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18
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45
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Cat. No. | Product Name | ||
---|---|---|---|
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72505L |
CTP Synthetase-IN-1 Ammonium salt
CTPS-IN-1 Ammonium salt,CTP Synthetase-IN-1 Ammonium salt(2338811-71-3 Free base) |
Others | Others |
CTP Synthetase-IN-1 Ammonium salt 是一种具有口服活性和高效性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂,具有潜在的抗菌抗炎抗肿瘤活性,可用于研究 SARS-CoV-2病毒感染。 | |||
T72505 |
CTP Synthetase-IN-1
|
Others | Others |
CTP Synthetase-IN-1 是一种具有口服活性和高效性的胞苷 5'-三磷酸合成酶 (CTPS) 抑制剂,具有潜在的抗肿瘤活性,在炎症动物模型中显示出抗炎活性,抑制人 CTPS1 和人 CTPS2,可用于研究关节炎和类风湿性关节炎。 | |||
T10303 |
Aminoacyl tRNA synthetase-IN-1
|
Others | Others |
Aminoacyl tRNA synthetase-IN-1 is an inhibitor of bacterial aminoacyl tRNA synthetase (aaRS). | |||
T74612 |
Aminoacyl tRNA synthetase-IN-2
|
Others | Others |
Aminoacyl tRNA synthetase-IN-2 (Compound 14) 是氨酰基-tRNA 合成酶 (aaRS) 抑制剂,可用于新型抗生素家族的开发。 | |||
T74932 |
Trypanothione synthetase-IN-1
|
Others | Others |
Trypanothione synthetase-IN-1 (Compound 1) 为一竞争性婴儿利什曼虫锥体胱甘肽合成酶(TryS)抑制剂,以三胺亚精胺为多胺S时,IC50值为14.8 μM。 | |||
T74933 |
Trypanothione synthetase-IN-2
|
Others | Others |
Trypanothione synthetase-IN-2 (Compound 3) 为竞争性婴儿利什曼虫锥虫胱甘肽合成酶 (TryS) 抑制剂,以三胺亚精胺作为多胺S时,IC50 值为5.4 μM。 | |||
T76124 |
Acyl coenzyme A synthetase
|
Others | Others |
Acyl coenzyme A synthetase (ACS),一种生化研究中常用的酶,主要通过两步硫酯化反应激活脂肪酸与辅酶A结合,形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径,以及参与TCA循环中的有氧呼吸提供了关键中间物。 | |||
T64056 |
Trypanothione synthetase-IN-4
|
Others | Others |
Trypanothione synthetase-IN-4 是一个 L. infantumTryS 抑制剂,其活性依赖于多胺底物的浓度。Trypanothione synthetase-IN-4 表现出较强的抗 leishmanicidal 效果 (EC50: 0.6 μM,SI (选择性指数): 35)。Trypanothione synthetase-IN-4 能够用于研究利什曼病。 | |||
T74934 |
Trypanothione synthetase-IN-3
|
Others | Others |
Trypanothione synthetase-IN-3是一种针对Trypanothione synthetase (TryS)的非竞争性混合双曲线抑制剂,其Ki值为0.8 μM。该化合物主要用于研究寄生虫,例如L. infantum。 | |||
T63688 |
Isoleucyl tRNA synthetase-IN-1
|
Others | Others |
Isoleucyl tRNA synthetase-IN-1 是选择性的、有效的靶向异亮基 tRNA 合成酶 (IleRS) 的抑制剂 (Ki: 88 nM)。 | |||
T63706 |
Isoleucyl tRNA synthetase-IN-2
|
Others | Others |
Isoleucyl tRNA synthetase-IN-2 是选择性的、有效的靶向异亮基 tRNA 合成酶 (IleRS) 的抑制剂 (Ki: 114 nM)。 | |||
T9533 |
BC-LI-0186
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
Others | Others |
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长,能够用于肺癌的相关研究。 | |||
T14141 |
AGI-24512
|
DNA | DNA Damage/DNA Repair |
AGI-24512 是一种具有高效性的蛋氨酸腺苷转移酶 2α (MAT2A) 抑制剂(IC50 :8 nM)。AGI-24512 在 MTAP 缺失的癌细胞中显示出抗增殖活性。AGI-24512 抑制 MAT2A 会在 MTAP 中诱导 DNA 损伤,常用抗癌化合物联用来研究癌症。 | |||
T11529 |
H3B-120
|
Others; Potassium Channel | Membrane transporter/Ion channel; Others |
H3B-120 是高选择性,竞争性的氨基甲酰磷酸合成酶 1 变构抑制剂,IC50为 1.5 μM,Ki 为 1.4 μM。它具有抗癌活性。 | |||
T8356 |
FPL 62064
|
Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Neuroscience |
FPL 62064 是 5-脂氧合酶和COX 双重抑制剂,具有抗炎活性,对 RBL-1 胞质 5-脂氧合酶和前列腺素合成酶 (环氧化酶) 的IC50值分别为 3.5 和 3.1 μM。 | |||
T0767 |
Sulfapyridine
磺胺吡啶,Sulfidine,Sulfidin,2-Sulfapyridine |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfapyridine (2-Sulfapyridine) 是一种磺酰胺类抗生素,是 Sulfasalazine 的代谢产物。它抑制重组 P. carinii 二氢蝶呤合成酶,IC50为 0.18 μM。它具有抗菌,抗炎和抗风湿作用。 | |||
T33565 |
NAAD sodium salt
NAAD钠盐,NAAD Na salt,Deamido Nad Sodium Salt,NAAD Na, NaAD |
Others | Others |
