规格

价格

库存

数量

50 mg

¥ 115

现货

100 mg

¥ 153

现货

500 mg

¥ 328

现货

1 g

¥ 418

现货

5 g

¥ 993

现货

10 g

¥ 1,460

现货

1 mL x 10 mM (in DMSO)

¥ 413

现货

生物活性

产品描述	Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor.
靶点活性	AT1 receptor:20 nM
体外活性	Losartan 与血管紧张素II竞争性地结合AT1受体。其抑制血管紧张素II结合50%所需浓度（IC50）为20 nM[1]。Losartan （40μM）影响ISC，但可阻止ANGII对ISC的作用[2]。Losartan 显著降低血管紧张素II介导的子宫内膜癌细胞增殖。Losartan 与抗miR-155联合使用，相比单药治疗具有更显著的抑制增殖效果[3]。
细胞实验	An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.
别名	洛沙坦钾, 氯沙坦钾, MK 954, DuP-753 potassium, DuP 753

化学信息

分子量	461.01
分子式	C₂₂H₂₂ClKN₆O
CAS No.	124750-99-8
Smiles	[K+].CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[n-]1
密度	0.986?g/mL?at 25?°C(lit.)

储存&溶解度

存储

溶解度信息

H2O: 46.1 mg/mL (100 mM), Sonication is recommended.

DMSO: 250 mg/mL (542.29 mM), Sonication is recommended.

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1692 mL	10.8458 mL	21.6915 mL	108.4575 mL
5 mM	0.4338 mL	2.1692 mL	4.3383 mL	21.6915 mL
10 mM	0.2169 mL	1.0846 mL	2.1692 mL	10.8458 mL
20 mM	0.1085 mL	0.5423 mL	1.0846 mL	5.4229 mL
50 mM	0.0434 mL	0.2169 mL	0.4338 mL	2.1692 mL
100 mM	0.0217 mL	0.1085 mL	0.2169 mL	1.0846 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Losartan potassium

Losartan potassium

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词

Losartan potassium

Losartan potassium

Losartan potassium 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

关键词