201
16
96
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40317 |
α/β-Hydrolase-IN-1
|
Others | Others |
α/β-Hydrolase-IN-1 demonstrates exceptional potency, with MICs of 50 μM (25 μg/mL) against M. smegmatis and 16 μM (8.4 μg/mL) against M. tuberculosis H37Ra, establishing it as a superior compound in this class. | |||
T12974 |
Soluble epoxide hydrolase inhibitor
|
Others | Others |
Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4). | |||
T83857 |
Soluble Epoxide Hydrolase PROTAC 1a
sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a |
Others | Others |
Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术,通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解,特异性抑制sEH的水解酶活性(IC50 = 0.8 nM),相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解,并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接,表明能减少ER应激。 | |||
T75409 |
Nucleoside hydrolase (IAGNH)
|
Others | Others |
Nucleoside hydrolase (IAGNH)为一种糖苷酶,专门催化核苷中N-糖苷键的裂解,从而促进核碱基与Rib的循环利用。 | |||
T7898 |
AUDA
|
Epoxide Hydrolase | Metabolism |
AUDA 是可溶性环氧化物水解酶 (sEH) 抑制剂,在小鼠和人 sEH 的IC50分别为 18 和 69 nM,具有抗炎特性。 | |||
T78174 |
Serine Hydrolase inhibitor-21
|
Others | Others |
Serine Hydrolase inhibitor-21(化合物8)为一种抑制丝氨酸水解酶的吡啶类化合物,其对BuChE的Ki值为429 nM,有望用于阿尔茨海默病的研究。 | |||
T7199 |
TPPU
|
Epoxide Hydrolase | Metabolism |
TPPU 是一种可溶性环氧化物水解酶(sEH)抑制剂,对猴子和人类的IC50分别为37和3.7 nM。 | |||
T6043 |
PF-3845
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
PF3845 是一种有效的、选择性的和不可逆的脂肪酸酰胺水解酶(FAAH)抑制剂,Ki 为 230 nM。它是将 FAAH 的丝氨酸亲核试剂氨基甲酸酯化的共价抑制剂,可以减少疼痛感、炎症和焦虑或抑郁。 | |||
T14557 |
BI-1935
|
Epoxide Hydrolase | Metabolism |
BI-1935 是可溶性环氧化物水解酶抑制剂,用于与心血管疾病相关的疾病的研究。 | |||
T10900 |
CUDA
|
PPAR; Epoxide Hydrolase | DNA Damage/DNA Repair; Metabolism |
CUDA 是一种可溶性环氧水解酶抑制剂,对小鼠 sEH 和人 sEH 作用的 IC50分别为 11.1 和 112 nM。它能选择性地上调过氧化物酶体增殖激活受体 PPARα的活性,有用于心血管疾病的研究潜力。 | |||
T17158 |
trans-AUCB
t-AUCB |
Epoxide Hydrolase | Metabolism |
trans-AUCB (t-AUCB) 是口服具有活力的、选择性的可溶性环氧水解酶 (sEH) 抑制剂,对人,小鼠和大鼠的 sEH 的IC50分别为 1.3 nM,8 nM,8 nM。它具有抗神经胶质瘤特性。 | |||
T14315 |
AR-9281
APAU |
Epoxide Hydrolase | Metabolism |
AR-9281 (APAU) 是选择性的可溶性环氧化物水解酶抑制剂,可用于研究高血压和 2 型糖尿病。 | |||
T2684 |
JNJ-1661010
JNJ1661010,Takeda-25,JNJ 1661010 |
FAAH | Metabolism; Neuroscience |
JNJ-1661010 (Takeda-25) 是一种有效的、选择性的、可以穿透血脑屏障的脂肪酸酰胺水解酶 (FAAH) 抑制剂,对大鼠和人 FAAH 的 IC50分别为 34 和 33 nM,可用于缓解疼痛的研究。 | |||
T11147 |
EC5026
BPN-19186 |
Epoxide Hydrolase | Metabolism |
EC5026 (BPN-19186) 是首创的,非阿片类的,可溶性环氧水解酶 (sEH) 抑制剂,它可有效缓解发炎性和神经性疼痛。 | |||
T28353 |
PDP-EA
|
FAAH | Metabolism; Neuroscience |
PDP-EA 是脂肪酸酰胺水解酶 (FAAH) 的激活剂,可增强 FAAH 的酰胺水解酶活性。 | |||
T9967 |
MAGL-IN-5
|
Lipid | Metabolism |
MAGL-IN-5 是一种非选择性脂肪酶抑制剂。 | |||
T17196 |
UC-1728
t-TUCB |
Epoxide Hydrolase | Metabolism |
UC-1728 (t-TUCB) 是一种兔子可溶性环氧化物水解酶抑制剂,兔子肝脏中测得其IC50=2 nM。 | |||
T9374 |
AA38-3
1-Piperidinecarboxylic acid, 4-nitrophenyl ester |
FAAH; Lipase; MAGL | Metabolism; Neuroscience |
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) 是丝氨酸水解酶抑制剂,能够抑制三种 SHs:ABHD6,ABHD11 和 FAAH。 | |||
T8844 |
Diflapolin
|
Others; FLAP; Epoxide Hydrolase | Immunology/Inflammation; Metabolism; Others |
Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂,具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性,IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成,IC50分别为 30 和 170 nM。 | |||
