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Targets Recommended: Glucocorticoid Receptor

123

抑制剂 & 化合物

8

天然产物

1

化合物库

15

重组蛋白

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Cat. No.	Product Name
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

Cat. No.	Product Name	Target	Signaling Pathways
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T3481	Bimolane	Topoisomerase	DNA Damage/DNA Repair
	Bimolane 是一种拓扑异构酶 II 抑制剂。
T14981	Clobetasone butyrate	Glucocorticoid Receptor	Endocrinology/Hormones
	Clobetasone butyrate 是糖皮质类固醇，特别是在皮肤上，具有局部抗炎活性。它可用于改善皮质类固醇反应性症状，如特应性皮炎、牛皮癣。
T16832	S18-000003	ROR	Metabolism
	S18-000003 是口服有活性的维甲酸相关孤儿受体 (RORγt) 选择性抑制剂，在竞争性结合试验中，对 hRORγt 的 IC50值小于 30 nM。它对 RORγt 的选择性比其他 ROR 家族成员 (IC50>10 μM)更高。它可用于银屑病的研究，胸腺畸变风险较低。
T17038	Tepilamide fumarate XP-23829	Others	Others
	Tepilamide fumarate (XP-23829) 是一种口服具有活性的延胡索酸酯，可用于研究中度到重度慢性斑块银屑病。
T9635	Cedirogant ABBV-157	ROR	Metabolism
	Cedirogant (ABBV-157) 是一种口服有活性的 RORγt 反向激动剂，可用于研究银屑病。
T12399	Peldesine BCX 34	Nucleoside Antimetabolite/Analog; HIV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Peldesine (BCX 34) 是一种有效的、竞争性的、可逆的和口服活性的嘌呤核苷磷酸化酶抑制剂。 Peldesine 抑制 T 细胞增殖，IC50 为 800 nM。 Peldesine 可用于皮肤 T 细胞淋巴瘤、牛皮癣和 HIV 感染的研究。
T14369	AZD-0284	ROR	Metabolism
	AZD-0284 是核受体 (RORγ) 的选择性反向激动剂。它对呼吸道疾病及斑块型寻常型银屑病具有潜在的应用价值。
T4050	GSK2981278 ROR gama modulator 1	ROR	Metabolism
	GSK2981278 (ROR gama modulator 1) 是 RORγ的选择性反向激动剂。它能够抑制 il17启动子的激活，并且干扰 RORγ-DNA 结合。
T1561	Clobetasol propionate Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725	Glucocorticoid Receptor; P450	Endocrinology/Hormones; Metabolism
	Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM)，而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇，对于牛皮癣和其他皮肤病具有潜在的研究价值。
T76779	Brodalumab LP 0160,KHK-4827,AMG-827	IL Receptor	Immunology/Inflammation
	Brodalumab (AMG 827) 是一种人源靶向白介素 17 受体 (IL-17R) IgG2 的单克隆抗体，常作为免疫抑制剂来治疗银屑病和牛皮藓。
T38105	Ixekizumab LY2439821	IL Receptor; Interleukin	Immunology/Inflammation
	Ixekizumab (LY2439821) 是一种人源化 IgG4 单克隆抗体，可选择性结合和中和白细胞介素 IL-17A ，Kd 值<3 pM。Ixekizumab 科阻断 IL-17A 与 IL-17RA 的结合，但不与其他 IL-17 家族成员结合。Ixekizumab 用于治疗中重度斑块型银屑病、银屑病关节炎和牛皮癣。
T62107	E-3620	5-HT Receptor	GPCR/G Protein; Neuroscience
	E-3620 是一种新型 5-HT3 受体拮抗剂，抑制顺铂诱导的比格犬呕吐。E-3620 可用于研究运动障碍、胃肠动力障碍、银屑病和牛皮癣。
T16802	Lonapalene RS4317	Lipoxygenase	Metabolism
	Lonapalene (RS4317) 是一种 5-脂氧合酶 (5-LO) 抑制剂，具有抗银屑病的功效。Lonapalene 可局部阻断皮肤炎症。
T68006	Orilotimod potassium APO805K1	Others	Others
	Orilotimod potassium (APO805K1)可用于研究斑块状银屑病。
T76784	Tildrakizumab MK 3222,SCH 900222	IL Receptor	Immunology/Inflammation
	Tildrakizumab (SCH 900222) 是一种有效的人源化抗-IL-23 (p19 亚基) 单克隆抗体。Tildrakizumab 靶向单链 IL-23 ，Kd 值为 136 pM。Tildrakizumab 可用于研究银屑病和牛皮癣。
T13911	Tacalcitol monohydrate Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate	Cysteine Protease	Proteases/Proteasome