NAAD sodium salt (NAAD Na salt) 是烟酰胺腺嘌呤二核苷酸合酶的底物,可用于研究底物的特异性和动力学。 | |||
T4380 |
Ac-CoA Synthase Inhibitor1
ACSS2 inhibitor |
RSV; Fatty Acid Synthase | Metabolism; Microbiology/Virology |
Ac-CoA Synthase Inhibitor1 (ACSS2 inhibitor) 是一种可逆的醋酸盐依赖性乙酰辅酶 A 合成酶 2 抑制剂,IC50为 0.6 µM,可抑制呼吸道合胞病毒。 | |||
T40656 |
Chlorobenzuron
|
Others | Others |
Chlorobenzuron 是一种有效的几丁质合成酶抑制剂,具有杀虫的活性,可以抑制幼虫发育和蛹化的作用。 | |||
T6120 |
Pralatrexate
Folotyn,10-炔丙基-10-去氮杂氨基蝶呤,10-Propargyl-10-deazaaminopterin,普拉曲沙 |
Apoptosis; DHFR; Antifolate; TAM Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors |
Pralatrexate (10-Propargyl-10-deazaaminopterin) 是一种抗叶酸剂,也是二氢叶酸还原酶抑制剂,Ki 值为 13.4 pM。它具有抗肿瘤活性,可研究复发/难治性 T 细胞淋巴瘤。它是叶酰聚谷氨酸合成酶的底物,具有改善的细胞摄取和保留能力。 | |||
T0005 |
Aspirin
阿司匹林,Acetylsalicylate,Acetylsalicylic Acid,邻乙酰水杨酸,ASA |
Mitophagy; Virus Protease; COX; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Aspirin (Acetylsalicylic Acid) 是一种选择性 COX 抑制剂,具有多种药理活性。它是组蛋白去乙酰化酶抑制剂,可上调细胞周期阻滞蛋白 p21,抑制携带 COX-1 的卵巢 Y 细胞。 它还抑制 HUVEC 和新生大鼠心室心肌细胞中 COX-2 的表达,分别减少 PG 的产生和 ERK 和 NF-KB 的下调。 | |||
T78227 |
L-Methioninamide hydrochloride
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
L-Methioninamide hydrochloride 是一种有效的甲硫氨酰-tRNA 合成酶 (Methionyl-tRNA synthetase) 抑制剂,能够降低CDDP毒性。 | |||
T22225 |
4-Methylsalicylic acid
|
Others | Others |
4-Methylsalicylic acid 用于抑制中链酰基辅酶A 合成酶。 | |||
T11919 |
LysRs-IN-1
9-carboxymethylguanine |
Others | Others |
LysRs-IN-1是一种赖氨酰-tRNA 合成酶(LysRs)的抑制剂。 | |||
T0123 |
Sulfanilamide
Sulphanilamide,磺胺,UK-124 |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfanilamide (UK-124) 是一种细菌二氢蝶酸合成酶抑制剂,IC50为320 μM。 | |||
T20121 |
L-Albizziin
NSC-132089,L-beta-Ureidoalanine,L-Albizziine,Albizzine,NSC 132089,Albizziin,L-脲基丙氨酸 |
Glutaminase | Proteases/Proteasome |
L-Albizziin (L-beta-Ureidoalanine) 是一种巯基试剂,是一种谷氨酰胺酶抑制剂,可用于研究癌症。 | |||
T0264 |
Zomepirac sodium salt
Zomepirac Sodium,佐美酸钠,McN-2783-21-98 |
PGE Synthase; PDE | Immunology/Inflammation; Metabolism |
Zomepirac sodium salt (McN-2783-21-98) 是前列腺素合成酶抑制剂。它是一种非甾体抗炎药,但能够导致免疫介导的肝损伤。 | |||
T7708 |
DL-Buthionine-(S,R)-sulfoximine
Butionine sulfoximine,丁基硫,NSC 381100,D,L-Buthionine-(S,R)-sulfoximine |
Others; Ferroptosis | Apoptosis; Others |
DL-Buthionine-(S,R)-sulfoximine (Butionine sulfoximine) 是 γ-谷氨酰半胱氨酸合成酶的抑制剂,用于治疗实体瘤。 | |||
T11497 |
Ganfeborole HCl
GSK3036656 HCl,GSK656 HCl |
Antibacterial | Microbiology/Virology |
Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物,是结核分枝杆菌(Mtb)亮氨酰-tRNA 合成酶(LeuRS;IC50:0.2 μM)的抑制剂。 | |||
T41299 |
L-Methionine-DL-sulfoximine
MSX,MSO |
Others | Others |
L-Methionine-DL-sulfoximine (MSO) 抑制谷氨酰胺合成酶,主要在代谢和形态上影响星形胶质细胞。L-Methionine-DL-sulfoximine 可用于惊厥相关研究。 | |||
T10098 |
PGS-IN-1
KME-4 |
Lipoxygenase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
PGS-IN-1 (KME-4)是一种前列腺素合成酶抑制剂,IC50=0.28 μM。它也可抑制5-脂肪氧合酶的活性,IC50=1.05 μM。 | |||
T4045 |
Epetraborole hydrochloride
GSK2251052 hydrochloride |
Antibacterial | Microbiology/Virology |
Epetraborole hydrochloride (GSK2251052 hydrochloride) 是一个新型 LeuRS 抑制剂,通过绑定 leucyl-tRNA 合成酶终端的腺苷核糖抑制蛋白合成,可研究 Gram-negative 细菌引起的感染。 | |||
T0789 |
PMSF
Phenylmethylsulfonyl fluoride,Benzylsulfonyl fluoride,苯甲基磺酰氟 |
Serine Protease; Cysteine Protease | Proteases/Proteasome |
PMSF (Phenylmethylsulfonyl fluoride) 是一种丝氨酸/半胱氨酸蛋白酶不可逆抑制剂,常用于制备细胞裂解物。 | |||
T35803 |
C14 Ceramide (d18:1/14:0)
Cer(d18:1/14:0),N-Myristoyl-D-sphingosine |
||
C14 Ceramide (d18:1/14:0) 是由神经酰胺合成酶 6 生成的一种内源性神经酰胺,可用于研究帕金森。 | |||
T0699 |