T2338 |
JZL195
|
FAAH; Lipase; Autophagy | Autophagy; Metabolism; Neuroscience |
JZL195 是一种选择性有效的脂肪酸酰胺水解酶和单酰甘油脂肪酶双重抑制剂,IC50s 分别为 2 和 4 nM。 | |||
T3215 |
JNJ-42165279
JNJ42165279 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
JNJ-42165279 是一种 FAAH 抑制剂,抑制 hFAAH 和 rFAAH,IC50分别为70 ± 8 nM 和 313 ± 28 nM。它对其他酶、离子通道、转运蛋白和受体具有高度选择性。 | |||
T7688 |
4-Nonylphenylboronic acid
|
FAAH | Metabolism; Neuroscience |
4-Nonylphenylboronic acid 是 FAAH 的抑制剂。 | |||
T8927 |
WWL 154
WWL-154 |
FAAH | Metabolism; Neuroscience |
WWL 154 是一种丝氨酸水解酶 (SH) 和脂肪酸酰胺水解酶 FAAH-4 抑制剂。 | |||
T4323 |
PF-04457845
PF04457845,PF 04457845 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
PF-04457845 是一种非常有效的选择性 FAAH 抑制剂,作用于 rFAAH 和 hFAAH,IC50分别为 7.4±0.62 nM 和 7.2±0.63 nM。 | |||
T8646 |
URB937
|
FAAH | Metabolism; Neuroscience |
URB937 是一种口服具有活性的、外周限制的FAAH 抑制剂,IC50=26.8 nM,可增加 anandamide 水平,但不能影响脑内 FAAH 水平 (无法透过血脑屏障)。 | |||
T21859 |
ARM1
|
Aminopeptidase; Epoxide Hydrolase | Metabolism |
ARM1 是氨基肽酶和环氧化物水解酶抑制剂,IC50分别为为7.61 µM 和12.4 µM。 | |||
T15802 |
LY2183240
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性,IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶,对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。 | |||
T1325 |
Carprofen
卡洛芬,Ridamyl,Imadyl,Rimadyl |
FAAH; COX; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; Neuroscience |
Carprofen (Ridamyl) 是多靶点FAAH/COX 抑制剂,能够抑制 COX-2,COX-1 和 FAAH 的活性,IC50值分别为 3.9 μM,22.3 μM 和 78.6 μM。它是一种丙酸衍生物和非甾体抗炎药,具有抗炎、镇痛和解热活性。 | |||
T3354 |
BIA 10-2474
BIA10-2474 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
BIA 10-2474 是一种长效可逆的脂肪酸酰胺水解酶抑制剂,与人类内源性大麻素系统相互作用,可增加中枢神经系统和外周组织,对大鼠大脑不同区域的 IC50值为50至70mg/kg。它用于治疗焦虑症、帕金森氏病和多发性硬化症、高血压或肥胖症的慢性疼痛。 | |||
T15430 |
GSK2256294A
GSK 2256294 |
Others; Epoxide Hydrolase | Metabolism; Others |
GSK2256294A (GSK 2256294) 是重组人、大鼠和小鼠 sEH 的有效特异性抑制剂,IC50 分别为 27 pM、61 pM 和 189 pM。 | |||
T6697 |
TCID
UCH-L3 Inhibitor |
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
TCID (UCH-L3 Inhibitor) 是一种有效的选择性神经元泛素 C 末端水解酶 L3 的 DUB 抑制剂,IC50为 0.6 μM。它对 L1 具有 125 倍的选择性,可减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。 | |||
T0355 |
Valpromide
Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide |
Epoxide Hydrolase; HSV | Metabolism; Microbiology/Virology |
Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物,用于治疗癫痫和一些情感障碍。 | |||
T21696 |
SC-57461A
N -甲基- N -[3 - [4 - (苯甲基)苯氧基]丙基Β-丙氨酸盐酸盐 |
Aminopeptidase | Metabolism |
SC-57461A 是一种口服有活力的非肽类白三烯 A4 (LTA4) 水解酶选择性抑制剂,它能够抑制重组人 (IC50: 2.5 nM) 、小鼠 (IC50: 3 nM) 和小鼠LTA4水解酶 (IC50: 23 nM) 。 | |||
T11256 |
FAAH inhibitor 1
Benzothiazole analog 3 |
FAAH | Metabolism; Neuroscience |
FAAH inhibitor 1 (Benzothiazole analog 3) 是一种有效的脂肪酸酰胺水解酶抑制剂,IC50 为 18 nM。 | |||
T15268 |
FAAH-IN-2
O-Desmorpholinopropyl Gefitinib,4-(3-氯-4-氟苯氨基)-7-甲氧基喹唑啉-6-醇 |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) 是一种脂肪酸酰胺水解酶的有效抑制剂。 | |||
T8315 |
1-Cyclohexyl-3-dodecyl urea
CDU,N-Cyclohexyl-N-dodecyl urea,NCND |
Epoxide Hydrolase | Metabolism |
1-Cyclohexyl-3-dodecyl urea (NCND) 是高选择性的可溶性环氧化物水解酶 (sEH) 抑制剂,能够增强血管紧张素 II (Ang II) 高血压中的环氧二十碳三烯酸 (EETs) 水平,并降低血压。 | |||
T6714 |
URB-597
KDS-4103,FAAH Inhibitor II |