	Tacalcitol monohydrate(Curatoderm monohydrate) 是一种维生素 D3 类似物，能通过调节钙离子促进骨发育，可用于研究银屑病。
T67943	RORγ inverse agonist 1	Others	Others
	RORγ inverse agonist 1具有抗炎活性，可用来治疗风湿和银屑病。
T83624	Selenium sulfide	Antibiotic	Microbiology/Virology
	Selenium sulfide 具有抗菌活性，常用于控制头皮屑、脂溢性皮炎和牛皮癣。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T28698	SC-22716 SC 22716,SC22716	Aminopeptidase	Metabolism
	SC-22716 是一种具有口服活性的白三烯 A4（LTA4）水解酶抑制剂。SC-22716 具有潜在的抗炎活性，可用于研究炎症性肠病和银屑病。
T25393	Etarotene RO15-1570,Arotinoid ethyl sulphone,RO-15-1570,RO 15-1570	Tyrosinase	Proteases/Proteasome
	Etarotene (Arotinoid ethyl sulphone) 是一种芦荟酸的乙基磺酰基衍生物，具有诱导分化和潜在的抗肿瘤活性。Etarotene 是一种胶原蛋白酶抑制剂，可用来研究银屑病。
T80800	WAY-616296	Others	Others
	WAY-616296 具有潜在的抗胆固醇活性，可用于研究糖尿病、高血压、银屑病和肥胖。
T76953	Xeligekimab GR 1501,GR-1501,GR1501	IL Receptor	Immunology/Inflammation
	Xeligekimab (GR 1501) 是一种选择性中和 IL-17A 的全人源单克隆抗体，具有潜在的抗炎活性，可用于研究斑块状银屑。
T24755	Salnacedin G-201,SCY,G-201,G201,SCY,G 201	Others	Others
	Salnacedin (G-201) 是一种小分子化合物，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究寻常痤疮、皮炎和银屑病。
T60052	BMS-905	TLR	Immunology/Inflammation
	BMS-905 是一种有效的 TLR7 和 TLR8 双重抑制剂，对 TLR9 和其他家族成员具有良好的特异性。 BMS-905可用于治疗牛皮癣、关节炎和狼疮等疾病的研究。
T71461	CPG-52364 CPG52364,CPG 52364	Others	Others
	CPG-52364 是一种在内体TLR与其配体之间相互作用的小分子化合物，是治疗银屑病的候选化合物。
T3620	Solcitinib 索西替尼,GLPG-0778,GSK-2586184	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Solcitinib (GLPG-0778) 是一种可口服的，选择性的竞争性JAK1抑制剂，IC50值为 9.8 nM，可用于银屑病的研究。它对其选择性是对 JAK2、JAK3 和 TYK2 的 11、55 和 23 倍。
T25080	Amiprilose SM1213,SM 1213,SM-1213	Antibacterial	Microbiology/Virology
	Amiprilose (SM 1213) 具有抗炎活性，抑制多种过度增殖细胞类型的增殖。Amiprilose 诱导淋巴因子诱导的巨噬细胞激活，可用于研究类风湿性关节炎和银屑病。
TQ0244	Calcipotriol monohydrate 钙泊三醇一水合物,卡泊三醇一水合物	Others	Others
	Calcipotriol monohydrate 是维生素 D3 的类似物，对维生素 D 受体具有高亲和力。Calcipotriol monohydrate 可用于银屑病研究。
T25130	Azaribine 2',3',5'-Tri-O-acetyl-6-azauridine,NSC 67239	Antiviral	Immunology/Inflammation
	Azaribine (2;,3;,5;-Tri-O-acetyl-6-azauridine) 是一种乳清碱单磷酸脱羧酶 (OMPD) 抑制剂，具有广谱的抗病毒活性，可抑制病毒基因组复制和基因转录。Azaribine 可用于研究寨卡病毒（ZIKV）感染，可用于研究银屑病关节炎和蕈样肉芽肿。
T2018	Apilimod 阿匹莫德,阿吡莫德,STA 5326	IL Receptor; PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Apilimod (STA 5326) 是一种有效的、高度选择性的PIKfyve 抑制剂，是一种 IL-12/IL-23 的有效抑制剂，抑制人和猴的 PBMC 细胞中的 IL-12，IC50值为 1 nM 和 2 nM。
T6696	Tazarotene 他扎罗汀,Tazorac,AGN 190168,Zorac	Retinoid Receptor; Autophagy	Autophagy; Metabolism
	Tazarotene (Zorac) 是一种选择性视黄酸受体激动剂，用于研究寻常痤疮和斑块状银屑病。
T37445	Etanercept	TNF	Apoptosis
	Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TNF biologically inactive. Etanercept has demonstrated efficacy in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
T77751	Imaprelimab PRX-003	Others	Others
	Imaprelimab (PRX-003) 是一种人源化抗黑素瘤细胞粘附分子 (MCAM) 的 IgG1κ 单克隆抗体。Imaprelimab 具有抗肿瘤活性，可用于研究炎症、肿瘤、银屑病。