Sulfamonomethoxine
磺胺间甲氧嘧啶,磺胺间甲氧嘧啶钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sulfamonomethoxine 是一种磺胺类抗菌剂。它可研究血液动力学,竞争性抑制剂二氢叶酸合成,从而阻断叶酸合成。 | |||
T69730 |
F092
|
PGE Synthase | Immunology/Inflammation |
F092 是一种高效的造血前列腺素 D 合成酶 (H-PGDS) 抑制剂, 可以用于研究过敏性炎症和与血管相关的疾病。 | |||
T7439 |
3-Methoxybenzamide
3-MBA,3-甲氧基苯甲酰胺 |
PARP; Antibacterial; Transferase | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
3-Methoxybenzamide (3-MBA) 是一种多聚 ADP-核糖合成酶的竞争性抑制剂,可抑制枯草芽孢杆菌的细胞分裂,诱导细胞凋亡。它可促进蓝薯植株的生长、微瘤化和转化效率。 | |||
T6236 |
Ozagrel
奥扎格雷,OKY-046,Domenan |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂,可抑制哮喘。它也是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T29457L |
5-Hydroxydecanoate sodium
|
Potassium Channel | Membrane transporter/Ion channel |
5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂,IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物,具有抗氧化性。 | |||
T9732 |
VY-3-135
|
Fatty Acid Synthase | Metabolism |
VY-3-135 是口服有效的乙酰辅酶 A 合成酶 2 (ACSS2)选择性 抑制剂,IC50为 44 nM,对重组人 ACSS1 或 ACSS3 没有抑制活性。它有效抑制 ACSS2 依赖性脂肪酸代谢,但对肿瘤中的基因表达没有影响。 | |||
T15608 |
Jarin-1
|
Others | Others |
Jarin-1 是一种茉莉酸-酰胺基合成酶 (JAR1) 抑制剂,IC50 为 3.8 μM。Jarin-1 特异性抑制拟南芥和其他植物中具有生物活性的 JA-Ile 的生物合成。 | |||
T14387 |
AZD9898
|
Leukotriene Receptor | GPCR/G Protein |
AZD9898 是一种白三烯-C4 合成酶抑制剂,IC50 为 0.28 nM。 AZD9898 可用于哮喘研究。 AZD9898 减轻 GABA 结合和肝毒性信号。 | |||
T6625 |
Ozagrel hydrochloride
Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl |
Thrombin; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂,用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂,可选择性抑制人血小板聚集,IC50为 53.12 μM。 | |||
T9085 |
JFD01307SC
[(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO] |
Antibacterial | Microbiology/Virology |
JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) 是一种谷氨酰胺合成酶抑制剂。 它是抗结核剂,可作为 L-谷氨酸盐的模拟物,靶向参与谷氨酰胺生物合成的酶。 | |||
T10783 |
CGS 15435
|
PPAR | DNA Damage/DNA Repair; Metabolism |
CGS 15435是一种有效的血栓素(TxA2)合成酶抑制剂(IC50: 1 nM)。CGS 15435作用于 PGI2合成酶、环氧合酶和脂合酶比作用于血栓素合成酶选择性低得多。 | |||
T5371 |
L-BUTHIONINE-(S,R)-SULFOXIMINE
L-Butionine sulfoximine,丁硫氨酸-亚砜亚胺 |
Others; Ferroptosis | Apoptosis; Others |
L-Buthionine-(S,R)-sulfoximine 是一种 γ-谷氨酰半胱氨酸合成酶抑制剂,具有细胞渗透性、不可逆性和快速起效性。L-Buthionine-(S,R)-sulfoximine 通过消耗 GSH 诱导细胞中的氧化应激。 | |||
T61194 |
D75-4590
|
Others | Others |
D75-4590是一种β-1,6-葡聚糖抑制剂。由于葡聚糖是细胞壁的主要成分,特别是β-1,6-葡聚糖,D75-4590可以通过抑制其合成酶来对抗真菌感染。 | |||
T60060 |
ACSS2-IN-2
MTB-9655 |
Fatty Acid Synthase | Metabolism |
ACSS2-IN-2 (MTB-9655) 是酰基辅酶 A 合成酶短链家族成员 2 (ACSS2) 抑制剂。ACSS2-IN-2 可抑制 ACSS2 活性,IC50 为 3.8 nM。ACSS2-IN-2 可用于多种疾病的研究,如病毒感染、代谢紊乱、神经精神疾病、炎症/自身免疫疾病和癌症。 | |||
T36866 |
3-Deazauridine
4-羟基-1-Β-D-呋喃核糖苷-2(1H)吡啶酮,NSC 126849 |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
3-Deazauridine (NSC-126849) 是一种尿苷的结构类似物,通过竞争性抑制胞苷三磷酸合成酶来抑制胞苷-5'-三磷酸的生物合成,这种合成酶被认为是这种核苷类似物的主要作用方式。 | |||
T23601 |
ABC1183
ABC 1183,ABC-1183 |
GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
ABC1183是一种抑制GSK3α, GSK3β和CDK9的新型二氨基噻唑。ABC1183通过诱导G2/M 阻滞和改变GSK3、糖原合成酶、β-catenin 磷酸化和MCL1表达降低细胞存活率来抑制多种癌细胞株的生长,并具有口服活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T6942 |
Picolinamide
2-Pyridinecarboxamide,2-Carbamoylpyridine,2-吡啶甲酰胺,2-Picolinamide,Picolinoylamide |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Picolinamide (Picolinoylamide) 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。 | |||
T7481 |
2-Hydroxycaprylic acid
2-hydroxyoctanoic acid,2-羟基辛酸 |
Others | Others |
2-Hydroxyoctanoic acid 是中链酰基辅酶 A 合成酶抑制剂 (Ki:500 μM)。 | |||