Mitophagy; FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
URB-597 (FAAH Inhibitor II) 是一种可口服的选择性FAAH 抑制剂。 它抑制大鼠脑膜、体外大鼠神经元和人肝微粒体中的 FAAH 活性,IC50分别为 5、0.5和 3 nM。它具有抗抑郁样作用,可研究缓解疼痛。 | |||
T23044 |
N,N'-Dicyclohexylurea
DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582,N,N-二环己脲 |
Epoxide Hydrolase | Metabolism |
N,N'-Dicyclohexylurea (AURORA KA-3582) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂。 | |||
T13529 |
Acetylhydrolase-IN-1
|
Others | Others |
Acetylhydrolase-IN-1 is an inhibitor of the esterase 1-Alkyl-2-acetylglycerophosphocholine (Alkylacetyl-GPC: acetylhydrolase). | |||
T10111 |
3-Deazaadenosine hydrochloride
|
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂,Ki 值为 3.9 µM。 它具有抗炎、抗增殖和抗 HIV 活性。 | |||
T8994 |
ML-226
ML226,ML-226 |
MAGL | Metabolism |
ML226 是 α/β hydrolase domain-containing protein 11 抑制剂,体外和原位的 IC50s 分别为 15 和 0.68 nM。 | |||
T22883 |
JW 480
|
Others | Others |
JW 480 是一种有效的丝氨酸水解酶 KIAA1363选择性抑制剂。 | |||
T2716 |
1,3-Diphenylurea
|
Epoxide Hydrolase | Metabolism |
1,3-Diphenylurea 与环氧化物水解酶活性有关。 | |||
T17260 |
WWL70
|
Lipase; MAGL | Metabolism |
WWL70 是选择性 α/β 水解酶结构域 6 抑制剂,其IC50=70 nM。 | |||
TQ0047 |
DG051
|
Aminopeptidase | Metabolism |
DG051 是有效的白三烯 A4 水解酶抑制剂,IC50=47 nM。 | |||
T63536 |
Dual FAAH/sEH-IN-1
|
FAAH; Epoxide Hydrolase | Metabolism; Neuroscience |
Dual FAAH/sEH-IN-1 是具有高度亲和力的sEH(可溶性环氧水解酶) (IC50: 9.6 nM) 和FAAH(脂肪酸酰胺水解酶) (IC50: 7 nM) 双重抑制剂,具有抗炎活性。 | |||
T15416 |
GR148672X
4,4,4-三氟-1-(2-噻吩基)-1,2,3-丁三酮 2-[(3-甲基苯基)腙] |
Others | Others |
GR148672X 是三酰甘油水解酶抑制剂(IC50:4 nM)。 | |||
T15635 |
JZP-430
|
Lipase; MAGL | Metabolism |
JZP-430 是不可逆的、高度选择性的 α/β 水解酶结构域 6 抑制剂,能够靶向抑制人类 ABHD6 ,其 IC50=44 nM。 | |||
T23602 |
ABC99
ABC 99,ABC-99 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
ABC99是 wnt 脱酰基酶的一种选择性不可逆抑制剂。ABC99抑制 NOTUM(IC50:13 nM)。它还显示了对丝氨酸水解酶家族的优良选择性。 | |||
T3715 |
Acebilustat
阿西鲁司特,CTX-4430 |
Aminopeptidase; LTR | Immunology/Inflammation; Metabolism |
Acebilustat (CTX-4430) 是一种具有口服活性的白三烯 A4 水解酶抑制剂,可用于炎症研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6794 |
N-(3-methoxybenzyl)-octadecanamide
|
Others | Others |
N-(3-methoxybenzyl)-octadecanamide 从玛卡 (Lepidium meyenii Walp.) 转化而来。 | |||
T2859 |
Biochanin A
4-Methylgenistein,鹰嘴豆芽素A,Olmelin |
EGFR; FAAH; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors |
Biochanin A (4-Methylgenistein) 是一种从红三叶车轴草中分离出来的异黄酮衍生物,具有抗癌特性。它是脂肪酸酰胺水解酶抑制剂,作用于小鼠、大鼠和人 FAAH,IC50分别为 1.8、1.4 和 2.4 μM。 | |||
TN1965 |
N-Benzyllinolenamide
N-苄基-(9Z,12Z,15Z)-十八碳三烯酰胺,N-Benzyllinolenamide |
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
N-Benzyllinolenamide 是从玛卡中得到的一种生物碱,是脂肪酰胺水解酶抑制剂,IC50 为 41.8 μM。 | |||
T12139 |
N-(3-Methoxybenzyl)Palmitamide
N-(3-甲氧基苄基)十六碳酰胺,玛卡酰胺杂质5 |
FAAH | Metabolism; Neuroscience |
N-(3-Methoxybenzyl)Palmitamide 是FAAH 抑制剂,可用于研究疼痛,炎症和中枢神经系统退行性疾病。 | |||
T3S2105 |
N-Benzylpalmitamide
Macamide 1,玛卡酰胺 B,N-苄基十六烷酰胺,N-Benzylhexadecanamide |
Others; FAAH; Autophagy | Autophagy; Metabolism; Neuroscience; Others |
N-Benzylpalmitamide (Macamide 1) 是从玛卡中得到的一种生物碱,可以时间依赖性方式抑制脂肪酸酰胺水解酶,有治疗疼痛、炎症和中枢神经系统退行性疾病的研究潜力。 | |||
T4859 |
1-Monomyristin
rac-Glycerol 1-myristate,Glyceryl myristate,1-肉豆蔻酸单甘油酯,肉豆寇酸单甘油酯,Monomyristin,2,3-Dihydroxypropyl tetradecanoate |