T76747	Fletikumab Anti-IL-20,NN-8226,NNC 0109-0012	Interleukin	Immunology/Inflammation
	Fletikumab (NNC0109-0012) 是一种针对 IL-20 的单克隆抗体，常当作 IL-20 抑制剂使用。Fletikumab 可用于研究类风湿关节炎和银屑病。
T75113	GLPG2534 GLPG-2534	IRAK	Immunology/Inflammation; NF-κB
	GLPG2534 是一种具有口服活性、选择性和有效性的 IRAK4 抑制剂，具有抗炎活性。GLPG2534 对人和小鼠 IRAK4 具有抑制作用，可用于研究银屑病和特应性皮炎。
T76775	Fezakinumab ILV 094	Interleukin	Immunology/Inflammation
	Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。
T73578	JY-2	FOXO1	Apoptosis
	JY-2 是一种具有口服活性和选择性的叉头转录因子 O1 (FoxO1) 抑制剂，具有抗糖尿病活性，对 FoxO1 转录有抑制作用。JY-2 可用于研究银屑病和糖尿病。
T9930	Secukinumab 苏金单抗,司库奇尤单抗	IL Receptor	Immunology/Inflammation
	Secukinumab 是一种完全人源化的单克隆抗 IL-17A 抗体，是一个被美国食品和药物管理局批准用于治疗中度至重度斑块型银屑病的抗体。
T77685	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile	PDK	PI3K/Akt/mTOR signaling
	6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile 是一种 PDK1 抑制剂，具有抗癌和抗增殖活性，可用来研究血管肉瘤、腺癌、多骨髓瘤、牛皮癣、前列腺癌和和阿尔茨海默病。
T0500	Chloroxine Capitrol,氯喔星	Antibacterial; Antibiotic	Microbiology/Virology
	Chloroxine (Capitrol) 是重要的 8-羟基喹啉衍生物之一，有抗细菌，抗真菌，抗原生动物和抗阿米巴虫活性，可研究肠道阿米巴病，还可研究头皮屑和头皮脂溢性皮炎。
T37379	Protectin D1 Neuroprotectin D1,NPD1	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素，是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤，抑制咪喹莫特诱导的银屑病样皮肤炎症。
T68108L	Moxilubant HCl Moxilubant hcl(146978-48-5 Free base)	LTR	Immunology/Inflammation
	Moxilubant HCl 是一种小分子白三烯 B4 受体 1（LTB4R）拮抗剂，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究银屑病和类风湿关节炎。
T7188	Piclidenoson CF-101,IB-MECA	Apoptosis; Adenosine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Piclidenoson (CF-101) 是一种具有口服活性的，选择性的腺苷 A3 受体激动剂。它在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡的作用，可研究自身免疫性炎症疾病和 COVID-19。
T7370	Talarozole R115866,他拉罗唑	Others; P450; Retinoid Receptor; Autophagy	Autophagy; Metabolism; Others
	Talarozole (R115866) 是一种口服性全反式维甲酸代谢阻断剂，可抑制 CYP26A1 和 CYP26B1，IC50 分别为 5.4 和 0.46 nM。它用于治疗痤疮、牛皮癣和其他角化疾病。
T22091	Imiquimod hydrochloride R837 hydrochloride,R-837 hydrochloride,Imiquimod HCl,R 837 hydrochloride	TLR	Immunology/Inflammation
	Imiquimod hydrochloride (R 837 hydrochloride) 是一种选择性的 toll 样受体 7 (TLR7) 激动剂和免疫反应调节剂，具有抗病毒和抗肿瘤活性。Imiquimod hydrochloride 可用于研究天疱疮叶状疱疮、皮肤癌和银屑病。
T77491	Prezalumab AMG 557	Others	Others
	Prezalumab (AMG 557) 是一种针对 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 可用于研究干燥综合征皮肤红斑狼疮、银屑病、系统性红斑狼疮关节炎和系统性红斑狼疮 (SLE)。
T60921L	PF-07038124 HCl PF-07038124 HCl（2415085-44-6 Free base)	IL Receptor; PDE	Immunology/Inflammation; Metabolism
	PF-07038124 HCl 是一种具有选择性和高效性的 PDE4 抑制剂，对 PDE4B2 的 IC50 为0.5 nM。PF-07038124 HCl 抑制 IL-13、IL-4 和 IFNγ，可用于研究特应性皮炎和斑块状银屑病等皮肤疾病。
T77170	Siplizumab MEDI-507	Others	Others
	Siplizumab (MEDI-507) 是一种人源化靶向 CD2 的 IgG1 单克隆抗体。Siplizumab 在体外选择性地消耗效应记忆 T 细胞并促进同种异体反应性调节性 T 细胞的相对扩增。Siplizumab 可用于治疗斑块状银屑病。

