losartan

Losartan (DuP-753) 是一种血管紧张素II 受体拮抗剂，能够与血管紧张素II 竞争性结合AT1受体(IC50:20 nM)。

Losartan potassium (DuP-753 potassium) 是一种血管紧张素 II 受体 1 型(AT1)拮抗剂，能够与血管紧张素 II 与 AT1 的结合竞争,其 IC50=20 nM。

Losartan Carboxaldehyde 是氯沙坦的中间醛代谢产物。它不能阻断 AT1-R ，但可以抑制内皮环氧合酶 (COX)-2 的表达，起到抗炎作用。

Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。

Losartan potassium impurity E is a compound of Valsartan impurity.

Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.

Losartan D4 Carboxylic Acid is the deuterium labeled Losartan, which is an angiotensin II receptor antagonist.

Losartan D4, the deuterium-labeled version of Losartan, functions as an angiotensin II receptor antagonist. It inhibits the interaction between angiotensin II and AT1 receptors by competing for binding, achieving an IC50 value of 20 nM.

Trityllosartan is an intermediate in the preparation of Losartan.

Antihypertensive agent 2 (Compound 4g) 为一种有效的血管紧张素 II 受体 1 拮抗剂，其降血压效能可与Losartan媲美或更胜一筹。