TN1800 |
Isosakuranin
|
Others | Others |
Isosakuranin 是一种提取自Paliurus ramosissimus果实中的天然产物,具有抗糖尿病作用。 | |||
T1465 |
Mupirocin
Pseudomonic acid,莫匹罗星,BRL-4910A |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Mupirocin (BRL-4910A) 是从Pseudomonas fluorescens 中分离得到的一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA,并抑制细菌蛋白和RNA 的合成起抗菌作用。 | |||
T21494 |
Oligomycin
寡霉素 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Oligomycin 是一种抗真菌抗生素,是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。 | |||
T2O2774 |
L-Asparagine
alpha-aminosuccinamic acid,L-天门冬氨酸,(-)-Asparagine,Asparamide,2-Aminosuccinamic acid,Asn,Altheine |
Endogenous Metabolite | Metabolism |
L-Asparagine (Asparamide) 是一种非必需氨基酸,可以参与神经和脑组织细胞功能的代谢控制。 | |||
T4735 |
2'-Deoxyuridine 5'-monophosphate disodium
2'-脱氧尿苷-5'-单磷酸二钠,2'-dUMP⋅2Na,2-脱氧尿嘧啶核苷-5'-单磷酸二钠盐,2'-Deoxyuridine 5'-monophosphate disodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt 能够被双底物酶胸苷酸合酶(TS) 还原甲基化为 dTMP (2'-deoxythymidine 5'-monophosphate)。其中 dTMP 是 DNA 合成所需的核苷酸。 | |||
T5515 |
Hemin
氯化血红素,Hemin chloride |
Mitophagy; Ferroptosis; Autophagy | Apoptosis; Autophagy |
Hemin (Hemin chloride) 是一种含有氯的含铁卟啉,一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性,可以减少患者的血红素缺乏,从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。 | |||
TN1982 |
Neoglycyrol
|
Others | Others |
Neoglycyrol 是分离自甘草的根中的化合物。它是由传统专利药通脉养心丸中筛选得到,具有潜在心肌保护作用。 | |||
TL0005 |
3,5-O-Dicaffeoylquinic acid
Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid |
Others | Others |
3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。 | |||
T5244 |
Aminomalonic acid
2-Aminopropanedioic Acid,氨基丙二酸,Aminomalonate |
Others; Endogenous Metabolite | Metabolism; Others |
Aminomalonic acid 是氨基内源性代谢产物,在体外能作为来源 Leukemia 5178Y/AR 和小鼠胰腺的L- 天冬酰胺合成酶的高效抑制剂 (Leukemia 5178Y/AR:Ki= 0.0023 M,小鼠胰腺:Ki= 0.0015 M)。它有潜力用作区分黑素瘤转移的不同阶段生物标志物。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T37753 |
Aureusimine B
|
Cysteine Protease; Antibacterial | Microbiology/Virology; Proteases/Proteasome |
Aureusimine B 是一种钙蛋白酶抑制剂,由金黄色葡萄球菌生物膜产生,可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。 | |||
T10582 |
Borrelidin
Treponemycin |
Others | Others |
Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei. | |||
T13199 |
Triacsin C
WS 1228A,FR 900190 |
Others | Others |
Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ,是一种花生四烯酰辅酶A合成酶和非特异性长链酰辅酶A合成酶的差异抑制剂,抗动脉粥样硬化活性,抑制 ACSL 活性, 抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 可用于研究轮状病毒感染和阿尔茨海默症。 | |||
TN1378 |
α-Viniferin
ALPHA-VINIFERIN,Alpha-葡萄素 |
P450; NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
α-Viniferin 也称为2-芳基苯并呋喃类黄酮,是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05305 |
alanyl-tRNA synthetase Protein, Human, Recombinant (His)
alanyl-tRNA synthetase,CMT2N |
Human | Baculovirus Insect Cells |
alanyl-tRNA synthetase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 109.2 kDa and the accession number is P49588. | |||
TMPY-02441 |
alanyl-tRNA synthetase Protein, Mouse, Recombinant (His)
sti,C76919,AI316495,alanyl-tRNA synthetase |
Mouse | Baculovirus Insect Cells |
alanyl-tRNA synthetase Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 108.3 kDa and the accession number is Q8BGQ7. | |||
TMPY-01461 |
EMAP-II/AIMP1 Protein, Human, Recombinant (His)
SCYE1,p43,EMAPII,aminoacyl tRNA synthetase complex-... |
Human | E. coli |