化合物

Cat.No: T2548

Target: Glucocorticoid Receptor

Cat.No: T3481

Target: Topoisomerase

Clobetasone butyrate

Cat.No: T14981

Target: Glucocorticoid Receptor

Cat.No: T16832

Target: ROR

Tepilamide fumarate

Cat.No: T17038

Synonym: XP-23829

Target: Others

Cat.No: T9635

Synonym: ABBV-157

Target: ROR

Cat.No: T12399

Synonym: BCX 34

Target: Nucleoside Antimetabolite/Analog, HIV Protease

Cat.No: T14369

Target: ROR

Cat.No: T4050

Synonym: ROR gama modulator 1

Target: ROR

Clobetasol propionate

Cat.No: T1561

Synonym: Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725

Target: Glucocorticoid Receptor, P450

Cat.No: T76779

Synonym: LP 0160,KHK-4827,AMG-827

Target: IL Receptor

Cat.No: T38105

Synonym: LY2439821

Target: IL Receptor, Interleukin

Cat.No: T62107

Target: 5-HT Receptor

Cat.No: T16802

Synonym: RS4317

Target: Lipoxygenase

Orilotimod potassium

Cat.No: T68006

Synonym: APO805K1

Target: Others

Cat.No: T76784

Synonym: MK 3222,SCH 900222

Target: IL Receptor

Tacalcitol monohydrate

Cat.No: T13911

Synonym: Curatoderm monohydrate,TV 02 monohydrate,TV-02H monohydrate,1,24(R)-Dihydroxyvitamin D3 monohydrate