Others; FAAH; Endogenous Metabolite; Antibacterial; Autophagy; Antifungal | Autophagy; Metabolism; Microbiology/Virology; Neuroscience; Others |
1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) 是从 Serenoa repens 中提取的,抑制脂肪酸酰胺水解酶活性(IC50=18 μM) 和 2-油酰甘油的水解 (IC50=32 μM)。它对白色念珠菌有抗真菌活性,对金黄色葡萄球菌和聚集性放线菌有抗菌活性。 | |||
T19615 |
α-Amylase
|
Amylase | Metabolism |
α-Amylase 是一种能够催化淀粉中 α-1,4-糖苷键水解的水解酶,使淀粉产生葡萄糖、麦芽糖等产物。 | |||
T16075 |
(Rac)-Idroxioleic acid
2-Hydroxyoleic acid,2-OHOA,2-羟基乳清酸,Minerval |
Apoptosis | Apoptosis |
(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种具有抗肿瘤作用的脂肪酸酰胺水解酶抑制剂。 它与质膜结合并改变脂质组织。 | |||
T3529 |
Bestatin hydrochloride
盐酸乌苯美司,Ubenimex hydrochloride,苯丁抑制素 |
Integrin; Aminopeptidase; Antibacterial; Antibiotic | Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Bestatin hydrochloride (Ubenimex hydrochloride) 是CD13(Aminopeptidase N)/APN 和leukotriene A4 hydrolase 抑制剂,可研究癌症。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
TN1761 |
Ikarisoside F
|
Others | Others |
Ikarisoside F and epimedin A can bind to AdoHcy hydrolase, inhibit the activity of AdoHcy hydrolase, thus regulating the cellular biomethylation as well as reducing cellular Hcy level. | |||
T62258 |
Bestatin trifluoroacetate
|
Others | Others |
Bestatin trifluoroacetate (Ubenimex trifluoroacetate) 是一种 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,经常用于研究癌症。 | |||
TN7377 |
Methyl ganoderate A
|
Others | Others |
Methyl ganoderate A, an inhibitor of Farnesyl protein transferase (FPT) with an IC50 of 38 µM, exhibits potential anticancer effects. Additionally, it inhibits fatty acid amide hydrolase (FAAH), further underscoring its therapeutic potential. | |||
T10369 |
Aristeromycin
U 99468 |
Antiviral | Immunology/Inflammation |
Aristeromycin (U 99468) 是一种靶向RNA病毒且具有广谱抗病毒作用的抗生素,是S-腺苷同型半胱氨酸水解酶 (AHCY) 抑制剂。 | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
Others | Others |
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
TN4592 |
Murrangatin
|
IL Receptor; TNF; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, |
Cat. No. | Product Name | Species | Expression System |
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TMPY-05055 |
GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)
GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase |
Human | HEK293 Cells |
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. | |||
TMPY-00877 |
Leukotriene A4 Hydrolase Protein, Human, Recombinant (His)
LAT4,leukotriene A4 hydrolase |
Human | Baculovirus Insect Cells |
Leukotriene A4 Hydrolase Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is A0A140VK27. | |||
TMPY-01658 |
Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His)
Lta4h,leukotriene A4 hydrolase |
Mouse | Baculovirus Insect Cells |
Leukotriene A4 Hydrolase Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is P24527. | |||
TMPH-02482 |
HIU hydrolase Protein, Mouse, Recombinant (His & Myc)
Transthyretin-related protein,5-hydroxyisourate hydrolas... |
Mouse | E. coli |
Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU). HIU hydrolase Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.6 kDa and the accession number is Q9CRB3. | |||
TMPY-00381 |
PSMA Protein, Human, Recombinant (His)
