modifier (SUMO), also known as SUMO homologue and SMT3, is a member of the superfamily of ubiquitin-like polypeptides that become covalently attached to various intracellular target proteins as a way to alter their function, location, and/or half-life. Small ubiquitin-like modifiers include SUMO1, SUMO2, SUMO3, and SUMO4. Except for SUMO4, all other SUMOs are ubiquitously expressed, including in the brain. In human, SUMO2 and SUMO3 are two highly homologous proteins, collect... |
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TMPY-03063
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SLITRK6 Protein, Human, Recombinant (His)
SLIT and NTRK like family member 6,SLITRK6,DFNMYP
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Human
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HEK293 Cells
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SLITRK6 belongs to the SLITRK family. Members of this family share two conserved leucine-rich repeat domains in the extracellular domain. SLITRK6 contains 11 LRR (leucine-rich) repeats, 2 LRRCT domains and 2 LRRNT domains. Expression of SlITRK proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. SLITRK6 is highly expressed in putamen with no expression in cerebral cortex. It also can be detected in adult and fetal lung and fetal liver. It can sup... |
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TMPJ-01033
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NXPH1 Protein, Human, Recombinant (His)
NXPH1,Neurexophilin-1,NPH1
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Human
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HEK293 Cells
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Neurexophilin-1 (NXPH1) is a member of Neurexophilin family. NXPH1 consist of 271 amino acis. It contains a 21 amino acid signal peptide, 86 amino acid propeptide, and 164 amino acid mature protein. NXPH1 is expressed in subpopulations of neurons within the cerebral cortex, cerebellum and olfactory bulb that are thought to be inhibitory interneurons. In humans, NXPH2 and NXPH3 are most similar to NXPH1, sharing 84% and 64% aa identity within the mature region, respectively. By contrast, NXPH4 d... |
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TMPY-02769
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RNASET2 Protein, Human, Recombinant (His)
bA514O12.3,RP11-514O12.3,RNASE6PL,ribonuclease T2
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Human
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Baculovirus Insect Cells
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RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy.... |
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TMPJ-01130
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NPTX1 Protein, Human, Recombinant (His)
Neuronal pentraxin-1,NPTX1,NP1
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Human
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HEK293 Cells
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Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) at excitatory synapses. Mature human NPTX1 shares 97% aa sequence identity with mouse, and rat NPTX1. It is produced by hippocampal, cerebral and cerebellar neurons, retinal ganglia and the inner nuclear layer of the retina. It is enriched on presynaptic axonal membranes where it ... |
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TMPJ-00916
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TIMP-2 Protein, Mouse, Recombinant (His)
metalloproteinase inhibitor 2,Tissue inhibitor of metallopro...
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Mouse
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HEK293 Cells
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Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi... |
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TMPJ-00709
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LY6H Protein, Human, Recombinant (His)
Ly-6H,LY6H,Lymphocyte Antigen 6H
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Human
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HEK293 Cells
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Lymphocyte Antigen 6H (LY6H) is a novel member of the LY6 family of glycosylphosphatidylinositol-anchored cell surface glycoproteins. LY6H contains one UPAR/Ly6 domain. Human LY6H is synthesized as a 140 amino acid precursor that contains a 25 amino acid signal sequence, 20 amino acid propeptide that is removed in the mature form, and a 90 amino acid mature chain. LY6H is highly expressed in the brain (cerebral cortex, amygdala, hippocampus and subthalamic nucleus) and in acute human leukemic ce... |
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TMPY-00344
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ARL6IP6 Protein, Human, Recombinant (mFc)
PFAAP1,AIP-6,ADP-ribosylation factor-like 6 interacting prot...