Target: Cysteine Protease

RORγ inverse agonist 1

Cat.No: T67943

Target: Others

Selenium sulfide

Cat.No: T83624

Target: Antibiotic

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Cat.No: T28698

Synonym: SC 22716,SC22716

Target: Aminopeptidase

Cat.No: T25393

Synonym: RO15-1570,Arotinoid ethyl sulphone,RO-15-1570,RO 15-1570

Target: Tyrosinase

Cat.No: T80800

Target: Others

Cat.No: T76953

Synonym: GR 1501,GR-1501,GR1501

Target: IL Receptor

Cat.No: T24755

Synonym: G-201,SCY,G-201,G201,SCY,G 201

Target: Others

Cat.No: T60052

Target: TLR

Cat.No: T71461

Synonym: CPG52364,CPG 52364

Target: Others

Cat.No: T3620

Synonym: 索西替尼,GLPG-0778,GSK-2586184

Target: JAK

Cat.No: T25080

Synonym: SM1213,SM 1213,SM-1213

Target: Antibacterial

Calcipotriol monohydrate

Cat.No: TQ0244

Synonym: 钙泊三醇一水合物,卡泊三醇一水合物

Target: Others

Cat.No: T25130

Synonym: 2',3',5'-Tri-O-acetyl-6-azauridine,NSC 67239

Target: Antiviral

Cat.No: T2018

Synonym: 阿匹莫德,阿吡莫德,STA 5326

Target: IL Receptor, PI3K, Interleukin

Cat.No: T6696

Synonym: 他扎罗汀,Tazorac,AGN 190168,Zorac

Target: Retinoid Receptor, Autophagy

Cat.No: T37445

Target: TNF

Cat.No: T77751

Synonym: PRX-003

Target: Others

Cat.No: T76747

Synonym: Anti-IL-20,NN-8226,NNC 0109-0012

Target: Interleukin

Cat.No: T75113

Synonym: GLPG-2534

Target: IRAK

Cat.No: T76775

Synonym: ILV 094

Target: Interleukin

Cat.No: T73578

Target: FOXO1

Cat.No: T9930

Synonym: 苏金单抗,司库奇尤单抗

Target: IL Receptor

6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile

Cat.No: T77685

Target: PDK

Cat.No: T0500

Synonym: Capitrol,氯喔星

Target: Antibacterial, Antibiotic

Cat.No: T37379

Synonym: Neuroprotectin D1,NPD1

Target: Akt, PI3K

Cat.No: T68108L

Synonym: Moxilubant hcl(146978-48-5 Free base)

Target: LTR

Cat.No: T7188

Synonym: CF-101,IB-MECA

Target: Apoptosis, Adenosine Receptor

Cat.No: T7370

Synonym: R115866,他拉罗唑

Target: Others, P450, Retinoid Receptor, Autophagy

Imiquimod hydrochloride

Cat.No: T22091

Synonym: R837 hydrochloride,R-837 hydrochloride,Imiquimod HCl,R 837 hydrochloride

Target: TLR

Cat.No: T77491

Synonym: AMG 557

Target: Others

PF-07038124 HCl

Cat.No: T60921L

Synonym: PF-07038124 HCl（2415085-44-6 Free base)

Target: IL Receptor, PDE

Cat.No: T77170

Synonym: MEDI-507

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1525	Convallatoxin K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷	NF-κB; P-gp; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Convallatoxin 是从铃兰分离得到的一种强心苷。它是 P-糖蛋白底物，并识别 Val982 是参与其转运的重要氨基酸。它是配体诱导的 MOR 胞吞作用的增强剂，通过激活PPARγ和抑制NF-κB 改善结肠炎，具有抗炎和抗增殖特性。
T4644	Tapinarof GSK2894512,Benvitimod,苯烯莫德,WBI 1001	AhR; Aryl Hydrocarbon Receptor	Immunology/Inflammation; Metabolism
	Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物，可消除炎症。它是芳烃受体 (AhR) 激动剂，EC50为 13 nM。
T1330	Acitretin 阿曲汀,Ro 10-1670,Etretin	Apoptosis; Retinoid Receptor; Autophagy	Apoptosis; Autophagy; Metabolism
	Acitretin (Ro 10-1670) 是一种维甲酸，可用于银屑病和阿尔兹海默症的研究。
T1068	Dithranol 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Dithranol (cignoline) 是蒽醌衍生物，可破坏线粒体功能和结构，用于治疗皮肤病。
TN6908	Polyporusterone A (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one
	Polyporusterone A 是一种从 P. umbellatus 的子实体中提取出来的三萜羧酸。Polyporusterone A 抑制自由基诱导的红细胞裂解 (溶血) ，可用于研究头发再生和牛皮癣。
TMA0394	Methyl tanshinonate	Antifection	Microbiology/Virology
	Methyl tanshinonate has antioxidant activity, it can treat psoriasis.
T40859	5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen	Others	Others
	5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.
T75486	Toddacoumalone	Others	Others
	Toddacoumalone 是一种天然PDE4 (磷酸二酯酶 4) 抑制剂，效力中等，活性分子特性不完善。具有研究银屑病等炎症性疾病潜力。