FGCP,GCP2,PSMA,GCPII,NAALAdase,folate hydrolase (pr... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.86 kDa and the accession number is Q04609-1. | |||
TMPH-01298 |
EPHX1 Protein, Human, Recombinant (His)
EPHX1,Microsomal epoxide hydrolase,Epoxide hydratas... |
Human | E. coli |
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. | |||
TMPY-03330 |
BPHL Protein, Human, Recombinant (His)
biphenyl hydrolase-like (serine hydrolase)... |
Human | E. coli |
BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir ... | |||
TMPY-00583 |
ADPRH Protein, Human, Recombinant (His)
ADP-ribosylarginine hydrolase,ARH1 |
Human | E. coli |
Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water and electrolyte losses. Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleaves the ADP-ribose-(arginine)protein bond, regenerating native protein and completing an ADP-ribosylation cycle. CT-catalyzed ADP-r... | |||
TMPH-03190 |
CPG2 Protein, Pseudomonas sp., Recombinant (GST)
Folate hydrolase G2,Pteroylmonoglutamic acid hy... |
Pseudomonas | E. coli |
Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity. CPG2 Protein, Pseudomonas sp., Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.7 kDa and the accession number is P06621. | |||
TMPH-00888 |
APEH Protein, Human, Recombinant (His)
Acylamino-acid-releasing enzyme,Acylaminoacyl-peptidase,Oxid... |
Human | E. coli |
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. APEH Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 85.2 kDa and the accession number is P13798. | |||
TMPH-00760 |
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His)
Cutin hydrolase,CUTA,Cutinase |
Neocosmosporum cucurbitae | P. pastoris (Yeast) |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is Q99174. | |||
TMPH-00761 |
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant
Cutin hydrolase,CUTA,Cutinase |
Neocosmosporum cucurbitae | E. coli |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.4 kDa and the accession number is Q99174. | |||
TMPH-00424 |
Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO)
Cutinase,CUTA,Cutin hydrolase |
Colletotrichum capsici | E. coli |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.0 kDa and the accession number is P10951. | |||
TMPY-00410 |
EPHX2 Protein, Human, Recombinant (His)
SEH,CEH,epoxide hydrolase 2, cytoplasmic |
Human | Baculovirus Insect Cells |
Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas... | |||
TMPY-01865 |
BLMH Protein, Mouse, Recombinant (His)
Bh,bleomycin hydrolase,Bmh,AI035728 |
Mouse | E. coli |
The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica... | |||
TMPH-00657 |
NlpD Protein, E. coli, Recombinant (His & SUMO)
Murein hydrolase activator NlpD,nlpD |
E. coli | E. coli |
Activator of the cell wall hydrolase AmiC. Required for septal murein cleavage and daughter cell separation during cell division. | |||
TMPH-01533 |
PPA1 Protein, Human, Recombinant (His)
Inorganic pyrophosphatase,PPA1,Pyrophosphate phospho-hyd... |
Human | E. coli |
N/A. PPA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 10.8 kDa and the accession number is Q15181. | |||
TMPY-01737 |
Meprin alpha/MEP1A Protein, Human, Recombinant (His)
meprin A, α (PABA peptide hydrolase),meprin A, alph... |
