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Compound 4o (Anti-inflammatory agent 91) 作为一种抗炎剂,通过抑制STAT3和NF-κB信号通路,有效降低炎性细胞因子的表达.此外,该化合物在研究银屑病相关的皮肤炎症中展示了其潜在应用价值.
Compound 4o (Anti-inflammatory agent 91) 作为一种抗炎剂,通过抑制STAT3和NF-κB信号通路,有效降低炎性细胞因子的表达.此外,该化合物在研究银屑病相关的皮肤炎症中展示了其潜在应用价值.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Anti-inflammatory agent 91 (Compound 4o) is a chemical compound known for its efficacy in reducing inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. It is utilized in research to study its potential in ameliorating skin inflammation associated with psoriasis. |
体外活性 | Anti-inflammatory agent 91(Compound 4o)(10-80 μM; 24 h)对 HaCaT 细胞活力无明显影响.在 LPS (1 μg/mL; 24 h) 诱导的 RAW264.7 和 HaCaT 细胞模型中,Anti-inflammatory agent 91在 (10-40 μM; 2 h) 范围内显著抑制 NO (IC 50 = 19.5 μM)、TNF-α与 IL-6 (仅限RAW264.7)以及 IL-17A (仅限HaCaT),显示出其抗炎效果. |
体内活性 | 抗炎药物91(Compound 4o)(25-100 mg/kg;局部涂抹,每日一次,持续5天)在由咪喹莫特诱发的银屑病小鼠模型中,通过抑制炎症相关细胞因子显著改善了银屑病症状. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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