EMAP-II/AIMP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 35 kDa and the accession number is Q12904-1. | |||
TMPJ-00979 |
GSH-S Protein, Human, Recombinant (His)
Glutathione Synthetase,GSS,GSH-S,GSH Synthetase... |
Human | E. coli |
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the secon... | |||
TMPJ-00989 |
MTHFS Protein, Human, Recombinant (His)
5-formyltetrahydrofolate cyclo-ligase,10-methenyl-tetrahydro... |
Human | E. coli |
5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increas... | |||
TMPY-03393 |
DARS Protein, Human, Recombinant (His)
aspartyl-tRNA synthetase,HBSL,aspRS |
Human | E. coli |
Aspartate tRNA ligase 1, also known as DARS, is part of a multienzyme complex of aminoacyl-tRNA synthetases. It belongs to the class-II aminoacyl-tRNA synthetase family. DARS charges its cognate tRNA with aspartate during protein biosynthesis. DARS catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | |||
TMPY-05413 |
HARS/HisRS Protein, Human, Recombinant (His)
histidyl-tRNA synthetase,USH3B,HRS |
Human | Baculovirus Insect Cells |
HARS/HisRS Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.6 kDa and the accession number is P12081-1. | |||
TMPY-04768 |
PRPS2 Protein, Human, Recombinant (His)
PRPS2,PRSII,phosphoribosyl pyrophosphate synthetase... |
Human | E. coli |
PRPS2, a subset of PRS, is reported to be a potential protein associated with Sertoli-cell only syndrome. PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells via the p53/Bcl-2/caspases signaling pathway. The gene for PRS II (PRPS2) is located at a different region of the X chromosome, namely Xpter-a21. The promoter region of the human PRPS2 gene was also GC-rich and contained a TATA-like sequence, four Sp1 binding sites and a homopyrimidine... | |||
TMPH-02488 |
ACSS2 Protein, Mouse, Recombinant (His)
Propionate--CoA ligase,AceCS1,Acyl-activating enzyme,Acetyl-... |
Mouse | E. coli |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity. ACSS2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.9 kDa and the accession number is Q9QXG4. | |||
TMPY-01427 |
AACS Protein, Human, Recombinant (His)
SUR-5,acetoacetyl-CoA synthetase,ACSF1 |
Human | Baculovirus Insect Cells |
Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. It had been improved that Acetoacetyl-CoA Synthetase is an essential enzyme for the synthesis of fatty acid and cholesterol from ketone bodies, was found to be highly expressed in mouse adipose tissue, and GC box and C/EBPs motif were crucial for AACS promoter ... | |||
TMPY-03448 |
AARSD1 Protein, Human, Recombinant (His)
AARSD1,alanyl-tRNA synthetase domain containing 1 |
Human | E. coli |
AARSD1 belongs to the class-II aminoacyl-tRNA synthetase family, Alax-L subfamily. AARSD1 binds 1 zinc ion per subunit functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala). Four transcript variants have been described for AARSD1: NM_25267.3, NM_113642.2, NM_1142653.1 and NM_1142654.1. It has been determined that the latter two variants represent a distinct upstream locus, which is now represented by GeneID:1885848 (PTGES3L), while the former two variants rep... | |||
TMPJ-00855 |
GLUL Protein, Human, Recombinant (His)
GLUL,GS,Glutamine Synthetase,Glutamate-Ammonia Liga... |
Human | E. coli |
Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part in cell prolifetation, inhibition of apoptosis, and cell signaling. Glutamine Synthetase is expressed during early fetal stages, and has a role in maintaining body PH by removing ammonia from circulation. Mutations in the GLUL gene are related to congenital glutamine deficiency. | |||