天然产物

Cat.No: TN1525

Synonym: K-毒毛旋花子配质-3-L-鼠李糖甙,铃兰毒苷

Target: NF-κB, P-gp, PPAR

Cat.No: T4644

Synonym: GSK2894512,Benvitimod,苯烯莫德,WBI 1001

Target: AhR, Aryl Hydrocarbon Receptor

Cat.No: T1330

Synonym: 阿曲汀,Ro 10-1670,Etretin

Target: Apoptosis, Retinoid Receptor, Autophagy

Cat.No: T1068

Synonym: 1,8,9-trihydroxyanthracene,cignoline,蒽林,Anthralin

Target: Others, DNA/RNA Synthesis

Polyporusterone A

Cat.No: TN6908

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R,5S)-2,3-dihydroxy-5,6-dimethylheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Methyl tanshinonate

Cat.No: TMA0394

Target: Antifection

5-Hydroxy-8-methoxypsoralen

Cat.No: T40859

Synonym: 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen

Target: Others

Cat.No: T75486

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02174	FABP5 Protein, Human, Recombinant PA-FABP,E-FABP,fatty acid binding protein 5 (psoriasis	Human	E. coli
	Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein which Belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid-binding proteins ( FABPs ) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. E-FABP / FABP5 is pre...
TMPJ-01073	FABP5 Protein, Human, Recombinant (His) Fatty Acid-Binding Protein Epidermal,PA-FABP,FABP5,Psori...	Human	E. coli
	Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP5 can be expressed in keratinocytes, and is highly expressed in psoriatic skin. FABP5 has been shown to be involved in keratinocyte differentiation. FABP5 has high specificity for fatty acids, the highest affinity for C18 chain...
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPJ-01189	S100A15A Protein, Mouse, Recombinant Protein S100-A15A,S100 calcium-binding protein A7A,Protein S...	Mouse	E. coli
	Members of the S100 protein family are involved in calcium- or zinc-dependent cellular functions and regulate immune-mechanisms, cell proliferation and differentiation. Some S100 members have been established as tumor markers because they are dysregulated during carcinogenesis. Psoriasin (S100A7) and koebnerisin (S100A15) are highly homologous proteins that have been first described in psoriasis, which is characterized by disturbed epidermal maturation and chronic inflammation. Several studies s...
TMPH-01951	S100A7A Protein, Human, Recombinant (His) Protein S100-A7A,S100A7A,S100 calcium-binding protein A7A,S1...	Human	P. pastoris (Yeast)
	May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases. S100A7A Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 13.2 kDa and the accession number is Q86SG5.
TMPY-04984	CXCL17 Protein, Human, Recombinant (His) Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligand 17,VCC-...	Human	P. pastoris (Yeast)
	Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski...
TMPK-01029	IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His) C3orf13,IL1RAP,IL-1 R3,IL-1 RAcP	Mouse	HEK293 Cells
	Interleukin (IL)-1R3 is the co-receptor in three signaling pathways that involve six cytokines of the IL-1 family (IL-1α, IL-1β, IL-33, IL-36α, IL-36β and IL-36γ). In many diseases, multiple cytokines contribute to disease pathogenesis. For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
TMPY-02497	S100A15 Protein, Mouse, Recombinant (His & MBP) S100a17l1,Gm1020,S100a15a,AY465109,S100A7f,S100A7L1,S100 cal...	Mouse	E. coli
	Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF-hand calcium-binding proteins and was recently identified in psoriasis, where it is significantly upregulated in lesional skin. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesti...
TMPJ-01312	TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc) Fibroblast growth factor-regulated protein 2,TNFRSF12,Tumor ...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inf...
TMPJ-00544	Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His) PRSS6,Serine Protease 6,hK7,Stratum Corneum Chymotryptic Enz...	Human	HEK293 Cells
	Human Kallikrein 7 is a member of the tissue kallikrein family of extracellular serine proteases that is made up of 15 members. It is predominantly expressed in the skin. A major physiological function of Kallikrein 7 is to regulate the desquamation process (the shedding of corneocytes from the outer layer of the epidermis) through proteolysis of the intercellular adhesive structures between corneocytes. Dysregulation of Kallikrein 7 has been linked to several inflammatory skin diseases includin...
TMPK-00668	IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His) NILR,IL-21 receptor,IL-21R,CD360	Cynomolgus	HEK293 Cells
	IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker i...
TMPY-01346	Psoriasin/S100A7 Protein, Human, Recombinant S100 calcium binding protein A7,PSOR1,S100A7c	Human	E. coli
	Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role...
TMPJ-00351	IL-23R Protein, Human, Recombinant (aa 24-353, hFc) IL-23 receptor,IL23R,Interleukin-23 receptor,IL-23R	Human	HEK293 Cells
	Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I...
TMPJ-01219	IL-23R Protein, Mouse, Recombinant (hFc) Il23r,IL-23R,interleukin 23 receptor,Interleukin-23 receptor...	Mouse	HEK293 Cells
	Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an...
TMPY-02163	PGLYRP1 Protein, Mouse, Recombinant (His) Tnfsf3l,peptidoglycan recognition protein 1,PGRP,Tasg7,Tag7,...	Mouse	HEK293 Cells
	Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 / PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1 / PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-posi...