Human | HEK293 Cells |
Meprin alpha/MEP1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.7 kDa and the accession number is Q16819. | |||
TMPH-01511 |
GLO2 Protein, Human, Recombinant (GST)
Glyoxalase II,Hydroxyacylglutathione hydrolase, mit... |
Human | E. coli |
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. | |||
TMPJ-00202 |
CD157 Protein, Human, Recombinant (hFc)
Cyclic ADP-ribose hydrolase 2,cADPr hydrolase |
Human | HEK293 Cells |
The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth. CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities followed with CD38. It plays a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derive... | |||
TMPH-00933 |
ADTRP Protein, Human, Recombinant (His & Myc)
Fatty acid esters of hydroxy fatty acids hydrolase ... |
Human | E. coli |
ADTRP Protein, Human, Recombinant (His & Myc) is expressed in in vitro E. coli expression system. | |||
TMPY-06325 |
USP14 Protein, Human, Recombinant (His)
USP14,Ubiquitin carboxyl-terminal hydrolase 14,TGT |
Human | E. coli |
USP14 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 56.9 kDa and the accession number is NP_005142.1. | |||
TMPH-00589 |
SpoT Protein, E. coli, Recombinant (His & Myc)
Bifunctional (p)ppGpp synthase/hydrolase SpoT,spoT |
E. coli | E. coli |
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response which coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c-di-GMP induces it. ppGpp activates transcription of CsrA-antagonistic small ... | |||
TMPH-01325 |
FAAH2 Protein, Human, Recombinant (His)
Amidase domain-containing protein,Anandamide amidohydrol... |
Human | E. coli |
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. FAAH2 Protein, Human, Recombinant (His) is expressed in E. coli e... | |||
TMPY-02288 |
Glyoxalase II/HAGH Protein, Human, Recombinant (His)
HAGH1,GLO2,GLX2,hydroxyacylglutathione hydrolase,GL... |
Human | E. coli |
HAGH (Hydroxyacylglutathione Hydrolase) is a Protein Coding gene. 3 alternative splicing and alternative initiation of human isoforms have been reported. The enzyme encoded by this gene is classified as a thioesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. HAGH belongs to the Metallo-beta-lactamase superfamily. HAGH is widely expressed in the kidney, liver, and other tissues. Diseases associated with HAGH include Hydroxyacyl Glutathio... | |||
TMPJ-00876 |
FAH Protein, Human, Recombinant (His)
Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,... |
Human | HEK293 Cells |
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep... | |||
TMPJ-00459 |
Esterase D Protein, Human, Recombinant (His)
FGH,Methylumbelliferyl-Acetate Deacetylase,ESD,S-Formylgluta... |
Human | E. coli |
Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acetylated sialic acids, which may involves in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson’s disease. | |||
TMPH-00893 |
AHCY Protein, Human, Recombinant (His & SUMO)
AdoHcyase,S-adenosyl-L-homocysteine hydrolase,SAHH,... |
Human | E. coli |
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. AHCY Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.6 kDa and the accession number is P23526. | |||
TMPH-00673 |
NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His)
NAD-capped RNA hydrolase NudC,nudC,NADH pyrophospha... |
E. coli | E. coli |
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates. NADH pyrophosphatase Protein, E. coli O157:H7, Recombina... | |||
TMPY-01318 |
Meprin alpha/MEP1A Protein, Mouse, Recombinant (His)
meprin A, alpha (PABA peptide hydrolase),AW107200,M... |
Mouse | HEK293 Cells |
Meprin alpha/MEP1A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69 kDa and the accession number is A0A0R4J043. | |||
TMPH-01599 |
LCTL Protein, Human, Recombinant (His & Myc)
Lactase-like protein,Klotho/lactase-phlorizin hydrolase<... |
Human | E. coli |
Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. LCTL Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 67.2 kDa and the accession number is Q6UWM7. | |||
TMPJ-01326 |
HDHD2 Protein, Human, Recombinant (His)
HDHD2,Haloacid Dehalogenase-Like Hydrolase Domain-C... |
Human | E. coli |
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22 (HDHD2) is a member of the HAD-like hydrolase superfamily. HDHD2 includes L-2-Haloacid Dehalogenase, Epoxide Hydrolases and Phosphatases. There are two active sites in HDHD2 - an L-2-Haloacid Dehalogenase and a Carboxylate group. The L-2-Haloacid Dehalogenase active site catalyzes the hydrolytic dehalogenation of D- and L-2-Haloalkanoic Acids, producing L- and D-2-Hydroxyalkanoic Acids. | |||
TMPH-02866 |
RBBP9 Protein, Mouse, Recombinant (His)
Retinoblastoma-binding protein 9,Putative hydrolase... |
Mouse | P. pastoris (Yeast) |
Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. RBBP9 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 22.4 kDa and t... | |||
TMPY-01390 |
PSMA Protein, Mouse, Recombinant (His)
mopsm,folate hydrolase (prostate-specific membrane ... |
Mouse | HEK293 Cells |
PSMA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 81.8 kDa and the accession number is O35409. | |||
TMPH-02549 |
FHIT Protein, Mouse, Recombinant (His)
Adenylylsulfatase,Adenylylsulfate-ammonia adenylyltransferas... |
Mouse | E. coli |
Possesses dinucleoside triphosphate hydrolase activity. Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate. Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monop... | |||
TMPJ-00190 |
CD38 Protein, Mouse, Recombinant (hFc)
ADP-ribosyl cyclase 1,cyclic ADP-ribose hydrolase,T... |
Mouse | HEK293 Cells |
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Th... | |||
TMPH-03323 |
LIPA Protein, Rat, Recombinant (His)
Lysosomal acid lipase/cholesteryl ester hydrolase,L... |
Rat | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is Q64194. | |||
TMPH-02749 |
LCTL Protein, Mouse, Recombinant (His & Myc)
Lactase-like protein,Klotho/lactase-phlorizin hydrolase<... |
Mouse | E. coli |
LCTL Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-00907 |
MACROD1 Protein, Human, Recombinant (His)
MACROD1,Protein LRP16,O-acetyl-ADP-ribose deacetylase MACROD... |
Human | E. coli |
MACROD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 41.5 kDa and the accession number is Q9BQ69. | |||
TMPH-00908 |
MACROD1 Protein, Human, Recombinant (His & Myc)
ADP-ribose glycohydrolase MACROD1,MACROD1,[Protein ... |
Human | Baculovirus Insect Cells |