TMPH-00877 |
ACSS1 Protein, Human, Recombinant (His)
Acetate--CoA ligase 2,KIAA1846,Acetyl-coenzyme A synthet... |
Human | P. pastoris (Yeast) |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. ACSS1 Protein, Human, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 73.6 kD... | |||
TMPJ-01122 |
KARS Protein, Human, Recombinant (His)
Lysine--tRNA Ligase,Lysyl-tRNA Synthetase,LysRS,KAR... |
Human | HEK293 Cells |
Lysine-tRNA ligase, also known as Lysyl-tRNA synthetase, LysRS, KARS and KIAA0070, belongs to the class-II aminoacyl-tRNA synthetase family. The N-terminal cytoplasmic domain (1-65) is a functional tRNA-binding domain, which is required for nuclear localization, is involved in the interaction with DARS, but has a repulsive role in the binding to EEF1A1. A central domain (208-259) is involved in homodimerization and is required for interaction with HIV-1 GAG and incorporation into virions. KARS c... | |||
TMPH-00876 |
ACSS1 Protein, Human, Recombinant (E. coli, His)
Acetate--CoA ligase 2,Acetyl-coenzyme A synthetase ... |
Human | E. coli |
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient. ACSS1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted... | |||
TMPH-00629 |
Gamma-GCS Protein, E. coli, Recombinant (His & SUMO)
Glutamate--cysteine ligase,Gamma-ECS,gshA,Gamma-glutamylcyst... |
E. coli | E. coli |
N/A. Gamma-GCS Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.3 kDa and the accession number is P0A6W9. | |||
TMPH-01565 |
IARS Protein, Human, Recombinant (His & Myc)
Isoleucine--tRNA ligase, cytoplasmic,Isoleucyl-tRNA synt... |
Human | E. coli |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. | |||
TMPY-03753 |
WARS Protein, Human, Recombinant (His)
tryptophanyl-tRNA synthetase,GAMMA-2,γ-2,IFI53,IFP5... |
Human | Baculovirus Insect Cells |
WARS, also known as TrpRS, is an aminoacyl-tRNA synthetase that belongs to the class-I aminoacyl-tRNA synthetase family. There are two forms of tryptophanyl-tRNA synthetase: a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. They catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in ... | |||
TMPH-02741 |
IARS1 Protein, Mouse, Recombinant (His & Myc)
Isoleucyl-tRNA synthetase,Iars1,Isoleucine--tRNA li... |
Mouse | E. coli |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. IARS1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.8 kDa and the accession number is Q8BU30. | |||
TMPH-00438 |
GLUL Protein, Cricetulus griseus, Recombinant (His)
Glutamine synthetase,GLUL,Glutamate--ammonia ligase... |
Chinese hamster | E. coli |
GLUL Protein, Cricetulus griseus, Recombinant (His) is expressed in E. coli. | |||
TMPH-02279 |
YARS1 Protein, Human, Recombinant (GST)
Tyrosine--tRNA ligase, cytoplasmic,Tyrosyl-tRNA syntheta... |
Human | E. coli |
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). YARS1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 86.0 kDa and the accession number is P54577. | |||
TMPH-00796 |
gltX1 Protein, Helicobacter pylori, Recombinant (His)
Glutamyl-tRNA synthetase 1,gltX1,Glutamate--tRNA li... |
Helicobacter pylori | P. pastoris (Yeast) |
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). | |||
TMPH-02150 |
SUCLG2 Protein, Human, Recombinant (His & SUMO)
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondr... |