重组蛋白

FABP5 Protein, Human, Recombinant

Cat.No: TMPY-02174

Species: Human

Expression System: E. coli

FABP5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01073

Species: Human

Expression System: E. coli

TNF beta Protein, Human, Recombinant

Cat.No: TMPY-02153

Species: Human

Expression System: E. coli

S100A15A Protein, Mouse, Recombinant

Cat.No: TMPJ-01189

Species: Mouse

Expression System: E. coli

S100A7A Protein, Human, Recombinant (His)

Cat.No: TMPH-01951

Species: Human

Expression System: P. pastoris (Yeast)

CXCL17 Protein, Human, Recombinant (His)

Cat.No: TMPY-04984

Species: Human

Expression System: P. pastoris (Yeast)

IL-1RAP/IL-1RAcP Protein, Mouse, Recombinant (aa 21-367, His)

Cat.No: TMPK-01029

Species: Mouse

Expression System: HEK293 Cells

S100A15 Protein, Mouse, Recombinant (His & MBP)

Cat.No: TMPY-02497

Species: Mouse

Expression System: E. coli

TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01312

Species: Mouse

Expression System: HEK293 Cells

Kallikrein 7/KLK7 Protein, Human, Recombinant (aa 23-252, His)

Cat.No: TMPJ-00544

Species: Human

Expression System: HEK293 Cells

IL-21R Protein, Cynomolgus, Recombinant (aa 41-254, His)

Cat.No: TMPK-00668

Species: Cynomolgus

Expression System: HEK293 Cells

Psoriasin/S100A7 Protein, Human, Recombinant

Cat.No: TMPY-01346

Species: Human

Expression System: E. coli

IL-23R Protein, Human, Recombinant (aa 24-353, hFc)

Cat.No: TMPJ-00351

Species: Human

Expression System: HEK293 Cells

IL-23R Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01219

Species: Mouse

Expression System: HEK293 Cells

PGLYRP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02163

Species: Mouse

Expression System: HEK293 Cells

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