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Human
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HEK293 Cells
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It had been found that a homozygous truncating mutation in ARL6IP6 as the likely cause of a syndromic form of CMTC associated with major dysmorphism, developmental delay, transient ischemic attacks and cerebral vascular malformations. This gene was previously implicated by genome wide association study (GWAS) as a susceptibility locus to ischemic stroke in young adults. We identify ARL6IP6 as a novel candidate gene for a syndromic form of CMTC. This suggests that ischemic stroke or transient isc... |
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TMPJ-00361
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Endoglin Protein, Human, Recombinant (Trx & His)
CD105,END,Endoglin,ENG
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Human
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E. coli
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Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an... |
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TMPJ-00858
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Ezrin Protein, Human, Recombinant
Villin-2,VIL2,EZR,p81,Ezrin,Cytovillin
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Human
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E. coli
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Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskele... |
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TMPY-03963
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CALCB Protein, Human, Recombinant (mFc)
CGRP-II,calcitonin-related polypeptide β,calcitonin-related ...
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Human
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HEK293 Cells
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CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, blood, and cerebrospinal fluid. CGRP immunolabeling (IL) was detected in epidermal keratinocytes at levels that were especially high and widespread in the skin of humans from locations afflicted with postherpetic neuralgia (PHN) and complex region pain syndrome type 1 (CRPS), of ... |
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TMPH-02613
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ATF-5 Protein, Mouse, Recombinant (His & Myc)
Transcription factor ATFx,Transcription factor-like protein ...
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Mouse
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E. coli
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Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip... |
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TMPJ-00490
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Serpin A5 Protein, Human, Recombinant (His)
Plasminogen Activator Inhibitor 3,Acrosomal Serine Protease ...
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Human
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HEK293 Cells
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Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes o... |
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TMPY-01303
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Serpin A3 Protein, Human, Recombinant (His)
ACT,GIG25,serpin peptidase inhibitor, clade A (alpha-1 antip...
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Human
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HEK293 Cells
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SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has been demonstrated to inhibit the activity of certain serine proteases, such as cathepsin G found in neutrophils, and chymases present in mast cells, by inducing a major conformational rearrangement, and thus protects some tissues from damage caused by proteolytic enzymes. This enzy... |
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TMPY-02091
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GAD67 Protein, Human, Recombinant (His)
SCP,CPSQ1,glutamate decarboxylase 1 (brain, 67kDa),GAD
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Human
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Baculovirus Insect Cells
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Glutamate decarboxylase 1, also known as 67 kDa glutamic acid decarboxylase, Glutamate decarboxylase 67 kDa isoform and GAD1, is a member of thegroup II decarboxylase family. GAD1 is expressed in benign and malignant prostatic tissue and may serve as a highly prostate-specific tissue biomarker. GAD1 isoform3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Tissue-specific markers are useful for identification of tumour type ... |
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TMPY-01479
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SPG3A Protein, Human, Recombinant (GST)
HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...
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Human
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Baculovirus Insect Cells
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Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and... |
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TMPY-02491
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LRRN3 Protein, Human, Recombinant (His)
NLRR3,FIGLER5,leucine rich repeat neuronal 3,NLRR-3
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Human
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Baculovirus Insect Cells
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Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. Leucine-rich repeats are short sequence motifs present in some proteins with diverse functions and cellular locations. All proteins containing these repeats are thought to be involved in protein-protein interactions. The crystal structure of ribonuclease inhibitor protein has revealed th... |
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TMPY-02718
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Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)
XLIS,doublecortin,LISX,DBCN,DC,SCLH
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Human
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E. coli
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DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion an... |
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TMPY-00186
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GHRH Protein, Human, Recombinant (hFc)
GRF,INN,growth hormone releasing hormone,GHRF
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Human
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HEK293 Cells
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The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl... |
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TMPY-01620
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MDGA2 Protein, Mouse, Recombinant (His)
6720489L24Rik,Adp,MAM domain containing glycosylphosphatidyl...
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Mouse
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HEK293 Cells
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MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single... |
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TMPY-04408
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CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)
calcium/calmodulin-dependent protein kinase II beta,CAM2,CAM...
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Human
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Baculovirus Insect Cells
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Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state. As a multifunctional protein kinase, the loss of activity may play a critical role in initiating the changes leading to... |
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