Human | E. coli |
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. SUCLG2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system wit... | |||
TMPH-03257 |
CPS1 Protein, Rat, Recombinant (His & Myc)
Carbamoyl-phosphate synthase [ammonia], mitochondrial,CPSase... |
Rat | E. coli |
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.7 kDa and the accession number is P07756. | |||
TMPH-02461 |
pylS Protein, Methanosarcina barkeri, Recombinant (His)
pylS,Pyrrolysine--tRNA ligase,Pyrrolysine--tRNA(Pyl) ligase,... |
Methanosarcina barkeri | E. coli |
Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG. pylS Protein, Methanosarcina barkeri, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.8 kDa and the accession number is Q46E77. | |||
TMPH-01037 |
CPS1 Protein, Human, Recombinant (His)
CPS1,CPSase I,Carbamoyl-phosphate synthetase I,Carb... |
Human | E. coli |
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P31327. | |||
TMPH-02560 |
CPS1 Protein, Mouse, Recombinant (His)
Carbamoyl-phosphate synthetase I,CPS1,CPSase I,Carb... |
Mouse | E. coli |
Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. | |||
TMPH-03432 |
ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His)
mRNA transport-defective protein 7,Acetyl-CoA carboxylase,Fa... |
Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 2-581, His) is expressed in E. coli expression system with N-10xHis tag. The predicted mol... | |||
TMPH-03431 |
ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His)
Acetyl-CoA carboxylase,ACC,Fatty acid synthetase 3,... |
Saccharomyces cerevisiae | E. coli |
Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in the synthesis of very-long-chain fatty acid synthesis which is required to maintain a functional nuclear envelope. Required for acylation and vacuolar membrane association of VAC8 which is necessary to maintain a normal morphology of the vacuole. ACC1 Protein, S. cerevisiae, Recombinant (aa 217-775, His) is expressed in E. coli expression system with N-10xHis tag. The predicted m... | |||
TMPH-03533 |
Ddl Protein, S. aureus, Recombinant (His & Myc)
ddl,D-alanylalanine synthetase,D-Ala-D-Ala ligase,D... |
Staphylococcus aureus | E. coli |
Cell wall formation. Ddl Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 47.7 kDa and the accession number is P63891. | |||
TMPY-03015 |
EMAP-II/AIMP1 Protein, Mouse, Recombinant
AIMP1,p43,Scye1,EMAPII,aminoacyl tRNA synthetase co... |
Mouse | E. coli |
EMAP-II/AIMP1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q62386. | |||
TMPH-02764 |
ACSL4 Protein, Mouse, Recombinant (His)
LACS 4,mACS4,Long-chain-fatty-acid--CoA ligase 4,Acsl4,Arach... |
Mouse | E. coli |
ACSL4 Protein, Mouse, Recombinant (His) is expressed in E. coli. | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPH-01547 |
Interferon alpha 21/IFNA21 Protein, Human, Recombinant (His)
IFNA21,Interferon alpha-21,Interferon alpha-F |
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPH-01544 |
Interferon alpha 14/IFNA14 Protein, Human, Recombinant (His & SUMO)
Interferon alpha-H,Interferon alpha-14,Interferon lambda-2-H... |
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPH-01546 |
Interferon alpha 17/IFNA17 Protein, Human, Recombinant (His)
Interferon alpha-T,Interferon alpha-88,IFNA17,Interferon alp... |
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha 17/IFNA17 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.3 kDa and the accession number is P01571. | |||