MACROD1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-01929 |
ABHD18 Protein, Human, Recombinant (His & SUMO)
Abhydrolase domain-containing protein 18,Alpha/beta... |
Human | E. coli |
ABHD18 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01626 |
LIPA Protein, Human, Recombinant (GST)
Lysosomal acid lipase/cholesteryl ester hydrolase,L... |
Human | E. coli |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 70.0 kDa and the accession number is P38571. | |||
TMPY-03572 |
PTRH2 Protein, Human, Recombinant (His)
PTH 2,PTH2,peptidyl-tRNA hydrolase 2,CGI-147,CFAP37... |
Human | E. coli |
PTH2, also known as PTRH2, is a mitochondrial protein that belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. When in the cytoplasm, PTRH2 regulates the function of 2 transcriptional regulators, TLE5 and TLE1, thus promoting caspase-independent cell death. | |||
TMPH-01740 |
SARM1 Protein, Human, Recombinant (His & Myc)
Tir-1 homolog,Sterile alpha and Armadillo repeat protein,Ste... |
Human | Baculovirus Insect Cells |
SARM1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 80.4 kDa and the accession number is Q6SZW1. | |||
TMPH-01625 |
LIPA Protein, Human, Recombinant (His)
Cholesteryl esterase,Lysosomal acid lipase/cholesteryl ester... |
Human | P. pastoris (Yeast) |
Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. LIPA Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P38571. | |||
TMPH-01741 |
SARM1 Protein, Human, Recombinant (His & KSI)
Sterile alpha and Armadillo repeat protein,Sterile alpha mot... |
Human | E. coli |
SARM1 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 48.8 kDa and the accession number is Q6SZW1. | |||
TMPH-02283 |
USP18 Protein, Human, Recombinant (His)
ISG15-specific-processing protease,Ubl thioesterase 18,Ubl c... |
Human | E. coli |
USP18 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 47.1 kDa and the accession number is Q9UMW8. | |||
TMPH-02284 |
USP26 Protein, Human, Recombinant (His)
USP26,Deubiquitinating enzyme 26,Ubiquitin thioesterase 26,U... |
Human | E. coli |
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. | |||
TMPH-01689 |
PLD6 Protein, Human, Recombinant (His)
Mitochondrial phospholipase,Choline phosphatase 6,Protein zu... |
Human | E. coli |
Presents phospholipase and nuclease activities, depending on the different physiological conditions. Interaction with Mitoguardin (MIGA1 or MIGA2) affects the dimer conformation, facilitating the lipase activity over the nuclease activity. Plays a key role in mitochondrial fusion and fission via its phospholipase activity. In its phospholipase role, it uses the mitochondrial lipid cardiolipin as substrate to generate phosphatidate (PA or 1,2-diacyl-sn-glycero-3-phosphate), a second messenger sig... | |||
TMPY-06960 |
PSMA Protein, Human, Recombinant (His & Avi), Biotinylated
GCPII,FGCP,folate hydrolase (prostate-specific memb... |
Human | HEK293 Cells |
PSMA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 82.72 kDa and the accession number is NP_004467.1. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T70882 |
Orlistat-d3
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Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... |