Maurocalcine is a cell-permeable agonist for ryanodine receptor (RyR) subtypes 1, 2, and 3. It enhances [3 H]ryanodine binding to RyR1 with an EC50 of 2558 nM and demonstrates an apparent affinity for RyR2 at 14 nM. This compound is suitable for in vivo cell tracking and other cellular imaging applications [1] [2] [3].

马洛卡尔钙素（Maurocalcine，100 nM，24小时）提高了RyR2对内源性钙激活因子（[Ca2+]i）的响应敏感度，并减弱了其对钙抑制因子（[Ca2+]i）的响应性。此外，马洛卡尔钙素（Maurocalcine，5μM，4小时/24小时）在HEK293细胞模型中未显示出任何细胞毒性效应。