TMPH-01545 |
Interferon alpha 16/IFNA16 Protein, Human, Recombinant (His)
Interferon alpha-16,Interferon alpha-WA,IFNA16 |
Human | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha 16/IFNA16 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.4 kDa and the accession number is P05015. | |||
TMPH-01549 |
Interferon epsilon/IFNE Protein, Human, Recombinant (His)
IFNE,Interferon epsilon,Interferon epsilon-1 |
Human | E. coli |
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections. | |||
TMPH-00276 |
Interferon alpha-G/IFNAG Protein, Bovine, Recombinant (His & SUMO)
Interferon alpha-G,IFNAG,IFN-alpha7 |
Bovine | E. coli |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Interferon alpha-G/IFNAG Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.2 kDa and the accession number is P49877. | |||
TMPJ-00611 |
SFP Protein, B.subtilis, Recombinant (His)
Surfactin synthase-activating enzyme,sfp,lpa-8,4'-phosphopan... |
Bacillus subtilis | E. coli |
The Bacillus subtilis enzyme Sfp, required for production of the lipoheptapeptide antibiotic surfactin, posttranslationally phosphopantetheinylates a serine residue in each of the seven peptidyl carrier protein domains of the first three subunits (SrfABC) of surfactin synthetase to yield docking sites for amino acid loading and peptide bond formation. | |||
TMPJ-00780 |
IFN-alpha 6/IFNA6 Protein, Human, Recombinant (His)
Interferon α-K,Interferon α-6,IFN α6,Interferon α-54,干扰素,Int... |
Human | HEK293 Cells |
Interferon α-6 (IFN-α6) is a secreted protein which belongs to the α/β interferon family. IFN-α6 is produced by macrophages, expressed at low level, only 1.0% of the average gene in this release. IFN-α6 contains interferon alpha, beta and delta domain. IFN-α has antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. | |||
TMPJ-00800 |
BPGM Protein, Human, Recombinant (His)
3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas... |
Human | E. coli |
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells... | |||
TMPJ-00988 |
SEPHS1 Protein, Human, Recombinant (His)
water dikinase 1,SELD,Selenophosphate synthase 1,SEPHS1,SPS1... |
Human | HEK293 Cells |
Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP.... | |||
TMPJ-00871 |
BAR Protein, S. hygroscopicus, Recombinant
bar,PPT N-acetyltransferase,Phosphinothricin-resistance prot... |
Streptomyces hygroscopicus | E. coli |
Phosphinothricin N-acetyltransferase (PAT) is an enzyme that acetylates the free NH2 group of L-phosphinothricin (L-PPT) in the presence of acetyl-CoA as a co-substrate. It is highly specific for L-PPT and does not acetylate other L-amino acids or structurally similar molecules. L-PPT is a glutamate analog that can inhibit glutamine synthetase activity in plants, resulting in the accumulation of ammonia to toxic levels and impairment of photosynthesis. The introduction of a PAT gene into a plant... | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-alphaC,MGC119879,干扰... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13032 |
Sulfamonomethoxine-d4
|
Others | Others |
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is an agent of long acting sulfonamide antibacterial, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
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5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. |